Gz - ADGRG5 complex model

GPCR CLASS (FAMILY)

B2 (Adhesion)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 84.5

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
01
iPTM Score: 0.7
01
PAE mean: 15.0
031


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:
R02G.hns1E02G.s2s3L01G.S3N16G.H3K08E12G.h4s6F08D09Y22G24L25C26G.H5GproteinN-Y-S8x63S2x45H6x37R8x49A8x60R6x34Q7x60D2x44R5x63GPCRInteractions:AromaticHydrophobicIonicPolarVan der waalsG Protein segments:G.hns1G.s2s3G.S3G.H3G.h4s6G.H5GPCR segments:TM2ICL2TM5TM6TM7H8

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

ACDEFGHIKLMNPQRSTVWY-_+van-der-waalshydrophobicionicaromaticpolar
null2x372x382x393x503x533x543x565x645x655x675x686x296x326x366x407x527x568x498x578x608x618x63G.H5.26G.H5.25G.H5.24G.H5.23G.H5.22G.H5.20G.H5.19G.H5.16G.H5.15G.H5.13G.H5.12G.H5.09G.H5.08G.h4s6.12G.h4s6.09G.h4s6.08G.h3s5.02G.h3s5.01G.H3.17G.H3.16G.S3.01G.s2s3.02G.s2s3.01G.hns1.03G.hns1.02G.HN.52Res. Pos.ADGRG5 (AFM_AGRG5_HUMAN_GNAZ_HUMAN)- (AFM_AGRG5_HUMAN_GNAZ_HUMAN)-----------------------DSLLLLRTLRLRHTLWQRQAFSDSLLLLRTLRLRHTLWQRQAFSSYRILNILECDDKEEGNNIWFTIQLRK

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.