G12 - ADGRG4 complex model

GPCR CLASS (FAMILY)

B2 (Adhesion)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 80.2

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 15.3


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Aromatic TM2 Y 2775 2x45 G.hns1 R 55 G.hns1.02
Polar C-term D 3072 - G.hfs2 K 209 G.hfs2.06
Polar TM6 K 2940 6x40 G.H5 L 380 G.H5.25
Hydrophobic TM6 K 2940 6x40 G.H5 L 380 G.H5.25
Van-der-waals TM6 K 2940 6x40 G.H5 L 380 G.H5.25
Hydrophobic ICL2 F 2842 - G.H5 V 366 G.H5.11
Hydrophobic C-term L 3038 - G.H2 Q 236 G.H2.05
Van-der-waals C-term L 3038 - G.H2 Q 236 G.H2.05
Hydrophobic TM3 L 2838 3x58 G.H5 I 378 G.H5.23
Van-der-waals TM3 L 2838 3x58 G.H5 I 378 G.H5.23
Polar TM3 A 2837 3x57 G.H5 N 374 G.H5.19
Hydrophobic TM3 A 2837 3x57 G.H5 N 374 G.H5.19
Van-der-waals TM3 A 2837 3x57 G.H5 N 374 G.H5.19
Hydrophobic C-term F 3066 - H.HA A 111 H.HA.25
Van-der-waals C-term F 3066 - H.HA A 111 H.HA.25
Polar C-term K 3030 - G.H2 F 239 G.H2.08
Hydrophobic C-term K 3030 - G.H2 F 239 G.H2.08
Van-der-waals C-term K 3030 - G.H2 F 239 G.H2.08
Hydrophobic TM5 Q 2919 5x60 G.H5 L 371 G.H5.16
Van-der-waals TM5 Q 2919 5x60 G.H5 L 371 G.H5.16
Hydrophobic C-term L 3037 - G.H3 T 279 G.H3.11
Hydrophobic TM6 L 2945 6x45 G.H5 I 378 G.H5.23
Van-der-waals TM6 L 2945 6x45 G.H5 I 378 G.H5.23
Hydrophobic C-term D 3069 - G.s4h3 M 262 G.s4h3.09
Ionic C-term E 3063 - G.s4h3 R 266 G.s4h3.13
Hydrophobic C-term L 3029 - G.H3 K 284 G.H3.16
Hydrophobic C-term F 3033 - G.H3 I 280 G.H3.12
Van-der-waals C-term F 3033 - G.H3 I 280 G.H3.12
Hydrophobic C-term L 3037 - G.H3 I 276 G.H3.08
Hydrophobic C-term L 3037 - G.H2 F 239 G.H2.08
Polar TM4 N 2848 4x41 G.HN R 52 G.HN.52
Hydrophobic TM3 M 2834 3x54 G.H5 I 378 G.H5.23
Hydrophobic C-term F 3066 - H.HA K 114 H.HA.28
Van-der-waals C-term F 3066 - H.HA K 114 H.HA.28
Polar C-term Y 3076 - H.hbhc A 138 H.hbhc.02
Hydrophobic C-term Y 3076 - H.hbhc A 138 H.hbhc.02
Van-der-waals C-term Y 3076 - H.hbhc A 138 H.hbhc.02
Hydrophobic TM5 L 2920 5x61 G.H5 M 379 G.H5.24
Van-der-waals TM5 L 2920 5x61 G.H5 M 379 G.H5.24
Polar C-term F 3066 - G.s4h3 R 265 G.s4h3.12
Hydrophobic C-term F 3066 - G.s4h3 R 265 G.s4h3.12
Van-der-waals C-term F 3066 - G.s4h3 R 265 G.s4h3.12
Hydrophobic C-term I 3064 - H.HA L 115 H.HA.29
Hydrophobic C-term L 3037 - G.H2 W 238 G.H2.07
Hydrophobic ICL3 K 2929 - G.h4s6 S 343 G.h4s6.12
Van-der-waals ICL3 K 2929 - G.h4s6 S 343 G.h4s6.12
Hydrophobic TM5 V 2916 5x57 G.H5 L 375 G.H5.20
Hydrophobic TM6 H 2937 6x37 G.H5 L 380 G.H5.25
Polar C-term L 3037 - G.H2 R 235 G.H2.04
Hydrophobic C-term L 3037 - G.H2 R 235 G.H2.04
Hydrophobic TM7 K 2990 7x61 G.H5 L 380 G.H5.25
Hydrophobic TM3 L 2838 3x58 G.H5 N 374 G.H5.19
Hydrophobic TM3 L 2838 3x58 G.H5 L 375 G.H5.20
Ionic C-term D 3069 - G.s4h3 R 265 G.s4h3.12
Polar C-term D 3069 - G.s4h3 R 265 G.s4h3.12
Hydrophobic C-term D 3069 - G.s4h3 R 265 G.s4h3.12
Van-der-waals C-term D 3069 - G.s4h3 R 265 G.s4h3.12
Hydrophobic TM3 L 2838 3x58 G.H5 L 371 G.H5.16
Van-der-waals TM3 L 2838 3x58 G.H5 L 371 G.H5.16
Hydrophobic TM6 T 2942 6x42 G.H5 M 379 G.H5.24
Hydrophobic C-term E 3034 - G.H2 Q 236 G.H2.05
Van-der-waals C-term E 3034 - G.H2 Q 236 G.H2.05
Hydrophobic TM7 F 2985 7x56 G.H5 L 380 G.H5.25
Van-der-waals TM7 F 2985 7x56 G.H5 L 380 G.H5.25
Hydrophobic C-term F 3071 - H.HA G 104 H.HA.18
Hydrophobic TM6 S 2944 6x44 G.H5 L 380 G.H5.25
Van-der-waals TM6 S 2944 6x44 G.H5 L 380 G.H5.25
Hydrophobic C-term P 3067 - H.HA K 114 H.HA.28
Van-der-waals C-term P 3067 - H.HA K 114 H.HA.28
Hydrophobic C-term E 3034 - G.H2 F 239 G.H2.08
Van-der-waals C-term E 3034 - G.H2 F 239 G.H2.08
Hydrophobic TM5 L 2920 5x61 G.H5 L 375 G.H5.20
Ionic C-term K 3030 - G.h2s4 D 243 G.h2s4.02
Polar C-term K 3030 - G.h2s4 D 243 G.h2s4.02
Hydrophobic ICL2 N 2843 - G.S3 I 221 G.S3.01
Van-der-waals ICL2 N 2843 - G.S3 I 221 G.S3.01
Hydrophobic C-term F 3071 - H.HA V 107 H.HA.21
Van-der-waals C-term F 3071 - H.HA V 107 H.HA.21
Hydrophobic ICL2 V 2841 - G.H5 L 371 G.H5.16
Hydrophobic ICL2 F 2842 - G.S1 V 58 G.S1.02
Polar TM6 H 2937 6x37 G.H5 Q 381 G.H5.26
Hydrophobic TM6 H 2937 6x37 G.H5 Q 381 G.H5.26
Van-der-waals TM6 H 2937 6x37 G.H5 Q 381 G.H5.26
Polar ICL2 Y 2845 - G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 Y 2845 - G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 Y 2845 - G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 F 2842 - G.H5 K 367 G.H5.12
Van-der-waals ICL2 F 2842 - G.H5 K 367 G.H5.12
Polar C-term S 3041 - G.H3 N 275 G.H3.07
Hydrophobic C-term S 3041 - G.H3 N 275 G.H3.07
Van-der-waals C-term S 3041 - G.H3 N 275 G.H3.07
Hydrophobic C-term S 3065 - H.HA K 114 H.HA.28
Van-der-waals C-term S 3065 - H.HA K 114 H.HA.28
Hydrophobic TM7 H 2986 7x57 G.H5 L 380 G.H5.25
Hydrophobic C-term L 3038 - G.H2 R 232 G.H2.01
Hydrophobic C-term Q 3026 - G.H3 L 285 G.H3.17
Hydrophobic C-term K 3036 - G.H3 T 279 G.H3.11
Ionic TM2 D 2774 2x44 G.hns1 R 55 G.hns1.02
Polar TM2 D 2774 2x44 G.hns1 R 55 G.hns1.02
Polar ICL2 N 2843 - G.s2s3 K 220 G.s2s3.02
Hydrophobic ICL2 N 2843 - G.s2s3 K 220 G.s2s3.02
Van-der-waals ICL2 N 2843 - G.s2s3 K 220 G.s2s3.02
Hydrophobic TM5 I 2927 5x68 G.h4s6 P 345 G.h4s6.20
Hydrophobic TM5 V 2923 5x64 G.H5 Q 372 G.H5.17
Hydrophobic C-term F 3033 - G.h2s4 F 242 G.h2s4.01
Van-der-waals C-term F 3033 - G.h2s4 F 242 G.h2s4.01
Hydrophobic C-term F 3071 - G.s4h3 M 262 G.s4h3.09
Van-der-waals C-term F 3071 - G.s4h3 M 262 G.s4h3.09
Hydrophobic TM6 G 2941 6x41 G.H5 M 379 G.H5.24
Van-der-waals TM6 G 2941 6x41 G.H5 M 379 G.H5.24
Hydrophobic TM5 V 2923 5x64 G.H5 L 371 G.H5.16
Hydrophobic ICL2 Y 2845 - G.HN R 52 G.HN.52
Van-der-waals ICL2 Y 2845 - G.HN R 52 G.HN.52
Hydrophobic C-term F 3033 - G.H3 F 286 G.H3.18
Hydrophobic C-term F 3033 - G.H2 F 239 G.H2.08
Van-der-waals C-term F 3033 - G.H2 F 239 G.H2.08
Ionic C-term D 3074 - G.hfs2 K 209 G.hfs2.06
Polar C-term D 3074 - G.hfs2 K 209 G.hfs2.06
Hydrophobic C-term D 3074 - G.hfs2 K 209 G.hfs2.06
Van-der-waals C-term D 3074 - G.hfs2 K 209 G.hfs2.06
Hydrophobic ICL2 F 2842 - G.H5 I 370 G.H5.15
Van-der-waals ICL2 F 2842 - G.H5 I 370 G.H5.15
Hydrophobic C-term I 3064 - H.HA K 114 H.HA.28
Van-der-waals C-term I 3064 - H.HA K 114 H.HA.28
Hydrophobic ICL2 F 2842 - G.S3 I 221 G.S3.01
Van-der-waals ICL2 F 2842 - G.S3 I 221 G.S3.01
Polar C-term I 3064 - G.s4h3 R 265 G.s4h3.12
Van-der-waals C-term I 3064 - G.s4h3 R 265 G.s4h3.12
Hydrophobic ICL2 V 2841 - G.H5 I 370 G.H5.15
Van-der-waals ICL2 V 2841 - G.H5 I 370 G.H5.15
Hydrophobic TM5 Q 2919 5x60 G.H5 L 375 G.H5.20
Hydrophobic C-term F 3033 - G.H3 T 279 G.H3.11
Van-der-waals C-term F 3033 - G.H3 T 279 G.H3.11
Hydrophobic C-term F 3033 - G.H3 N 283 G.H3.15
Van-der-waals C-term F 3033 - G.H3 N 283 G.H3.15
Polar C-term D 3072 - G.s3h2 Q 231 G.s3h2.03
Van-der-waals C-term D 3072 - G.s3h2 Q 231 G.s3h2.03
Aromatic ICL2 F 2842 - G.H5 F 363 G.H5.08
Hydrophobic ICL2 F 2842 - G.H5 F 363 G.H5.08
Van-der-waals ICL2 F 2842 - G.H5 F 363 G.H5.08
Hydrophobic ICL2 V 2841 - G.H5 K 367 G.H5.12
Hydrophobic TM5 V 2923 5x64 G.H5 L 375 G.H5.20
Hydrophobic C-term F 3071 - H.HA K 103 H.HA.17
Van-der-waals C-term F 3071 - H.HA K 103 H.HA.17
Hydrophobic TM3 A 2837 3x57 G.H5 I 378 G.H5.23
Hydrophobic C-term F 3066 - H.hdhe F 173 H.hdhe.01
Hydrophobic C-term K 3030 - G.H3 L 285 G.H3.17
Hydrophobic C-term F 3066 - H.HA D 110 H.HA.24
Van-der-waals C-term F 3066 - H.HA D 110 H.HA.24
Hydrophobic TM6 D 2938 6x38 G.H5 M 379 G.H5.24
Hydrophobic C-term D 3072 - G.hfs2 A 207 G.hfs2.04
Van-der-waals C-term D 3072 - G.hfs2 A 207 G.hfs2.04