GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 83.9
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 12.7
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM2 | R | 623 | 2x46 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | TM2 | R | 623 | 2x46 | G.H5 | G | 352 | G.H5.24 |
Polar | ICL3 | E | 776 | - | G.S6 | M | 323 | G.S6.05 |
Hydrophobic | ICL3 | E | 776 | - | G.S6 | M | 323 | G.S6.05 |
Van-der-waals | ICL3 | E | 776 | - | G.S6 | M | 323 | G.S6.05 |
Van-der-waals | C-term | L | 903 | - | H.HA | Q | 68 | H.HA.06 |
Hydrophobic | ICL3 | V | 774 | - | G.H5 | D | 337 | G.H5.09 |
Hydrophobic | ICL2 | F | 690 | - | G.S3 | L | 195 | G.S3.01 |
Van-der-waals | ICL2 | F | 690 | - | G.S3 | L | 195 | G.S3.01 |
Polar | TM2 | S | 620 | 2x43 | G.H5 | G | 350 | G.H5.22 |
Hydrophobic | TM2 | S | 620 | 2x43 | G.H5 | G | 350 | G.H5.22 |
Van-der-waals | TM2 | S | 620 | 2x43 | G.H5 | G | 350 | G.H5.22 |
Hydrophobic | TM3 | L | 682 | 3x54 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | ICL2 | F | 690 | - | G.H5 | F | 336 | G.H5.08 |
Hydrophobic | C-term | Y | 889 | - | G.H2 | H | 214 | G.H2.09 |
Van-der-waals | C-term | Y | 889 | - | G.H2 | H | 214 | G.H2.09 |
Hydrophobic | TM5 | K | 768 | 5x60 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | ICL3 | G | 775 | - | G.S6 | C | 321 | G.S6.03 |
Van-der-waals | ICL3 | G | 775 | - | G.S6 | C | 321 | G.S6.03 |
Hydrophobic | TM3 | I | 686 | 3x58 | G.H5 | L | 348 | G.H5.20 |
Polar | TM6 | K | 791 | 6x40 | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | TM6 | K | 791 | 6x40 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | TM6 | S | 792 | 6x41 | G.H5 | L | 353 | G.H5.25 |
Polar | TM4 | H | 696 | 4x40 | G.HN | K | 24 | G.HN.48 |
Van-der-waals | TM4 | H | 696 | 4x40 | G.HN | K | 24 | G.HN.48 |
Hydrophobic | ICL3 | L | 778 | - | G.H4 | Q | 305 | G.H4.12 |
Polar | C-term | Y | 889 | - | G.H2 | K | 211 | G.H2.06 |
Van-der-waals | C-term | Y | 889 | - | G.H2 | K | 211 | G.H2.06 |
Hydrophobic | ICL2 | H | 692 | - | G.hns1 | K | 32 | G.hns1.03 |
Hydrophobic | ICL3 | T | 773 | - | G.S6 | Y | 320 | G.S6.02 |
Polar | ICL3 | R | 777 | - | G.S6 | I | 319 | G.S6.01 |
Hydrophobic | ICL3 | R | 777 | - | G.S6 | I | 319 | G.S6.01 |
Van-der-waals | ICL3 | R | 777 | - | G.S6 | I | 319 | G.S6.01 |
Hydrophobic | ICL3 | T | 773 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | ICL3 | T | 773 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Polar | ICL2 | H | 692 | - | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | ICL2 | H | 692 | - | G.hns1 | A | 31 | G.hns1.02 |
Van-der-waals | ICL2 | H | 692 | - | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | C-term | F | 906 | - | G.hfs2 | T | 183 | G.hfs2.06 |
Van-der-waals | C-term | F | 906 | - | G.hfs2 | T | 183 | G.hfs2.06 |
Hydrophobic | TM5 | L | 769 | 5x61 | G.H5 | L | 348 | G.H5.20 |
Polar | TM2 | T | 619 | 2x42 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM5 | V | 765 | 5x57 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | ICL3 | V | 774 | - | G.S6 | Y | 320 | G.S6.02 |
Van-der-waals | ICL3 | V | 774 | - | G.S6 | Y | 320 | G.S6.02 |
Polar | ICL3 | E | 776 | - | G.S6 | C | 321 | G.S6.03 |
Van-der-waals | ICL3 | E | 776 | - | G.S6 | C | 321 | G.S6.03 |
Hydrophobic | TM6 | L | 796 | 6x45 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | ICL3 | V | 774 | - | G.H5 | A | 338 | G.H5.10 |
Hydrophobic | C-term | L | 903 | - | H.HA | Y | 69 | H.HA.07 |
Van-der-waals | ICL3 | T | 773 | - | G.H5 | D | 341 | G.H5.13 |
Ionic | ICL3 | R | 777 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | ICL3 | R | 777 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | ICL3 | R | 777 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | TM6 | I | 795 | 6x44 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | C-term | Y | 889 | - | G.H2 | C | 215 | G.H2.10 |
Van-der-waals | C-term | Y | 889 | - | G.H2 | C | 215 | G.H2.10 |
Polar | TM6 | S | 792 | 6x41 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | ICL2 | V | 689 | - | G.H5 | I | 343 | G.H5.15 |
Van-der-waals | ICL2 | V | 689 | - | G.H5 | I | 343 | G.H5.15 |
Hydrophobic | ICL2 | F | 690 | - | G.H5 | T | 340 | G.H5.12 |
Van-der-waals | ICL2 | F | 690 | - | G.H5 | T | 340 | G.H5.12 |
Polar | ICL3 | V | 774 | - | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | ICL3 | V | 774 | - | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | ICL3 | V | 774 | - | G.H5 | D | 341 | G.H5.13 |
Aromatic | ICL3 | R | 777 | - | G.S6 | Y | 320 | G.S6.02 |
Hydrophobic | TM3 | L | 682 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | TM5 | V | 765 | 5x57 | G.H5 | L | 348 | G.H5.20 |
Polar | C-term | I | 901 | - | H.HA | Q | 68 | H.HA.06 |
Hydrophobic | TM5 | L | 769 | 5x61 | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | TM5 | L | 769 | 5x61 | G.H5 | Y | 354 | G.H5.26 |
Polar | ICL3 | E | 776 | - | G.H4 | Q | 305 | G.H4.12 |
Van-der-waals | ICL3 | E | 776 | - | G.H4 | Q | 305 | G.H4.12 |
Polar | TM6 | R | 788 | 6x37 | G.H5 | Y | 354 | G.H5.26 |
Aromatic | TM6 | R | 788 | 6x37 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | TM6 | R | 788 | 6x37 | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | TM6 | R | 788 | 6x37 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | ICL3 | L | 778 | - | G.H4 | A | 302 | G.H4.08 |
Van-der-waals | ICL3 | L | 778 | - | G.H4 | A | 302 | G.H4.08 |
Polar | C-term | Y | 889 | - | G.H2 | W | 212 | G.H2.07 |
Hydrophobic | C-term | Y | 889 | - | G.H2 | W | 212 | G.H2.07 |
Van-der-waals | C-term | Y | 889 | - | G.H2 | W | 212 | G.H2.07 |
Polar | TM2 | R | 623 | 2x46 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM2 | R | 623 | 2x46 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM2 | R | 623 | 2x46 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM3 | L | 682 | 3x54 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM2 | T | 619 | 2x42 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM2 | T | 619 | 2x42 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | ICL2 | V | 689 | - | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | ICL2 | V | 689 | - | G.H5 | I | 344 | G.H5.16 |
Ionic | ICL3 | E | 776 | - | G.S6 | H | 322 | G.S6.04 |
Polar | ICL3 | E | 776 | - | G.S6 | H | 322 | G.S6.04 |
Hydrophobic | ICL3 | E | 776 | - | G.S6 | H | 322 | G.S6.04 |
Ionic | TM6 | R | 788 | 6x37 | G.h4s6 | E | 318 | G.h4s6.12 |
Polar | TM6 | R | 788 | 6x37 | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | TM6 | R | 788 | 6x37 | G.h4s6 | E | 318 | G.h4s6.12 |
Polar | TM3 | R | 685 | 3x57 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM3 | R | 685 | 3x57 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | TM3 | R | 685 | 3x57 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | ICL2 | F | 690 | - | G.H5 | I | 343 | G.H5.15 |
Van-der-waals | ICL2 | F | 690 | - | G.H5 | I | 343 | G.H5.15 |