G12 - ADGRF2 complex model

GPCR CLASS (FAMILY)

B2 (Adhesion)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 80.0

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 16.4


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 I 547 3x58 G.H5 L 375 G.H5.20
Van-der-waals TM3 I 547 3x58 G.H5 L 375 G.H5.20
Hydrophobic ICL1 I 480 - G.H5 N 374 G.H5.19
Van-der-waals ICL1 I 480 - G.H5 N 374 G.H5.19
Hydrophobic ICL1 I 480 - G.H5 I 378 G.H5.23
Van-der-waals ICL1 I 480 - G.H5 I 378 G.H5.23
Polar TM4 S 557 4x40 G.HN R 52 G.HN.52
Van-der-waals TM4 S 557 4x40 G.HN R 52 G.HN.52
Hydrophobic TM5 K 628 5x60 G.H5 L 371 G.H5.16
Hydrophobic TM6 L 655 6x39 G.H5 M 379 G.H5.24
Van-der-waals TM6 L 655 6x39 G.H5 M 379 G.H5.24
Hydrophobic TM2 R 484 2x46 G.H5 L 380 G.H5.25
Van-der-waals TM2 R 484 2x46 G.H5 L 380 G.H5.25
Hydrophobic ICL2 F 551 - G.H5 K 367 G.H5.12
Van-der-waals ICL2 F 551 - G.H5 K 367 G.H5.12
Hydrophobic TM5 V 625 5x57 G.H5 L 375 G.H5.20
Polar TM6 N 651 6x35 G.H5 Q 381 G.H5.26
Hydrophobic TM6 N 651 6x35 G.H5 Q 381 G.H5.26
Van-der-waals TM6 N 651 6x35 G.H5 Q 381 G.H5.26
Hydrophobic TM6 I 654 6x38 G.H5 L 380 G.H5.25
Polar ICL2 T 553 - G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 T 553 - G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 T 553 - G.hns1 R 56 G.hns1.03
Hydrophobic TM3 G 546 3x57 G.H5 I 378 G.H5.23
Hydrophobic ICL2 H 552 - G.S3 I 221 G.S3.01
Hydrophobic TM7 D 693 7x53 G.H5 L 380 G.H5.25
Van-der-waals TM7 D 693 7x53 G.H5 L 380 G.H5.25
Hydrophobic ICL2 F 551 - G.H5 V 366 G.H5.11
Polar TM2 R 484 2x46 G.H5 D 377 G.H5.22
Van-der-waals TM2 R 484 2x46 G.H5 D 377 G.H5.22
Polar TM2 R 484 2x46 G.H5 I 378 G.H5.23
Hydrophobic TM2 R 484 2x46 G.H5 I 378 G.H5.23
Van-der-waals TM2 R 484 2x46 G.H5 I 378 G.H5.23
Ionic ICL1 E 479 - G.hns1 R 55 G.hns1.02
Polar ICL1 E 479 - G.hns1 R 55 G.hns1.02
Hydrophobic ICL1 E 479 - G.hns1 R 55 G.hns1.02
Van-der-waals ICL1 E 479 - G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 V 550 - G.H5 I 370 G.H5.15
Van-der-waals ICL2 V 550 - G.H5 I 370 G.H5.15
Hydrophobic ICL2 V 550 - G.H5 L 371 G.H5.16
Aromatic ICL2 F 551 - G.H5 F 363 G.H5.08
Hydrophobic ICL2 F 551 - G.H5 F 363 G.H5.08
Van-der-waals ICL2 F 551 - G.H5 F 363 G.H5.08
Hydrophobic TM3 I 543 3x54 G.H5 I 378 G.H5.23
Van-der-waals TM3 I 543 3x54 G.H5 I 378 G.H5.23
Hydrophobic TM6 L 658 6x42 G.H5 L 380 G.H5.25
Hydrophobic ICL2 V 550 - G.H5 K 367 G.H5.12
Van-der-waals ICL2 V 550 - G.H5 K 367 G.H5.12
Polar ICL2 T 553 - G.hns1 R 55 G.hns1.02
Hydrophobic TM3 I 543 3x54 G.H5 M 379 G.H5.24
Hydrophobic ICL2 F 551 - G.S1 V 58 G.S1.02
Polar ICL3 Q 640 - G.h4s6 R 342 G.h4s6.11
Hydrophobic TM4 P 555 4x38 G.HN R 52 G.HN.52
Van-der-waals TM4 P 555 4x38 G.HN R 52 G.HN.52
Hydrophobic TM5 V 625 5x57 G.H5 M 379 G.H5.24
Van-der-waals TM5 V 625 5x57 G.H5 M 379 G.H5.24
Hydrophobic ICL1 I 480 - G.H5 D 377 G.H5.22
Hydrophobic TM3 I 547 3x58 G.H5 L 371 G.H5.16
Van-der-waals TM3 I 547 3x58 G.H5 L 371 G.H5.16
Hydrophobic TM6 N 651 6x35 G.H5 M 379 G.H5.24
Van-der-waals TM6 N 651 6x35 G.H5 M 379 G.H5.24
Polar TM3 G 546 3x57 G.H5 N 374 G.H5.19
Hydrophobic TM3 G 546 3x57 G.H5 N 374 G.H5.19
Van-der-waals TM3 G 546 3x57 G.H5 N 374 G.H5.19
Hydrophobic ICL2 F 551 - G.S3 I 221 G.S3.01
Van-der-waals ICL2 F 551 - G.S3 I 221 G.S3.01
Polar ICL3 R 647 - G.H5 Q 381 G.H5.26
Hydrophobic ICL3 R 647 - G.H5 Q 381 G.H5.26
Van-der-waals ICL3 R 647 - G.H5 Q 381 G.H5.26
Polar ICL1 T 481 - G.H5 D 377 G.H5.22
Hydrophobic ICL2 F 551 - G.H5 I 370 G.H5.15
Van-der-waals ICL2 F 551 - G.H5 I 370 G.H5.15
Polar ICL1 T 478 - G.H5 D 377 G.H5.22
Hydrophobic ICL1 T 478 - G.H5 D 377 G.H5.22
Van-der-waals ICL1 T 478 - G.H5 D 377 G.H5.22
Polar ICL3 A 632 - G.H5 Q 372 G.H5.17
Hydrophobic ICL3 A 632 - G.H5 Q 372 G.H5.17