G12 - ADGRF5 complex model

GPCR CLASS (FAMILY)

B2 (Adhesion)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 80.2

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 15.1


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic C-term F 1317 - G.H2 R 235 G.H2.04
Van-der-waals C-term F 1317 - G.H2 R 235 G.H2.04
Hydrophobic TM3 L 1115 3x58 G.H5 L 371 G.H5.16
Van-der-waals TM3 L 1115 3x58 G.H5 L 371 G.H5.16
Hydrophobic ICL2 I 1118 - G.H5 K 367 G.H5.12
Hydrophobic C-term F 1317 - G.h2s4 F 242 G.h2s4.01
Polar TM5 I 1202 5x66 G.H5 D 368 G.H5.13
Hydrophobic ICL2 L 1119 - G.S1 V 58 G.S1.02
Hydrophobic C-term F 1313 - G.h2s4 F 242 G.h2s4.01
Hydrophobic C-term L 1316 - G.H3 T 279 G.H3.11
Ionic ICL2 E 1121 - G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 E 1121 - G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 E 1121 - G.hns1 R 55 G.hns1.02
Hydrophobic C-term P 1328 - G.S2 E 213 G.S2.03
Van-der-waals C-term P 1328 - G.S2 E 213 G.S2.03
Polar ICL2 E 1121 - G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 E 1121 - G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 E 1121 - G.hns1 R 56 G.hns1.03
Hydrophobic TM5 I 1202 5x66 G.H5 F 361 G.H5.06
Van-der-waals TM5 I 1202 5x66 G.H5 F 361 G.H5.06
Hydrophobic TM6 V 1223 6x44 G.H5 L 380 G.H5.25
Van-der-waals TM6 V 1223 6x44 G.H5 L 380 G.H5.25
Ionic H8 K 1272 8x49 G.H5 D 377 G.H5.22
Polar H8 K 1272 8x49 G.H5 D 377 G.H5.22
Van-der-waals H8 K 1272 8x49 G.H5 D 377 G.H5.22
Hydrophobic TM5 V 1193 5x57 G.H5 M 379 G.H5.24
Hydrophobic TM5 S 1201 5x65 G.h4s6 P 345 G.h4s6.20
Polar C-term N 1346 - G.s4h3 R 265 G.s4h3.12
Hydrophobic C-term N 1346 - G.s4h3 R 265 G.s4h3.12
Van-der-waals C-term N 1346 - G.s4h3 R 265 G.s4h3.12
Hydrophobic ICL2 L 1119 - G.H5 F 363 G.H5.08
Van-der-waals ICL2 L 1119 - G.H5 F 363 G.H5.08
Hydrophobic TM5 G 1203 5x67 G.S6 L 346 G.S6.01
Van-der-waals TM5 G 1203 5x67 G.S6 L 346 G.S6.01
Hydrophobic TM5 I 1197 5x61 G.H5 L 375 G.H5.20
Polar TM2 R 1050 2x46 G.H5 D 377 G.H5.22
Hydrophobic TM2 R 1050 2x46 G.H5 D 377 G.H5.22
Van-der-waals TM2 R 1050 2x46 G.H5 D 377 G.H5.22
Polar TM6 K 1219 6x40 G.H5 L 380 G.H5.25
Hydrophobic TM6 K 1219 6x40 G.H5 L 380 G.H5.25
Van-der-waals TM6 K 1219 6x40 G.H5 L 380 G.H5.25
Polar C-term L 1316 - G.H2 Q 236 G.H2.05
Polar C-term L 1344 - G.s4h3 R 265 G.s4h3.12
Hydrophobic C-term L 1344 - G.s4h3 R 265 G.s4h3.12
Van-der-waals C-term L 1344 - G.s4h3 R 265 G.s4h3.12
Hydrophobic TM3 L 1115 3x58 G.H5 L 375 G.H5.20
Van-der-waals TM3 L 1115 3x58 G.H5 L 375 G.H5.20
Polar C-term S 1326 - G.S2 I 211 G.S2.01
Van-der-waals C-term S 1326 - G.S2 I 211 G.S2.01
Hydrophobic TM5 S 1201 5x65 G.S6 F 347 G.S6.02
Hydrophobic C-term I 1309 - G.h4s6 R 340 G.h4s6.09
Van-der-waals C-term I 1309 - G.h4s6 R 340 G.h4s6.09
Hydrophobic C-term L 1345 - H.HA D 110 H.HA.24
Van-der-waals C-term L 1345 - H.HA D 110 H.HA.24
Hydrophobic C-term L 1316 - G.H2 R 235 G.H2.04
Van-der-waals C-term L 1316 - G.H2 R 235 G.H2.04
Hydrophobic C-term V 1325 - G.S2 E 213 G.S2.03
Hydrophobic TM5 G 1203 5x67 G.S6 F 347 G.S6.02
Van-der-waals TM5 G 1203 5x67 G.S6 F 347 G.S6.02
Hydrophobic TM5 I 1202 5x66 G.S6 F 347 G.S6.02
Hydrophobic C-term L 1344 - H.HA V 107 H.HA.21
Hydrophobic ICL2 I 1118 - G.H5 L 371 G.H5.16
Polar C-term Y 1323 - G.H2 Q 240 G.H2.09
Hydrophobic C-term Y 1323 - G.H2 Q 240 G.H2.09
Van-der-waals C-term Y 1323 - G.H2 Q 240 G.H2.09
Hydrophobic H8 D 1270 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 D 1270 8x47 G.H5 L 380 G.H5.25
Polar H8 K 1272 8x49 G.H5 Q 381 G.H5.26
Van-der-waals H8 K 1272 8x49 G.H5 Q 381 G.H5.26
Hydrophobic TM5 V 1193 5x57 G.H5 L 375 G.H5.20
Hydrophobic TM3 R 1114 3x57 G.H5 I 378 G.H5.23
Hydrophobic TM5 G 1203 5x67 G.h4s6 P 345 G.h4s6.20
Hydrophobic H8 L 1271 8x48 G.H5 Q 381 G.H5.26
Van-der-waals H8 L 1271 8x48 G.H5 Q 381 G.H5.26
Hydrophobic TM5 K 1196 5x60 G.H5 L 371 G.H5.16
Polar C-term T 1331 - H.HA E 92 H.HA.06
Van-der-waals C-term T 1331 - H.HA E 92 H.HA.06
Hydrophobic C-term F 1313 - G.H3 N 283 G.H3.15
Van-der-waals C-term F 1313 - G.H3 N 283 G.H3.15
Polar C-term G 1318 - G.H2 Q 236 G.H2.05
Hydrophobic C-term G 1318 - G.H2 Q 236 G.H2.05
Van-der-waals C-term G 1318 - G.H2 Q 236 G.H2.05
Hydrophobic TM3 L 1111 3x54 G.H5 I 378 G.H5.23
Van-der-waals TM3 L 1111 3x54 G.H5 I 378 G.H5.23
Hydrophobic C-term F 1317 - G.H2 Q 236 G.H2.05
Hydrophobic ICL1 T 1046 - G.H5 D 377 G.H5.22
Hydrophobic TM6 S 1220 6x41 G.H5 M 379 G.H5.24
Van-der-waals TM6 S 1220 6x41 G.H5 M 379 G.H5.24
Polar TM3 R 1114 3x57 G.H5 N 374 G.H5.19
Hydrophobic TM3 R 1114 3x57 G.H5 N 374 G.H5.19
Van-der-waals TM3 R 1114 3x57 G.H5 N 374 G.H5.19
Polar C-term Y 1323 - G.H2 K 237 G.H2.06
Hydrophobic C-term Y 1323 - G.H2 K 237 G.H2.06
Van-der-waals C-term Y 1323 - G.H2 K 237 G.H2.06
Hydrophobic TM3 L 1115 3x58 G.H5 I 378 G.H5.23
Polar ICL1 T 1046 - G.H5 N 374 G.H5.19
Polar H8 L 1271 8x48 G.H5 L 380 G.H5.25
Polar TM4 S 1123 4x38 G.HN R 52 G.HN.52
Hydrophobic TM4 S 1123 4x38 G.HN R 52 G.HN.52
Van-der-waals TM4 S 1123 4x38 G.HN R 52 G.HN.52
Hydrophobic C-term F 1317 - G.H2 W 238 G.H2.07
Van-der-waals C-term F 1317 - G.H2 W 238 G.H2.07
Polar TM5 D 1204 5x68 G.S6 L 346 G.S6.01
Van-der-waals TM5 D 1204 5x68 G.S6 L 346 G.S6.01
Hydrophobic C-term F 1313 - G.H3 I 280 G.H3.12
Hydrophobic C-term P 1328 - G.S2 V 212 G.S2.02
Van-der-waals C-term P 1328 - G.S2 V 212 G.S2.02
Hydrophobic C-term L 1316 - G.H3 I 276 G.H3.08
Hydrophobic C-term L 1345 - H.HA A 111 H.HA.25
Hydrophobic C-term F 1317 - G.H3 I 280 G.H3.12
Hydrophobic ICL2 L 1119 - G.H5 K 367 G.H5.12
Van-der-waals ICL2 L 1119 - G.H5 K 367 G.H5.12
Polar C-term S 1343 - G.s4h3 R 265 G.s4h3.12
Van-der-waals C-term S 1343 - G.s4h3 R 265 G.s4h3.12
Hydrophobic ICL3 K 1205 - G.h4s6 P 345 G.h4s6.20
Hydrophobic TM7 G 1266 7x57 G.H5 L 380 G.H5.25
Hydrophobic ICL2 L 1119 - G.S3 I 221 G.S3.01
Van-der-waals ICL2 L 1119 - G.S3 I 221 G.S3.01
Hydrophobic TM2 R 1050 2x46 G.H5 L 380 G.H5.25
Van-der-waals TM2 R 1050 2x46 G.H5 L 380 G.H5.25
Hydrophobic TM5 S 1201 5x65 G.H5 D 368 G.H5.13
Van-der-waals TM5 S 1201 5x65 G.H5 D 368 G.H5.13
Hydrophobic TM6 L 1224 6x45 G.H5 M 379 G.H5.24
Van-der-waals TM6 L 1224 6x45 G.H5 M 379 G.H5.24
Polar ICL1 N 1044 - G.H5 D 377 G.H5.22
Van-der-waals ICL1 N 1044 - G.H5 D 377 G.H5.22
Polar TM2 R 1050 2x46 G.H5 I 378 G.H5.23
Hydrophobic TM2 R 1050 2x46 G.H5 I 378 G.H5.23
Van-der-waals TM2 R 1050 2x46 G.H5 I 378 G.H5.23
Hydrophobic TM7 F 1265 7x56 G.H5 L 380 G.H5.25
Van-der-waals TM7 F 1265 7x56 G.H5 L 380 G.H5.25
Ionic TM5 D 1204 5x68 G.S6 H 348 G.S6.03
Polar TM5 D 1204 5x68 G.S6 H 348 G.S6.03
Hydrophobic TM5 D 1204 5x68 G.S6 H 348 G.S6.03
Van-der-waals TM5 D 1204 5x68 G.S6 H 348 G.S6.03
Hydrophobic C-term L 1335 - H.hbhc G 139 H.hbhc.03
Hydrophobic C-term L 1345 - G.s4h3 R 265 G.s4h3.12
Van-der-waals C-term L 1345 - G.s4h3 R 265 G.s4h3.12
Hydrophobic ICL2 I 1118 - G.H5 I 370 G.H5.15
Van-der-waals ICL2 I 1118 - G.H5 I 370 G.H5.15
Hydrophobic C-term L 1345 - H.HA K 114 H.HA.28
Van-der-waals C-term L 1345 - H.HA K 114 H.HA.28
Hydrophobic ICL2 L 1119 - G.H5 I 370 G.H5.15
Van-der-waals ICL2 L 1119 - G.H5 I 370 G.H5.15
Hydrophobic C-term F 1313 - G.H3 T 279 G.H3.11
Van-der-waals C-term F 1313 - G.H3 T 279 G.H3.11
Hydrophobic C-term F 1317 - G.H3 T 279 G.H3.11
Aromatic C-term F 1317 - G.H2 F 239 G.H2.08
Hydrophobic C-term F 1317 - G.H2 F 239 G.H2.08
Van-der-waals C-term F 1317 - G.H2 F 239 G.H2.08
Hydrophobic TM5 I 1202 5x66 G.H5 H 364 G.H5.09
Van-der-waals TM5 I 1202 5x66 G.H5 H 364 G.H5.09
Ionic C-term R 1312 - G.H3 E 278 G.H3.10
Polar C-term R 1312 - G.H3 E 278 G.H3.10
Van-der-waals C-term R 1312 - G.H3 E 278 G.H3.10
Polar C-term Y 1323 - G.H2 Q 236 G.H2.05
Hydrophobic C-term Y 1323 - G.H2 Q 236 G.H2.05
Van-der-waals C-term Y 1323 - G.H2 Q 236 G.H2.05
Polar ICL2 H 1120 - G.hns1 R 56 G.hns1.03
Aromatic ICL2 H 1120 - G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 H 1120 - G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 H 1120 - G.hns1 R 56 G.hns1.03
Hydrophobic TM5 I 1197 5x61 G.H5 M 379 G.H5.24
Hydrophobic C-term P 1328 - G.S2 H 214 G.S2.04
Aromatic C-term F 1313 - G.H2 F 239 G.H2.08
Hydrophobic C-term F 1313 - G.H2 F 239 G.H2.08
Van-der-waals C-term F 1313 - G.H2 F 239 G.H2.08
Polar TM6 Q 1216 6x37 G.H5 Q 381 G.H5.26
Hydrophobic TM6 Q 1216 6x37 G.H5 Q 381 G.H5.26
Van-der-waals TM6 Q 1216 6x37 G.H5 Q 381 G.H5.26
Hydrophobic ICL1 T 1046 - G.H5 I 378 G.H5.23