Gz - ADGRG1 complex model

GPCR CLASS (FAMILY)

B2 (Adhesion)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 84.0

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.8


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic C-term I 683 - G.H3 E 246 G.H3.04
Van-der-waals C-term I 683 - G.H3 E 246 G.H3.04
Hydrophobic C-term I 683 - G.H2 R 206 G.H2.01
Van-der-waals C-term I 683 - G.H2 R 206 G.H2.01
Van-der-waals ICL1 R 436 - G.HN R 24 G.HN.48
Polar TM6 T 611 6x41 G.H5 G 353 G.H5.24
Hydrophobic TM6 T 611 6x41 G.H5 G 353 G.H5.24
Van-der-waals TM6 T 611 6x41 G.H5 G 353 G.H5.24
Hydrophobic TM5 L 599 5x64 G.h4s6 E 319 G.h4s6.12
Van-der-waals TM5 L 599 5x64 G.h4s6 E 319 G.h4s6.12
Polar ICL2 Y 511 - G.HN Q 28 G.HN.52
Hydrophobic ICL2 Y 511 - G.HN Q 28 G.HN.52
Van-der-waals ICL2 Y 511 - G.HN Q 28 G.HN.52
Hydrophobic C-term L 681 - G.H3 I 254 G.H3.12
Hydrophobic C-term L 681 - G.H2 W 212 G.H2.07
Hydrophobic C-term L 681 - G.H3 S 253 G.H3.11
Van-der-waals C-term L 681 - G.H3 S 253 G.H3.11
Hydrophobic TM5 L 599 5x64 G.H5 D 342 G.H5.13
Van-der-waals TM5 L 599 5x64 G.H5 D 342 G.H5.13
Hydrophobic TM5 I 596 5x61 G.H5 L 354 G.H5.25
Hydrophobic TM5 M 592 5x57 G.H5 L 349 G.H5.20
Van-der-waals TM5 M 592 5x57 G.H5 L 349 G.H5.20
Hydrophobic ICL1 K 437 - G.H5 Y 351 G.H5.22
Polar ICL1 R 436 - G.hns1 R 31 G.hns1.02
Van-der-waals ICL1 R 436 - G.hns1 R 31 G.hns1.02
Hydrophobic TM3 V 504 3x58 G.H5 L 349 G.H5.20
Hydrophobic TM5 I 596 5x61 G.H5 L 349 G.H5.20
Hydrophobic ICL2 V 507 - G.H5 T 341 G.H5.12
Van-der-waals ICL2 V 507 - G.H5 T 341 G.H5.12
Hydrophobic TM5 M 592 5x57 G.H5 I 352 G.H5.23
Hydrophobic ICL2 F 508 - G.s2s3 K 193 G.s2s3.01
Van-der-waals ICL2 F 508 - G.s2s3 K 193 G.s2s3.01
Hydrophobic ICL1 P 438 - G.H5 Y 351 G.H5.22
Van-der-waals ICL1 P 438 - G.H5 Y 351 G.H5.22
Hydrophobic C-term L 681 - G.h2s4 F 216 G.h2s4.01
Hydrophobic TM5 M 592 5x57 G.H5 L 354 G.H5.25
Van-der-waals TM5 M 592 5x57 G.H5 L 354 G.H5.25
Hydrophobic TM5 Q 595 5x60 G.H5 I 345 G.H5.16
Hydrophobic C-term I 683 - G.H2 R 209 G.H2.04
Van-der-waals C-term I 683 - G.H2 R 209 G.H2.04
Hydrophobic TM6 L 615 6x45 G.H5 I 352 G.H5.23
Ionic TM5 R 600 5x65 G.h4s6 E 319 G.h4s6.12
Hydrophobic TM5 R 600 5x65 G.h4s6 E 319 G.h4s6.12
Van-der-waals TM5 R 600 5x65 G.h4s6 E 319 G.h4s6.12
Hydrophobic ICL2 F 508 - G.H5 I 344 G.H5.15
Hydrophobic ICL2 F 508 - G.S3 L 195 G.S3.01
Van-der-waals ICL2 F 508 - G.S3 L 195 G.S3.01
Hydrophobic TM3 L 503 3x57 G.H5 I 352 G.H5.23
Hydrophobic ICL2 F 508 - G.S3 F 197 G.S3.03
Ionic TM5 R 598 5x63 G.H5 D 342 G.H5.13
Polar TM5 R 598 5x63 G.H5 D 342 G.H5.13
Hydrophobic TM5 R 598 5x63 G.H5 D 342 G.H5.13
Van-der-waals TM5 R 598 5x63 G.H5 D 342 G.H5.13
Hydrophobic TM6 T 611 6x41 G.H5 L 354 G.H5.25
Van-der-waals TM6 T 611 6x41 G.H5 L 354 G.H5.25
Polar TM3 L 503 3x57 G.H5 N 348 G.H5.19
Hydrophobic TM3 L 503 3x57 G.H5 N 348 G.H5.19
Van-der-waals TM3 L 503 3x57 G.H5 N 348 G.H5.19
Aromatic TM2 Y 441 2x45 G.hns1 R 31 G.hns1.02
Hydrophobic TM2 Y 441 2x45 G.hns1 R 31 G.hns1.02
Van-der-waals TM2 Y 441 2x45 G.hns1 R 31 G.hns1.02
Polar ICL1 R 439 - G.H5 Y 351 G.H5.22
Hydrophobic ICL1 R 439 - G.H5 Y 351 G.H5.22
Van-der-waals ICL1 R 439 - G.H5 Y 351 G.H5.22
Hydrophobic ICL2 Y 511 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 Y 511 - G.hns1 R 32 G.hns1.03
Ionic ICL1 R 436 - G.HN D 20 G.HN.44
Polar ICL1 R 436 - G.HN D 20 G.HN.44
Van-der-waals ICL1 R 436 - G.HN D 20 G.HN.44
Hydrophobic TM6 L 612 6x42 G.H5 L 354 G.H5.25
Hydrophobic TM7 M 661 7x60 G.H5 I 352 G.H5.23
Van-der-waals TM7 M 661 7x60 G.H5 I 352 G.H5.23
Ionic ICL1 R 435 - G.h2s4 E 217 G.h2s4.02
Polar ICL1 R 435 - G.h2s4 E 217 G.h2s4.02
Hydrophobic TM5 L 599 5x64 G.H5 L 349 G.H5.20
Hydrophobic ICL2 F 508 - G.H5 F 337 G.H5.08
Hydrophobic ICL2 V 507 - G.H5 I 345 G.H5.16
Van-der-waals ICL2 V 507 - G.H5 I 345 G.H5.16
Polar ICL1 K 437 - G.hns1 R 31 G.hns1.02
Hydrophobic ICL1 K 437 - G.hns1 R 31 G.hns1.02
Van-der-waals ICL1 K 437 - G.hns1 R 31 G.hns1.02
Hydrophobic TM5 L 599 5x64 G.S6 Y 321 G.S6.02
Polar TM6 H 608 6x38 G.H5 L 354 G.H5.25
Hydrophobic TM6 H 608 6x38 G.H5 L 354 G.H5.25
Van-der-waals TM6 H 608 6x38 G.H5 L 354 G.H5.25
Polar ICL1 R 436 - G.HN S 27 G.HN.51
Van-der-waals ICL1 R 436 - G.HN S 27 G.HN.51
Polar ICL1 R 439 - G.H5 K 350 G.H5.21
Van-der-waals ICL1 R 439 - G.H5 K 350 G.H5.21
Hydrophobic C-term L 681 - G.H3 L 250 G.H3.08
Hydrophobic TM5 L 599 5x64 G.H5 Q 346 G.H5.17
Hydrophobic TM7 M 661 7x60 G.H5 G 353 G.H5.24
Van-der-waals TM7 M 661 7x60 G.H5 G 353 G.H5.24
Hydrophobic ICL1 P 438 - G.hns1 R 31 G.hns1.02
Van-der-waals ICL1 P 438 - G.hns1 R 31 G.hns1.02
Polar TM5 R 600 5x65 G.H5 C 355 G.H5.26
Hydrophobic TM5 R 600 5x65 G.H5 C 355 G.H5.26
Van-der-waals TM5 R 600 5x65 G.H5 C 355 G.H5.26
Hydrophobic ICL2 F 508 - G.H5 T 341 G.H5.12
Van-der-waals ICL2 F 508 - G.H5 T 341 G.H5.12
Hydrophobic TM5 L 599 5x64 G.H5 I 345 G.H5.16
Van-der-waals TM5 L 599 5x64 G.H5 I 345 G.H5.16
Polar TM5 R 600 5x65 G.H5 L 354 G.H5.25
Hydrophobic ICL2 V 507 - G.H5 I 344 G.H5.15