Gz - α1D-adrenoceptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 69.5

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.7
PAE mean: 13.1


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL2 S 201 34x50 G.H5 T 341 G.H5.12
Polar TM6 R 342 6x29 G.h4s6 E 316 G.h4s6.09
Van-der-waals TM6 R 342 6x29 G.h4s6 E 316 G.h4s6.09
Polar TM7 S 405 7x56 G.H5 I 352 G.H5.23
Hydrophobic TM7 S 405 7x56 G.H5 I 352 G.H5.23
Van-der-waals TM7 S 405 7x56 G.H5 I 352 G.H5.23
Polar C-term L 567 - G.H2 K 210 G.H2.05
Van-der-waals C-term L 567 - G.H2 K 210 G.H2.05
Hydrophobic ICL2 S 201 34x50 G.H5 I 344 G.H5.15
Hydrophobic ICL2 K 203 34x52 G.S3 L 195 G.S3.01
Hydrophobic TM5 L 288 5x72 G.H5 D 342 G.H5.13
Hydrophobic TM6 L 350 6x37 G.H5 L 354 G.H5.25
Van-der-waals TM6 L 350 6x37 G.H5 L 354 G.H5.25
Hydrophobic ICL3 V 292 - G.h4s6 E 319 G.h4s6.12
Van-der-waals ICL3 V 292 - G.h4s6 E 319 G.h4s6.12
Hydrophobic TM3 V 198 3x54 G.H5 N 348 G.H5.19
Polar TM3 G 197 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM3 G 197 3x53 G.H5 N 348 G.H5.19
Van-der-waals TM3 G 197 3x53 G.H5 N 348 G.H5.19
Hydrophobic ICL2 A 206 34x55 G.hns1 R 32 G.hns1.03
Ionic ICL3 R 296 - G.H4 E 309 G.H4.16
Polar ICL3 R 296 - G.H4 E 309 G.H4.16
Hydrophobic ICL3 R 296 - G.H4 E 309 G.H4.16
Van-der-waals ICL3 R 296 - G.H4 E 309 G.H4.16
Hydrophobic TM5 A 281 5x65 G.H5 L 349 G.H5.20
Van-der-waals TM5 A 281 5x65 G.H5 L 349 G.H5.20
Hydrophobic C-term Y 434 - G.H2 I 213 G.H2.08
Polar ICL3 E 295 - G.H4 V 302 G.H4.08
Hydrophobic ICL3 E 295 - G.H4 V 302 G.H4.08
Van-der-waals ICL3 E 295 - G.H4 V 302 G.H4.08
Hydrophobic C-term V 539 - G.h1ha S 58 G.h1ha.01
Van-der-waals ICL3 E 295 - G.H4 Q 305 G.H4.12
Polar TM5 T 284 5x68 G.H5 D 342 G.H5.13
Hydrophobic TM5 T 284 5x68 G.H5 D 342 G.H5.13
Van-der-waals TM5 T 284 5x68 G.H5 D 342 G.H5.13
Hydrophobic TM5 L 288 5x72 G.S6 Y 321 G.S6.02
Van-der-waals TM5 L 288 5x72 G.S6 Y 321 G.S6.02
Polar TM4 E 210 4x39 G.HN Q 28 G.HN.52
Hydrophobic TM4 E 210 4x39 G.HN Q 28 G.HN.52
Van-der-waals TM4 E 210 4x39 G.HN Q 28 G.HN.52
Hydrophobic ICL2 L 202 34x51 G.H5 F 337 G.H5.08
Van-der-waals ICL2 L 202 34x51 G.H5 F 337 G.H5.08
Hydrophobic ICL2 L 202 34x51 G.H5 V 340 G.H5.11
Polar TM7 S 405 7x56 G.H5 Y 351 G.H5.22
Hydrophobic ICL2 S 201 34x50 G.H5 I 345 G.H5.16
Hydrophobic TM5 V 277 5x61 G.H5 L 349 G.H5.20
Hydrophobic TM7 S 405 7x56 G.H5 G 353 G.H5.24
Polar TM6 A 346 6x33 G.H5 L 354 G.H5.25
Hydrophobic TM6 A 346 6x33 G.H5 L 354 G.H5.25
Van-der-waals TM6 A 346 6x33 G.H5 L 354 G.H5.25
Hydrophobic ICL2 L 202 34x51 G.H5 I 344 G.H5.15
Van-der-waals ICL2 L 202 34x51 G.H5 I 344 G.H5.15
Hydrophobic TM5 V 277 5x61 G.H5 L 354 G.H5.25
Van-der-waals TM5 V 277 5x61 G.H5 L 354 G.H5.25
Hydrophobic TM3 V 198 3x54 G.H5 L 349 G.H5.20
Hydrophobic TM5 V 280 5x64 G.H5 I 345 G.H5.16
Polar H8 E 408 8x49 G.H5 Y 351 G.H5.22
Hydrophobic H8 E 408 8x49 G.H5 Y 351 G.H5.22
Hydrophobic ICL3 R 330 - G.h4s6 K 315 G.h4s6.08
Van-der-waals ICL3 R 330 - G.h4s6 K 315 G.h4s6.08
Polar ICL3 R 296 - G.H4 R 306 G.H4.13
Hydrophobic ICL3 R 296 - G.H4 R 306 G.H4.13
Van-der-waals ICL3 R 296 - G.H4 R 306 G.H4.13
Hydrophobic TM6 K 345 6x32 G.H5 L 354 G.H5.25
Polar TM5 S 287 5x71 G.H5 D 342 G.H5.13
Hydrophobic TM5 S 287 5x71 G.H5 D 342 G.H5.13
Van-der-waals TM5 S 287 5x71 G.H5 D 342 G.H5.13
Polar C-term I 572 - G.H3 S 253 G.H3.11
Hydrophobic C-term I 572 - G.H3 S 253 G.H3.11
Van-der-waals C-term I 572 - G.H3 S 253 G.H3.11
Hydrophobic TM5 T 284 5x68 G.H5 Q 346 G.H5.17
Ionic ICL2 K 203 34x52 G.s2s3 E 194 G.s2s3.02
Polar ICL2 K 203 34x52 G.s2s3 E 194 G.s2s3.02
Hydrophobic ICL2 K 203 34x52 G.s2s3 E 194 G.s2s3.02
Van-der-waals ICL2 K 203 34x52 G.s2s3 E 194 G.s2s3.02
Hydrophobic TM6 T 349 6x36 G.H5 L 354 G.H5.25
Van-der-waals TM6 T 349 6x36 G.H5 L 354 G.H5.25
Polar TM6 T 349 6x36 G.H5 G 353 G.H5.24
Hydrophobic TM6 T 349 6x36 G.H5 G 353 G.H5.24
Van-der-waals TM6 T 349 6x36 G.H5 G 353 G.H5.24
Ionic TM4 E 210 4x39 G.hns1 R 31 G.hns1.02
Polar TM4 E 210 4x39 G.hns1 R 31 G.hns1.02
Van-der-waals TM4 E 210 4x39 G.hns1 R 31 G.hns1.02
Polar TM2 N 132 2x40 G.H5 Y 351 G.H5.22
Van-der-waals TM2 N 132 2x40 G.H5 Y 351 G.H5.22
Hydrophobic ICL3 E 295 - G.S6 F 324 G.S6.05
Van-der-waals ICL3 E 295 - G.S6 F 324 G.S6.05
Hydrophobic ICL2 P 205 34x54 G.hns1 R 31 G.hns1.02
Van-der-waals ICL2 P 205 34x54 G.hns1 R 31 G.hns1.02
Hydrophobic C-term I 572 - G.H2 K 210 G.H2.05
Ionic ICL3 R 330 - G.H4 D 310 G.H4.17
Polar ICL3 R 330 - G.H4 D 310 G.H4.17
Van-der-waals ICL3 R 330 - G.H4 D 310 G.H4.17
Hydrophobic TM3 R 194 3x50 G.H5 I 352 G.H5.23
Hydrophobic TM6 K 345 6x32 G.H5 G 353 G.H5.24
Van-der-waals TM6 K 345 6x32 G.H5 G 353 G.H5.24
Hydrophobic ICL2 L 202 34x51 G.S1 I 34 G.S1.02
Hydrophobic TM5 T 284 5x68 G.H5 I 345 G.H5.16
Van-der-waals TM5 T 284 5x68 G.H5 I 345 G.H5.16
Hydrophobic TM3 V 198 3x54 G.H5 I 352 G.H5.23
Ionic ICL3 R 296 - G.H4 D 310 G.H4.17
Polar ICL3 R 296 - G.H4 D 310 G.H4.17
Hydrophobic ICL3 R 296 - G.H4 D 310 G.H4.17
Van-der-waals ICL3 R 296 - G.H4 D 310 G.H4.17
Polar ICL2 K 203 34x52 G.s2s3 K 193 G.s2s3.01
Van-der-waals ICL2 K 203 34x52 G.s2s3 K 193 G.s2s3.01
Polar TM6 R 342 6x29 G.H5 Q 346 G.H5.17
Van-der-waals TM6 R 342 6x29 G.H5 Q 346 G.H5.17
Polar ICL2 P 205 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 P 205 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic TM5 L 288 5x72 G.H5 Q 346 G.H5.17
Van-der-waals TM5 L 288 5x72 G.H5 Q 346 G.H5.17
Ionic C-term E 569 - G.H2 R 206 G.H2.01
Hydrophobic C-term E 569 - G.H2 R 206 G.H2.01
Van-der-waals C-term E 569 - G.H2 R 206 G.H2.01
Ionic TM6 R 342 6x29 G.h4s6 E 319 G.h4s6.12
Polar TM6 R 342 6x29 G.h4s6 E 319 G.h4s6.12
Polar TM6 K 345 6x32 G.H5 C 355 G.H5.26
Hydrophobic TM6 K 345 6x32 G.H5 C 355 G.H5.26
Van-der-waals TM6 K 345 6x32 G.H5 C 355 G.H5.26
Hydrophobic TM5 L 288 5x72 G.h4s6 E 319 G.h4s6.12
Aromatic C-term W 438 - G.H2 K 211 G.H2.06
Hydrophobic C-term W 438 - G.H2 K 211 G.H2.06
Van-der-waals C-term W 438 - G.H2 K 211 G.H2.06
Hydrophobic ICL2 L 202 34x51 G.S3 L 195 G.S3.01
Van-der-waals ICL2 L 202 34x51 G.S3 L 195 G.S3.01
Hydrophobic C-term I 572 - G.H2 R 209 G.H2.04
Van-der-waals C-term I 572 - G.H2 R 209 G.H2.04
Hydrophobic ICL2 L 202 34x51 G.H5 T 341 G.H5.12
Van-der-waals ICL2 L 202 34x51 G.H5 T 341 G.H5.12
Aromatic C-term W 431 - G.H2 H 214 G.H2.09
Hydrophobic C-term W 431 - G.H2 H 214 G.H2.09
Van-der-waals C-term W 431 - G.H2 H 214 G.H2.09