GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 83.7
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 15.3
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | ICL2 | F | 703 | - | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | ICL2 | F | 703 | - | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | TM7 | H | 844 | 7x57 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | TM7 | H | 844 | 7x57 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | TM3 | V | 694 | 3x58 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | ICL3 | V | 787 | - | G.h4s6 | P | 341 | G.h4s6.20 |
Van-der-waals | ICL3 | V | 787 | - | G.h4s6 | P | 341 | G.h4s6.20 |
Hydrophobic | TM6 | L | 796 | 6x38 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM6 | L | 796 | 6x38 | G.H5 | M | 375 | G.H5.24 |
Polar | ICL3 | N | 784 | - | G.H5 | D | 364 | G.H5.13 |
Van-der-waals | ICL3 | N | 784 | - | G.H5 | D | 364 | G.H5.13 |
Hydrophobic | ICL3 | L | 790 | - | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | ICL3 | L | 790 | - | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | ICL2 | V | 700 | - | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | TM5 | R | 779 | 5x64 | G.H5 | L | 367 | G.H5.16 |
Hydrophobic | ICL3 | V | 787 | - | G.S6 | L | 342 | G.S6.01 |
Polar | TM6 | K | 799 | 6x41 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM6 | K | 799 | 6x41 | G.H5 | M | 375 | G.H5.24 |
Polar | ICL2 | L | 697 | - | G.H5 | N | 370 | G.H5.19 |
Hydrophobic | ICL2 | L | 697 | - | G.H5 | N | 370 | G.H5.19 |
Van-der-waals | ICL2 | L | 697 | - | G.H5 | N | 370 | G.H5.19 |
Hydrophobic | TM6 | L | 796 | 6x38 | G.H5 | L | 374 | G.H5.23 |
Polar | ICL3 | T | 789 | - | G.h4s6 | Q | 339 | G.h4s6.13 |
Hydrophobic | TM6 | D | 792 | 6x34 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | ICL2 | V | 700 | - | G.hns1 | K | 46 | G.hns1.02 |
Van-der-waals | ICL2 | V | 700 | - | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | ICL2 | K | 698 | - | G.H5 | L | 367 | G.H5.16 |
Hydrophobic | ICL2 | V | 700 | - | G.S1 | L | 48 | G.S1.01 |
Hydrophobic | ICL3 | V | 787 | - | G.S6 | Y | 343 | G.S6.02 |
Van-der-waals | ICL3 | V | 787 | - | G.S6 | Y | 343 | G.S6.02 |
Hydrophobic | TM5 | L | 776 | 5x61 | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | TM5 | L | 776 | 5x61 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | TM5 | V | 783 | 5x68 | G.H5 | D | 364 | G.H5.13 |
Van-der-waals | TM5 | V | 783 | 5x68 | G.H5 | D | 364 | G.H5.13 |
Hydrophobic | TM6 | L | 796 | 6x38 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | ICL2 | L | 697 | - | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | ICL3 | T | 789 | - | G.h4s6 | Q | 338 | G.h4s6.12 |
Van-der-waals | ICL3 | T | 789 | - | G.h4s6 | Q | 338 | G.h4s6.12 |
Hydrophobic | ICL2 | V | 700 | - | G.S1 | V | 49 | G.S1.02 |
Van-der-waals | ICL2 | V | 700 | - | G.S1 | V | 49 | G.S1.02 |
Polar | ICL2 | L | 697 | - | G.H5 | L | 367 | G.H5.16 |
Hydrophobic | ICL2 | L | 697 | - | G.H5 | L | 367 | G.H5.16 |
Van-der-waals | ICL2 | L | 697 | - | G.H5 | L | 367 | G.H5.16 |
Polar | ICL3 | T | 789 | - | G.H5 | H | 368 | G.H5.17 |
Van-der-waals | ICL3 | T | 789 | - | G.H5 | H | 368 | G.H5.17 |
Hydrophobic | TM5 | L | 776 | 5x61 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | ICL3 | L | 790 | - | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | TM6 | L | 795 | 6x37 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | TM3 | L | 690 | 3x54 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | TM5 | L | 780 | 5x65 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | TM5 | V | 783 | 5x68 | G.H5 | L | 367 | G.H5.16 |
Van-der-waals | TM5 | V | 783 | 5x68 | G.H5 | L | 367 | G.H5.16 |
Polar | ICL2 | N | 701 | - | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | ICL2 | N | 701 | - | G.hns1 | K | 46 | G.hns1.02 |
Van-der-waals | ICL2 | N | 701 | - | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | ICL2 | F | 703 | - | G.H5 | N | 370 | G.H5.19 |
Van-der-waals | ICL2 | F | 703 | - | G.H5 | N | 370 | G.H5.19 |
Hydrophobic | ICL2 | V | 699 | - | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | ICL3 | S | 788 | - | G.H5 | H | 368 | G.H5.17 |
Polar | ICL3 | L | 790 | - | G.H5 | H | 368 | G.H5.17 |
Hydrophobic | ICL3 | L | 790 | - | G.H5 | H | 368 | G.H5.17 |
Polar | C-term | Q | 870 | - | G.H3 | R | 279 | G.H3.16 |
Hydrophobic | C-term | I | 874 | - | G.H3 | N | 278 | G.H3.15 |
Van-der-waals | C-term | I | 874 | - | G.H3 | N | 278 | G.H3.15 |
Hydrophobic | C-term | L | 876 | - | G.H3 | T | 274 | G.H3.11 |
Van-der-waals | C-term | L | 876 | - | G.H3 | T | 274 | G.H3.11 |
Polar | TM2 | N | 634 | 2x46 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | TM2 | N | 634 | 2x46 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | TM2 | N | 634 | 2x46 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | ICL2 | K | 698 | - | G.H5 | I | 366 | G.H5.15 |
Hydrophobic | ICL2 | F | 703 | - | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | TM3 | M | 693 | 3x57 | G.H5 | L | 374 | G.H5.23 |
Polar | ICL2 | S | 705 | - | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | ICL2 | S | 705 | - | G.hns1 | K | 46 | G.hns1.02 |
Van-der-waals | ICL2 | S | 705 | - | G.hns1 | K | 46 | G.hns1.02 |
Polar | ICL2 | S | 704 | - | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | ICL2 | S | 704 | - | G.hns1 | K | 46 | G.hns1.02 |
Van-der-waals | ICL2 | S | 704 | - | G.hns1 | K | 46 | G.hns1.02 |
Polar | TM6 | K | 799 | 6x41 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | TM6 | K | 799 | 6x41 | G.H5 | Q | 377 | G.H5.26 |
Polar | H8 | N | 848 | 8x47 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | H8 | N | 848 | 8x47 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | H8 | N | 848 | 8x47 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | ICL2 | F | 703 | - | G.H5 | Q | 373 | G.H5.22 |
Van-der-waals | ICL2 | F | 703 | - | G.H5 | Q | 373 | G.H5.22 |
Hydrophobic | H8 | G | 849 | 8x48 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | ICL2 | V | 700 | - | G.H5 | I | 366 | G.H5.15 |
Van-der-waals | ICL2 | V | 700 | - | G.H5 | I | 366 | G.H5.15 |
Hydrophobic | H8 | Q | 850 | 8x49 | G.H5 | L | 376 | G.H5.25 |
Polar | ICL2 | V | 699 | - | G.H5 | N | 370 | G.H5.19 |
Van-der-waals | ICL2 | V | 699 | - | G.H5 | N | 370 | G.H5.19 |
Hydrophobic | ICL3 | T | 789 | - | G.h4s6 | K | 340 | G.h4s6.19 |
Polar | ICL2 | N | 701 | - | G.hns1 | V | 45 | G.hns1.01 |
Hydrophobic | TM5 | V | 783 | 5x68 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | TM3 | M | 693 | 3x57 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | TM3 | M | 693 | 3x57 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | ICL2 | V | 699 | - | G.H5 | I | 366 | G.H5.15 |
Van-der-waals | ICL2 | V | 699 | - | G.H5 | I | 366 | G.H5.15 |
Hydrophobic | ICL2 | V | 700 | - | G.h2s4 | T | 241 | G.h2s4.05 |