GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 86.3
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 11.2
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | C-term | G | 887 | - | G.H3 | T | 257 | G.H3.11 |
Hydrophobic | TM3 | I | 686 | 3x58 | G.H5 | L | 349 | G.H5.16 |
Hydrophobic | TM3 | L | 678 | 3x50 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM6 | I | 795 | 6x44 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM3 | I | 686 | 3x58 | G.H5 | L | 353 | G.H5.20 |
Hydrophobic | C-term | H | 893 | - | G.H3 | W | 263 | G.H3.17 |
Hydrophobic | TM3 | L | 682 | 3x54 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | ICL3 | L | 778 | - | G.H4 | K | 311 | G.H4.13 |
Van-der-waals | ICL3 | L | 778 | - | G.H4 | K | 311 | G.H4.13 |
Hydrophobic | ICL2 | V | 689 | - | G.H5 | I | 348 | G.H5.15 |
Polar | C-term | F | 891 | - | G.H3 | Y | 261 | G.H3.15 |
Hydrophobic | C-term | F | 891 | - | G.H3 | Y | 261 | G.H3.15 |
Van-der-waals | C-term | F | 891 | - | G.H3 | Y | 261 | G.H3.15 |
Hydrophobic | TM2 | R | 623 | 2x46 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM2 | R | 623 | 2x46 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM5 | K | 768 | 5x60 | G.H5 | L | 349 | G.H5.16 |
Polar | C-term | Y | 889 | - | G.H2 | R | 213 | G.H2.04 |
Hydrophobic | C-term | Y | 889 | - | G.H2 | R | 213 | G.H2.04 |
Van-der-waals | C-term | Y | 889 | - | G.H2 | R | 213 | G.H2.04 |
Hydrophobic | ICL2 | F | 690 | - | G.S1 | L | 40 | G.S1.02 |
Van-der-waals | ICL2 | F | 690 | - | G.S1 | L | 40 | G.S1.02 |
Hydrophobic | C-term | F | 891 | - | G.H2 | I | 217 | G.H2.08 |
Hydrophobic | ICL2 | V | 689 | - | G.H5 | K | 345 | G.H5.12 |
Van-der-waals | ICL2 | V | 689 | - | G.H5 | K | 345 | G.H5.12 |
Polar | H8 | D | 842 | 8x47 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | H8 | D | 842 | 8x47 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | H8 | D | 842 | 8x47 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | ICL3 | V | 774 | - | G.S6 | Y | 325 | G.S6.02 |
Van-der-waals | ICL3 | V | 774 | - | G.S6 | Y | 325 | G.S6.02 |
Hydrophobic | TM6 | L | 796 | 6x45 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM6 | L | 796 | 6x45 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | ICL2 | F | 690 | - | G.H5 | K | 345 | G.H5.12 |
Van-der-waals | ICL2 | F | 690 | - | G.H5 | K | 345 | G.H5.12 |
Polar | TM2 | S | 620 | 2x43 | G.H5 | E | 355 | G.H5.22 |
Hydrophobic | TM2 | S | 620 | 2x43 | G.H5 | E | 355 | G.H5.22 |
Hydrophobic | ICL3 | G | 775 | - | G.S6 | S | 326 | G.S6.03 |
Van-der-waals | ICL3 | G | 775 | - | G.S6 | S | 326 | G.S6.03 |
Polar | TM6 | S | 792 | 6x41 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM6 | S | 792 | 6x41 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM6 | S | 792 | 6x41 | G.H5 | L | 358 | G.H5.25 |
Polar | TM2 | T | 619 | 2x42 | G.H5 | N | 352 | G.H5.19 |
Hydrophobic | TM6 | R | 788 | 6x37 | G.H5 | V | 359 | G.H5.26 |
Van-der-waals | TM6 | R | 788 | 6x37 | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | C-term | F | 906 | - | G.S2 | Y | 192 | G.S2.04 |
Polar | TM6 | K | 791 | 6x40 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | TM6 | K | 791 | 6x40 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | TM6 | K | 791 | 6x40 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | ICL3 | L | 778 | - | G.H4 | L | 310 | G.H4.12 |
Polar | TM2 | Q | 618 | 2x41 | G.hns1 | R | 37 | G.hns1.02 |
Hydrophobic | TM2 | Q | 618 | 2x41 | G.hns1 | R | 37 | G.hns1.02 |
Van-der-waals | TM2 | Q | 618 | 2x41 | G.hns1 | R | 37 | G.hns1.02 |
Polar | ICL3 | E | 776 | - | G.S6 | S | 326 | G.S6.03 |
Hydrophobic | ICL3 | E | 776 | - | G.S6 | S | 326 | G.S6.03 |
Van-der-waals | ICL3 | E | 776 | - | G.S6 | S | 326 | G.S6.03 |
Polar | TM6 | R | 788 | 6x37 | G.H5 | Q | 350 | G.H5.17 |
Aromatic | ICL2 | F | 690 | - | G.H5 | F | 341 | G.H5.08 |
Hydrophobic | ICL2 | F | 690 | - | G.H5 | F | 341 | G.H5.08 |
Van-der-waals | ICL2 | F | 690 | - | G.H5 | F | 341 | G.H5.08 |
Hydrophobic | C-term | F | 891 | - | G.H3 | I | 258 | G.H3.12 |
Hydrophobic | C-term | H | 893 | - | G.H2 | I | 217 | G.H2.08 |
Van-der-waals | C-term | H | 893 | - | G.H2 | I | 217 | G.H2.08 |
Hydrophobic | C-term | F | 891 | - | G.H3 | L | 254 | G.H3.08 |
Hydrophobic | ICL2 | F | 690 | - | G.S3 | I | 199 | G.S3.01 |
Van-der-waals | ICL2 | F | 690 | - | G.S3 | I | 199 | G.S3.01 |
Polar | ICL3 | E | 776 | - | G.S6 | F | 328 | G.S6.05 |
Hydrophobic | ICL3 | E | 776 | - | G.S6 | F | 328 | G.S6.05 |
Van-der-waals | ICL3 | E | 776 | - | G.S6 | F | 328 | G.S6.05 |
Polar | TM2 | S | 617 | 2x40 | G.H5 | E | 355 | G.H5.22 |
Hydrophobic | TM2 | S | 617 | 2x40 | G.H5 | E | 355 | G.H5.22 |
Van-der-waals | TM2 | S | 617 | 2x40 | G.H5 | E | 355 | G.H5.22 |
Hydrophobic | ICL3 | E | 776 | - | G.H4 | L | 310 | G.H4.12 |
Hydrophobic | ICL3 | L | 778 | - | G.H4 | E | 307 | G.H4.09 |
Polar | C-term | Y | 889 | - | G.H2 | R | 210 | G.H2.01 |
Hydrophobic | C-term | Y | 889 | - | G.H2 | R | 210 | G.H2.01 |
Van-der-waals | C-term | Y | 889 | - | G.H2 | R | 210 | G.H2.01 |
Polar | TM3 | L | 681 | 3x53 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM3 | L | 681 | 3x53 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM3 | L | 681 | 3x53 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | C-term | F | 891 | - | G.H2 | R | 213 | G.H2.04 |
Van-der-waals | C-term | F | 891 | - | G.H2 | R | 213 | G.H2.04 |
Ionic | H8 | K | 844 | 8x49 | G.H5 | E | 355 | G.H5.22 |
Polar | H8 | K | 844 | 8x49 | G.H5 | E | 355 | G.H5.22 |
Van-der-waals | H8 | K | 844 | 8x49 | G.H5 | E | 355 | G.H5.22 |
Polar | C-term | Y | 889 | - | G.H3 | E | 250 | G.H3.04 |
Hydrophobic | C-term | Y | 889 | - | G.H3 | E | 250 | G.H3.04 |
Van-der-waals | C-term | Y | 889 | - | G.H3 | E | 250 | G.H3.04 |
Hydrophobic | ICL3 | V | 774 | - | G.H5 | A | 342 | G.H5.09 |
Hydrophobic | ICL2 | F | 690 | - | G.H5 | V | 344 | G.H5.11 |
Ionic | C-term | K | 886 | - | G.s4h3 | E | 245 | G.s4h3.14 |
Polar | C-term | K | 886 | - | G.s4h3 | E | 245 | G.s4h3.14 |
Van-der-waals | C-term | K | 886 | - | G.s4h3 | E | 245 | G.s4h3.14 |
Polar | ICL2 | M | 693 | - | G.hns1 | R | 37 | G.hns1.02 |
Hydrophobic | TM5 | L | 769 | 5x61 | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | TM2 | T | 619 | 2x42 | G.H5 | E | 355 | G.H5.22 |
Hydrophobic | ICL3 | T | 773 | - | G.S6 | Y | 325 | G.S6.02 |
Hydrophobic | ICL3 | T | 773 | - | G.h4s6 | I | 323 | G.h4s6.20 |
Polar | ICL2 | H | 692 | - | G.hns1 | R | 37 | G.hns1.02 |
Hydrophobic | ICL2 | H | 692 | - | G.hns1 | R | 37 | G.hns1.02 |
Van-der-waals | ICL2 | H | 692 | - | G.hns1 | R | 37 | G.hns1.02 |
Polar | TM3 | L | 682 | 3x54 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM3 | L | 682 | 3x54 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM6 | R | 788 | 6x37 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM6 | R | 788 | 6x37 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | C-term | F | 891 | - | G.H2 | W | 216 | G.H2.07 |
Van-der-waals | C-term | F | 891 | - | G.H2 | W | 216 | G.H2.07 |
Hydrophobic | C-term | S | 892 | - | G.H2 | I | 217 | G.H2.08 |
Polar | TM6 | K | 791 | 6x40 | G.H5 | V | 359 | G.H5.26 |
Van-der-waals | TM6 | K | 791 | 6x40 | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | TM2 | T | 619 | 2x42 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | ICL3 | G | 775 | - | G.H5 | F | 339 | G.H5.06 |
Van-der-waals | ICL3 | G | 775 | - | G.H5 | F | 339 | G.H5.06 |
Polar | TM2 | R | 623 | 2x46 | G.H5 | E | 355 | G.H5.22 |
Hydrophobic | TM2 | R | 623 | 2x46 | G.H5 | E | 355 | G.H5.22 |
Van-der-waals | TM2 | R | 623 | 2x46 | G.H5 | E | 355 | G.H5.22 |
Aromatic | C-term | F | 891 | - | G.h2s4 | F | 220 | G.h2s4.01 |
Hydrophobic | C-term | F | 891 | - | G.h2s4 | F | 220 | G.h2s4.01 |
Hydrophobic | C-term | F | 891 | - | G.H3 | T | 257 | G.H3.11 |
Hydrophobic | TM6 | I | 795 | 6x44 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | TM6 | I | 795 | 6x44 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | C-term | Y | 889 | - | G.H3 | T | 257 | G.H3.11 |
Van-der-waals | C-term | Y | 889 | - | G.H3 | T | 257 | G.H3.11 |
Hydrophobic | C-term | Y | 889 | - | G.H3 | L | 254 | G.H3.08 |
Hydrophobic | C-term | F | 906 | - | G.H1 | R | 60 | G.H1.09 |
Van-der-waals | C-term | F | 906 | - | G.H1 | R | 60 | G.H1.09 |
Hydrophobic | ICL2 | V | 689 | - | G.H5 | L | 349 | G.H5.16 |
Hydrophobic | TM5 | V | 765 | 5x57 | G.H5 | L | 358 | G.H5.25 |
Polar | TM2 | R | 623 | 2x46 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | TM2 | R | 623 | 2x46 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | TM2 | R | 623 | 2x46 | G.H5 | N | 357 | G.H5.24 |
Polar | TM3 | R | 685 | 3x57 | G.H5 | N | 352 | G.H5.19 |
Hydrophobic | TM3 | R | 685 | 3x57 | G.H5 | N | 352 | G.H5.19 |
Van-der-waals | TM3 | R | 685 | 3x57 | G.H5 | N | 352 | G.H5.19 |
Ionic | ICL3 | E | 776 | - | G.S6 | H | 327 | G.S6.04 |
Polar | ICL3 | E | 776 | - | G.S6 | H | 327 | G.S6.04 |
Hydrophobic | ICL3 | E | 776 | - | G.S6 | H | 327 | G.S6.04 |
Van-der-waals | ICL3 | E | 776 | - | G.S6 | H | 327 | G.S6.04 |
Hydrophobic | ICL3 | V | 774 | - | G.H5 | F | 339 | G.H5.06 |
Van-der-waals | ICL3 | V | 774 | - | G.H5 | F | 339 | G.H5.06 |
Hydrophobic | ICL2 | F | 690 | - | G.H5 | I | 348 | G.H5.15 |
Van-der-waals | ICL2 | F | 690 | - | G.H5 | I | 348 | G.H5.15 |
Hydrophobic | TM5 | L | 769 | 5x61 | G.H5 | L | 353 | G.H5.20 |