GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 79.9
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 12.6
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM5 | R | 1050 | 5x64 | G.H5 | L | 364 | G.H5.16 |
Van-der-waals | TM5 | R | 1050 | 5x64 | G.H5 | L | 364 | G.H5.16 |
Ionic | TM5 | K | 1053 | 5x67 | G.H5 | D | 361 | G.H5.13 |
Polar | TM5 | K | 1053 | 5x67 | G.H5 | D | 361 | G.H5.13 |
Hydrophobic | TM5 | R | 1050 | 5x64 | G.H5 | L | 368 | G.H5.20 |
Hydrophobic | ICL2 | V | 962 | - | G.H5 | R | 360 | G.H5.12 |
Hydrophobic | C-term | G | 1212 | - | G.H1 | H | 66 | G.H1.12 |
Polar | TM3 | H | 954 | 3x53 | G.H5 | Y | 367 | G.H5.19 |
Aromatic | TM3 | H | 954 | 3x53 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | TM3 | H | 954 | 3x53 | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | TM3 | H | 954 | 3x53 | G.H5 | Y | 367 | G.H5.19 |
Polar | C-term | V | 1214 | - | G.S2 | S | 198 | G.S2.07 |
Hydrophobic | TM6 | S | 1072 | 6x44 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | TM6 | S | 1072 | 6x44 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | ICL2 | Y | 966 | - | G.hns1 | R | 40 | G.hns1.02 |
Van-der-waals | ICL2 | Y | 966 | - | G.hns1 | R | 40 | G.hns1.02 |
Hydrophobic | C-term | F | 1210 | - | G.S2 | Y | 195 | G.S2.04 |
Ionic | TM5 | R | 1050 | 5x64 | G.H5 | D | 361 | G.H5.13 |
Polar | TM5 | R | 1050 | 5x64 | G.H5 | D | 361 | G.H5.13 |
Hydrophobic | TM5 | R | 1050 | 5x64 | G.H5 | D | 361 | G.H5.13 |
Van-der-waals | TM5 | R | 1050 | 5x64 | G.H5 | D | 361 | G.H5.13 |
Polar | C-term | Q | 1208 | - | G.S2 | C | 196 | G.S2.05 |
Hydrophobic | C-term | Q | 1208 | - | G.S2 | C | 196 | G.S2.05 |
Van-der-waals | C-term | Q | 1208 | - | G.S2 | C | 196 | G.S2.05 |
Hydrophobic | ICL2 | F | 963 | - | G.H5 | V | 363 | G.H5.15 |
Hydrophobic | ICL2 | V | 962 | - | G.H5 | L | 364 | G.H5.16 |
Hydrophobic | TM7 | K | 1118 | 7x61 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | TM7 | K | 1118 | 7x61 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | TM3 | L | 959 | 3x58 | G.H5 | L | 364 | G.H5.16 |
Van-der-waals | TM3 | L | 959 | 3x58 | G.H5 | L | 364 | G.H5.16 |
Hydrophobic | C-term | R | 1207 | - | G.S3 | R | 205 | G.S3.04 |
Van-der-waals | C-term | R | 1207 | - | G.S3 | R | 205 | G.S3.04 |
Hydrophobic | TM2 | P | 897 | 2x46 | G.H5 | I | 371 | G.H5.23 |
Van-der-waals | TM2 | P | 897 | 2x46 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | C-term | Q | 1208 | - | G.S2 | Y | 195 | G.S2.04 |
Van-der-waals | C-term | Q | 1208 | - | G.S2 | Y | 195 | G.S2.04 |
Van-der-waals | C-term | G | 1212 | - | G.S2 | S | 198 | G.S2.07 |
Hydrophobic | C-term | V | 1214 | - | G.H1 | I | 65 | G.H1.11 |
Van-der-waals | C-term | V | 1214 | - | G.H1 | I | 65 | G.H1.11 |
Hydrophobic | ICL2 | F | 963 | - | G.H5 | R | 360 | G.H5.12 |
Van-der-waals | ICL2 | F | 963 | - | G.H5 | R | 360 | G.H5.12 |
Hydrophobic | C-term | G | 1212 | - | G.h1ha | G | 67 | G.h1ha.01 |
Van-der-waals | C-term | G | 1212 | - | G.h1ha | G | 67 | G.h1ha.01 |
Polar | TM3 | M | 955 | 3x54 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | TM3 | M | 955 | 3x54 | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | TM3 | M | 955 | 3x54 | G.H5 | Y | 367 | G.H5.19 |
Polar | ICL2 | N | 964 | - | G.s2s3 | K | 201 | G.s2s3.02 |
Hydrophobic | ICL2 | N | 964 | - | G.s2s3 | K | 201 | G.s2s3.02 |
Van-der-waals | ICL2 | N | 964 | - | G.s2s3 | K | 201 | G.s2s3.02 |
Polar | TM6 | S | 1069 | 6x41 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | TM6 | S | 1069 | 6x41 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | TM6 | S | 1069 | 6x41 | G.H5 | L | 373 | G.H5.25 |
Polar | C-term | Y | 1196 | - | H.HA | E | 74 | H.HA.03 |
Van-der-waals | C-term | Y | 1196 | - | H.HA | E | 74 | H.HA.03 |
Polar | C-term | N | 1201 | - | G.HN | Q | 35 | G.HN.50 |
Hydrophobic | C-term | N | 1201 | - | G.HN | Q | 35 | G.HN.50 |
Van-der-waals | C-term | N | 1201 | - | G.HN | Q | 35 | G.HN.50 |
Hydrophobic | C-term | F | 1210 | - | G.S2 | F | 197 | G.S2.06 |
Van-der-waals | C-term | F | 1210 | - | G.S2 | F | 197 | G.S2.06 |
Polar | C-term | S | 1205 | - | G.S2 | E | 194 | G.S2.03 |
Polar | TM7 | F | 1113 | 7x56 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | TM7 | F | 1113 | 7x56 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | TM3 | A | 958 | 3x57 | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | TM3 | A | 958 | 3x57 | G.H5 | Y | 367 | G.H5.19 |
Polar | C-term | L | 1206 | - | G.S2 | E | 194 | G.S2.03 |
Van-der-waals | C-term | L | 1206 | - | G.S2 | E | 194 | G.S2.03 |
Hydrophobic | ICL2 | F | 963 | - | G.S3 | T | 202 | G.S3.01 |
Van-der-waals | ICL2 | F | 963 | - | G.S3 | T | 202 | G.S3.01 |
Polar | TM7 | H | 1114 | 7x57 | G.H5 | I | 371 | G.H5.23 |
Polar | C-term | V | 1216 | - | G.s2s3 | Q | 200 | G.s2s3.01 |
Hydrophobic | C-term | V | 1216 | - | G.s2s3 | Q | 200 | G.s2s3.01 |
Van-der-waals | C-term | V | 1216 | - | G.s2s3 | Q | 200 | G.s2s3.01 |
Hydrophobic | ICL2 | Y | 966 | - | G.HN | K | 37 | G.HN.52 |
Polar | C-term | V | 1214 | - | G.s2s3 | Q | 200 | G.s2s3.01 |
Polar | TM7 | M | 1117 | 7x60 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | TM7 | M | 1117 | 7x60 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | TM7 | M | 1117 | 7x60 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | C-term | V | 1216 | - | G.S2 | V | 199 | G.S2.08 |
Polar | C-term | S | 1205 | - | G.S2 | N | 193 | G.S2.02 |
Polar | ICL2 | N | 964 | - | G.S3 | T | 202 | G.S3.01 |
Hydrophobic | ICL2 | N | 964 | - | G.S3 | T | 202 | G.S3.01 |
Van-der-waals | ICL2 | N | 964 | - | G.S3 | T | 202 | G.S3.01 |
Polar | C-term | Q | 1208 | - | G.S2 | E | 194 | G.S2.03 |
Van-der-waals | C-term | Q | 1208 | - | G.S2 | E | 194 | G.S2.03 |
Hydrophobic | TM2 | P | 897 | 2x46 | G.H5 | Y | 367 | G.H5.19 |
Polar | C-term | S | 1205 | - | G.S2 | I | 192 | G.S2.01 |
Hydrophobic | C-term | S | 1205 | - | G.S2 | I | 192 | G.S2.01 |
Van-der-waals | C-term | S | 1205 | - | G.S2 | I | 192 | G.S2.01 |
Hydrophobic | ICL2 | F | 963 | - | G.S1 | L | 43 | G.S1.02 |
Van-der-waals | ICL2 | F | 963 | - | G.S1 | L | 43 | G.S1.02 |
Hydrophobic | C-term | V | 1214 | - | G.H1 | H | 66 | G.H1.12 |
Van-der-waals | C-term | V | 1214 | - | G.H1 | H | 66 | G.H1.12 |
Polar | C-term | L | 1206 | - | G.S2 | I | 192 | G.S2.01 |
Van-der-waals | C-term | L | 1206 | - | G.S2 | I | 192 | G.S2.01 |
Aromatic | C-term | F | 1210 | - | G.H1 | R | 63 | G.H1.09 |
Hydrophobic | C-term | F | 1210 | - | G.H1 | R | 63 | G.H1.09 |
Van-der-waals | C-term | F | 1210 | - | G.H1 | R | 63 | G.H1.09 |
Hydrophobic | C-term | V | 1216 | - | G.H1 | H | 66 | G.H1.12 |
Van-der-waals | C-term | V | 1216 | - | G.H1 | H | 66 | G.H1.12 |
Polar | TM5 | R | 1054 | 5x68 | G.h4s6 | R | 337 | G.h4s6.19 |
Van-der-waals | TM5 | R | 1054 | 5x68 | G.h4s6 | R | 337 | G.h4s6.19 |
Polar | C-term | C | 1209 | - | G.S2 | C | 196 | G.S2.05 |
Hydrophobic | C-term | C | 1209 | - | G.S2 | C | 196 | G.S2.05 |
Van-der-waals | C-term | C | 1209 | - | G.S2 | C | 196 | G.S2.05 |
Hydrophobic | TM5 | I | 1047 | 5x61 | G.H5 | L | 368 | G.H5.20 |
Polar | C-term | K | 1217 | - | G.H5 | R | 353 | G.H5.05 |
Polar | C-term | T | 1218 | - | G.s2s3 | Q | 200 | G.s2s3.01 |
Hydrophobic | C-term | T | 1218 | - | G.s2s3 | Q | 200 | G.s2s3.01 |
Van-der-waals | C-term | T | 1218 | - | G.s2s3 | Q | 200 | G.s2s3.01 |
Polar | C-term | F | 1210 | - | G.S2 | C | 196 | G.S2.05 |
Van-der-waals | C-term | F | 1210 | - | G.S2 | C | 196 | G.S2.05 |
Hydrophobic | C-term | V | 1216 | - | G.H5 | R | 353 | G.H5.05 |
Van-der-waals | C-term | V | 1216 | - | G.H5 | R | 353 | G.H5.05 |
Polar | C-term | Y | 1196 | - | G.H1 | R | 63 | G.H1.09 |
Van-der-waals | C-term | Y | 1196 | - | G.H1 | R | 63 | G.H1.09 |
Ionic | C-term | R | 1207 | - | G.S1 | E | 42 | G.S1.01 |
Polar | C-term | R | 1207 | - | G.S1 | E | 42 | G.S1.01 |
Hydrophobic | C-term | R | 1207 | - | G.S1 | E | 42 | G.S1.01 |
Van-der-waals | C-term | R | 1207 | - | G.S1 | E | 42 | G.S1.01 |
Hydrophobic | C-term | L | 1206 | - | G.S2 | N | 193 | G.S2.02 |
Van-der-waals | C-term | L | 1206 | - | G.S2 | N | 193 | G.S2.02 |
Hydrophobic | TM5 | I | 1047 | 5x61 | G.H5 | L | 373 | G.H5.25 |
Ionic | C-term | R | 1207 | - | G.S2 | E | 194 | G.S2.03 |
Hydrophobic | C-term | R | 1207 | - | G.S2 | E | 194 | G.S2.03 |
Van-der-waals | C-term | R | 1207 | - | G.S2 | E | 194 | G.S2.03 |
Polar | TM6 | R | 1068 | 6x40 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | TM6 | R | 1068 | 6x40 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | TM6 | R | 1068 | 6x40 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | TM6 | R | 1065 | 6x37 | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | TM6 | R | 1065 | 6x37 | G.H5 | L | 374 | G.H5.26 |
Polar | TM3 | V | 960 | 3x59 | G.H5 | R | 360 | G.H5.12 |
Polar | TM7 | K | 1118 | 7x61 | G.H5 | E | 370 | G.H5.22 |
Hydrophobic | TM7 | K | 1118 | 7x61 | G.H5 | E | 370 | G.H5.22 |
Van-der-waals | TM7 | K | 1118 | 7x61 | G.H5 | E | 370 | G.H5.22 |
Polar | C-term | F | 1210 | - | G.S2 | S | 198 | G.S2.07 |
Hydrophobic | ICL2 | V | 962 | - | G.H5 | V | 363 | G.H5.15 |
Van-der-waals | ICL2 | V | 962 | - | G.H5 | V | 363 | G.H5.15 |
Hydrophobic | TM5 | V | 1043 | 5x57 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | TM6 | L | 1073 | 6x45 | G.H5 | L | 373 | G.H5.25 |
Aromatic | ICL2 | F | 963 | - | G.H5 | F | 356 | G.H5.08 |
Hydrophobic | ICL2 | F | 963 | - | G.H5 | F | 356 | G.H5.08 |
Van-der-waals | ICL2 | F | 963 | - | G.H5 | F | 356 | G.H5.08 |
Hydrophobic | C-term | F | 1210 | - | G.h1ha | G | 67 | G.h1ha.01 |
Hydrophobic | TM5 | R | 1050 | 5x64 | G.h4s6 | R | 338 | G.h4s6.20 |
Hydrophobic | TM3 | A | 958 | 3x57 | G.H5 | L | 364 | G.H5.16 |
Van-der-waals | TM3 | A | 958 | 3x57 | G.H5 | L | 364 | G.H5.16 |
Polar | C-term | R | 1207 | - | G.S2 | C | 196 | G.S2.05 |
Hydrophobic | C-term | R | 1207 | - | G.S2 | C | 196 | G.S2.05 |
Van-der-waals | C-term | R | 1207 | - | G.S2 | C | 196 | G.S2.05 |
Hydrophobic | TM3 | M | 955 | 3x54 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | TM3 | L | 959 | 3x58 | G.H5 | L | 368 | G.H5.20 |
Hydrophobic | TM3 | L | 959 | 3x58 | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | TM3 | L | 959 | 3x58 | G.H5 | Y | 367 | G.H5.19 |
Polar | TM5 | R | 1054 | 5x68 | G.h4s6 | R | 335 | G.h4s6.17 |
Hydrophobic | TM5 | R | 1054 | 5x68 | G.h4s6 | R | 335 | G.h4s6.17 |
Van-der-waals | TM5 | R | 1054 | 5x68 | G.h4s6 | R | 335 | G.h4s6.17 |
Ionic | H8 | E | 1119 | 8x48 | G.h4s6 | R | 335 | G.h4s6.17 |
Hydrophobic | ICL2 | F | 963 | - | G.H5 | V | 359 | G.H5.11 |