GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 79.0
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.8
PAE mean: 12.8
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM5 | V | 808 | 5x57 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | ICL2 | F | 727 | - | G.H5 | R | 367 | G.H5.12 |
Van-der-waals | ICL2 | F | 727 | - | G.H5 | R | 367 | G.H5.12 |
Polar | TM6 | S | 834 | 6x41 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM6 | S | 834 | 6x41 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM6 | S | 834 | 6x41 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM3 | L | 723 | 3x58 | G.H5 | L | 375 | G.H5.20 |
Van-der-waals | TM3 | L | 723 | 3x58 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | ICL3 | L | 821 | - | G.H4 | L | 333 | G.H4.16 |
Van-der-waals | ICL3 | L | 821 | - | G.H4 | L | 333 | G.H4.16 |
Hydrophobic | C-term | F | 968 | - | G.S2 | R | 198 | G.S2.05 |
Van-der-waals | C-term | F | 968 | - | G.S2 | R | 198 | G.S2.05 |
Polar | TM6 | Q | 830 | 6x37 | G.H5 | L | 381 | G.H5.26 |
Hydrophobic | TM2 | D | 659 | 2x44 | G.H5 | Q | 377 | G.H5.22 |
Polar | TM3 | E | 715 | 3x50 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | TM3 | E | 715 | 3x50 | G.H5 | Y | 378 | G.H5.23 |
Van-der-waals | TM3 | E | 715 | 3x50 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | ICL3 | L | 821 | - | G.H4 | D | 330 | G.H4.13 |
Van-der-waals | ICL3 | L | 821 | - | G.H4 | D | 330 | G.H4.13 |
Hydrophobic | ICL3 | L | 821 | - | G.H4 | R | 334 | G.H4.17 |
Polar | TM6 | S | 834 | 6x41 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | TM6 | S | 834 | 6x41 | G.H5 | E | 379 | G.H5.24 |
Van-der-waals | TM6 | S | 834 | 6x41 | G.H5 | E | 379 | G.H5.24 |
Aromatic | ICL2 | F | 727 | - | G.H5 | F | 363 | G.H5.08 |
Hydrophobic | ICL2 | F | 727 | - | G.H5 | F | 363 | G.H5.08 |
Van-der-waals | ICL2 | F | 727 | - | G.H5 | F | 363 | G.H5.08 |
Hydrophobic | TM3 | A | 722 | 3x57 | G.H5 | H | 374 | G.H5.19 |
Van-der-waals | TM3 | A | 722 | 3x57 | G.H5 | H | 374 | G.H5.19 |
Hydrophobic | C-term | F | 968 | - | G.S2 | F | 199 | G.S2.06 |
Polar | ICL2 | Y | 730 | - | G.hns1 | K | 40 | G.hns1.02 |
Hydrophobic | ICL2 | Y | 730 | - | G.hns1 | K | 40 | G.hns1.02 |
Van-der-waals | ICL2 | Y | 730 | - | G.hns1 | K | 40 | G.hns1.02 |
Hydrophobic | TM2 | P | 661 | 2x46 | G.H5 | Y | 378 | G.H5.23 |
Van-der-waals | TM2 | P | 661 | 2x46 | G.H5 | Y | 378 | G.H5.23 |
Polar | ICL2 | R | 732 | - | G.HN | Q | 33 | G.HN.48 |
Hydrophobic | ICL2 | R | 732 | - | G.HN | Q | 33 | G.HN.48 |
Van-der-waals | ICL2 | R | 732 | - | G.HN | Q | 33 | G.HN.48 |
Ionic | TM5 | K | 818 | 5x67 | G.H5 | D | 368 | G.H5.13 |
Polar | TM5 | K | 818 | 5x67 | G.H5 | D | 368 | G.H5.13 |
Van-der-waals | TM5 | K | 818 | 5x67 | G.H5 | D | 368 | G.H5.13 |
Hydrophobic | TM6 | L | 838 | 6x45 | G.H5 | L | 380 | G.H5.25 |
Polar | TM3 | K | 725 | 3x60 | G.H5 | R | 367 | G.H5.12 |
Van-der-waals | TM3 | K | 725 | 3x60 | G.H5 | R | 367 | G.H5.12 |
Polar | ICL3 | Q | 820 | - | G.S6 | C | 346 | G.S6.01 |
Van-der-waals | ICL3 | Q | 820 | - | G.S6 | C | 346 | G.S6.01 |
Polar | TM3 | H | 718 | 3x53 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | TM3 | H | 718 | 3x53 | G.H5 | Y | 378 | G.H5.23 |
Van-der-waals | TM3 | H | 718 | 3x53 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | ICL2 | V | 726 | - | G.H5 | R | 367 | G.H5.12 |
Hydrophobic | TM5 | L | 812 | 5x61 | G.H5 | L | 381 | G.H5.26 |
Hydrophobic | C-term | F | 968 | - | G.h1ha | V | 67 | G.h1ha.01 |
Van-der-waals | C-term | F | 968 | - | G.h1ha | V | 67 | G.h1ha.01 |
Polar | TM3 | L | 723 | 3x58 | G.H5 | Q | 371 | G.H5.16 |
Hydrophobic | TM3 | L | 723 | 3x58 | G.H5 | Q | 371 | G.H5.16 |
Van-der-waals | TM3 | L | 723 | 3x58 | G.H5 | Q | 371 | G.H5.16 |
Hydrophobic | ICL2 | R | 732 | - | G.HN | L | 37 | G.HN.52 |
Polar | ICL2 | N | 728 | - | G.s2s3 | K | 203 | G.s2s3.02 |
Van-der-waals | ICL2 | N | 728 | - | G.s2s3 | K | 203 | G.s2s3.02 |
Van-der-waals | ICL3 | R | 825 | - | G.H5 | L | 381 | G.H5.26 |
Hydrophobic | TM6 | L | 841 | 6x48 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | TM7 | K | 883 | 7x61 | G.H5 | E | 379 | G.H5.24 |
Van-der-waals | TM7 | K | 883 | 7x61 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | TM5 | L | 812 | 5x61 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM5 | L | 812 | 5x61 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | C-term | W | 907 | - | G.H3 | W | 268 | G.H3.17 |
Hydrophobic | ICL2 | F | 727 | - | G.H5 | C | 366 | G.H5.11 |
Hydrophobic | TM2 | P | 661 | 2x46 | G.H5 | Q | 377 | G.H5.22 |
Hydrophobic | ICL2 | F | 727 | - | G.S3 | V | 204 | G.S3.01 |
Van-der-waals | ICL2 | F | 727 | - | G.S3 | V | 204 | G.S3.01 |
Hydrophobic | ICL2 | V | 726 | - | G.H5 | I | 370 | G.H5.15 |
Van-der-waals | ICL2 | V | 726 | - | G.H5 | I | 370 | G.H5.15 |
Hydrophobic | ICL2 | Y | 730 | - | G.HN | L | 37 | G.HN.52 |
Van-der-waals | ICL2 | Y | 730 | - | G.HN | L | 37 | G.HN.52 |
Hydrophobic | ICL3 | L | 821 | - | G.h4s6 | T | 337 | G.h4s6.03 |
Van-der-waals | ICL3 | L | 821 | - | G.h4s6 | T | 337 | G.h4s6.03 |
Hydrophobic | ICL2 | F | 727 | - | G.H5 | I | 370 | G.H5.15 |
Van-der-waals | ICL2 | F | 727 | - | G.H5 | I | 370 | G.H5.15 |
Aromatic | ICL2 | F | 727 | - | G.S1 | H | 43 | G.S1.02 |
Hydrophobic | ICL2 | F | 727 | - | G.S1 | H | 43 | G.S1.02 |
Van-der-waals | ICL2 | F | 727 | - | G.S1 | H | 43 | G.S1.02 |
Hydrophobic | TM5 | L | 812 | 5x61 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | ICL3 | Q | 820 | - | G.h4s6 | T | 337 | G.h4s6.03 |
Hydrophobic | C-term | L | 977 | - | G.S2 | I | 194 | G.S2.01 |
Hydrophobic | TM5 | I | 815 | 5x64 | G.H5 | R | 372 | G.H5.17 |
Hydrophobic | TM5 | I | 815 | 5x64 | G.H5 | L | 381 | G.H5.26 |
Hydrophobic | TM5 | I | 815 | 5x64 | G.H5 | L | 375 | G.H5.20 |
Van-der-waals | TM5 | I | 815 | 5x64 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | TM3 | M | 719 | 3x54 | G.H5 | Y | 378 | G.H5.23 |
Van-der-waals | TM3 | M | 719 | 3x54 | G.H5 | Y | 378 | G.H5.23 |
Polar | TM3 | V | 724 | 3x59 | G.H5 | R | 367 | G.H5.12 |
Van-der-waals | TM3 | V | 724 | 3x59 | G.H5 | R | 367 | G.H5.12 |
Polar | TM7 | K | 883 | 7x61 | G.H5 | Q | 377 | G.H5.22 |
Van-der-waals | TM7 | K | 883 | 7x61 | G.H5 | Q | 377 | G.H5.22 |
Hydrophobic | TM5 | V | 808 | 5x57 | G.H5 | L | 375 | G.H5.20 |
Ionic | TM6 | R | 833 | 6x40 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | TM3 | L | 723 | 3x58 | G.H5 | H | 374 | G.H5.19 |
Hydrophobic | ICL2 | V | 726 | - | G.H5 | Q | 371 | G.H5.16 |
Van-der-waals | ICL2 | V | 726 | - | G.H5 | Q | 371 | G.H5.16 |