G12 - α2C-adrenoceptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 86.6

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 12.9


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 V 157 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 V 157 34x51 G.S3 I 221 G.S3.01
Polar H8 N 441 8x47 G.H5 D 377 G.H5.22
Polar ICL3 V 251 - G.H4 Q 333 G.H4.13
Hydrophobic ICL3 V 251 - G.H4 Q 333 G.H4.13
Van-der-waals ICL3 V 251 - G.H4 Q 333 G.H4.13
Hydrophobic ICL2 A 156 34x50 G.H5 I 370 G.H5.15
Van-der-waals ICL2 A 156 34x50 G.H5 I 370 G.H5.15
Hydrophobic TM3 V 153 3x54 G.H5 I 378 G.H5.23
Van-der-waals TM3 V 153 3x54 G.H5 I 378 G.H5.23
Hydrophobic TM3 V 153 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 V 153 3x54 G.H5 L 371 G.H5.16
Polar ICL2 L 161 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 L 161 34x55 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 L 161 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 V 157 34x51 G.H5 I 370 G.H5.15
Polar ICL3 R 248 - G.h4s6 K 344 G.h4s6.19
Hydrophobic ICL3 R 248 - G.h4s6 K 344 G.h4s6.19
Van-der-waals ICL3 R 248 - G.h4s6 K 344 G.h4s6.19
Hydrophobic TM7 Y 437 7x53 G.H5 M 379 G.H5.24
Van-der-waals TM7 Y 437 7x53 G.H5 M 379 G.H5.24
Polar ICL2 A 156 34x50 G.H5 N 374 G.H5.19
Polar ICL3 R 248 - G.h4s6 S 343 G.h4s6.12
Hydrophobic ICL3 R 248 - G.h4s6 S 343 G.h4s6.12
Van-der-waals ICL3 R 248 - G.h4s6 S 343 G.h4s6.12
Polar ICL2 N 160 34x54 G.H5 N 374 G.H5.19
Hydrophobic ICL2 N 160 34x54 G.H5 N 374 G.H5.19
Van-der-waals ICL2 N 160 34x54 G.H5 N 374 G.H5.19
Hydrophobic TM5 I 233 5x61 G.H5 I 378 G.H5.23
Hydrophobic TM3 R 149 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 149 3x50 G.H5 I 378 G.H5.23
Hydrophobic ICL3 V 251 - G.H4 R 329 G.H4.09
Van-der-waals ICL3 V 251 - G.H4 R 329 G.H4.09
Hydrophobic TM5 I 233 5x61 G.H5 L 380 G.H5.25
Van-der-waals TM5 I 233 5x61 G.H5 L 380 G.H5.25
Hydrophobic TM5 A 237 5x65 G.H5 L 375 G.H5.20
Hydrophobic ICL2 N 160 34x54 G.H5 I 370 G.H5.15
Van-der-waals ICL2 N 160 34x54 G.H5 I 370 G.H5.15
Hydrophobic ICL2 A 156 34x50 G.H5 L 371 G.H5.16
Hydrophobic ICL2 V 157 34x51 G.H5 K 367 G.H5.12
Hydrophobic TM7 F 440 7x56 G.H5 M 379 G.H5.24
Van-der-waals TM7 F 440 7x56 G.H5 M 379 G.H5.24
Hydrophobic TM3 R 149 3x50 G.H5 M 379 G.H5.24
Van-der-waals TM3 R 149 3x50 G.H5 M 379 G.H5.24
Hydrophobic TM6 F 380 6x33 G.H5 L 380 G.H5.25
Hydrophobic TM5 A 237 5x65 G.H5 L 380 G.H5.25
Polar TM6 R 376 6x29 G.H5 Q 381 G.H5.26
Hydrophobic TM6 R 376 6x29 G.H5 Q 381 G.H5.26
Polar TM5 R 240 5x68 G.H5 L 371 G.H5.16
Hydrophobic TM5 R 240 5x68 G.H5 L 371 G.H5.16
Van-der-waals TM5 R 240 5x68 G.H5 L 371 G.H5.16
Hydrophobic TM5 L 244 5x72 G.h4s6 P 345 G.h4s6.20
Van-der-waals TM5 L 244 5x72 G.h4s6 P 345 G.h4s6.20
Polar TM2 Q 86 2x39 G.H5 D 377 G.H5.22
Polar TM3 S 152 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 S 152 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 S 152 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM5 R 240 5x68 G.H5 L 375 G.H5.20
Van-der-waals TM5 R 240 5x68 G.H5 L 375 G.H5.20
Polar ICL3 R 248 - G.h4s6 R 342 G.h4s6.11
Van-der-waals ICL3 R 248 - G.h4s6 R 342 G.h4s6.11
Hydrophobic TM4 R 166 4x40 G.HN R 52 G.HN.52
Van-der-waals TM4 R 166 4x40 G.HN R 52 G.HN.52
Hydrophobic TM6 L 384 6x37 G.H5 L 380 G.H5.25
Polar TM5 R 240 5x68 G.H5 Q 372 G.H5.17
Hydrophobic TM5 R 240 5x68 G.H5 Q 372 G.H5.17
Van-der-waals TM5 R 240 5x68 G.H5 Q 372 G.H5.17
Polar TM6 R 379 6x32 G.H5 Q 381 G.H5.26
Hydrophobic TM6 R 379 6x32 G.H5 Q 381 G.H5.26
Van-der-waals TM6 R 379 6x32 G.H5 Q 381 G.H5.26
Ionic ICL2 R 163 34x57 G.H5 D 377 G.H5.22
Hydrophobic ICL2 L 161 34x55 G.S3 I 221 G.S3.01
Hydrophobic H8 N 441 8x47 G.H5 M 379 G.H5.24
Polar C-term Q 462 - G.H3 K 284 G.H3.16
Hydrophobic C-term Q 462 - G.H3 K 284 G.H3.16
Van-der-waals C-term Q 462 - G.H3 K 284 G.H3.16
Hydrophobic TM6 V 383 6x36 G.H5 L 380 G.H5.25
Hydrophobic TM3 V 153 3x54 G.H5 L 375 G.H5.20
Ionic TM5 R 240 5x68 G.H5 D 368 G.H5.13
Polar TM5 R 240 5x68 G.H5 D 368 G.H5.13
Hydrophobic TM5 R 240 5x68 G.H5 D 368 G.H5.13
Van-der-waals TM5 R 240 5x68 G.H5 D 368 G.H5.13