GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 61.1
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.5
iPTM Score: 0.6
PAE mean: 15.8
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | ICL2 | R | 1045 | - | G.hns1 | A | 31 | G.hns1.02 |
Van-der-waals | ICL2 | R | 1045 | - | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | ICL2 | L | 1044 | - | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | ICL2 | L | 1044 | - | G.H5 | C | 351 | G.H5.23 |
Polar | TM6 | R | 1131 | 6x34 | G.H5 | Y | 354 | G.H5.26 |
Aromatic | TM6 | R | 1131 | 6x34 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | TM6 | R | 1131 | 6x34 | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | TM6 | R | 1131 | 6x34 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | C-term | S | 1468 | - | G.h1ha | E | 58 | G.h1ha.01 |
Van-der-waals | C-term | S | 1468 | - | G.h1ha | E | 58 | G.h1ha.01 |
Hydrophobic | C-term | C | 1233 | - | G.H3 | F | 259 | G.H3.17 |
Van-der-waals | C-term | C | 1233 | - | G.H3 | F | 259 | G.H3.17 |
Hydrophobic | C-term | M | 1222 | - | G.H3 | K | 258 | G.H3.16 |
Van-der-waals | C-term | M | 1222 | - | G.H3 | K | 258 | G.H3.16 |
Hydrophobic | TM5 | I | 1123 | 5x67 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM5 | I | 1123 | 5x67 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM4 | R | 1052 | 4x45 | G.HN | K | 24 | G.HN.48 |
Polar | C-term | E | 1226 | - | G.H3 | S | 253 | G.H3.11 |
Hydrophobic | C-term | L | 1348 | - | H.HA | V | 72 | H.HA.10 |
Van-der-waals | C-term | L | 1348 | - | H.HA | V | 72 | H.HA.10 |
Hydrophobic | TM5 | T | 1124 | 5x68 | G.H5 | D | 337 | G.H5.09 |
Hydrophobic | C-term | T | 1343 | - | H.HA | R | 86 | H.HA.24 |
Van-der-waals | C-term | T | 1343 | - | H.HA | R | 86 | H.HA.24 |
Polar | C-term | E | 1483 | - | G.H2 | H | 214 | G.H2.09 |
Hydrophobic | C-term | E | 1483 | - | G.H2 | H | 214 | G.H2.09 |
Van-der-waals | C-term | E | 1483 | - | G.H2 | H | 214 | G.H2.09 |
Hydrophobic | C-term | F | 1482 | - | G.H2 | C | 215 | G.H2.10 |
Van-der-waals | C-term | F | 1482 | - | G.H2 | C | 215 | G.H2.10 |
Polar | C-term | S | 1468 | - | G.S2 | T | 191 | G.S2.07 |
Hydrophobic | C-term | S | 1468 | - | G.S2 | T | 191 | G.S2.07 |
Van-der-waals | C-term | S | 1468 | - | G.S2 | T | 191 | G.S2.07 |
Hydrophobic | C-term | L | 1348 | - | H.HA | Q | 68 | H.HA.06 |
Polar | ICL3 | D | 1125 | - | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | ICL3 | D | 1125 | - | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | ICL3 | D | 1125 | - | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | C-term | R | 1472 | - | G.H1 | V | 50 | G.H1.05 |
Hydrophobic | C-term | Y | 1477 | - | G.S3 | F | 200 | G.S3.06 |
Hydrophobic | ICL3 | L | 1128 | - | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | C-term | L | 1470 | - | G.H1 | K | 54 | G.H1.09 |
Van-der-waals | C-term | L | 1470 | - | G.H1 | K | 54 | G.H1.09 |
Hydrophobic | C-term | L | 1470 | - | G.S2 | T | 188 | G.S2.04 |
Van-der-waals | C-term | L | 1470 | - | G.S2 | T | 188 | G.S2.04 |
Polar | C-term | T | 1343 | - | G.s4h3 | H | 236 | G.s4h3.09 |
Polar | C-term | S | 1469 | - | G.h1ha | E | 58 | G.h1ha.01 |
Hydrophobic | C-term | S | 1469 | - | G.h1ha | E | 58 | G.h1ha.01 |
Van-der-waals | C-term | S | 1469 | - | G.h1ha | E | 58 | G.h1ha.01 |
Hydrophobic | H8 | E | 1190 | 8x49 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | H8 | E | 1190 | 8x49 | G.H5 | G | 352 | G.H5.24 |
Ionic | C-term | D | 1228 | - | G.H2 | K | 210 | G.H2.05 |
Polar | C-term | D | 1228 | - | G.H2 | K | 210 | G.H2.05 |
Hydrophobic | C-term | D | 1228 | - | G.H2 | K | 210 | G.H2.05 |
Van-der-waals | C-term | D | 1228 | - | G.H2 | K | 210 | G.H2.05 |
Polar | TM5 | T | 1124 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM5 | T | 1124 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM5 | T | 1124 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM6 | A | 1132 | 6x35 | G.H5 | L | 348 | G.H5.20 |
Polar | C-term | Y | 1345 | - | G.hfs2 | R | 179 | G.hfs2.02 |
Aromatic | C-term | Y | 1345 | - | G.hfs2 | R | 179 | G.hfs2.02 |
Hydrophobic | C-term | Y | 1345 | - | G.hfs2 | R | 179 | G.hfs2.02 |
Van-der-waals | C-term | Y | 1345 | - | G.hfs2 | R | 179 | G.hfs2.02 |
Hydrophobic | C-term | F | 1225 | - | G.H2 | W | 212 | G.H2.07 |
Van-der-waals | C-term | F | 1225 | - | G.H2 | W | 212 | G.H2.07 |
Hydrophobic | C-term | F | 1225 | - | G.H3 | S | 253 | G.H3.11 |
Van-der-waals | C-term | F | 1225 | - | G.H3 | S | 253 | G.H3.11 |
Hydrophobic | C-term | L | 1470 | - | G.H1 | H | 57 | G.H1.12 |
Ionic | TM5 | D | 1121 | 5x65 | G.s2s3 | K | 193 | G.s2s3.01 |
Polar | TM5 | D | 1121 | 5x65 | G.s2s3 | K | 193 | G.s2s3.01 |
Van-der-waals | TM5 | D | 1121 | 5x65 | G.s2s3 | K | 193 | G.s2s3.01 |
Hydrophobic | C-term | R | 1472 | - | G.S2 | V | 186 | G.S2.02 |
Van-der-waals | C-term | R | 1472 | - | G.S2 | V | 186 | G.S2.02 |
Hydrophobic | C-term | V | 1229 | - | G.H3 | F | 259 | G.H3.17 |
Hydrophobic | TM3 | V | 1040 | 3x58 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | TM3 | V | 1040 | 3x58 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | C-term | R | 1472 | - | G.S2 | E | 187 | G.S2.03 |
Van-der-waals | C-term | R | 1472 | - | G.S2 | E | 187 | G.S2.03 |
Hydrophobic | TM3 | A | 1039 | 3x57 | G.H5 | L | 348 | G.H5.20 |
Polar | C-term | T | 1223 | - | G.H3 | S | 253 | G.H3.11 |
Van-der-waals | C-term | T | 1223 | - | G.H3 | S | 253 | G.H3.11 |
Hydrophobic | C-term | Y | 1477 | - | G.S2 | I | 185 | G.S2.01 |
Hydrophobic | C-term | L | 1470 | - | G.S2 | F | 190 | G.S2.06 |
Van-der-waals | C-term | L | 1470 | - | G.S2 | F | 190 | G.S2.06 |
Hydrophobic | C-term | V | 1229 | - | G.H2 | I | 213 | G.H2.08 |
Van-der-waals | C-term | V | 1229 | - | G.H2 | I | 213 | G.H2.08 |
Polar | TM3 | G | 1042 | 3x60 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | TM3 | G | 1042 | 3x60 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | C-term | V | 1467 | - | G.h1ha | D | 59 | G.h1ha.02 |
Van-der-waals | C-term | V | 1467 | - | G.h1ha | D | 59 | G.h1ha.02 |
Hydrophobic | C-term | M | 1486 | - | G.H2 | I | 213 | G.H2.08 |
Van-der-waals | C-term | M | 1486 | - | G.H2 | I | 213 | G.H2.08 |
Polar | C-term | E | 1471 | - | G.S2 | H | 189 | G.S2.05 |
Hydrophobic | C-term | S | 1475 | - | G.S3 | F | 200 | G.S3.06 |
Polar | H8 | R | 1188 | 8x47 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | H8 | R | 1188 | 8x47 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | H8 | R | 1188 | 8x47 | G.H5 | G | 352 | G.H5.24 |
Polar | ICL2 | R | 1045 | - | G.hns1 | A | 30 | G.hns1.01 |
Hydrophobic | ICL2 | R | 1045 | - | G.hns1 | A | 30 | G.hns1.01 |
Van-der-waals | ICL2 | R | 1045 | - | G.hns1 | A | 30 | G.hns1.01 |
Hydrophobic | TM2 | R | 980 | 2x46 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM2 | R | 980 | 2x46 | G.H5 | L | 353 | G.H5.25 |
Ionic | C-term | R | 1489 | - | G.h2s4 | E | 217 | G.h2s4.02 |
Polar | C-term | R | 1489 | - | G.h2s4 | E | 217 | G.h2s4.02 |
Hydrophobic | C-term | R | 1489 | - | G.h2s4 | E | 217 | G.h2s4.02 |
Van-der-waals | C-term | R | 1489 | - | G.h2s4 | E | 217 | G.h2s4.02 |
Polar | C-term | S | 1475 | - | G.S2 | I | 185 | G.S2.01 |
Hydrophobic | C-term | S | 1475 | - | G.S2 | I | 185 | G.S2.01 |
Van-der-waals | C-term | S | 1475 | - | G.S2 | I | 185 | G.S2.01 |
Hydrophobic | TM3 | A | 1039 | 3x57 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | C-term | V | 1346 | - | H.HA | S | 75 | H.HA.13 |
Van-der-waals | C-term | V | 1346 | - | H.HA | S | 75 | H.HA.13 |
Hydrophobic | C-term | M | 1486 | - | G.h2s4 | E | 217 | G.h2s4.02 |
Hydrophobic | C-term | V | 1346 | - | H.hbhc | D | 116 | H.hbhc.04 |
Ionic | C-term | R | 1489 | - | G.h2s4 | D | 218 | G.h2s4.03 |
Polar | C-term | R | 1489 | - | G.h2s4 | D | 218 | G.h2s4.03 |
Hydrophobic | C-term | R | 1489 | - | G.h2s4 | D | 218 | G.h2s4.03 |
Van-der-waals | C-term | R | 1489 | - | G.h2s4 | D | 218 | G.h2s4.03 |
Hydrophobic | ICL2 | L | 1044 | - | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | ICL2 | L | 1044 | - | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | C-term | V | 1346 | - | H.hbhc | T | 117 | H.hbhc.05 |
Van-der-waals | C-term | V | 1346 | - | H.hbhc | T | 117 | H.hbhc.05 |
Hydrophobic | C-term | V | 1236 | - | G.H2 | H | 214 | G.H2.09 |
Polar | TM2 | S | 978 | 2x44 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM2 | S | 978 | 2x44 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM2 | S | 978 | 2x44 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | C-term | V | 1229 | - | G.H3 | N | 257 | G.H3.15 |
Van-der-waals | C-term | V | 1229 | - | G.H3 | N | 257 | G.H3.15 |
Polar | ICL2 | R | 1045 | - | G.HN | G | 27 | G.HN.51 |
Hydrophobic | ICL2 | R | 1045 | - | G.HN | G | 27 | G.HN.51 |
Van-der-waals | ICL2 | R | 1045 | - | G.HN | G | 27 | G.HN.51 |
Hydrophobic | C-term | F | 1482 | - | G.H2 | K | 211 | G.H2.06 |
Van-der-waals | C-term | F | 1482 | - | G.H2 | K | 211 | G.H2.06 |
Polar | C-term | I | 1485 | - | G.H2 | H | 214 | G.H2.09 |
Hydrophobic | C-term | I | 1485 | - | G.H2 | H | 214 | G.H2.09 |
Van-der-waals | C-term | I | 1485 | - | G.H2 | H | 214 | G.H2.09 |
Hydrophobic | ICL3 | L | 1128 | - | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | ICL3 | L | 1128 | - | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | C-term | F | 1225 | - | G.H3 | I | 254 | G.H3.12 |
Hydrophobic | C-term | M | 1486 | - | G.H3 | F | 259 | G.H3.17 |
Van-der-waals | C-term | M | 1486 | - | G.H3 | F | 259 | G.H3.17 |
Polar | C-term | R | 1473 | - | G.S2 | E | 187 | G.S2.03 |
Van-der-waals | C-term | R | 1473 | - | G.S2 | E | 187 | G.S2.03 |
Hydrophobic | C-term | A | 1478 | - | G.S2 | I | 185 | G.S2.01 |
Hydrophobic | TM6 | R | 1131 | 6x34 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | C-term | L | 1348 | - | G.hfs2 | V | 180 | G.hfs2.03 |
Polar | TM2 | R | 980 | 2x46 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM2 | R | 980 | 2x46 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM2 | R | 980 | 2x46 | G.H5 | C | 351 | G.H5.23 |
Polar | TM3 | A | 1039 | 3x57 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM3 | A | 1039 | 3x57 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | TM3 | A | 1039 | 3x57 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM5 | I | 1123 | 5x67 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | TM5 | I | 1123 | 5x67 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | TM3 | G | 1042 | 3x60 | G.H5 | I | 343 | G.H5.15 |
Hydrophobic | C-term | F | 1482 | - | G.S2 | I | 185 | G.S2.01 |
Hydrophobic | C-term | M | 1486 | - | G.h2s4 | F | 216 | G.h2s4.01 |
Van-der-waals | C-term | M | 1486 | - | G.h2s4 | F | 216 | G.h2s4.01 |
Hydrophobic | C-term | V | 1467 | - | G.h1ha | E | 58 | G.h1ha.01 |
Van-der-waals | C-term | V | 1467 | - | G.h1ha | E | 58 | G.h1ha.01 |
Polar | C-term | M | 1486 | - | G.H2 | H | 214 | G.H2.09 |
Hydrophobic | C-term | M | 1486 | - | G.H2 | H | 214 | G.H2.09 |
Van-der-waals | C-term | M | 1486 | - | G.H2 | H | 214 | G.H2.09 |
Hydrophobic | C-term | S | 1475 | - | G.S2 | E | 187 | G.S2.03 |
Hydrophobic | ICL3 | L | 1128 | - | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | ICL3 | L | 1128 | - | G.H5 | I | 344 | G.H5.16 |
Ionic | C-term | D | 1342 | - | G.hfs2 | K | 181 | G.hfs2.04 |
Hydrophobic | C-term | L | 1470 | - | G.H1 | M | 53 | G.H1.08 |
Polar | C-term | L | 1470 | - | G.h1ha | E | 58 | G.h1ha.01 |
Hydrophobic | C-term | L | 1470 | - | G.h1ha | E | 58 | G.h1ha.01 |
Van-der-waals | C-term | L | 1470 | - | G.h1ha | E | 58 | G.h1ha.01 |
Hydrophobic | ICL3 | L | 1128 | - | G.H5 | A | 345 | G.H5.17 |
Van-der-waals | ICL3 | L | 1128 | - | G.H5 | A | 345 | G.H5.17 |
Polar | H8 | R | 1188 | 8x47 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | C-term | A | 1232 | - | G.H2 | I | 213 | G.H2.08 |
Van-der-waals | C-term | A | 1232 | - | G.H2 | I | 213 | G.H2.08 |
Ionic | C-term | R | 1472 | - | G.S3 | D | 201 | G.S3.07 |
Polar | C-term | R | 1472 | - | G.S3 | D | 201 | G.S3.07 |
Van-der-waals | C-term | R | 1472 | - | G.S3 | D | 201 | G.S3.07 |
Hydrophobic | C-term | F | 1225 | - | G.H3 | L | 250 | G.H3.08 |
Hydrophobic | TM6 | S | 1135 | 6x38 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | S | 1135 | 6x38 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | C-term | F | 1482 | - | G.H2 | W | 212 | G.H2.07 |
Van-der-waals | C-term | F | 1482 | - | G.H2 | W | 212 | G.H2.07 |
Polar | TM3 | Q | 1035 | 3x53 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM3 | Q | 1035 | 3x53 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | Q | 1035 | 3x53 | G.H5 | C | 351 | G.H5.23 |
Polar | C-term | L | 1470 | - | G.S2 | H | 189 | G.S2.05 |
Hydrophobic | C-term | L | 1470 | - | G.S2 | H | 189 | G.S2.05 |
Van-der-waals | C-term | L | 1470 | - | G.S2 | H | 189 | G.S2.05 |
Hydrophobic | C-term | F | 1482 | - | G.H2 | I | 213 | G.H2.08 |
Van-der-waals | C-term | F | 1482 | - | G.H2 | I | 213 | G.H2.08 |
Hydrophobic | C-term | K | 1490 | - | G.H3 | F | 259 | G.H3.17 |
Van-der-waals | C-term | K | 1490 | - | G.H3 | F | 259 | G.H3.17 |
Polar | C-term | F | 1482 | - | G.H2 | H | 214 | G.H2.09 |
Aromatic | C-term | F | 1482 | - | G.H2 | H | 214 | G.H2.09 |
Hydrophobic | C-term | F | 1482 | - | G.H2 | H | 214 | G.H2.09 |
Van-der-waals | C-term | F | 1482 | - | G.H2 | H | 214 | G.H2.09 |
Polar | TM2 | S | 978 | 2x44 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | TM2 | S | 978 | 2x44 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | ICL3 | L | 1128 | - | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | ICL3 | L | 1128 | - | G.H5 | D | 341 | G.H5.13 |