GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 84.5
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 12.7
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM6 | K | 973 | 6x40 | G.H5 | L | 393 | G.H5.25 |
Polar | TM5 | R | 953 | 5x63 | G.H5 | R | 385 | G.H5.17 |
Van-der-waals | TM5 | R | 953 | 5x63 | G.H5 | R | 385 | G.H5.17 |
Hydrophobic | ICL3 | L | 956 | - | G.S6 | P | 361 | G.S6.03 |
Van-der-waals | ICL3 | L | 956 | - | G.S6 | P | 361 | G.S6.03 |
Polar | TM3 | Q | 869 | 3x57 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | TM3 | Q | 869 | 3x57 | G.H5 | H | 387 | G.H5.19 |
Van-der-waals | TM3 | Q | 869 | 3x57 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | C-term | W | 1068 | - | G.H3 | W | 281 | G.H3.17 |
Hydrophobic | TM5 | L | 951 | 5x61 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM5 | L | 951 | 5x61 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | ICL1 | I | 804 | - | G.H5 | Q | 390 | G.H5.22 |
Hydrophobic | TM5 | L | 951 | 5x61 | G.H5 | L | 388 | G.H5.20 |
Hydrophobic | TM5 | L | 951 | 5x61 | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | TM5 | L | 951 | 5x61 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | TM6 | I | 977 | 6x44 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | TM6 | I | 977 | 6x44 | G.H5 | E | 392 | G.H5.24 |
Polar | H8 | K | 1026 | 8x49 | G.H5 | R | 389 | G.H5.21 |
Hydrophobic | ICL3 | S | 957 | - | G.h4s6 | Y | 358 | G.h4s6.20 |
Hydrophobic | ICL2 | F | 874 | - | G.S3 | V | 217 | G.S3.01 |
Van-der-waals | ICL2 | F | 874 | - | G.S3 | V | 217 | G.S3.01 |
Polar | ICL2 | Q | 876 | - | G.hns1 | R | 38 | G.hns1.02 |
Hydrophobic | ICL2 | Q | 876 | - | G.hns1 | R | 38 | G.hns1.02 |
Van-der-waals | ICL2 | Q | 876 | - | G.hns1 | R | 38 | G.hns1.02 |
Polar | ICL1 | N | 802 | - | G.H5 | Q | 390 | G.H5.22 |
Van-der-waals | ICL1 | N | 802 | - | G.H5 | Q | 390 | G.H5.22 |
Polar | TM6 | K | 973 | 6x40 | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | TM6 | K | 973 | 6x40 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | ICL3 | E | 958 | - | G.h4s6 | T | 350 | G.h4s6.03 |
Hydrophobic | ICL2 | V | 873 | - | G.H5 | R | 380 | G.H5.12 |
Polar | TM2 | R | 808 | 2x46 | G.H5 | Q | 390 | G.H5.22 |
Hydrophobic | TM2 | R | 808 | 2x46 | G.H5 | Q | 390 | G.H5.22 |
Van-der-waals | TM2 | R | 808 | 2x46 | G.H5 | Q | 390 | G.H5.22 |
Hydrophobic | ICL2 | F | 874 | - | G.H5 | R | 380 | G.H5.12 |
Polar | ICL2 | F | 874 | - | G.S1 | H | 41 | G.S1.02 |
Aromatic | ICL2 | F | 874 | - | G.S1 | H | 41 | G.S1.02 |
Hydrophobic | ICL2 | F | 874 | - | G.S1 | H | 41 | G.S1.02 |
Van-der-waals | ICL2 | F | 874 | - | G.S1 | H | 41 | G.S1.02 |
Ionic | TM6 | K | 973 | 6x40 | G.H5 | E | 392 | G.H5.24 |
Polar | TM6 | K | 973 | 6x40 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | TM6 | K | 973 | 6x40 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | TM6 | K | 973 | 6x40 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | ICL3 | L | 956 | - | G.S6 | Y | 360 | G.S6.02 |
Hydrophobic | ICL1 | I | 804 | - | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | ICL1 | I | 804 | - | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | ICL2 | V | 873 | - | G.H5 | I | 383 | G.H5.15 |
Van-der-waals | ICL2 | V | 873 | - | G.H5 | I | 383 | G.H5.15 |
Hydrophobic | ICL1 | I | 804 | - | G.H5 | H | 387 | G.H5.19 |
Van-der-waals | ICL1 | I | 804 | - | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | H8 | D | 1024 | 8x47 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | H8 | D | 1024 | 8x47 | G.H5 | E | 392 | G.H5.24 |
Ionic | H8 | K | 1026 | 8x49 | G.H5 | E | 392 | G.H5.24 |
Polar | H8 | K | 1026 | 8x49 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | H8 | K | 1026 | 8x49 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | ICL3 | S | 957 | - | G.H4 | L | 346 | G.H4.16 |
Polar | TM2 | R | 808 | 2x46 | G.H5 | Y | 391 | G.H5.23 |
Aromatic | TM2 | R | 808 | 2x46 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM2 | R | 808 | 2x46 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM2 | R | 808 | 2x46 | G.H5 | Y | 391 | G.H5.23 |
Polar | TM3 | L | 870 | 3x58 | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | TM3 | L | 870 | 3x58 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | ICL2 | F | 874 | - | G.S3 | F | 219 | G.S3.03 |
Ionic | TM5 | R | 953 | 5x63 | G.H5 | D | 381 | G.H5.13 |
Polar | TM5 | R | 953 | 5x63 | G.H5 | D | 381 | G.H5.13 |
Van-der-waals | TM5 | R | 953 | 5x63 | G.H5 | D | 381 | G.H5.13 |
Hydrophobic | TM3 | L | 866 | 3x54 | G.H5 | L | 393 | G.H5.25 |
Aromatic | ICL2 | F | 874 | - | G.H5 | F | 376 | G.H5.08 |
Hydrophobic | ICL2 | F | 874 | - | G.H5 | F | 376 | G.H5.08 |
Van-der-waals | ICL2 | F | 874 | - | G.H5 | F | 376 | G.H5.08 |
Polar | H8 | R | 1025 | 8x48 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | H8 | R | 1025 | 8x48 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | H8 | R | 1025 | 8x48 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | TM5 | K | 950 | 5x60 | G.H5 | L | 388 | G.H5.20 |
Hydrophobic | TM6 | I | 977 | 6x44 | G.H5 | L | 393 | G.H5.25 |
Aromatic | C-term | W | 1068 | - | G.H3 | R | 280 | G.H3.16 |
Hydrophobic | C-term | W | 1068 | - | G.H3 | R | 280 | G.H3.16 |
Van-der-waals | C-term | W | 1068 | - | G.H3 | R | 280 | G.H3.16 |
Polar | TM5 | K | 950 | 5x60 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | TM5 | K | 950 | 5x60 | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | TM5 | K | 950 | 5x60 | G.H5 | Q | 384 | G.H5.16 |
Polar | ICL3 | P | 954 | - | G.H5 | R | 385 | G.H5.17 |
Hydrophobic | TM6 | L | 978 | 6x45 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | ICL3 | L | 956 | - | G.S6 | H | 362 | G.S6.04 |
Hydrophobic | TM3 | L | 870 | 3x58 | G.H5 | L | 388 | G.H5.20 |
Hydrophobic | ICL2 | F | 874 | - | G.H5 | C | 379 | G.H5.11 |
Polar | TM3 | Q | 869 | 3x57 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM3 | Q | 869 | 3x57 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM3 | Q | 869 | 3x57 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | ICL2 | V | 873 | - | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | ICL2 | V | 873 | - | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | ICL2 | F | 874 | - | G.H5 | I | 383 | G.H5.15 |
Polar | ICL3 | S | 957 | - | G.S6 | C | 359 | G.S6.01 |
Hydrophobic | ICL3 | S | 957 | - | G.S6 | C | 359 | G.S6.01 |
Van-der-waals | ICL3 | S | 957 | - | G.S6 | C | 359 | G.S6.01 |
Hydrophobic | ICL3 | S | 955 | - | G.H5 | R | 385 | G.H5.17 |
Hydrophobic | TM6 | A | 974 | 6x41 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | ICL1 | K | 803 | - | G.hns1 | R | 38 | G.hns1.02 |
Polar | TM3 | L | 866 | 3x54 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM3 | L | 866 | 3x54 | G.H5 | Y | 391 | G.H5.23 |