GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 84.3
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 14.3
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | TM7 | Q | 506 | 7x60 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | TM7 | Q | 506 | 7x60 | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | TM7 | Q | 506 | 7x60 | G.H5 | L | 374 | G.H5.23 |
Polar | TM6 | H | 454 | 6x37 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | TM6 | H | 454 | 6x37 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | TM6 | H | 454 | 6x37 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | TM3 | L | 343 | 3x58 | G.H5 | L | 367 | G.H5.16 |
Van-der-waals | TM3 | L | 343 | 3x58 | G.H5 | L | 367 | G.H5.16 |
Hydrophobic | ICL2 | N | 348 | - | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | ICL2 | V | 346 | - | G.H5 | L | 367 | G.H5.16 |
Van-der-waals | ICL2 | V | 346 | - | G.H5 | L | 367 | G.H5.16 |
Polar | ICL2 | Y | 347 | - | G.H5 | F | 359 | G.H5.08 |
Aromatic | ICL2 | Y | 347 | - | G.H5 | F | 359 | G.H5.08 |
Hydrophobic | ICL2 | Y | 347 | - | G.H5 | F | 359 | G.H5.08 |
Van-der-waals | ICL2 | Y | 347 | - | G.H5 | F | 359 | G.H5.08 |
Polar | H8 | E | 513 | 8x53 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | H8 | E | 513 | 8x53 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | H8 | E | 513 | 8x53 | G.H5 | Q | 377 | G.H5.26 |
Polar | TM6 | R | 451 | 6x34 | G.h4s6 | Q | 338 | G.h4s6.12 |
Van-der-waals | TM6 | R | 451 | 6x34 | G.h4s6 | Q | 338 | G.h4s6.12 |
Polar | H8 | S | 510 | 8x50 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | H8 | S | 510 | 8x50 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | TM2 | L | 280 | 2x46 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | TM6 | T | 458 | 6x41 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM6 | T | 458 | 6x41 | G.H5 | M | 375 | G.H5.24 |
Polar | TM3 | G | 344 | 3x59 | G.H5 | K | 363 | G.H5.12 |
Ionic | ICL3 | D | 446 | - | G.H4 | R | 331 | G.H4.16 |
Polar | ICL3 | D | 446 | - | G.H4 | R | 331 | G.H4.16 |
Van-der-waals | ICL3 | D | 446 | - | G.H4 | R | 331 | G.H4.16 |
Polar | ICL2 | N | 348 | - | G.s2s3 | N | 215 | G.s2s3.02 |
Van-der-waals | ICL2 | N | 348 | - | G.s2s3 | N | 215 | G.s2s3.02 |
Hydrophobic | ICL2 | V | 346 | - | G.H5 | I | 366 | G.H5.15 |
Van-der-waals | ICL2 | V | 346 | - | G.H5 | I | 366 | G.H5.15 |
Hydrophobic | ICL2 | Y | 347 | - | G.H5 | V | 362 | G.H5.11 |
Van-der-waals | ICL2 | Y | 347 | - | G.H5 | V | 362 | G.H5.11 |
Hydrophobic | ICL3 | R | 444 | - | G.H5 | R | 360 | G.H5.09 |
Van-der-waals | ICL3 | R | 444 | - | G.H5 | R | 360 | G.H5.09 |
Hydrophobic | TM7 | W | 502 | 7x56 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM7 | W | 502 | 7x56 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | TM5 | L | 441 | 5x64 | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | TM5 | L | 441 | 5x64 | G.H5 | L | 371 | G.H5.20 |
Polar | H8 | A | 520 | 8x60 | G.H3 | R | 279 | G.H3.16 |
Hydrophobic | H8 | A | 520 | 8x60 | G.H3 | R | 279 | G.H3.16 |
Van-der-waals | H8 | A | 520 | 8x60 | G.H3 | R | 279 | G.H3.16 |
Hydrophobic | ICL3 | A | 445 | - | G.h4s6 | P | 341 | G.h4s6.20 |
Polar | TM7 | Q | 506 | 7x60 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | TM7 | Q | 506 | 7x60 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | TM7 | Q | 506 | 7x60 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | TM3 | L | 343 | 3x58 | G.H5 | L | 374 | G.H5.23 |
Ionic | TM5 | R | 440 | 5x63 | G.H5 | D | 364 | G.H5.13 |
Hydrophobic | TM5 | L | 441 | 5x64 | G.H5 | L | 367 | G.H5.16 |
Hydrophobic | H8 | R | 509 | 8x49 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | H8 | R | 509 | 8x49 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | H8 | R | 509 | 8x49 | G.H5 | M | 375 | G.H5.24 |
Polar | H8 | F | 521 | 8x61 | G.H3 | R | 279 | G.H3.16 |
Hydrophobic | H8 | F | 521 | 8x61 | G.H3 | R | 279 | G.H3.16 |
Van-der-waals | H8 | F | 521 | 8x61 | G.H3 | R | 279 | G.H3.16 |
Hydrophobic | ICL2 | Y | 347 | - | G.S3 | F | 218 | G.S3.03 |
Polar | ICL2 | Y | 347 | - | G.H5 | K | 363 | G.H5.12 |
Hydrophobic | ICL2 | Y | 347 | - | G.H5 | K | 363 | G.H5.12 |
Van-der-waals | ICL2 | Y | 347 | - | G.H5 | K | 363 | G.H5.12 |
Polar | ICL2 | Y | 350 | - | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | ICL2 | Y | 350 | - | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | ICL2 | Y | 350 | - | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | TM2 | L | 280 | 2x46 | G.H5 | Q | 373 | G.H5.22 |
Van-der-waals | TM2 | L | 280 | 2x46 | G.H5 | Q | 373 | G.H5.22 |
Hydrophobic | TM2 | L | 280 | 2x46 | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | TM2 | L | 280 | 2x46 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | TM5 | T | 437 | 5x60 | G.H5 | L | 367 | G.H5.16 |
Ionic | ICL3 | R | 444 | - | G.H5 | D | 364 | G.H5.13 |
Polar | ICL3 | R | 444 | - | G.H5 | D | 364 | G.H5.13 |
Hydrophobic | ICL3 | R | 444 | - | G.H5 | D | 364 | G.H5.13 |
Van-der-waals | ICL3 | R | 444 | - | G.H5 | D | 364 | G.H5.13 |
Polar | H8 | S | 523 | 8x63 | G.H3 | R | 279 | G.H3.16 |
Hydrophobic | H8 | S | 523 | 8x63 | G.H3 | R | 279 | G.H3.16 |
Van-der-waals | H8 | S | 523 | 8x63 | G.H3 | R | 279 | G.H3.16 |
Polar | TM7 | Q | 506 | 7x60 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | TM7 | Q | 506 | 7x60 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM7 | Q | 506 | 7x60 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | ICL2 | Y | 350 | - | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | ICL2 | Y | 347 | - | G.H5 | I | 366 | G.H5.15 |
Van-der-waals | ICL2 | Y | 347 | - | G.H5 | I | 366 | G.H5.15 |
Hydrophobic | ICL2 | Y | 347 | - | G.S3 | V | 216 | G.S3.01 |
Van-der-waals | ICL2 | Y | 347 | - | G.S3 | V | 216 | G.S3.01 |
Polar | TM3 | L | 342 | 3x57 | G.H5 | N | 370 | G.H5.19 |
Hydrophobic | TM3 | L | 342 | 3x57 | G.H5 | N | 370 | G.H5.19 |
Van-der-waals | TM3 | L | 342 | 3x57 | G.H5 | N | 370 | G.H5.19 |
Hydrophobic | TM5 | L | 438 | 5x61 | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | TM5 | L | 438 | 5x61 | G.H5 | L | 371 | G.H5.20 |
Polar | C-term | S | 524 | - | G.H3 | R | 279 | G.H3.16 |
Hydrophobic | C-term | S | 524 | - | G.H3 | R | 279 | G.H3.16 |
Van-der-waals | C-term | S | 524 | - | G.H3 | R | 279 | G.H3.16 |
Hydrophobic | ICL2 | Y | 347 | - | G.S1 | V | 49 | G.S1.02 |
Hydrophobic | ICL2 | V | 346 | - | G.H5 | K | 363 | G.H5.12 |
Van-der-waals | ICL2 | V | 346 | - | G.H5 | K | 363 | G.H5.12 |
Hydrophobic | TM3 | L | 342 | 3x57 | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | TM3 | L | 342 | 3x57 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | TM3 | L | 343 | 3x58 | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | TM3 | L | 343 | 3x58 | G.H5 | L | 371 | G.H5.20 |
Polar | ICL2 | Y | 350 | - | G.HN | T | 43 | G.HN.52 |
Hydrophobic | ICL2 | Y | 350 | - | G.HN | T | 43 | G.HN.52 |
Van-der-waals | ICL2 | Y | 350 | - | G.HN | T | 43 | G.HN.52 |
Hydrophobic | TM5 | L | 441 | 5x64 | G.H5 | D | 364 | G.H5.13 |
Van-der-waals | TM5 | L | 441 | 5x64 | G.H5 | D | 364 | G.H5.13 |
Polar | TM6 | R | 451 | 6x34 | G.h4s6 | Q | 339 | G.h4s6.13 |
Van-der-waals | TM6 | R | 451 | 6x34 | G.h4s6 | Q | 339 | G.h4s6.13 |
Hydrophobic | TM3 | L | 339 | 3x54 | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | TM3 | L | 339 | 3x54 | G.H5 | L | 374 | G.H5.23 |