Gs - ADGRG3 complex model

GPCR CLASS (FAMILY)

B2 (Adhesion)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 85.0

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 12.6


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM7 W 520 7x56 G.H5 L 393 G.H5.25
Hydrophobic TM5 K 456 5x60 G.H5 Q 384 G.H5.16
Van-der-waals TM5 K 456 5x60 G.H5 Q 384 G.H5.16
Polar TM6 K 474 6x37 G.H5 L 394 G.H5.26
Hydrophobic TM6 K 474 6x37 G.H5 L 394 G.H5.26
Van-der-waals TM6 K 474 6x37 G.H5 L 394 G.H5.26
Aromatic ICL2 F 371 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 F 371 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 F 371 - G.S1 H 41 G.S1.02
Polar TM6 T 478 6x41 G.H5 E 392 G.H5.24
Hydrophobic ICL2 F 371 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 F 371 - G.H5 R 380 G.H5.12
Hydrophobic TM5 L 460 5x64 G.H5 L 388 G.H5.20
Van-der-waals TM5 L 460 5x64 G.H5 L 388 G.H5.20
Hydrophobic TM2 A 305 2x46 G.H5 Y 391 G.H5.23
Van-der-waals TM2 A 305 2x46 G.H5 Y 391 G.H5.23
Polar ICL2 N 372 - G.s2s3 K 216 G.s2s3.02
Hydrophobic ICL2 N 372 - G.s2s3 K 216 G.s2s3.02
Van-der-waals ICL2 N 372 - G.s2s3 K 216 G.s2s3.02
Hydrophobic ICL2 G 376 - G.HN Q 35 G.HN.52
Van-der-waals ICL2 G 376 - G.HN Q 35 G.HN.52
Polar TM3 H 362 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM3 H 362 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 H 362 3x53 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 V 370 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 V 370 - G.H5 I 383 G.H5.15
Hydrophobic ICL2 F 371 - G.S3 V 217 G.S3.01
Van-der-waals ICL2 F 371 - G.S3 V 217 G.S3.01
Hydrophobic TM2 H 309 2x50 G.H5 Y 391 G.H5.23
Polar TM3 A 367 3x58 G.H5 Q 384 G.H5.16
Hydrophobic TM3 A 367 3x58 G.H5 Q 384 G.H5.16
Van-der-waals TM3 A 367 3x58 G.H5 Q 384 G.H5.16
Hydrophobic TM5 L 460 5x64 G.H5 D 381 G.H5.13
Van-der-waals TM5 L 460 5x64 G.H5 D 381 G.H5.13
Aromatic ICL2 F 371 - G.H5 F 376 G.H5.08
Hydrophobic ICL2 F 371 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 F 371 - G.H5 F 376 G.H5.08
Polar TM3 V 368 3x59 G.H5 R 380 G.H5.12
Van-der-waals TM3 V 368 3x59 G.H5 R 380 G.H5.12
Hydrophobic TM5 I 457 5x61 G.H5 L 388 G.H5.20
Hydrophobic TM7 L 524 7x60 G.H5 E 392 G.H5.24
Van-der-waals TM7 L 524 7x60 G.H5 E 392 G.H5.24
Hydrophobic TM5 L 460 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 L 460 5x64 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 F 371 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 F 371 - G.H5 I 383 G.H5.15
Polar TM5 T 464 5x68 G.H5 R 385 G.H5.17
Hydrophobic TM5 T 464 5x68 G.H5 R 385 G.H5.17
Van-der-waals TM5 T 464 5x68 G.H5 R 385 G.H5.17
Hydrophobic TM6 L 482 6x45 G.H5 L 393 G.H5.25
Hydrophobic ICL2 N 372 - G.S3 V 217 G.S3.01
Hydrophobic ICL2 F 371 - G.H5 C 379 G.H5.11
Hydrophobic TM7 L 524 7x60 G.H5 Y 391 G.H5.23
Van-der-waals TM7 L 524 7x60 G.H5 Y 391 G.H5.23
Polar TM3 L 366 3x57 G.H5 H 387 G.H5.19
Hydrophobic TM3 L 366 3x57 G.H5 H 387 G.H5.19
Van-der-waals TM3 L 366 3x57 G.H5 H 387 G.H5.19
Hydrophobic ICL2 V 370 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 V 370 - G.H5 R 380 G.H5.12
Polar ICL2 Y 374 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 Y 374 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 Y 374 - G.hns1 R 38 G.hns1.02
Hydrophobic TM3 A 367 3x58 G.H5 L 388 G.H5.20
Hydrophobic TM6 T 478 6x41 G.H5 L 393 G.H5.25
Van-der-waals TM6 T 478 6x41 G.H5 L 393 G.H5.25
Hydrophobic TM5 T 464 5x68 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM5 T 464 5x68 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM5 I 457 5x61 G.H5 L 393 G.H5.25
Hydrophobic ICL2 Y 374 - G.HN Q 35 G.HN.52
Van-der-waals ICL2 Y 374 - G.HN Q 35 G.HN.52
Hydrophobic ICL2 F 371 - G.S3 F 219 G.S3.03
Hydrophobic TM3 L 366 3x57 G.H5 Y 391 G.H5.23
Van-der-waals TM3 L 366 3x57 G.H5 Y 391 G.H5.23
Ionic TM6 K 474 6x37 G.H5 E 392 G.H5.24
Polar TM6 K 474 6x37 G.H5 E 392 G.H5.24
Hydrophobic TM6 K 474 6x37 G.H5 E 392 G.H5.24
Van-der-waals TM6 K 474 6x37 G.H5 E 392 G.H5.24
Hydrophobic ICL2 V 370 - G.H5 Q 384 G.H5.16
Polar TM5 L 460 5x64 G.H5 R 385 G.H5.17
Hydrophobic TM5 L 460 5x64 G.H5 R 385 G.H5.17
Van-der-waals TM5 L 460 5x64 G.H5 R 385 G.H5.17