Gs -
α1D-adrenoceptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 71.0
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.8
PAE mean: 11.6
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | C-term | I | 572 | - | G.H2 | R | 231 | G.H2.04 |
Van-der-waals | C-term | I | 572 | - | G.H2 | R | 231 | G.H2.04 |
Ionic | TM4 | E | 210 | 4x39 | G.hns1 | R | 38 | G.hns1.02 |
Polar | TM4 | E | 210 | 4x39 | G.hns1 | R | 38 | G.hns1.02 |
Van-der-waals | TM4 | E | 210 | 4x39 | G.hns1 | R | 38 | G.hns1.02 |
Aromatic | ICL2 | Y | 204 | 34x53 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | ICL2 | Y | 204 | 34x53 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | ICL3 | G | 291 | - | G.S6 | P | 361 | G.S6.03 |
Hydrophobic | TM3 | V | 198 | 3x54 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | ICL3 | K | 293 | - | G.H4 | L | 346 | G.H4.16 |
Van-der-waals | ICL3 | K | 293 | - | G.H4 | L | 346 | G.H4.16 |
Hydrophobic | ICL3 | K | 293 | - | G.h4s6 | T | 350 | G.h4s6.03 |
Hydrophobic | TM6 | A | 346 | 6x33 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM6 | A | 346 | 6x33 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | ICL3 | K | 293 | - | G.H4 | R | 347 | G.H4.17 |
Ionic | TM4 | E | 210 | 4x39 | G.HN | K | 34 | G.HN.51 |
Polar | TM4 | E | 210 | 4x39 | G.HN | K | 34 | G.HN.51 |
Van-der-waals | TM4 | E | 210 | 4x39 | G.HN | K | 34 | G.HN.51 |
Hydrophobic | C-term | I | 572 | - | G.H2 | R | 232 | G.H2.05 |
Van-der-waals | C-term | I | 572 | - | G.H2 | R | 232 | G.H2.05 |
Hydrophobic | C-term | L | 544 | - | G.S3 | N | 218 | G.S3.02 |
Van-der-waals | C-term | L | 544 | - | G.S3 | N | 218 | G.S3.02 |
Hydrophobic | C-term | A | 558 | - | G.S2 | F | 208 | G.S2.02 |
Hydrophobic | ICL2 | L | 202 | 34x51 | G.S3 | V | 217 | G.S3.01 |
Hydrophobic | TM5 | T | 284 | 5x68 | G.H5 | R | 385 | G.H5.17 |
Van-der-waals | TM5 | T | 284 | 5x68 | G.H5 | R | 385 | G.H5.17 |
Polar | ICL2 | S | 201 | 34x50 | G.H5 | R | 380 | G.H5.12 |
Van-der-waals | ICL2 | S | 201 | 34x50 | G.H5 | R | 380 | G.H5.12 |
Hydrophobic | ICL2 | L | 202 | 34x51 | G.H5 | R | 380 | G.H5.12 |
Van-der-waals | ICL2 | L | 202 | 34x51 | G.H5 | R | 380 | G.H5.12 |
Hydrophobic | TM5 | L | 288 | 5x72 | G.H5 | R | 385 | G.H5.17 |
Van-der-waals | TM5 | L | 288 | 5x72 | G.H5 | R | 385 | G.H5.17 |
Hydrophobic | C-term | V | 539 | - | G.S2 | V | 214 | G.S2.08 |
Polar | TM4 | E | 210 | 4x39 | G.HN | Q | 31 | G.HN.48 |
Van-der-waals | TM4 | E | 210 | 4x39 | G.HN | Q | 31 | G.HN.48 |
Ionic | C-term | H | 548 | - | G.h1ha | E | 74 | G.h1ha.10 |
Polar | C-term | H | 548 | - | G.h1ha | E | 74 | G.h1ha.10 |
Hydrophobic | C-term | H | 548 | - | G.h1ha | E | 74 | G.h1ha.10 |
Van-der-waals | C-term | H | 548 | - | G.h1ha | E | 74 | G.h1ha.10 |
Ionic | C-term | E | 569 | - | G.H2 | R | 231 | G.H2.04 |
Hydrophobic | TM5 | L | 288 | 5x72 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | C-term | I | 572 | - | G.h2s4 | F | 238 | G.h2s4.01 |
Hydrophobic | C-term | S | 543 | - | G.h1ha | N | 66 | G.h1ha.02 |
Hydrophobic | ICL2 | L | 202 | 34x51 | G.H5 | C | 379 | G.H5.11 |
Hydrophobic | ICL2 | S | 201 | 34x50 | G.H5 | I | 383 | G.H5.15 |
Polar | TM3 | V | 198 | 3x54 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | TM3 | V | 198 | 3x54 | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | TM3 | V | 198 | 3x54 | G.H5 | Q | 384 | G.H5.16 |
Polar | TM6 | T | 349 | 6x36 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | TM6 | T | 349 | 6x36 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | TM6 | T | 349 | 6x36 | G.H5 | E | 392 | G.H5.24 |
Polar | C-term | Y | 564 | - | G.H2 | Q | 236 | G.H2.09 |
Hydrophobic | C-term | Y | 564 | - | G.H2 | Q | 236 | G.H2.09 |
Van-der-waals | C-term | Y | 564 | - | G.H2 | Q | 236 | G.H2.09 |
Ionic | H8 | K | 410 | 8x51 | G.H5 | E | 392 | G.H5.24 |
Polar | H8 | K | 410 | 8x51 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | ICL2 | L | 202 | 34x51 | G.H5 | I | 383 | G.H5.15 |
Van-der-waals | ICL2 | L | 202 | 34x51 | G.H5 | I | 383 | G.H5.15 |
Polar | ICL2 | K | 203 | 34x52 | G.s2s3 | D | 215 | G.s2s3.01 |
Hydrophobic | ICL2 | K | 203 | 34x52 | G.s2s3 | D | 215 | G.s2s3.01 |
Van-der-waals | ICL2 | K | 203 | 34x52 | G.s2s3 | D | 215 | G.s2s3.01 |
Hydrophobic | C-term | L | 561 | - | G.H2 | K | 233 | G.H2.06 |
Van-der-waals | C-term | L | 561 | - | G.H2 | K | 233 | G.H2.06 |
Hydrophobic | TM5 | L | 288 | 5x72 | G.h4s6 | Y | 358 | G.h4s6.20 |
Van-der-waals | TM5 | L | 288 | 5x72 | G.h4s6 | Y | 358 | G.h4s6.20 |
Hydrophobic | C-term | C | 556 | - | G.S2 | F | 208 | G.S2.02 |
Van-der-waals | C-term | C | 556 | - | G.S2 | F | 208 | G.S2.02 |
Hydrophobic | C-term | V | 539 | - | G.s2s3 | D | 215 | G.s2s3.01 |
Van-der-waals | C-term | V | 539 | - | G.s2s3 | D | 215 | G.s2s3.01 |
Polar | C-term | V | 542 | - | G.S2 | Q | 213 | G.S2.07 |
Van-der-waals | C-term | V | 542 | - | G.S2 | Q | 213 | G.S2.07 |
Ionic | ICL3 | K | 293 | - | G.H4 | D | 343 | G.H4.13 |
Polar | ICL3 | K | 293 | - | G.H4 | D | 343 | G.H4.13 |
Hydrophobic | ICL3 | K | 293 | - | G.H4 | D | 343 | G.H4.13 |
Van-der-waals | ICL3 | K | 293 | - | G.H4 | D | 343 | G.H4.13 |
Hydrophobic | ICL2 | S | 201 | 34x50 | G.H5 | H | 387 | G.H5.19 |
Polar | C-term | Y | 564 | - | G.H2 | R | 232 | G.H2.05 |
Hydrophobic | C-term | Y | 564 | - | G.H2 | R | 232 | G.H2.05 |
Van-der-waals | C-term | Y | 564 | - | G.H2 | R | 232 | G.H2.05 |
Hydrophobic | ICL3 | V | 292 | - | G.h4s6 | T | 350 | G.h4s6.03 |
Hydrophobic | TM5 | V | 277 | 5x61 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM5 | V | 277 | 5x61 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | TM2 | T | 131 | 2x39 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM5 | V | 280 | 5x64 | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | TM5 | V | 280 | 5x64 | G.H5 | Q | 384 | G.H5.16 |
Polar | ICL2 | L | 202 | 34x51 | G.S1 | H | 41 | G.S1.02 |
Hydrophobic | ICL2 | L | 202 | 34x51 | G.S1 | H | 41 | G.S1.02 |
Van-der-waals | ICL2 | L | 202 | 34x51 | G.S1 | H | 41 | G.S1.02 |
Hydrophobic | TM5 | A | 281 | 5x65 | G.H5 | L | 388 | G.H5.20 |
Hydrophobic | TM3 | V | 198 | 3x54 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | ICL3 | G | 291 | - | G.H4 | L | 346 | G.H4.16 |
Van-der-waals | ICL3 | G | 291 | - | G.H4 | L | 346 | G.H4.16 |
Hydrophobic | ICL2 | P | 205 | 34x54 | G.hns1 | A | 39 | G.hns1.03 |
Polar | ICL1 | Q | 128 | 12x51 | G.hns1 | R | 38 | G.hns1.02 |
Hydrophobic | C-term | L | 567 | - | G.H2 | I | 235 | G.H2.08 |
Hydrophobic | C-term | L | 544 | - | G.S2 | Q | 213 | G.S2.07 |
Van-der-waals | C-term | L | 544 | - | G.S2 | Q | 213 | G.S2.07 |
Hydrophobic | ICL2 | P | 205 | 34x54 | G.hns1 | R | 38 | G.hns1.02 |
Van-der-waals | ICL2 | P | 205 | 34x54 | G.hns1 | R | 38 | G.hns1.02 |
Hydrophobic | C-term | I | 572 | - | G.H3 | N | 279 | G.H3.15 |
Van-der-waals | C-term | I | 572 | - | G.H3 | N | 279 | G.H3.15 |
Aromatic | TM3 | R | 194 | 3x50 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM3 | R | 194 | 3x50 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM3 | R | 194 | 3x50 | G.H5 | Y | 391 | G.H5.23 |
Polar | TM3 | G | 197 | 3x53 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | TM3 | G | 197 | 3x53 | G.H5 | H | 387 | G.H5.19 |
Van-der-waals | TM3 | G | 197 | 3x53 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | C-term | L | 561 | - | G.H2 | Q | 236 | G.H2.09 |
Van-der-waals | C-term | L | 561 | - | G.H2 | Q | 236 | G.H2.09 |
Hydrophobic | TM4 | T | 209 | 4x38 | G.HN | Q | 35 | G.HN.52 |
Van-der-waals | TM4 | T | 209 | 4x38 | G.HN | Q | 35 | G.HN.52 |
Hydrophobic | C-term | A | 541 | - | G.H1 | H | 64 | G.H1.12 |
Hydrophobic | TM3 | V | 198 | 3x54 | G.H5 | L | 388 | G.H5.20 |
Polar | TM6 | K | 345 | 6x32 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | TM6 | K | 345 | 6x32 | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | TM6 | K | 345 | 6x32 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | TM6 | K | 345 | 6x32 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | TM6 | K | 345 | 6x32 | G.H5 | E | 392 | G.H5.24 |
Ionic | C-term | E | 569 | - | G.H2 | R | 228 | G.H2.01 |
Polar | C-term | L | 561 | - | G.H2 | R | 232 | G.H2.05 |
Van-der-waals | C-term | L | 561 | - | G.H2 | R | 232 | G.H2.05 |
Hydrophobic | ICL2 | L | 202 | 34x51 | G.S3 | F | 219 | G.S3.03 |
Polar | ICL3 | R | 296 | - | G.hgh4 | T | 319 | G.hgh4.09 |
Hydrophobic | ICL3 | R | 296 | - | G.hgh4 | T | 319 | G.hgh4.09 |
Van-der-waals | ICL3 | R | 296 | - | G.hgh4 | T | 319 | G.hgh4.09 |
Ionic | ICL3 | R | 294 | - | G.hgh4 | D | 323 | G.hgh4.13 |
Hydrophobic | ICL3 | R | 294 | - | G.hgh4 | D | 323 | G.hgh4.13 |
Van-der-waals | ICL3 | R | 294 | - | G.hgh4 | D | 323 | G.hgh4.13 |
Polar | TM5 | T | 284 | 5x68 | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | TM5 | T | 284 | 5x68 | G.H5 | Q | 384 | G.H5.16 |
Polar | ICL2 | S | 201 | 34x50 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | ICL2 | S | 201 | 34x50 | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | C-term | A | 541 | - | G.S2 | Q | 213 | G.S2.07 |
Hydrophobic | TM6 | R | 342 | 6x29 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | TM6 | L | 350 | 6x37 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM6 | L | 350 | 6x37 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | TM7 | S | 405 | 7x56 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | TM7 | S | 405 | 7x56 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | ICL2 | L | 202 | 34x51 | G.H5 | F | 376 | G.H5.08 |
Van-der-waals | ICL2 | L | 202 | 34x51 | G.H5 | F | 376 | G.H5.08 |
Hydrophobic | ICL2 | K | 203 | 34x52 | G.S3 | V | 217 | G.S3.01 |
Van-der-waals | ICL2 | K | 203 | 34x52 | G.S3 | V | 217 | G.S3.01 |
Hydrophobic | TM6 | T | 349 | 6x36 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | TM5 | T | 284 | 5x68 | G.H5 | L | 388 | G.H5.20 |