GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 84.5
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 13.3
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | TM2 | T | 442 | 2x46 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM2 | T | 442 | 2x46 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM2 | T | 442 | 2x46 | G.H5 | Y | 391 | G.H5.23 |
Polar | ICL2 | F | 508 | - | G.S1 | H | 41 | G.S1.02 |
Aromatic | ICL2 | F | 508 | - | G.S1 | H | 41 | G.S1.02 |
Hydrophobic | ICL2 | F | 508 | - | G.S1 | H | 41 | G.S1.02 |
Van-der-waals | ICL2 | F | 508 | - | G.S1 | H | 41 | G.S1.02 |
Hydrophobic | ICL2 | Y | 511 | - | G.hns1 | R | 38 | G.hns1.02 |
Van-der-waals | ICL2 | Y | 511 | - | G.hns1 | R | 38 | G.hns1.02 |
Hydrophobic | ICL2 | V | 507 | - | G.H5 | H | 387 | G.H5.19 |
Van-der-waals | ICL2 | V | 507 | - | G.H5 | H | 387 | G.H5.19 |
Polar | ICL1 | R | 436 | - | G.h2s4 | N | 239 | G.h2s4.02 |
Hydrophobic | ICL2 | F | 508 | - | G.S3 | V | 217 | G.S3.01 |
Van-der-waals | ICL2 | F | 508 | - | G.S3 | V | 217 | G.S3.01 |
Hydrophobic | TM3 | L | 503 | 3x57 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM3 | L | 503 | 3x57 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM5 | L | 599 | 5x64 | G.H5 | L | 394 | G.H5.26 |
Polar | TM3 | L | 503 | 3x57 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | TM3 | L | 503 | 3x57 | G.H5 | H | 387 | G.H5.19 |
Van-der-waals | TM3 | L | 503 | 3x57 | G.H5 | H | 387 | G.H5.19 |
Polar | TM2 | D | 440 | 2x44 | G.H5 | Q | 390 | G.H5.22 |
Hydrophobic | TM2 | D | 440 | 2x44 | G.H5 | Q | 390 | G.H5.22 |
Van-der-waals | TM2 | D | 440 | 2x44 | G.H5 | Q | 390 | G.H5.22 |
Hydrophobic | TM2 | H | 446 | 2x50 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | ICL2 | P | 513 | - | G.HN | Q | 35 | G.HN.52 |
Van-der-waals | ICL2 | P | 513 | - | G.HN | Q | 35 | G.HN.52 |
Polar | TM5 | L | 599 | 5x64 | G.H5 | R | 385 | G.H5.17 |
Hydrophobic | TM5 | L | 599 | 5x64 | G.H5 | R | 385 | G.H5.17 |
Van-der-waals | TM5 | L | 599 | 5x64 | G.H5 | R | 385 | G.H5.17 |
Aromatic | ICL2 | F | 508 | - | G.H5 | F | 376 | G.H5.08 |
Hydrophobic | ICL2 | F | 508 | - | G.H5 | F | 376 | G.H5.08 |
Van-der-waals | ICL2 | F | 508 | - | G.H5 | F | 376 | G.H5.08 |
Hydrophobic | TM6 | L | 615 | 6x45 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM5 | M | 592 | 5x57 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM5 | M | 592 | 5x57 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | TM6 | H | 608 | 6x38 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | TM6 | L | 612 | 6x42 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | ICL1 | R | 439 | - | G.HN | K | 34 | G.HN.51 |
Hydrophobic | TM5 | R | 600 | 5x65 | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | TM5 | R | 600 | 5x65 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | ICL2 | V | 507 | - | G.H5 | I | 383 | G.H5.15 |
Van-der-waals | ICL2 | V | 507 | - | G.H5 | I | 383 | G.H5.15 |
Hydrophobic | ICL2 | F | 508 | - | G.H5 | R | 380 | G.H5.12 |
Van-der-waals | ICL2 | F | 508 | - | G.H5 | R | 380 | G.H5.12 |
Hydrophobic | TM5 | I | 596 | 5x61 | G.H5 | L | 388 | G.H5.20 |
Polar | TM6 | T | 611 | 6x41 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | TM6 | T | 611 | 6x41 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | TM3 | V | 504 | 3x58 | G.H5 | L | 388 | G.H5.20 |
Hydrophobic | TM6 | T | 611 | 6x41 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM6 | T | 611 | 6x41 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | C-term | Q | 664 | - | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | C-term | Q | 664 | - | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | ICL2 | F | 508 | - | G.H5 | I | 383 | G.H5.15 |
Van-der-waals | ICL2 | F | 508 | - | G.H5 | I | 383 | G.H5.15 |
Hydrophobic | ICL1 | R | 439 | - | G.hns1 | R | 38 | G.hns1.02 |
Van-der-waals | ICL1 | R | 439 | - | G.hns1 | R | 38 | G.hns1.02 |
Hydrophobic | ICL2 | F | 508 | - | G.H5 | C | 379 | G.H5.11 |
Hydrophobic | ICL2 | V | 507 | - | G.H5 | R | 380 | G.H5.12 |
Van-der-waals | ICL2 | V | 507 | - | G.H5 | R | 380 | G.H5.12 |
Polar | C-term | A | 665 | - | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | C-term | A | 665 | - | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | C-term | A | 665 | - | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | ICL2 | V | 507 | - | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | ICL2 | V | 507 | - | G.H5 | Q | 384 | G.H5.16 |
Polar | TM6 | H | 608 | 6x38 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | TM6 | H | 608 | 6x38 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM6 | H | 608 | 6x38 | G.H5 | L | 393 | G.H5.25 |
Polar | C-term | G | 668 | - | G.h4s6 | R | 356 | G.h4s6.12 |
Polar | TM3 | N | 499 | 3x53 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM3 | N | 499 | 3x53 | G.H5 | Y | 391 | G.H5.23 |
Polar | TM3 | V | 505 | 3x59 | G.H5 | R | 380 | G.H5.12 |
Van-der-waals | TM3 | V | 505 | 3x59 | G.H5 | R | 380 | G.H5.12 |
Hydrophobic | ICL2 | T | 510 | - | G.H5 | H | 387 | G.H5.19 |
Van-der-waals | ICL2 | T | 510 | - | G.H5 | H | 387 | G.H5.19 |
Ionic | ICL1 | R | 436 | - | G.h2s4 | D | 240 | G.h2s4.03 |
Polar | ICL1 | R | 436 | - | G.h2s4 | D | 240 | G.h2s4.03 |
Hydrophobic | ICL1 | R | 436 | - | G.h2s4 | D | 240 | G.h2s4.03 |
Van-der-waals | ICL1 | R | 436 | - | G.h2s4 | D | 240 | G.h2s4.03 |
Hydrophobic | TM7 | M | 661 | 7x60 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | TM7 | M | 661 | 7x60 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | TM6 | T | 611 | 6x41 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM6 | T | 611 | 6x41 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | ICL2 | F | 508 | - | G.S3 | F | 219 | G.S3.03 |
Hydrophobic | TM5 | M | 592 | 5x57 | G.H5 | L | 388 | G.H5.20 |
Polar | TM3 | V | 504 | 3x58 | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | TM3 | V | 504 | 3x58 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | TM7 | W | 657 | 7x56 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | ICL2 | Y | 511 | - | G.HN | Q | 35 | G.HN.52 |
Van-der-waals | ICL2 | Y | 511 | - | G.HN | Q | 35 | G.HN.52 |
Hydrophobic | TM5 | L | 599 | 5x64 | G.H5 | L | 388 | G.H5.20 |
Van-der-waals | TM5 | L | 599 | 5x64 | G.H5 | L | 388 | G.H5.20 |
Hydrophobic | TM5 | L | 599 | 5x64 | G.H5 | D | 381 | G.H5.13 |
Van-der-waals | TM5 | L | 599 | 5x64 | G.H5 | D | 381 | G.H5.13 |
Hydrophobic | TM7 | M | 661 | 7x60 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM7 | M | 661 | 7x60 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM5 | I | 596 | 5x61 | G.H5 | L | 393 | G.H5.25 |