GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 88.5
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 11.4
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | ICL2 | L | 451 | - | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | ICL2 | L | 451 | - | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | ICL2 | L | 451 | - | G.H5 | N | 347 | G.H5.19 |
Polar | TM6 | K | 553 | 6x41 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | TM6 | K | 553 | 6x41 | G.H5 | F | 354 | G.H5.26 |
Van-der-waals | TM6 | K | 553 | 6x41 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | TM5 | L | 537 | 5x68 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | ICL3 | I | 544 | - | G.H5 | K | 345 | G.H5.17 |
Polar | ICL3 | N | 538 | - | G.H5 | D | 337 | G.H5.09 |
Hydrophobic | ICL3 | N | 538 | - | G.H5 | D | 337 | G.H5.09 |
Van-der-waals | ICL3 | N | 538 | - | G.H5 | D | 337 | G.H5.09 |
Polar | TM2 | N | 386 | 2x44 | G.H5 | D | 350 | G.H5.22 |
Van-der-waals | TM2 | N | 386 | 2x44 | G.H5 | D | 350 | G.H5.22 |
Polar | ICL2 | Y | 456 | - | G.H5 | D | 350 | G.H5.22 |
Hydrophobic | ICL2 | Y | 456 | - | G.H5 | D | 350 | G.H5.22 |
Van-der-waals | ICL2 | Y | 456 | - | G.H5 | D | 350 | G.H5.22 |
Polar | ICL3 | T | 543 | - | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | ICL3 | T | 543 | - | G.H5 | D | 341 | G.H5.13 |
Polar | ICL3 | T | 543 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | ICL3 | T | 543 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | ICL3 | T | 543 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | C-term | F | 644 | - | G.H2 | W | 211 | G.H2.07 |
Hydrophobic | ICL3 | V | 541 | - | G.S6 | Y | 320 | G.S6.02 |
Van-der-waals | ICL3 | V | 541 | - | G.S6 | Y | 320 | G.S6.02 |
Hydrophobic | TM5 | L | 534 | 5x65 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | ICL2 | T | 452 | - | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | ICL2 | V | 454 | - | G.S1 | V | 34 | G.S1.02 |
Van-der-waals | ICL2 | V | 454 | - | G.S1 | V | 34 | G.S1.02 |
Hydrophobic | ICL2 | V | 454 | - | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | ICL2 | V | 453 | - | G.hns1 | A | 31 | G.hns1.02 |
Van-der-waals | ICL2 | V | 453 | - | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | ICL2 | V | 453 | - | G.H5 | I | 343 | G.H5.15 |
Van-der-waals | ICL2 | V | 453 | - | G.H5 | I | 343 | G.H5.15 |
Hydrophobic | C-term | F | 644 | - | G.H2 | I | 212 | G.H2.08 |
Van-der-waals | C-term | F | 644 | - | G.H3 | S | 252 | G.H3.11 |
Hydrophobic | TM3 | L | 444 | 3x54 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | ICL3 | I | 544 | - | G.H5 | I | 344 | G.H5.16 |
Polar | ICL2 | L | 451 | - | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | ICL2 | L | 451 | - | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | ICL2 | L | 451 | - | G.H5 | I | 344 | G.H5.16 |
Polar | ICL3 | I | 544 | - | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | ICL3 | I | 544 | - | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | ICL3 | I | 544 | - | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM6 | K | 553 | 6x41 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | K | 553 | 6x41 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | C-term | K | 607 | - | G.h4s6 | T | 316 | G.h4s6.10 |
Van-der-waals | C-term | K | 607 | - | G.h4s6 | T | 316 | G.h4s6.10 |
Hydrophobic | TM6 | Q | 557 | 6x45 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | C-term | Q | 603 | - | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | TM3 | T | 447 | 3x57 | G.H5 | N | 347 | G.H5.19 |
Polar | ICL2 | N | 455 | - | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | ICL2 | N | 455 | - | G.hns1 | A | 31 | G.hns1.02 |
Van-der-waals | ICL2 | N | 455 | - | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | ICL3 | V | 541 | - | G.H5 | F | 334 | G.H5.06 |
Van-der-waals | ICL3 | V | 541 | - | G.H5 | F | 334 | G.H5.06 |
Polar | ICL3 | T | 543 | - | G.S6 | Y | 320 | G.S6.02 |
Hydrophobic | ICL3 | T | 543 | - | G.S6 | Y | 320 | G.S6.02 |
Van-der-waals | ICL3 | T | 543 | - | G.S6 | Y | 320 | G.S6.02 |
Hydrophobic | TM3 | T | 447 | 3x57 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | ICL2 | L | 451 | - | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | C-term | F | 644 | - | G.H3 | I | 253 | G.H3.12 |
Polar | ICL2 | V | 454 | - | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | ICL2 | V | 454 | - | G.hns1 | A | 31 | G.hns1.02 |
Van-der-waals | ICL2 | V | 454 | - | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | TM5 | L | 537 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Polar | C-term | K | 607 | - | G.h4s6 | D | 315 | G.h4s6.09 |
Hydrophobic | C-term | K | 607 | - | G.h4s6 | D | 315 | G.h4s6.09 |
Van-der-waals | C-term | K | 607 | - | G.h4s6 | D | 315 | G.h4s6.09 |
Hydrophobic | ICL2 | V | 453 | - | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | TM5 | L | 537 | 5x68 | G.H5 | T | 340 | G.H5.12 |
Hydrophobic | TM3 | L | 444 | 3x54 | G.H5 | L | 353 | G.H5.25 |
Polar | ICL2 | V | 453 | - | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | ICL2 | V | 453 | - | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM5 | L | 530 | 5x61 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | TM7 | Y | 598 | 7x57 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | TM5 | L | 534 | 5x65 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | ICL2 | T | 452 | - | G.H5 | T | 340 | G.H5.12 |
Polar | ICL3 | S | 542 | - | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | ICL3 | S | 542 | - | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | ICL3 | S | 542 | - | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM6 | A | 554 | 6x42 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | C-term | F | 644 | - | G.h2s4 | F | 215 | G.h2s4.01 |
Hydrophobic | ICL2 | V | 454 | - | G.h2s4 | T | 219 | G.h2s4.05 |
Hydrophobic | ICL2 | L | 451 | - | G.H5 | I | 343 | G.H5.15 |
Hydrophobic | TM5 | L | 530 | 5x61 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM5 | L | 530 | 5x61 | G.H5 | L | 353 | G.H5.25 |
Polar | TM2 | S | 388 | 2x46 | G.H5 | D | 350 | G.H5.22 |
Hydrophobic | TM2 | S | 388 | 2x46 | G.H5 | D | 350 | G.H5.22 |
Van-der-waals | TM2 | S | 388 | 2x46 | G.H5 | D | 350 | G.H5.22 |
Hydrophobic | ICL2 | T | 452 | - | G.H5 | I | 343 | G.H5.15 |
Van-der-waals | ICL2 | T | 452 | - | G.H5 | I | 343 | G.H5.15 |
Hydrophobic | TM6 | L | 550 | 6x38 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | C-term | Q | 604 | - | G.H5 | K | 349 | G.H5.21 |
Polar | TM3 | N | 450 | 3x60 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM2 | S | 388 | 2x46 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | ICL2 | V | 454 | - | G.S1 | E | 33 | G.S1.01 |
Van-der-waals | ICL2 | V | 454 | - | G.S1 | E | 33 | G.S1.01 |
Hydrophobic | ICL2 | V | 454 | - | G.H5 | I | 343 | G.H5.15 |
Van-der-waals | ICL2 | V | 454 | - | G.H5 | I | 343 | G.H5.15 |
Hydrophobic | ICL2 | Y | 456 | - | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | ICL2 | Y | 456 | - | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM6 | L | 550 | 6x38 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | L | 550 | 6x38 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | ICL3 | V | 541 | - | G.H5 | D | 337 | G.H5.09 |
Hydrophobic | ICL3 | V | 541 | - | G.H5 | A | 338 | G.H5.10 |