G12 - β2-adrenoceptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 83.7

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 13.1


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 F 139 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 F 139 34x51 G.H5 I 370 G.H5.15
Hydrophobic TM5 A 226 5x65 G.H5 M 379 G.H5.24
Polar ICL2 S 143 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 S 143 34x55 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 S 143 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 F 139 34x51 G.H5 V 366 G.H5.11
Ionic TM5 K 232 5x71 G.H5 D 368 G.H5.13
Polar TM5 K 232 5x71 G.H5 D 368 G.H5.13
Hydrophobic TM5 K 232 5x71 G.H5 D 368 G.H5.13
Van-der-waals TM5 K 232 5x71 G.H5 D 368 G.H5.13
Hydrophobic ICL3 F 240 - G.H4 V 332 G.H4.12
Van-der-waals ICL3 F 240 - G.H4 V 332 G.H4.12
Hydrophobic ICL2 F 139 34x51 G.S1 V 58 G.S1.02
Hydrophobic TM3 I 135 3x54 G.H5 L 375 G.H5.20
Van-der-waals TM3 I 135 3x54 G.H5 L 375 G.H5.20
Hydrophobic C-term N 352 - G.H3 K 284 G.H3.16
Van-der-waals C-term N 352 - G.H3 K 284 G.H3.16
Hydrophobic ICL2 P 138 34x50 G.H5 I 370 G.H5.15
Van-der-waals ICL2 P 138 34x50 G.H5 I 370 G.H5.15
Polar TM3 A 134 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 A 134 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 A 134 3x53 G.H5 N 374 G.H5.19
Hydrophobic ICL2 F 139 34x51 G.H5 K 367 G.H5.12
Van-der-waals ICL2 F 139 34x51 G.H5 K 367 G.H5.12
Hydrophobic TM5 Q 229 5x68 G.H5 L 375 G.H5.20
Hydrophobic ICL3 F 240 - G.H4 D 336 G.H4.16
Hydrophobic TM6 A 271 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 A 271 6x33 G.H5 M 379 G.H5.24
Hydrophobic ICL3 F 240 - G.H4 Q 333 G.H4.13
Polar TM5 Q 229 5x68 G.H5 D 368 G.H5.13
Hydrophobic TM5 Q 229 5x68 G.H5 D 368 G.H5.13
Van-der-waals TM5 Q 229 5x68 G.H5 D 368 G.H5.13
Hydrophobic TM6 L 275 6x37 G.H5 M 379 G.H5.24
Hydrophobic TM6 T 274 6x36 G.H5 L 380 G.H5.25
Hydrophobic TM3 I 135 3x54 G.H5 I 378 G.H5.23
Van-der-waals TM3 I 135 3x54 G.H5 I 378 G.H5.23
Hydrophobic TM3 I 135 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 I 135 3x54 G.H5 L 371 G.H5.16
Aromatic ICL3 F 240 - G.S6 H 348 G.S6.03
Hydrophobic ICL3 F 240 - G.S6 H 348 G.S6.03
Van-der-waals ICL3 F 240 - G.S6 H 348 G.S6.03
Polar C-term G 353 - G.H3 K 284 G.H3.16
Van-der-waals C-term G 353 - G.H3 K 284 G.H3.16
Hydrophobic ICL2 F 139 34x51 G.S3 F 223 G.S3.03
Hydrophobic TM5 A 226 5x65 G.H5 L 375 G.H5.20
Van-der-waals TM5 A 226 5x65 G.H5 L 375 G.H5.20
Hydrophobic TM5 E 237 5x76 G.h4s6 P 345 G.h4s6.20
Polar C-term S 355 - G.h4s6 R 340 G.h4s6.09
Aromatic ICL2 F 139 34x51 G.H5 F 363 G.H5.08
Hydrophobic ICL2 F 139 34x51 G.H5 F 363 G.H5.08
Van-der-waals ICL2 F 139 34x51 G.H5 F 363 G.H5.08
Hydrophobic TM5 I 233 5x72 G.h4s6 P 345 G.h4s6.20
Hydrophobic TM7 R 328 7x55 G.H5 L 380 G.H5.25
Hydrophobic TM3 R 131 3x50 G.H5 I 378 G.H5.23
Hydrophobic ICL2 Q 142 34x54 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 Q 142 34x54 G.hns1 R 55 G.hns1.02
Polar TM5 Q 229 5x68 G.H5 Q 372 G.H5.17
Hydrophobic TM5 Q 229 5x68 G.H5 Q 372 G.H5.17
Van-der-waals TM5 Q 229 5x68 G.H5 Q 372 G.H5.17
Hydrophobic TM3 A 134 3x53 G.H5 I 378 G.H5.23
Polar ICL3 Q 243 - G.H4 R 329 G.H4.09
Hydrophobic ICL3 Q 243 - G.H4 R 329 G.H4.09
Van-der-waals ICL3 Q 243 - G.H4 R 329 G.H4.09
Polar TM6 T 274 6x36 G.H5 M 379 G.H5.24
Hydrophobic TM6 T 274 6x36 G.H5 M 379 G.H5.24
Van-der-waals TM6 T 274 6x36 G.H5 M 379 G.H5.24
Hydrophobic ICL2 F 139 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 F 139 34x51 G.S3 I 221 G.S3.01
Polar C-term G 351 - G.H3 K 284 G.H3.16
Hydrophobic C-term G 351 - G.H3 K 284 G.H3.16
Van-der-waals C-term G 351 - G.H3 K 284 G.H3.16
Hydrophobic TM5 Q 229 5x68 G.H5 L 371 G.H5.16
Hydrophobic TM5 I 233 5x72 G.H5 Q 372 G.H5.17
Van-der-waals TM5 I 233 5x72 G.H5 Q 372 G.H5.17
Polar C-term Y 354 - G.H2 Q 236 G.H2.05
Hydrophobic C-term Y 354 - G.H2 Q 236 G.H2.05
Van-der-waals C-term Y 354 - G.H2 Q 236 G.H2.05
Hydrophobic TM7 I 325 7x52 G.H5 L 380 G.H5.25
Van-der-waals TM7 I 325 7x52 G.H5 L 380 G.H5.25
Hydrophobic ICL2 P 138 34x50 G.H5 K 367 G.H5.12