Gt2 - ADGRG5 complex model

GPCR CLASS (FAMILY)

B2 (Adhesion)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 86.1

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 13.5


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar C-term S 524 - G.H3 K 257 G.H3.16
Hydrophobic C-term S 524 - G.H3 K 257 G.H3.16
Van-der-waals C-term S 524 - G.H3 K 257 G.H3.16
Hydrophobic ICL3 A 445 - G.h4s6 E 318 G.h4s6.12
Hydrophobic TM2 L 280 2x46 G.H5 D 350 G.H5.22
Van-der-waals TM2 L 280 2x46 G.H5 D 350 G.H5.22
Polar ICL2 Y 350 - G.HN D 28 G.HN.52
Hydrophobic ICL2 Y 350 - G.HN D 28 G.HN.52
Van-der-waals ICL2 Y 350 - G.HN D 28 G.HN.52
Hydrophobic ICL2 Y 347 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 Y 347 - G.H5 I 343 G.H5.15
Hydrophobic TM5 L 438 5x61 G.H5 L 348 G.H5.20
Van-der-waals TM5 L 438 5x61 G.H5 L 348 G.H5.20
Ionic TM6 R 451 6x34 G.h4s6 E 318 G.h4s6.12
Polar TM6 R 451 6x34 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 R 451 6x34 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 R 451 6x34 G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL2 I 349 - G.H5 N 347 G.H5.19
Polar ICL2 N 348 - G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 N 348 - G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 N 348 - G.s2s3 D 193 G.s2s3.02
Hydrophobic TM5 L 441 5x64 G.H5 I 344 G.H5.16
Van-der-waals TM5 L 441 5x64 G.H5 I 344 G.H5.16
Polar TM6 R 451 6x34 G.h4s6 D 315 G.h4s6.09
Hydrophobic TM6 R 451 6x34 G.h4s6 D 315 G.h4s6.09
Van-der-waals TM6 R 451 6x34 G.h4s6 D 315 G.h4s6.09
Polar TM7 Q 506 7x60 G.H5 C 351 G.H5.23
Hydrophobic TM7 Q 506 7x60 G.H5 C 351 G.H5.23
Van-der-waals TM7 Q 506 7x60 G.H5 C 351 G.H5.23
Hydrophobic ICL2 V 346 - G.H5 I 344 G.H5.16
Van-der-waals ICL2 V 346 - G.H5 I 344 G.H5.16
Hydrophobic TM3 L 342 3x57 G.H5 C 351 G.H5.23
Van-der-waals TM3 L 342 3x57 G.H5 C 351 G.H5.23
Ionic ICL3 R 444 - G.H5 D 341 G.H5.13
Polar ICL3 R 444 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 R 444 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 R 444 - G.H5 D 341 G.H5.13
Polar ICL3 D 446 - G.S6 I 319 G.S6.01
Van-der-waals ICL3 D 446 - G.S6 I 319 G.S6.01
Hydrophobic TM7 W 502 7x56 G.H5 G 352 G.H5.24
Van-der-waals TM7 W 502 7x56 G.H5 G 352 G.H5.24
Hydrophobic TM5 T 437 5x60 G.H5 I 344 G.H5.16
Polar ICL2 N 348 - G.hns1 K 32 G.hns1.03
Hydrophobic ICL2 N 348 - G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 N 348 - G.hns1 K 32 G.hns1.03
Hydrophobic ICL3 D 446 - G.H4 L 308 G.H4.16
Van-der-waals ICL3 D 446 - G.H4 L 308 G.H4.16
Polar TM6 R 451 6x34 G.h4s6 V 316 G.h4s6.10
Van-der-waals TM6 R 451 6x34 G.h4s6 V 316 G.h4s6.10
Polar TM6 T 458 6x41 G.H5 L 353 G.H5.25
Hydrophobic TM6 T 458 6x41 G.H5 L 353 G.H5.25
Van-der-waals TM6 T 458 6x41 G.H5 L 353 G.H5.25
Polar ICL2 Y 347 - G.H5 T 340 G.H5.12
Hydrophobic ICL2 Y 347 - G.H5 T 340 G.H5.12
Van-der-waals ICL2 Y 347 - G.H5 T 340 G.H5.12
Hydrophobic TM7 W 502 7x56 G.H5 L 353 G.H5.25
Van-der-waals TM7 W 502 7x56 G.H5 L 353 G.H5.25
Polar TM3 L 342 3x57 G.H5 N 347 G.H5.19
Hydrophobic TM3 L 342 3x57 G.H5 N 347 G.H5.19
Van-der-waals TM3 L 342 3x57 G.H5 N 347 G.H5.19
Polar TM5 L 441 5x64 G.H5 K 345 G.H5.17
Hydrophobic TM5 L 441 5x64 G.H5 K 345 G.H5.17
Van-der-waals TM5 L 441 5x64 G.H5 K 345 G.H5.17
Hydrophobic TM7 Q 506 7x60 G.H5 G 352 G.H5.24
Polar ICL2 Y 350 - G.HN Q 24 G.HN.48
Hydrophobic ICL2 Y 350 - G.HN Q 24 G.HN.48
Van-der-waals ICL2 Y 350 - G.HN Q 24 G.HN.48
Hydrophobic TM6 L 462 6x45 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 462 6x45 G.H5 L 353 G.H5.25
Hydrophobic TM6 H 454 6x37 G.H5 F 354 G.H5.26
Hydrophobic ICL2 Y 347 - G.s2s3 K 192 G.s2s3.01
Polar H8 R 509 8x49 G.H5 F 354 G.H5.26
Hydrophobic H8 R 509 8x49 G.H5 F 354 G.H5.26
Van-der-waals H8 R 509 8x49 G.H5 F 354 G.H5.26
Ionic H8 E 513 8x53 G.H5 K 349 G.H5.21
Polar H8 E 513 8x53 G.H5 K 349 G.H5.21
Ionic TM5 R 440 5x63 G.H5 D 337 G.H5.09
Polar TM5 R 440 5x63 G.H5 D 337 G.H5.09
Van-der-waals TM5 R 440 5x63 G.H5 D 337 G.H5.09
Polar H8 R 509 8x49 G.H5 L 353 G.H5.25
Polar C-term T 527 - G.H3 K 257 G.H3.16
Van-der-waals C-term T 527 - G.H3 K 257 G.H3.16
Hydrophobic ICL2 V 346 - G.H5 T 340 G.H5.12
Hydrophobic ICL2 Y 347 - G.S3 L 194 G.S3.01
Van-der-waals ICL2 Y 347 - G.S3 L 194 G.S3.01
Hydrophobic TM3 L 339 3x54 G.H5 L 353 G.H5.25
Hydrophobic TM3 L 343 3x58 G.H5 I 344 G.H5.16
Hydrophobic ICL2 Y 347 - G.H5 F 336 G.H5.08
Van-der-waals ICL2 Y 347 - G.H5 F 336 G.H5.08
Hydrophobic TM5 L 438 5x61 G.H5 F 354 G.H5.26
Polar ICL3 D 446 - G.S6 S 321 G.S6.03
Hydrophobic ICL3 D 446 - G.S6 S 321 G.S6.03
Van-der-waals ICL3 D 446 - G.S6 S 321 G.S6.03
Ionic ICL3 D 446 - G.H4 K 304 G.H4.12
Polar ICL3 D 446 - G.H4 K 304 G.H4.12
Hydrophobic ICL3 D 446 - G.H4 K 304 G.H4.12
Van-der-waals ICL3 D 446 - G.H4 K 304 G.H4.12
Hydrophobic TM2 L 280 2x46 G.H5 C 351 G.H5.23
Van-der-waals TM2 L 280 2x46 G.H5 C 351 G.H5.23
Hydrophobic TM5 L 441 5x64 G.H5 L 348 G.H5.20
Ionic ICL3 R 444 - G.H5 D 337 G.H5.09
Polar ICL3 R 444 - G.H5 D 337 G.H5.09
Hydrophobic ICL3 R 444 - G.H5 D 337 G.H5.09
Van-der-waals ICL3 R 444 - G.H5 D 337 G.H5.09
Hydrophobic ICL3 R 444 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 R 444 - G.S6 Y 320 G.S6.02
Hydrophobic ICL3 P 448 - G.h4s6 K 314 G.h4s6.08
Van-der-waals ICL3 P 448 - G.h4s6 K 314 G.h4s6.08
Hydrophobic TM3 L 343 3x58 G.H5 L 348 G.H5.20
Van-der-waals TM3 L 343 3x58 G.H5 L 348 G.H5.20
Hydrophobic ICL2 V 346 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 V 346 - G.H5 I 343 G.H5.15
Polar ICL2 V 346 - G.H5 N 347 G.H5.19
Hydrophobic TM5 L 441 5x64 G.H5 D 341 G.H5.13
Van-der-waals TM5 L 441 5x64 G.H5 D 341 G.H5.13
Hydrophobic ICL3 A 445 - G.S6 Y 320 G.S6.02