GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 83.4
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 12.4
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | C-term | L | 3029 | - | G.H3 | P | 258 | G.H3.16 |
Polar | C-term | L | 3029 | - | G.H3 | Y | 257 | G.H3.15 |
Hydrophobic | C-term | L | 3029 | - | G.H3 | Y | 257 | G.H3.15 |
Hydrophobic | TM3 | L | 2838 | 3x58 | G.H5 | F | 352 | G.H5.23 |
Hydrophobic | C-term | E | 3063 | - | G.S2 | I | 186 | G.S2.02 |
Hydrophobic | TM5 | L | 2920 | 5x61 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM6 | G | 2941 | 6x41 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM6 | G | 2941 | 6x41 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | ICL2 | V | 2841 | - | G.H5 | K | 341 | G.H5.12 |
Hydrophobic | C-term | L | 3038 | - | G.H2 | R | 206 | G.H2.01 |
Van-der-waals | C-term | L | 3038 | - | G.H2 | R | 206 | G.H2.01 |
Hydrophobic | TM3 | M | 2834 | 3x54 | G.H5 | F | 352 | G.H5.23 |
Polar | TM2 | Y | 2775 | 2x45 | G.hns1 | R | 33 | G.hns1.02 |
Aromatic | TM2 | Y | 2775 | 2x45 | G.hns1 | R | 33 | G.hns1.02 |
Hydrophobic | TM2 | Y | 2775 | 2x45 | G.hns1 | R | 33 | G.hns1.02 |
Van-der-waals | TM2 | Y | 2775 | 2x45 | G.hns1 | R | 33 | G.hns1.02 |
Hydrophobic | TM5 | L | 2920 | 5x61 | G.H5 | V | 355 | G.H5.26 |
Hydrophobic | C-term | L | 3038 | - | G.H2 | R | 210 | G.H2.05 |
Van-der-waals | C-term | L | 3038 | - | G.H2 | R | 210 | G.H2.05 |
Hydrophobic | TM5 | I | 2927 | 5x68 | G.h4s6 | V | 319 | G.h4s6.20 |
Polar | TM7 | F | 2985 | 7x56 | G.H5 | N | 353 | G.H5.24 |
Van-der-waals | TM7 | F | 2985 | 7x56 | G.H5 | N | 353 | G.H5.24 |
Polar | C-term | S | 3044 | - | G.s4h3 | C | 238 | G.s4h3.11 |
Hydrophobic | C-term | S | 3044 | - | G.s4h3 | C | 238 | G.s4h3.11 |
Van-der-waals | C-term | S | 3044 | - | G.s4h3 | C | 238 | G.s4h3.11 |
Hydrophobic | ICL2 | F | 2842 | - | G.H5 | V | 340 | G.H5.11 |
Hydrophobic | TM6 | L | 2945 | 6x45 | G.H5 | L | 354 | G.H5.25 |
Polar | TM7 | M | 2989 | 7x60 | G.H5 | N | 353 | G.H5.24 |
Hydrophobic | TM7 | M | 2989 | 7x60 | G.H5 | N | 353 | G.H5.24 |
Van-der-waals | TM7 | M | 2989 | 7x60 | G.H5 | N | 353 | G.H5.24 |
Aromatic | C-term | F | 3033 | - | G.H3 | Y | 257 | G.H3.15 |
Hydrophobic | C-term | F | 3033 | - | G.H3 | Y | 257 | G.H3.15 |
Van-der-waals | C-term | F | 3033 | - | G.H3 | Y | 257 | G.H3.15 |
Polar | TM7 | K | 2990 | 7x61 | G.H5 | E | 351 | G.H5.22 |
Van-der-waals | TM7 | K | 2990 | 7x61 | G.H5 | E | 351 | G.H5.22 |
Hydrophobic | C-term | S | 3041 | - | G.s4h3 | E | 241 | G.s4h3.14 |
Polar | TM6 | H | 2937 | 6x37 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM6 | H | 2937 | 6x37 | G.H5 | L | 354 | G.H5.25 |
Polar | TM6 | H | 2937 | 6x37 | G.H5 | V | 355 | G.H5.26 |
Hydrophobic | TM6 | H | 2937 | 6x37 | G.H5 | V | 355 | G.H5.26 |
Van-der-waals | TM6 | H | 2937 | 6x37 | G.H5 | V | 355 | G.H5.26 |
Polar | TM3 | A | 2837 | 3x57 | G.H5 | N | 348 | G.H5.19 |
Hydrophobic | TM3 | A | 2837 | 3x57 | G.H5 | N | 348 | G.H5.19 |
Van-der-waals | TM3 | A | 2837 | 3x57 | G.H5 | N | 348 | G.H5.19 |
Hydrophobic | C-term | P | 3061 | - | G.S2 | I | 186 | G.S2.02 |
Van-der-waals | C-term | P | 3061 | - | G.S2 | I | 186 | G.S2.02 |
Hydrophobic | C-term | K | 3030 | - | G.H2 | I | 213 | G.H2.08 |
Van-der-waals | C-term | K | 3030 | - | G.H2 | I | 213 | G.H2.08 |
Polar | C-term | S | 3062 | - | G.S2 | E | 187 | G.S2.03 |
Hydrophobic | TM5 | V | 2923 | 5x64 | G.H5 | Q | 346 | G.H5.17 |
Aromatic | C-term | F | 3066 | - | G.H2 | H | 214 | G.H2.09 |
Hydrophobic | C-term | F | 3066 | - | G.H2 | H | 214 | G.H2.09 |
Van-der-waals | C-term | F | 3066 | - | G.H2 | H | 214 | G.H2.09 |
Polar | TM5 | Q | 2926 | 5x67 | G.H5 | D | 342 | G.H5.13 |
Hydrophobic | C-term | L | 3037 | - | G.H2 | R | 209 | G.H2.04 |
Van-der-waals | C-term | L | 3037 | - | G.H2 | R | 209 | G.H2.04 |
Polar | ICL2 | N | 2843 | - | G.s2s3 | N | 194 | G.s2s3.02 |
Hydrophobic | ICL2 | N | 2843 | - | G.s2s3 | N | 194 | G.s2s3.02 |
Van-der-waals | ICL2 | N | 2843 | - | G.s2s3 | N | 194 | G.s2s3.02 |
Hydrophobic | C-term | L | 3037 | - | G.H2 | W | 212 | G.H2.07 |
Hydrophobic | TM5 | V | 2923 | 5x64 | G.H5 | L | 345 | G.H5.16 |
Hydrophobic | TM3 | A | 2837 | 3x57 | G.H5 | F | 352 | G.H5.23 |
Hydrophobic | TM5 | V | 2916 | 5x57 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM5 | V | 2923 | 5x64 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | C-term | P | 3040 | - | G.H2 | R | 206 | G.H2.01 |
Hydrophobic | C-term | A | 3046 | - | G.s4h3 | E | 237 | G.s4h3.10 |
Van-der-waals | C-term | A | 3046 | - | G.s4h3 | E | 237 | G.s4h3.10 |
Hydrophobic | TM3 | L | 2838 | 3x58 | G.H5 | L | 345 | G.H5.16 |
Van-der-waals | TM3 | L | 2838 | 3x58 | G.H5 | L | 345 | G.H5.16 |
Polar | ICL2 | N | 2843 | - | G.S3 | I | 195 | G.S3.01 |
Hydrophobic | ICL2 | N | 2843 | - | G.S3 | I | 195 | G.S3.01 |
Van-der-waals | ICL2 | N | 2843 | - | G.S3 | I | 195 | G.S3.01 |
Polar | TM4 | N | 2848 | 4x41 | G.HN | K | 30 | G.HN.52 |
Hydrophobic | TM2 | P | 2776 | 2x46 | G.H5 | F | 352 | G.H5.23 |
Hydrophobic | C-term | F | 3033 | - | G.H2 | I | 213 | G.H2.08 |
Van-der-waals | C-term | E | 3063 | - | G.S2 | I | 185 | G.S2.01 |
Hydrophobic | ICL2 | V | 2841 | - | G.H5 | I | 344 | G.H5.15 |
Van-der-waals | ICL2 | V | 2841 | - | G.H5 | I | 344 | G.H5.15 |
Hydrophobic | C-term | L | 3037 | - | G.H3 | L | 250 | G.H3.08 |
Van-der-waals | C-term | L | 3037 | - | G.H3 | L | 250 | G.H3.08 |
Hydrophobic | TM7 | K | 2990 | 7x61 | G.H5 | N | 353 | G.H5.24 |
Hydrophobic | C-term | F | 3066 | - | G.S2 | I | 185 | G.S2.01 |
Hydrophobic | C-term | F | 3033 | - | G.H3 | I | 254 | G.H3.12 |
Hydrophobic | ICL2 | F | 2842 | - | G.H5 | F | 337 | G.H5.08 |
Hydrophobic | C-term | F | 3033 | - | G.h2s4 | F | 216 | G.h2s4.01 |
Van-der-waals | C-term | F | 3033 | - | G.h2s4 | F | 216 | G.h2s4.01 |
Hydrophobic | ICL2 | F | 2842 | - | G.S1 | L | 36 | G.S1.02 |
Hydrophobic | TM5 | Q | 2919 | 5x60 | G.H5 | L | 345 | G.H5.16 |
Polar | ICL2 | Y | 2845 | - | G.hns1 | R | 34 | G.hns1.03 |
Hydrophobic | ICL2 | Y | 2845 | - | G.hns1 | R | 34 | G.hns1.03 |
Van-der-waals | ICL2 | Y | 2845 | - | G.hns1 | R | 34 | G.hns1.03 |
Hydrophobic | C-term | K | 3036 | - | G.H3 | T | 253 | G.H3.11 |
Polar | ICL2 | N | 2843 | - | G.s2s3 | E | 193 | G.s2s3.01 |
Van-der-waals | ICL2 | N | 2843 | - | G.s2s3 | E | 193 | G.s2s3.01 |
Hydrophobic | C-term | F | 3066 | - | G.H2 | K | 211 | G.H2.06 |
Aromatic | TM3 | H | 2833 | 3x53 | G.H5 | F | 352 | G.H5.23 |
Hydrophobic | TM3 | H | 2833 | 3x53 | G.H5 | F | 352 | G.H5.23 |
Van-der-waals | TM3 | H | 2833 | 3x53 | G.H5 | F | 352 | G.H5.23 |
Hydrophobic | TM3 | L | 2838 | 3x58 | G.H5 | N | 348 | G.H5.19 |
Van-der-waals | TM3 | L | 2838 | 3x58 | G.H5 | N | 348 | G.H5.19 |
Ionic | ICL3 | K | 2929 | - | G.h4s6 | E | 317 | G.h4s6.12 |
Polar | ICL3 | K | 2929 | - | G.h4s6 | E | 317 | G.h4s6.12 |
Hydrophobic | ICL3 | K | 2929 | - | G.h4s6 | E | 317 | G.h4s6.12 |
Van-der-waals | ICL3 | K | 2929 | - | G.h4s6 | E | 317 | G.h4s6.12 |
Polar | TM6 | K | 2940 | 6x40 | G.H5 | N | 353 | G.H5.24 |
Hydrophobic | TM6 | K | 2940 | 6x40 | G.H5 | N | 353 | G.H5.24 |
Van-der-waals | TM6 | K | 2940 | 6x40 | G.H5 | N | 353 | G.H5.24 |
Hydrophobic | ICL2 | F | 2842 | - | G.S3 | I | 195 | G.S3.01 |
Van-der-waals | ICL2 | F | 2842 | - | G.S3 | I | 195 | G.S3.01 |
Polar | C-term | I | 3064 | - | G.S2 | I | 185 | G.S2.01 |
Hydrophobic | C-term | I | 3064 | - | G.S2 | I | 185 | G.S2.01 |
Ionic | TM2 | D | 2774 | 2x44 | G.hns1 | R | 33 | G.hns1.02 |
Hydrophobic | C-term | F | 3033 | - | G.H3 | T | 253 | G.H3.11 |
Van-der-waals | C-term | F | 3033 | - | G.H3 | T | 253 | G.H3.11 |
Hydrophobic | TM5 | L | 2920 | 5x61 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | TM3 | E | 2830 | 3x50 | G.H5 | F | 352 | G.H5.23 |
Van-der-waals | TM3 | E | 2830 | 3x50 | G.H5 | F | 352 | G.H5.23 |
Polar | ICL2 | Y | 2845 | - | G.HN | K | 30 | G.HN.52 |
Hydrophobic | ICL2 | Y | 2845 | - | G.HN | K | 30 | G.HN.52 |
Van-der-waals | ICL2 | Y | 2845 | - | G.HN | K | 30 | G.HN.52 |
Hydrophobic | TM3 | L | 2838 | 3x58 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | ICL2 | F | 2842 | - | G.H5 | K | 341 | G.H5.12 |
Van-der-waals | ICL2 | F | 2842 | - | G.H5 | K | 341 | G.H5.12 |
Polar | TM7 | H | 2986 | 7x57 | G.H5 | F | 352 | G.H5.23 |
Hydrophobic | C-term | L | 3037 | - | G.H3 | I | 254 | G.H3.12 |
Hydrophobic | ICL2 | F | 2842 | - | G.H5 | I | 344 | G.H5.15 |
Van-der-waals | ICL2 | F | 2842 | - | G.H5 | I | 344 | G.H5.15 |