Gs -
β1-adrenoceptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 83.6
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 11.9
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
Gβ,
Gγ,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | TM5 | Q | 254 | 5x68 | G.H5 | R | 385 | G.H5.17 |
Hydrophobic | TM5 | Q | 254 | 5x68 | G.H5 | R | 385 | G.H5.17 |
Van-der-waals | TM5 | Q | 254 | 5x68 | G.H5 | R | 385 | G.H5.17 |
Polar | ICL3 | R | 264 | - | G.hgh4 | T | 320 | G.hgh4.10 |
Hydrophobic | ICL3 | R | 264 | - | G.hgh4 | T | 320 | G.hgh4.10 |
Hydrophobic | C-term | P | 421 | - | G.H3 | W | 281 | G.H3.17 |
Hydrophobic | ICL2 | F | 164 | 34x51 | G.H5 | R | 380 | G.H5.12 |
Van-der-waals | ICL2 | F | 164 | 34x51 | G.H5 | R | 380 | G.H5.12 |
Hydrophobic | TM3 | I | 160 | 3x54 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | ICL2 | F | 164 | 34x51 | G.H5 | I | 383 | G.H5.15 |
Van-der-waals | ICL2 | F | 164 | 34x51 | G.H5 | I | 383 | G.H5.15 |
Hydrophobic | ICL3 | F | 265 | - | G.h4s6 | T | 350 | G.h4s6.03 |
Van-der-waals | ICL3 | F | 265 | - | G.h4s6 | T | 350 | G.h4s6.03 |
Polar | TM6 | T | 325 | 6x36 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | TM6 | T | 325 | 6x36 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | TM6 | T | 325 | 6x36 | G.H5 | E | 392 | G.H5.24 |
Polar | C-term | P | 420 | - | G.h3s5 | R | 283 | G.h3s5.01 |
Hydrophobic | C-term | P | 420 | - | G.h3s5 | R | 283 | G.h3s5.01 |
Van-der-waals | C-term | P | 420 | - | G.h3s5 | R | 283 | G.h3s5.01 |
Hydrophobic | TM3 | I | 160 | 3x54 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | ICL3 | F | 265 | - | G.H4 | R | 347 | G.H4.17 |
Hydrophobic | TM3 | I | 160 | 3x54 | G.H5 | H | 387 | G.H5.19 |
Ionic | H8 | R | 384 | 8x51 | G.H5 | E | 392 | G.H5.24 |
Polar | H8 | R | 384 | 8x51 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | H8 | R | 384 | 8x51 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | TM5 | V | 247 | 5x61 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM5 | V | 247 | 5x61 | G.H5 | L | 393 | G.H5.25 |
Polar | C-term | A | 427 | - | G.H5 | R | 389 | G.H5.21 |
Van-der-waals | C-term | A | 427 | - | G.H5 | R | 389 | G.H5.21 |
Hydrophobic | C-term | W | 448 | - | G.H3 | N | 271 | G.H3.07 |
Hydrophobic | TM3 | I | 160 | 3x54 | G.H5 | L | 388 | G.H5.20 |
Van-der-waals | ICL2 | Q | 167 | 34x54 | G.hns1 | R | 38 | G.hns1.02 |
Polar | C-term | P | 421 | - | G.h3s5 | R | 283 | G.h3s5.01 |
Van-der-waals | C-term | P | 421 | - | G.h3s5 | R | 283 | G.h3s5.01 |
Polar | TM2 | T | 93 | 2x39 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM2 | T | 93 | 2x39 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | ICL3 | E | 262 | - | G.h4s6 | T | 350 | G.h4s6.03 |
Hydrophobic | C-term | A | 426 | - | G.h4s6 | R | 356 | G.h4s6.12 |
Polar | ICL2 | Q | 167 | 34x54 | G.S1 | H | 41 | G.S1.02 |
Hydrophobic | ICL2 | Q | 167 | 34x54 | G.S1 | H | 41 | G.S1.02 |
Van-der-waals | ICL2 | Q | 167 | 34x54 | G.S1 | H | 41 | G.S1.02 |
Hydrophobic | ICL2 | Y | 166 | 34x53 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | ICL2 | P | 163 | 34x50 | G.H5 | I | 383 | G.H5.15 |
Van-der-waals | ICL2 | P | 163 | 34x50 | G.H5 | I | 383 | G.H5.15 |
Hydrophobic | TM6 | K | 321 | 6x32 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | TM5 | Q | 254 | 5x68 | G.H5 | L | 388 | G.H5.20 |
Polar | ICL3 | R | 264 | - | G.hgh4 | T | 319 | G.hgh4.09 |
Van-der-waals | ICL3 | R | 264 | - | G.hgh4 | T | 319 | G.hgh4.09 |
Hydrophobic | TM6 | L | 326 | 6x37 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM6 | L | 326 | 6x37 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | ICL3 | R | 264 | - | G.hgh4 | P | 321 | G.hgh4.11 |
Van-der-waals | ICL3 | R | 264 | - | G.hgh4 | P | 321 | G.hgh4.11 |
Polar | TM3 | D | 155 | 3x49 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | ICL2 | F | 164 | 34x51 | G.H5 | C | 379 | G.H5.11 |
Aromatic | ICL2 | F | 164 | 34x51 | G.H5 | F | 376 | G.H5.08 |
Hydrophobic | ICL2 | F | 164 | 34x51 | G.H5 | F | 376 | G.H5.08 |
Van-der-waals | ICL2 | F | 164 | 34x51 | G.H5 | F | 376 | G.H5.08 |
Hydrophobic | TM3 | R | 156 | 3x50 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM3 | R | 156 | 3x50 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | ICL2 | F | 164 | 34x51 | G.S3 | F | 219 | G.S3.03 |
Polar | C-term | S | 423 | - | G.h3s5 | T | 284 | G.h3s5.02 |
Hydrophobic | C-term | S | 423 | - | G.h3s5 | T | 284 | G.h3s5.02 |
Van-der-waals | C-term | S | 423 | - | G.h3s5 | T | 284 | G.h3s5.02 |
Polar | TM6 | K | 321 | 6x32 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | TM6 | K | 321 | 6x32 | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | TM6 | K | 321 | 6x32 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | C-term | A | 426 | - | G.H5 | R | 389 | G.H5.21 |
Hydrophobic | TM3 | A | 159 | 3x53 | G.H5 | Y | 391 | G.H5.23 |
Ionic | TM5 | K | 257 | 5x71 | G.H5 | D | 381 | G.H5.13 |
Polar | TM5 | K | 257 | 5x71 | G.H5 | D | 381 | G.H5.13 |
Hydrophobic | TM5 | K | 257 | 5x71 | G.H5 | D | 381 | G.H5.13 |
Van-der-waals | TM5 | K | 257 | 5x71 | G.H5 | D | 381 | G.H5.13 |
Hydrophobic | ICL2 | F | 164 | 34x51 | G.S3 | V | 217 | G.S3.01 |
Van-der-waals | ICL2 | F | 164 | 34x51 | G.S3 | V | 217 | G.S3.01 |
Hydrophobic | ICL3 | F | 265 | - | G.H4 | D | 343 | G.H4.13 |
Van-der-waals | ICL3 | F | 265 | - | G.H4 | D | 343 | G.H4.13 |
Polar | C-term | W | 448 | - | G.H3 | S | 275 | G.H3.11 |
Hydrophobic | C-term | W | 448 | - | G.H3 | S | 275 | G.H3.11 |
Van-der-waals | C-term | W | 448 | - | G.H3 | S | 275 | G.H3.11 |
Hydrophobic | TM5 | I | 258 | 5x72 | G.h4s6 | Y | 358 | G.h4s6.20 |
Hydrophobic | ICL3 | F | 265 | - | G.H4 | L | 346 | G.H4.16 |
Van-der-waals | ICL3 | F | 265 | - | G.H4 | L | 346 | G.H4.16 |
Hydrophobic | C-term | W | 448 | - | G.H3 | L | 272 | G.H3.08 |
Ionic | TM7 | R | 379 | 7x55 | G.H5 | E | 392 | G.H5.24 |
Polar | TM7 | R | 379 | 7x55 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | TM7 | R | 379 | 7x55 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | TM7 | R | 379 | 7x55 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | C-term | G | 453 | - | G.s4h3 | D | 260 | G.s4h3.11 |
Polar | TM3 | I | 160 | 3x54 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | TM3 | I | 160 | 3x54 | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | TM3 | I | 160 | 3x54 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | TM5 | I | 258 | 5x72 | G.H5 | R | 385 | G.H5.17 |
Van-der-waals | TM5 | I | 258 | 5x72 | G.H5 | R | 385 | G.H5.17 |
Polar | ICL3 | R | 264 | - | G.hgh4 | Y | 318 | G.hgh4.08 |
Van-der-waals | ICL3 | R | 264 | - | G.hgh4 | Y | 318 | G.hgh4.08 |
Hydrophobic | TM5 | I | 258 | 5x72 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | ICL3 | C | 261 | - | G.H4 | L | 346 | G.H4.16 |
Polar | C-term | S | 423 | - | G.h2s4 | N | 239 | G.h2s4.02 |
Hydrophobic | TM6 | T | 325 | 6x36 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | ICL2 | P | 163 | 34x50 | G.H5 | R | 380 | G.H5.12 |
Polar | TM5 | Q | 254 | 5x68 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | TM5 | Q | 254 | 5x68 | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | TM5 | Q | 254 | 5x68 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | TM5 | A | 251 | 5x65 | G.H5 | L | 388 | G.H5.20 |
Hydrophobic | ICL2 | P | 163 | 34x50 | G.H5 | H | 387 | G.H5.19 |
Aromatic | ICL2 | F | 164 | 34x51 | G.S1 | H | 41 | G.S1.02 |
Hydrophobic | ICL2 | F | 164 | 34x51 | G.S1 | H | 41 | G.S1.02 |
Van-der-waals | ICL2 | F | 164 | 34x51 | G.S1 | H | 41 | G.S1.02 |
Polar | TM5 | Q | 254 | 5x68 | G.H5 | D | 381 | G.H5.13 |
Hydrophobic | TM5 | Q | 254 | 5x68 | G.H5 | D | 381 | G.H5.13 |
Van-der-waals | TM5 | Q | 254 | 5x68 | G.H5 | D | 381 | G.H5.13 |
Hydrophobic | TM6 | A | 322 | 6x33 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM6 | A | 322 | 6x33 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | TM5 | V | 255 | 5x69 | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | TM5 | V | 255 | 5x69 | G.H5 | L | 394 | G.H5.26 |
Polar | TM3 | A | 159 | 3x53 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | TM3 | A | 159 | 3x53 | G.H5 | H | 387 | G.H5.19 |
Van-der-waals | TM3 | A | 159 | 3x53 | G.H5 | H | 387 | G.H5.19 |
Ionic | ICL3 | R | 264 | - | G.H4 | D | 343 | G.H4.13 |
Polar | ICL3 | R | 264 | - | G.H4 | D | 343 | G.H4.13 |
Van-der-waals | ICL3 | R | 264 | - | G.H4 | D | 343 | G.H4.13 |