G12 - ADGRG6 complex model

GPCR CLASS (FAMILY)

B2 (Adhesion)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 78.4

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.8


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 L 959 3x58 G.H5 L 375 G.H5.20
Van-der-waals TM3 L 959 3x58 G.H5 L 375 G.H5.20
Hydrophobic ICL2 F 963 - G.H5 V 366 G.H5.11
Hydrophobic TM3 L 959 3x58 G.H5 L 371 G.H5.16
Van-der-waals TM3 L 959 3x58 G.H5 L 371 G.H5.16
Hydrophobic TM7 K 1118 7x61 G.H5 L 380 G.H5.25
Van-der-waals TM7 K 1118 7x61 G.H5 L 380 G.H5.25
Hydrophobic ICL2 Y 966 - G.hns1 R 55 G.hns1.02
Hydrophobic TM2 P 897 2x46 G.H5 I 378 G.H5.23
Hydrophobic TM2 P 897 2x46 G.H5 D 377 G.H5.22
Van-der-waals TM2 P 897 2x46 G.H5 D 377 G.H5.22
Hydrophobic ICL2 F 963 - G.H5 K 367 G.H5.12
Van-der-waals ICL2 F 963 - G.H5 K 367 G.H5.12
Ionic TM5 R 1050 5x64 G.H5 D 368 G.H5.13
Polar TM5 R 1050 5x64 G.H5 D 368 G.H5.13
Van-der-waals TM5 R 1050 5x64 G.H5 D 368 G.H5.13
Polar TM6 S 1069 6x41 G.H5 Q 381 G.H5.26
Van-der-waals TM6 S 1069 6x41 G.H5 Q 381 G.H5.26
Hydrophobic TM6 R 1065 6x37 G.H5 Q 381 G.H5.26
Polar TM3 A 958 3x57 G.H5 N 374 G.H5.19
Hydrophobic TM3 A 958 3x57 G.H5 N 374 G.H5.19
Van-der-waals TM3 A 958 3x57 G.H5 N 374 G.H5.19
Hydrophobic TM3 L 959 3x58 G.H5 I 378 G.H5.23
Van-der-waals TM3 L 959 3x58 G.H5 I 378 G.H5.23
Hydrophobic ICL2 Y 966 - G.HN A 53 G.HN.53
Ionic TM5 K 1053 5x67 G.H5 D 368 G.H5.13
Polar TM5 K 1053 5x67 G.H5 D 368 G.H5.13
Van-der-waals TM5 K 1053 5x67 G.H5 D 368 G.H5.13
Hydrophobic TM5 I 1047 5x61 G.H5 L 375 G.H5.20
Hydrophobic ICL2 F 963 - G.S3 I 221 G.S3.01
Van-der-waals ICL2 F 963 - G.S3 I 221 G.S3.01
Hydrophobic TM6 L 1073 6x45 G.H5 M 379 G.H5.24
Van-der-waals TM6 L 1073 6x45 G.H5 M 379 G.H5.24
Polar C-term D 1141 - G.H3 K 284 G.H3.16
Van-der-waals C-term D 1141 - G.H3 K 284 G.H3.16
Hydrophobic TM5 R 1050 5x64 G.H5 L 375 G.H5.20
Van-der-waals TM5 R 1050 5x64 G.H5 L 375 G.H5.20
Hydrophobic ICL2 N 964 - G.S3 I 221 G.S3.01
Hydrophobic TM2 L 901 2x50 G.H5 L 380 G.H5.25
Hydrophobic TM5 Q 1046 5x60 G.H5 L 371 G.H5.16
Van-der-waals TM5 Q 1046 5x60 G.H5 L 371 G.H5.16
Polar C-term T 1145 - G.H3 K 284 G.H3.16
Hydrophobic C-term T 1145 - G.H3 K 284 G.H3.16
Van-der-waals C-term T 1145 - G.H3 K 284 G.H3.16
Hydrophobic TM7 H 1114 7x57 G.H5 L 380 G.H5.25
Van-der-waals TM7 H 1114 7x57 G.H5 L 380 G.H5.25
Hydrophobic TM2 P 897 2x46 G.H5 L 380 G.H5.25
Hydrophobic TM3 M 955 3x54 G.H5 I 378 G.H5.23
Polar ICL2 N 964 - G.s2s3 K 220 G.s2s3.02
Van-der-waals ICL2 N 964 - G.s2s3 K 220 G.s2s3.02
Hydrophobic TM5 V 1043 5x57 G.H5 L 375 G.H5.20
Aromatic ICL2 F 963 - G.H5 F 363 G.H5.08
Hydrophobic ICL2 F 963 - G.H5 F 363 G.H5.08
Van-der-waals ICL2 F 963 - G.H5 F 363 G.H5.08
Polar ICL2 Y 966 - G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 Y 966 - G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 Y 966 - G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 V 962 - G.H5 K 367 G.H5.12
Van-der-waals ICL2 V 962 - G.H5 K 367 G.H5.12
Hydrophobic TM6 S 1069 6x41 G.H5 M 379 G.H5.24
Van-der-waals TM6 S 1069 6x41 G.H5 M 379 G.H5.24
Hydrophobic TM3 L 959 3x58 G.H5 N 374 G.H5.19
Hydrophobic ICL2 F 963 - G.H5 I 370 G.H5.15
Van-der-waals ICL2 F 963 - G.H5 I 370 G.H5.15
Hydrophobic ICL2 F 963 - G.S1 V 58 G.S1.02
Hydrophobic ICL2 V 962 - G.H5 L 371 G.H5.16
Hydrophobic TM3 A 958 3x57 G.H5 I 378 G.H5.23
Van-der-waals TM3 A 958 3x57 G.H5 I 378 G.H5.23
Polar TM5 R 1050 5x64 G.H5 L 371 G.H5.16
Hydrophobic TM5 R 1050 5x64 G.H5 L 371 G.H5.16
Van-der-waals TM5 R 1050 5x64 G.H5 L 371 G.H5.16
Hydrophobic ICL2 V 962 - G.H5 I 370 G.H5.15
Van-der-waals ICL2 V 962 - G.H5 I 370 G.H5.15
Hydrophobic TM6 S 1072 6x44 G.H5 M 379 G.H5.24
Van-der-waals TM6 S 1072 6x44 G.H5 M 379 G.H5.24
Hydrophobic ICL2 Y 966 - G.HN R 52 G.HN.52
Van-der-waals ICL2 Y 966 - G.HN R 52 G.HN.52
Hydrophobic TM5 I 1047 5x61 G.H5 M 379 G.H5.24
Polar TM3 V 960 3x59 G.H5 K 367 G.H5.12
Van-der-waals TM3 V 960 3x59 G.H5 K 367 G.H5.12
Hydrophobic TM5 R 1050 5x64 G.H5 Q 372 G.H5.17
Van-der-waals TM5 R 1050 5x64 G.H5 Q 372 G.H5.17