GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 78.7
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 14.6
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | TM5 | Q | 2926 | 5x67 | G.H5 | D | 364 | G.H5.13 |
Hydrophobic | TM7 | H | 2986 | 7x57 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | TM5 | L | 2920 | 5x61 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | TM3 | L | 2838 | 3x58 | G.H5 | N | 370 | G.H5.19 |
Ionic | ICL3 | K | 2929 | - | G.h4s6 | D | 336 | G.h4s6.10 |
Polar | ICL3 | K | 2929 | - | G.h4s6 | D | 336 | G.h4s6.10 |
Polar | TM6 | K | 2940 | 6x40 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | TM6 | K | 2940 | 6x40 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | TM6 | K | 2940 | 6x40 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | TM3 | L | 2838 | 3x58 | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | TM3 | L | 2838 | 3x58 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | C-term | C | 3077 | - | H.HB | M | 123 | H.HB.10 |
Hydrophobic | TM5 | V | 2923 | 5x64 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | TM5 | I | 2927 | 5x68 | G.H5 | H | 368 | G.H5.17 |
Hydrophobic | ICL2 | V | 2841 | - | G.H5 | I | 366 | G.H5.15 |
Van-der-waals | ICL2 | V | 2841 | - | G.H5 | I | 366 | G.H5.15 |
Polar | TM6 | H | 2937 | 6x37 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | TM6 | H | 2937 | 6x37 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | TM6 | H | 2937 | 6x37 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | TM5 | Q | 2919 | 5x60 | G.H5 | L | 367 | G.H5.16 |
Polar | C-term | Y | 3076 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Van-der-waals | C-term | Y | 3076 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Hydrophobic | C-term | D | 3072 | - | H.hbhc | A | 133 | H.hbhc.06 |
Polar | C-term | P | 3075 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Van-der-waals | C-term | P | 3075 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Hydrophobic | TM2 | Y | 2775 | 2x45 | G.HN | T | 43 | G.HN.52 |
Van-der-waals | TM2 | Y | 2775 | 2x45 | G.HN | T | 43 | G.HN.52 |
Hydrophobic | TM5 | V | 2923 | 5x64 | G.H5 | H | 368 | G.H5.17 |
Van-der-waals | TM5 | V | 2923 | 5x64 | G.H5 | H | 368 | G.H5.17 |
Hydrophobic | ICL2 | F | 2842 | - | G.H5 | I | 366 | G.H5.15 |
Van-der-waals | ICL2 | F | 2842 | - | G.H5 | I | 366 | G.H5.15 |
Polar | ICL2 | Y | 2845 | - | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | ICL2 | Y | 2845 | - | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | ICL2 | Y | 2845 | - | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | TM3 | L | 2838 | 3x58 | G.H5 | L | 367 | G.H5.16 |
Van-der-waals | TM3 | L | 2838 | 3x58 | G.H5 | L | 367 | G.H5.16 |
Hydrophobic | C-term | C | 3077 | - | H.HA | D | 101 | H.HA.24 |
Hydrophobic | C-term | P | 3075 | - | G.s4h3 | M | 257 | G.s4h3.09 |
Van-der-waals | C-term | P | 3075 | - | G.s4h3 | M | 257 | G.s4h3.09 |
Ionic | TM2 | D | 2774 | 2x44 | G.hns1 | K | 46 | G.hns1.02 |
Polar | TM2 | D | 2774 | 2x44 | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | ICL2 | V | 2841 | - | G.H5 | K | 363 | G.H5.12 |
Van-der-waals | ICL2 | V | 2841 | - | G.H5 | K | 363 | G.H5.12 |
Hydrophobic | C-term | Y | 3076 | - | H.hdhe | Q | 169 | H.hdhe.02 |
Van-der-waals | C-term | Y | 3076 | - | H.hdhe | Q | 169 | H.hdhe.02 |
Hydrophobic | C-term | Y | 3076 | - | H.HA | V | 98 | H.HA.21 |
Van-der-waals | C-term | Y | 3076 | - | H.HA | V | 98 | H.HA.21 |
Polar | ICL2 | Y | 2845 | - | G.HN | T | 43 | G.HN.52 |
Hydrophobic | ICL2 | Y | 2845 | - | G.HN | T | 43 | G.HN.52 |
Van-der-waals | ICL2 | Y | 2845 | - | G.HN | T | 43 | G.HN.52 |
Polar | C-term | C | 3077 | - | H.HA | K | 105 | H.HA.28 |
Van-der-waals | C-term | C | 3077 | - | H.HA | K | 105 | H.HA.28 |
Hydrophobic | TM6 | G | 2941 | 6x41 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM6 | G | 2941 | 6x41 | G.H5 | M | 375 | G.H5.24 |
Aromatic | ICL2 | F | 2842 | - | G.H5 | F | 359 | G.H5.08 |
Hydrophobic | ICL2 | F | 2842 | - | G.H5 | F | 359 | G.H5.08 |
Van-der-waals | ICL2 | F | 2842 | - | G.H5 | F | 359 | G.H5.08 |
Hydrophobic | C-term | Y | 3076 | - | G.s4h3 | M | 257 | G.s4h3.09 |
Van-der-waals | C-term | Y | 3076 | - | G.s4h3 | M | 257 | G.s4h3.09 |
Hydrophobic | TM7 | F | 2985 | 7x56 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | TM7 | F | 2985 | 7x56 | G.H5 | L | 376 | G.H5.25 |
Polar | TM3 | V | 2839 | 3x59 | G.H5 | K | 363 | G.H5.12 |
Hydrophobic | TM7 | K | 2990 | 7x61 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | TM6 | S | 2944 | 6x44 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | TM6 | S | 2944 | 6x44 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | ICL2 | F | 2842 | - | G.S1 | V | 49 | G.S1.02 |
Hydrophobic | TM2 | P | 2776 | 2x46 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | C-term | Y | 3076 | - | H.hdhe | L | 170 | H.hdhe.03 |
Hydrophobic | C-term | S | 3079 | - | H.HA | K | 105 | H.HA.28 |
Hydrophobic | ICL2 | F | 2842 | - | G.H5 | V | 362 | G.H5.11 |
Hydrophobic | TM5 | L | 2920 | 5x61 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM5 | L | 2920 | 5x61 | G.H5 | M | 375 | G.H5.24 |
Polar | C-term | S | 3078 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Van-der-waals | C-term | S | 3078 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Hydrophobic | TM3 | M | 2834 | 3x54 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | TM5 | V | 2916 | 5x57 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | ICL2 | F | 2842 | - | G.S3 | V | 216 | G.S3.01 |
Van-der-waals | ICL2 | F | 2842 | - | G.S3 | V | 216 | G.S3.01 |
Hydrophobic | ICL2 | Y | 2845 | - | G.HN | Y | 44 | G.HN.53 |
Hydrophobic | TM5 | Q | 2919 | 5x60 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | ICL2 | N | 2843 | - | G.S3 | V | 216 | G.S3.01 |
Hydrophobic | ICL2 | F | 2842 | - | G.H5 | K | 363 | G.H5.12 |
Van-der-waals | ICL2 | F | 2842 | - | G.H5 | K | 363 | G.H5.12 |
Hydrophobic | C-term | D | 3072 | - | H.hbhc | R | 128 | H.hbhc.01 |
Van-der-waals | C-term | D | 3072 | - | H.hbhc | R | 128 | H.hbhc.01 |
Hydrophobic | TM3 | L | 2838 | 3x58 | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | TM3 | L | 2838 | 3x58 | G.H5 | L | 371 | G.H5.20 |
Polar | TM6 | H | 2937 | 6x37 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | TM6 | H | 2937 | 6x37 | G.H5 | L | 376 | G.H5.25 |
Ionic | C-term | D | 3074 | - | H.HA | K | 94 | H.HA.17 |
Polar | TM3 | A | 2837 | 3x57 | G.H5 | N | 370 | G.H5.19 |
Hydrophobic | TM3 | A | 2837 | 3x57 | G.H5 | N | 370 | G.H5.19 |
Van-der-waals | TM3 | A | 2837 | 3x57 | G.H5 | N | 370 | G.H5.19 |
Hydrophobic | ICL2 | V | 2841 | - | G.H5 | L | 367 | G.H5.16 |
Polar | ICL2 | N | 2843 | - | G.s2s3 | N | 215 | G.s2s3.02 |
Hydrophobic | ICL2 | N | 2843 | - | G.s2s3 | N | 215 | G.s2s3.02 |
Van-der-waals | ICL2 | N | 2843 | - | G.s2s3 | N | 215 | G.s2s3.02 |
Polar | C-term | Y | 3076 | - | G.hfs2 | R | 200 | G.hfs2.02 |