Gi1 - α2A-adrenoceptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 87.5

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 10.7


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM7 F 444 7x56 G.H5 G 352 G.H5.24
Hydrophobic ICL2 A 153 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 A 153 34x50 G.H5 I 344 G.H5.16
Hydrophobic TM4 T 161 4x38 G.hns1 R 32 G.hns1.03
Van-der-waals TM4 T 161 4x38 G.hns1 R 32 G.hns1.03
Hydrophobic TM3 I 150 3x54 G.H5 N 347 G.H5.19
Polar TM6 R 383 6x29 G.h4s6 D 315 G.h4s6.09
Hydrophobic TM6 R 383 6x29 G.h4s6 D 315 G.h4s6.09
Van-der-waals TM6 R 383 6x29 G.h4s6 D 315 G.h4s6.09
Hydrophobic ICL2 L 158 34x55 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 L 158 34x55 G.s2s3 D 193 G.s2s3.02
Polar ICL2 L 158 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 L 158 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 L 158 34x55 G.hns1 R 32 G.hns1.03
Polar TM2 Q 83 2x39 G.H5 D 350 G.H5.22
Hydrophobic TM5 I 234 5x61 G.H5 L 353 G.H5.25
Van-der-waals TM5 I 234 5x61 G.H5 L 353 G.H5.25
Hydrophobic TM5 R 241 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 R 241 5x68 G.H5 I 344 G.H5.16
Hydrophobic TM6 F 387 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 L 391 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 391 6x37 G.H5 L 353 G.H5.25
Ionic ICL3 K 373 - G.H4 D 309 G.H4.17
Ionic ICL3 R 249 - G.H5 D 341 G.H5.13
Polar ICL3 R 249 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 R 249 - G.H5 D 341 G.H5.13
Hydrophobic TM3 I 150 3x54 G.H5 C 351 G.H5.23
Polar TM3 R 146 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 146 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 146 3x50 G.H5 C 351 G.H5.23
Hydrophobic ICL2 A 153 34x50 G.H5 I 343 G.H5.15
Hydrophobic TM6 V 390 6x36 G.H5 L 353 G.H5.25
Hydrophobic ICL2 I 154 34x51 G.H5 T 340 G.H5.12
Van-der-waals ICL2 I 154 34x51 G.H5 T 340 G.H5.12
Ionic TM5 R 241 5x68 G.H5 D 341 G.H5.13
Polar TM5 R 241 5x68 G.H5 D 341 G.H5.13
Hydrophobic ICL2 I 154 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 I 154 34x51 G.S3 L 194 G.S3.01
Hydrophobic TM5 P 246 5x73 G.S6 Y 320 G.S6.02
Van-der-waals TM5 P 246 5x73 G.S6 Y 320 G.S6.02
Polar TM3 S 149 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 S 149 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 S 149 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 I 150 3x54 G.H5 I 344 G.H5.16
Polar TM5 P 246 5x73 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM5 P 246 5x73 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM5 P 246 5x73 G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL2 I 154 34x51 G.H5 F 336 G.H5.08
Van-der-waals ICL2 I 154 34x51 G.H5 F 336 G.H5.08
Hydrophobic ICL2 L 158 34x55 G.S3 L 194 G.S3.01
Polar H8 N 445 8x47 G.H5 D 350 G.H5.22
Hydrophobic TM6 R 383 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 383 6x29 G.H5 F 354 G.H5.26
Hydrophobic TM3 I 150 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 150 3x54 G.H5 L 348 G.H5.20