G15 -
β3-adrenoceptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 80.6
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.5
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | TM6 | R | 289 | 6x32 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | TM6 | R | 289 | 6x32 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | ICL3 | R | 277 | - | G.h4s6 | G | 322 | G.h4s6.04 |
Hydrophobic | TM6 | R | 289 | 6x32 | G.h4s6 | R | 335 | G.h4s6.17 |
Van-der-waals | TM6 | R | 289 | 6x32 | G.h4s6 | R | 335 | G.h4s6.17 |
Polar | C-term | L | 400 | - | G.S2 | S | 198 | G.S2.07 |
Hydrophobic | C-term | L | 400 | - | G.S2 | S | 198 | G.S2.07 |
Van-der-waals | C-term | L | 400 | - | G.S2 | S | 198 | G.S2.07 |
Polar | TM7 | R | 348 | 7x55 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | TM7 | R | 348 | 7x55 | G.H5 | N | 372 | G.H5.24 |
Polar | C-term | C | 397 | - | G.S2 | C | 196 | G.S2.05 |
Hydrophobic | C-term | C | 397 | - | G.S2 | C | 196 | G.S2.05 |
Van-der-waals | C-term | C | 397 | - | G.S2 | C | 196 | G.S2.05 |
Polar | ICL3 | R | 277 | - | G.h4s6 | T | 321 | G.h4s6.03 |
Hydrophobic | ICL3 | R | 277 | - | G.h4s6 | T | 321 | G.h4s6.03 |
Van-der-waals | ICL3 | R | 277 | - | G.h4s6 | T | 321 | G.h4s6.03 |
Polar | ICL2 | R | 144 | 34x52 | G.s2s3 | Q | 200 | G.s2s3.01 |
Hydrophobic | ICL2 | R | 144 | 34x52 | G.s2s3 | Q | 200 | G.s2s3.01 |
Van-der-waals | ICL2 | R | 144 | 34x52 | G.s2s3 | Q | 200 | G.s2s3.01 |
Ionic | ICL3 | R | 277 | - | G.h4s6 | D | 325 | G.h4s6.07 |
Polar | ICL3 | R | 277 | - | G.h4s6 | D | 325 | G.h4s6.07 |
Van-der-waals | ICL3 | R | 277 | - | G.h4s6 | D | 325 | G.h4s6.07 |
Hydrophobic | TM3 | V | 139 | 3x54 | G.H5 | L | 368 | G.H5.20 |
Aromatic | ICL2 | Y | 145 | 34x53 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | ICL2 | Y | 145 | 34x53 | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | ICL2 | Y | 145 | 34x53 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | ICL2 | L | 143 | 34x51 | G.H5 | R | 360 | G.H5.12 |
Van-der-waals | ICL2 | L | 143 | 34x51 | G.H5 | R | 360 | G.H5.12 |
Hydrophobic | TM5 | Q | 234 | 5x68 | G.h4s6 | R | 338 | G.h4s6.20 |
Van-der-waals | TM5 | Q | 234 | 5x68 | G.h4s6 | R | 338 | G.h4s6.20 |
Hydrophobic | C-term | L | 400 | - | G.h1ha | G | 67 | G.h1ha.01 |
Van-der-waals | C-term | L | 400 | - | G.h1ha | G | 67 | G.h1ha.01 |
Hydrophobic | ICL2 | L | 143 | 34x51 | G.H5 | V | 359 | G.H5.11 |
Polar | TM6 | T | 293 | 6x36 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | TM6 | T | 293 | 6x36 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | TM6 | T | 293 | 6x36 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | ICL2 | P | 142 | 34x50 | G.H5 | L | 364 | G.H5.16 |
Hydrophobic | ICL3 | R | 278 | - | G.h4s6 | K | 331 | G.h4s6.13 |
Van-der-waals | ICL3 | R | 278 | - | G.h4s6 | K | 331 | G.h4s6.13 |
Hydrophobic | ICL2 | A | 147 | 34x55 | G.hns1 | G | 41 | G.hns1.03 |
Polar | TM6 | R | 289 | 6x32 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | TM6 | R | 289 | 6x32 | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | TM6 | R | 289 | 6x32 | G.H5 | L | 374 | G.H5.26 |
Polar | ICL2 | R | 144 | 34x52 | G.s2s3 | K | 201 | G.s2s3.02 |
Hydrophobic | ICL2 | R | 144 | 34x52 | G.s2s3 | K | 201 | G.s2s3.02 |
Van-der-waals | ICL2 | R | 144 | 34x52 | G.s2s3 | K | 201 | G.s2s3.02 |
Hydrophobic | TM5 | A | 231 | 5x65 | G.H5 | L | 368 | G.H5.20 |
Hydrophobic | TM3 | V | 139 | 3x54 | G.H5 | L | 364 | G.H5.16 |
Van-der-waals | TM3 | V | 139 | 3x54 | G.H5 | L | 364 | G.H5.16 |
Hydrophobic | TM3 | A | 138 | 3x53 | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | TM3 | A | 138 | 3x53 | G.H5 | Y | 367 | G.H5.19 |
Polar | ICL2 | P | 142 | 34x50 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | ICL2 | P | 142 | 34x50 | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | ICL2 | P | 142 | 34x50 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | ICL2 | L | 143 | 34x51 | G.H5 | V | 363 | G.H5.15 |
Hydrophobic | TM3 | R | 135 | 3x50 | G.H5 | I | 371 | G.H5.23 |
Van-der-waals | TM3 | R | 135 | 3x50 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | TM5 | V | 230 | 5x64 | G.H5 | L | 364 | G.H5.16 |
Hydrophobic | C-term | Q | 398 | - | G.h1ha | A | 68 | G.h1ha.02 |
Van-der-waals | C-term | Q | 398 | - | G.h1ha | A | 68 | G.h1ha.02 |
Hydrophobic | TM5 | V | 227 | 5x61 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | TM5 | V | 227 | 5x61 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | TM5 | L | 235 | 5x69 | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | TM5 | L | 235 | 5x69 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | TM5 | Q | 234 | 5x68 | G.H5 | L | 368 | G.H5.20 |
Hydrophobic | TM6 | R | 286 | 6x29 | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | TM6 | R | 286 | 6x29 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | TM6 | L | 294 | 6x37 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | TM6 | L | 294 | 6x37 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | C-term | L | 400 | - | G.S2 | F | 197 | G.S2.06 |
Ionic | ICL3 | E | 248 | - | G.H4 | R | 318 | G.H4.17 |
Polar | ICL3 | E | 248 | - | G.H4 | R | 318 | G.H4.17 |
Ionic | C-term | R | 395 | - | G.S2 | E | 194 | G.S2.03 |
Polar | C-term | R | 395 | - | G.S2 | E | 194 | G.S2.03 |
Van-der-waals | C-term | R | 395 | - | G.S2 | E | 194 | G.S2.03 |
Hydrophobic | TM3 | V | 139 | 3x54 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | TM5 | L | 238 | 5x72 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | C-term | L | 400 | - | G.H1 | H | 66 | G.H1.12 |
Van-der-waals | C-term | L | 400 | - | G.H1 | H | 66 | G.H1.12 |
Hydrophobic | TM5 | L | 238 | 5x72 | G.h4s6 | R | 338 | G.h4s6.20 |
Van-der-waals | TM5 | L | 238 | 5x72 | G.h4s6 | R | 338 | G.h4s6.20 |
Hydrophobic | ICL2 | P | 142 | 34x50 | G.H5 | R | 360 | G.H5.12 |
Van-der-waals | ICL2 | P | 142 | 34x50 | G.H5 | R | 360 | G.H5.12 |
Hydrophobic | ICL3 | F | 245 | - | G.H4 | T | 317 | G.H4.16 |
Van-der-waals | ICL3 | F | 245 | - | G.H4 | T | 317 | G.H4.16 |
Hydrophobic | ICL2 | L | 143 | 34x51 | G.H5 | F | 356 | G.H5.08 |
Van-der-waals | ICL2 | L | 143 | 34x51 | G.H5 | F | 356 | G.H5.08 |
Hydrophobic | TM5 | A | 231 | 5x65 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | TM5 | Q | 234 | 5x68 | G.H5 | L | 364 | G.H5.16 |
Van-der-waals | TM5 | Q | 234 | 5x68 | G.H5 | L | 364 | G.H5.16 |
Hydrophobic | C-term | R | 395 | - | G.S3 | R | 205 | G.S3.04 |
Hydrophobic | ICL2 | L | 143 | 34x51 | G.S3 | T | 202 | G.S3.01 |
Hydrophobic | TM6 | A | 290 | 6x33 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | C-term | L | 400 | - | G.h1ha | A | 68 | G.h1ha.02 |
Van-der-waals | C-term | L | 400 | - | G.h1ha | A | 68 | G.h1ha.02 |
Aromatic | C-term | W | 405 | - | G.H5 | R | 353 | G.H5.05 |
Van-der-waals | C-term | W | 405 | - | G.H5 | R | 353 | G.H5.05 |
Polar | TM5 | Q | 234 | 5x68 | G.H5 | D | 361 | G.H5.13 |
Hydrophobic | TM5 | Q | 234 | 5x68 | G.H5 | D | 361 | G.H5.13 |
Van-der-waals | TM5 | Q | 234 | 5x68 | G.H5 | D | 361 | G.H5.13 |
Hydrophobic | TM6 | T | 293 | 6x36 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | ICL3 | F | 245 | - | G.H4 | L | 313 | G.H4.12 |
Hydrophobic | ICL2 | L | 143 | 34x51 | G.S1 | L | 43 | G.S1.02 |
Van-der-waals | ICL2 | L | 143 | 34x51 | G.S1 | L | 43 | G.S1.02 |
Hydrophobic | ICL2 | P | 142 | 34x50 | G.H5 | V | 363 | G.H5.15 |
Van-der-waals | ICL2 | P | 142 | 34x50 | G.H5 | V | 363 | G.H5.15 |