Gq - ADGRD1 complex model

GPCR CLASS (FAMILY)

B2 (Adhesion)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 86.5

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 11.2


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 I 741 5x64 G.H5 L 353 G.H5.20
Van-der-waals TM5 I 741 5x64 G.H5 L 353 G.H5.20
Ionic ICL2 D 669 - G.hns1 R 38 G.hns1.03
Polar ICL2 D 669 - G.hns1 R 38 G.hns1.03
Hydrophobic ICL2 D 669 - G.hns1 R 38 G.hns1.03
Van-der-waals ICL2 D 669 - G.hns1 R 38 G.hns1.03
Hydrophobic ICL2 F 665 - G.H5 V 344 G.H5.11
Hydrophobic ICL2 E 668 - G.hns1 R 37 G.hns1.02
Van-der-waals ICL2 E 668 - G.hns1 R 37 G.hns1.02
Hydrophobic TM5 I 741 5x64 G.H5 L 349 G.H5.16
Hydrophobic TM3 H 656 3x53 G.H5 Y 356 G.H5.23
Van-der-waals TM3 H 656 3x53 G.H5 Y 356 G.H5.23
Van-der-waals C-term L 871 - G.H3 Y 261 G.H3.15
Hydrophobic TM6 V 764 6x44 G.H5 L 358 G.H5.25
Polar ICL2 S 670 - G.HN R 34 G.HN.52
Hydrophobic ICL2 S 670 - G.HN R 34 G.HN.52
Van-der-waals ICL2 S 670 - G.HN R 34 G.HN.52
Hydrophobic TM3 V 661 3x58 G.H5 L 349 G.H5.16
Van-der-waals TM3 V 661 3x58 G.H5 L 349 G.H5.16
Hydrophobic ICL2 F 665 - G.H5 I 348 G.H5.15
Van-der-waals ICL2 F 665 - G.H5 I 348 G.H5.15
Hydrophobic ICL2 V 664 - G.H5 K 345 G.H5.12
Van-der-waals ICL2 V 664 - G.H5 K 345 G.H5.12
Hydrophobic TM3 M 660 3x57 G.H5 Y 356 G.H5.23
Van-der-waals TM3 M 660 3x57 G.H5 Y 356 G.H5.23
Hydrophobic TM3 L 657 3x54 G.H5 L 358 G.H5.25
Hydrophobic C-term V 869 - G.H2 R 214 G.H2.05
Van-der-waals C-term V 869 - G.H2 R 214 G.H2.05
Ionic TM2 R 601 2x46 G.H5 E 355 G.H5.22
Polar TM2 R 601 2x46 G.H5 E 355 G.H5.22
Hydrophobic TM2 R 601 2x46 G.H5 E 355 G.H5.22
Van-der-waals TM2 R 601 2x46 G.H5 E 355 G.H5.22
Polar TM3 E 653 3x50 G.H5 Y 356 G.H5.23
Aromatic ICL2 F 665 - G.H5 F 341 G.H5.08
Hydrophobic ICL2 F 665 - G.H5 F 341 G.H5.08
Van-der-waals ICL2 F 665 - G.H5 F 341 G.H5.08
Hydrophobic TM5 V 737 5x60 G.H5 L 349 G.H5.16
Hydrophobic TM5 V 734 5x57 G.H5 L 358 G.H5.25
Aromatic TM2 R 601 2x46 G.H5 Y 356 G.H5.23
Polar TM6 K 760 6x40 G.H5 N 357 G.H5.24
Hydrophobic TM6 K 760 6x40 G.H5 N 357 G.H5.24
Van-der-waals TM6 K 760 6x40 G.H5 N 357 G.H5.24
Hydrophobic TM6 L 757 6x37 G.H5 V 359 G.H5.26
Van-der-waals TM6 L 757 6x37 G.H5 V 359 G.H5.26
Hydrophobic TM6 A 761 6x41 G.H5 L 358 G.H5.25
Hydrophobic TM3 L 657 3x54 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 V 664 - G.H5 L 349 G.H5.16
Hydrophobic TM5 I 738 5x61 G.H5 L 358 G.H5.25
Hydrophobic ICL2 F 665 - G.H5 K 345 G.H5.12
Van-der-waals ICL2 F 665 - G.H5 K 345 G.H5.12
Polar H8 N 810 8x47 G.H5 N 357 G.H5.24
Hydrophobic H8 N 810 8x47 G.H5 N 357 G.H5.24
Van-der-waals H8 N 810 8x47 G.H5 N 357 G.H5.24
Polar TM3 M 660 3x57 G.H5 N 352 G.H5.19
Hydrophobic TM3 M 660 3x57 G.H5 N 352 G.H5.19
Van-der-waals TM3 M 660 3x57 G.H5 N 352 G.H5.19
Polar TM6 K 760 6x40 G.H5 V 359 G.H5.26
Van-der-waals TM6 K 760 6x40 G.H5 V 359 G.H5.26
Hydrophobic H8 E 812 8x49 G.H5 E 355 G.H5.22
Van-der-waals H8 E 812 8x49 G.H5 E 355 G.H5.22
Hydrophobic TM2 H 605 2x50 G.H5 Y 356 G.H5.23
Polar TM2 N 599 2x44 G.H5 E 355 G.H5.22
Hydrophobic TM5 I 741 5x64 G.H5 Q 350 G.H5.17
Van-der-waals TM5 I 741 5x64 G.H5 Q 350 G.H5.17
Hydrophobic TM6 L 765 6x45 G.H5 L 358 G.H5.25
Hydrophobic ICL2 F 665 - G.S3 V 199 G.S3.01
Polar H8 S 811 8x48 G.H5 N 357 G.H5.24
Van-der-waals H8 S 811 8x48 G.H5 N 357 G.H5.24
Hydrophobic ICL2 V 664 - G.H5 I 348 G.H5.15
Van-der-waals ICL2 V 664 - G.H5 I 348 G.H5.15
Polar TM3 I 662 3x59 G.H5 K 345 G.H5.12
Hydrophobic TM3 V 661 3x58 G.H5 L 353 G.H5.20
Hydrophobic C-term L 871 - G.H3 T 257 G.H3.11
Hydrophobic ICL2 F 665 - G.S1 L 40 G.S1.02
Hydrophobic TM5 I 738 5x61 G.H5 L 353 G.H5.20
Hydrophobic ICL2 F 665 - G.s2s3 S 198 G.s2s3.02