G12 - ADGRF3 complex model

GPCR CLASS (FAMILY)

B2 (Adhesion)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 81.7

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 14.6


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM2 R 808 2x46 G.H5 L 380 G.H5.25
Van-der-waals TM2 R 808 2x46 G.H5 L 380 G.H5.25
Hydrophobic TM4 A 878 4x38 G.hns1 R 55 G.hns1.02
Van-der-waals TM4 A 878 4x38 G.hns1 R 55 G.hns1.02
Hydrophobic ICL3 L 956 - G.H5 A 365 G.H5.10
Ionic ICL3 E 958 - G.S6 H 348 G.S6.03
Hydrophobic ICL3 E 958 - G.S6 H 348 G.S6.03
Hydrophobic ICL3 L 956 - G.H5 F 361 G.H5.06
Hydrophobic ICL3 S 957 - G.S6 F 347 G.S6.02
Van-der-waals ICL3 S 957 - G.S6 F 347 G.S6.02
Hydrophobic TM5 L 951 5x61 G.H5 L 375 G.H5.20
Polar TM3 Q 869 3x57 G.H5 N 374 G.H5.19
Van-der-waals TM3 Q 869 3x57 G.H5 N 374 G.H5.19
Hydrophobic ICL2 V 873 - G.H5 L 371 G.H5.16
Van-der-waals ICL2 V 873 - G.H5 L 371 G.H5.16
Hydrophobic TM6 G 970 6x37 G.H5 M 379 G.H5.24
Van-der-waals TM6 G 970 6x37 G.H5 M 379 G.H5.24
Hydrophobic TM6 I 977 6x44 G.H5 M 379 G.H5.24
Van-der-waals TM6 I 977 6x44 G.H5 M 379 G.H5.24
Polar ICL1 N 802 - G.H5 D 377 G.H5.22
Van-der-waals ICL1 N 802 - G.H5 D 377 G.H5.22
Hydrophobic ICL2 F 874 - G.H5 K 367 G.H5.12
Polar TM4 H 880 4x40 G.HN R 52 G.HN.52
Hydrophobic ICL3 S 955 - G.h4s6 P 345 G.h4s6.20
Van-der-waals ICL3 S 955 - G.h4s6 P 345 G.h4s6.20
Hydrophobic ICL3 S 957 - G.h4s6 P 345 G.h4s6.20
Van-der-waals ICL3 S 957 - G.h4s6 P 345 G.h4s6.20
Polar H8 K 1026 8x49 G.H5 Q 381 G.H5.26
Van-der-waals H8 K 1026 8x49 G.H5 Q 381 G.H5.26
Hydrophobic ICL2 F 874 - G.S1 V 58 G.S1.02
Van-der-waals ICL2 F 874 - G.S1 V 58 G.S1.02
Van-der-waals ICL3 E 963 - G.h4s6 P 345 G.h4s6.20
Hydrophobic TM3 L 870 3x58 G.H5 L 375 G.H5.20
Van-der-waals TM3 L 870 3x58 G.H5 L 375 G.H5.20
Hydrophobic TM3 L 866 3x54 G.H5 I 378 G.H5.23
Van-der-waals TM3 L 866 3x54 G.H5 I 378 G.H5.23
Hydrophobic TM3 L 870 3x58 G.H5 L 371 G.H5.16
Van-der-waals TM3 L 870 3x58 G.H5 L 371 G.H5.16
Polar ICL2 H 875 - G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 H 875 - G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 H 875 - G.hns1 R 56 G.hns1.03
Hydrophobic ICL3 L 956 - G.S6 F 347 G.S6.02
Hydrophobic TM6 A 974 6x41 G.H5 M 379 G.H5.24
Van-der-waals TM6 A 974 6x41 G.H5 M 379 G.H5.24
Polar TM6 K 973 6x40 G.H5 M 379 G.H5.24
Van-der-waals TM6 K 973 6x40 G.H5 M 379 G.H5.24
Hydrophobic TM6 I 977 6x44 G.H5 L 380 G.H5.25
Van-der-waals TM6 I 977 6x44 G.H5 L 380 G.H5.25
Hydrophobic ICL3 S 955 - G.S6 F 347 G.S6.02
Hydrophobic ICL2 F 874 - G.H5 I 370 G.H5.15
Van-der-waals ICL2 F 874 - G.H5 I 370 G.H5.15
Van-der-waals TM3 Q 869 3x57 G.H5 I 378 G.H5.23
Hydrophobic TM7 G 1020 7x57 G.H5 L 380 G.H5.25
Van-der-waals TM7 G 1020 7x57 G.H5 L 380 G.H5.25
Hydrophobic ICL2 F 874 - G.H5 V 366 G.H5.11
Polar ICL3 S 957 - G.S6 L 346 G.S6.01
Hydrophobic ICL3 S 957 - G.S6 L 346 G.S6.01
Van-der-waals ICL3 S 957 - G.S6 L 346 G.S6.01
Polar H8 R 1025 8x48 G.H5 L 380 G.H5.25
Hydrophobic ICL2 F 874 - G.S3 F 223 G.S3.03
Hydrophobic TM4 R 881 4x41 G.HN R 52 G.HN.52
Van-der-waals TM4 R 881 4x41 G.HN R 52 G.HN.52
Polar TM2 R 808 2x46 G.H5 D 377 G.H5.22
Hydrophobic TM2 R 808 2x46 G.H5 D 377 G.H5.22
Van-der-waals TM2 R 808 2x46 G.H5 D 377 G.H5.22
Hydrophobic ICL2 V 873 - G.H5 I 370 G.H5.15
Van-der-waals ICL2 V 873 - G.H5 I 370 G.H5.15
Hydrophobic ICL3 L 956 - G.H5 H 364 G.H5.09
Van-der-waals ICL3 L 956 - G.H5 H 364 G.H5.09
Polar TM2 R 808 2x46 G.H5 I 378 G.H5.23
Hydrophobic TM2 R 808 2x46 G.H5 I 378 G.H5.23
Van-der-waals TM2 R 808 2x46 G.H5 I 378 G.H5.23
Hydrophobic TM5 L 951 5x61 G.H5 M 379 G.H5.24
Van-der-waals TM5 L 951 5x61 G.H5 M 379 G.H5.24
Hydrophobic TM7 F 1019 7x56 G.H5 L 380 G.H5.25
Van-der-waals TM7 F 1019 7x56 G.H5 L 380 G.H5.25
Hydrophobic H8 D 1024 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 D 1024 8x47 G.H5 L 380 G.H5.25
Aromatic ICL2 F 874 - G.H5 F 363 G.H5.08
Hydrophobic ICL2 F 874 - G.H5 F 363 G.H5.08
Van-der-waals ICL2 F 874 - G.H5 F 363 G.H5.08
Hydrophobic ICL1 K 803 - G.hns1 R 55 G.hns1.02
Van-der-waals ICL1 K 803 - G.hns1 R 55 G.hns1.02
Hydrophobic ICL1 I 804 - G.H5 D 377 G.H5.22
Hydrophobic TM5 K 950 5x60 G.H5 L 371 G.H5.16
Polar ICL2 Q 876 - G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 Q 876 - G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 Q 876 - G.hns1 R 55 G.hns1.02
Polar TM6 K 973 6x40 G.H5 L 380 G.H5.25
Hydrophobic TM6 K 973 6x40 G.H5 L 380 G.H5.25
Van-der-waals TM6 K 973 6x40 G.H5 L 380 G.H5.25
Hydrophobic ICL2 F 874 - G.S3 I 221 G.S3.01
Van-der-waals ICL2 F 874 - G.S3 I 221 G.S3.01
Hydrophobic ICL2 V 873 - G.H5 K 367 G.H5.12
Polar ICL3 L 956 - G.H5 D 368 G.H5.13
Hydrophobic TM6 K 973 6x40 G.H5 Q 381 G.H5.26
Hydrophobic TM5 K 950 5x60 G.H5 L 375 G.H5.20
Ionic H8 K 1026 8x49 G.H5 D 377 G.H5.22
Polar H8 K 1026 8x49 G.H5 D 377 G.H5.22
Van-der-waals H8 K 1026 8x49 G.H5 D 377 G.H5.22
Hydrophobic ICL1 I 804 - G.H5 N 374 G.H5.19
Van-der-waals ICL1 I 804 - G.H5 N 374 G.H5.19