G12 - ADGRG7 complex model

GPCR CLASS (FAMILY)

B2 (Adhesion)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 79.4

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 14.6


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 L 555 3x58 G.H5 N 374 G.H5.19
Hydrophobic ICL3 S 660 - G.S6 F 347 G.S6.02
Hydrophobic TM6 V 676 6x45 G.H5 L 380 G.H5.25
Van-der-waals TM6 V 676 6x45 G.H5 L 380 G.H5.25
Hydrophobic TM1 Q 456 1x61 G.H5 M 379 G.H5.24
Van-der-waals TM1 Q 456 1x61 G.H5 M 379 G.H5.24
Hydrophobic ICL3 L 658 - G.H5 D 368 G.H5.13
Van-der-waals ICL3 L 658 - G.H5 D 368 G.H5.13
Hydrophobic ICL3 T 661 - G.S6 H 348 G.S6.03
Van-der-waals ICL3 T 659 - G.S6 F 347 G.S6.02
Hydrophobic ICL3 L 658 - G.S6 F 347 G.S6.02
Van-der-waals ICL3 L 658 - G.S6 F 347 G.S6.02
Hydrophobic ICL1 R 463 12x51 G.H5 D 377 G.H5.22
Van-der-waals ICL1 R 463 12x51 G.H5 D 377 G.H5.22
Hydrophobic TM3 L 555 3x58 G.H5 L 375 G.H5.20
Van-der-waals TM3 L 555 3x58 G.H5 L 375 G.H5.20
Van-der-waals TM6 K 668 6x37 G.H5 Q 381 G.H5.26
Polar ICL1 K 464 - G.H5 N 374 G.H5.19
Van-der-waals ICL1 K 464 - G.H5 N 374 G.H5.19
Van-der-waals ICL2 T 558 - G.H5 K 367 G.H5.12
Polar ICL3 S 660 - G.S6 L 346 G.S6.01
Hydrophobic ICL3 S 660 - G.S6 L 346 G.S6.01
Van-der-waals ICL3 S 660 - G.S6 L 346 G.S6.01
Hydrophobic TM3 L 551 3x54 G.H5 I 378 G.H5.23
Van-der-waals TM3 L 551 3x54 G.H5 I 378 G.H5.23
Hydrophobic ICL2 M 559 - G.H5 F 363 G.H5.08
Hydrophobic TM6 S 675 6x44 G.H5 L 380 G.H5.25
Van-der-waals TM6 S 675 6x44 G.H5 L 380 G.H5.25
Hydrophobic ICL2 P 561 - G.hns1 R 55 G.hns1.02
Hydrophobic TM3 L 554 3x57 G.H5 I 378 G.H5.23
Van-der-waals TM3 L 554 3x57 G.H5 I 378 G.H5.23
Hydrophobic ICL2 T 558 - G.H5 L 371 G.H5.16
Van-der-waals ICL2 T 558 - G.H5 L 371 G.H5.16
Polar ICL3 T 661 - G.h4s6 R 339 G.h4s6.08
Hydrophobic TM7 T 724 7x61 G.H5 M 379 G.H5.24
Hydrophobic ICL2 M 559 - G.S3 F 223 G.S3.03
Hydrophobic ICL3 L 658 - G.H5 H 364 G.H5.09
Polar TM7 R 723 7x60 G.H5 L 380 G.H5.25
Hydrophobic ICL3 S 660 - G.h4s6 P 345 G.h4s6.20
Van-der-waals ICL3 S 660 - G.h4s6 P 345 G.h4s6.20
Hydrophobic TM2 V 467 2x46 G.H5 I 378 G.H5.23
Hydrophobic ICL2 M 559 - G.H5 V 366 G.H5.11
Aromatic TM4 H 565 4x41 G.HN R 52 G.HN.52
Hydrophobic TM2 L 471 2x50 G.H5 M 379 G.H5.24
Van-der-waals TM2 L 471 2x50 G.H5 M 379 G.H5.24
Hydrophobic TM5 L 651 5x62 G.H5 L 375 G.H5.20
Hydrophobic ICL2 T 558 - G.H5 I 370 G.H5.15
Hydrophobic TM3 L 555 3x58 G.H5 I 378 G.H5.23
Hydrophobic TM5 N 657 5x68 G.H5 F 361 G.H5.06
Van-der-waals TM5 N 657 5x68 G.H5 F 361 G.H5.06
Ionic ICL1 K 464 - G.H5 D 377 G.H5.22
Polar ICL1 K 464 - G.H5 D 377 G.H5.22
Hydrophobic ICL1 K 464 - G.H5 D 377 G.H5.22
Van-der-waals ICL1 K 464 - G.H5 D 377 G.H5.22
Polar TM6 S 672 6x41 G.H5 L 380 G.H5.25
Hydrophobic TM6 S 672 6x41 G.H5 L 380 G.H5.25
Van-der-waals TM6 S 672 6x41 G.H5 L 380 G.H5.25
Hydrophobic ICL2 M 559 - G.H5 I 370 G.H5.15
Van-der-waals ICL2 M 559 - G.H5 I 370 G.H5.15
Hydrophobic ICL3 L 658 - G.H5 F 361 G.H5.06
Polar TM7 R 723 7x60 G.H5 Q 381 G.H5.26
Van-der-waals TM7 R 723 7x60 G.H5 Q 381 G.H5.26
Hydrophobic ICL3 L 658 - G.H5 A 365 G.H5.10
Van-der-waals ICL3 L 658 - G.H5 A 365 G.H5.10
Hydrophobic TM5 V 650 5x61 G.H5 L 371 G.H5.16
Van-der-waals TM5 V 650 5x61 G.H5 L 371 G.H5.16
Hydrophobic TM7 Y 720 7x57 G.H5 L 380 G.H5.25
Polar ICL3 T 659 - G.S6 H 348 G.S6.03
Hydrophobic ICL3 T 659 - G.S6 H 348 G.S6.03
Van-der-waals ICL3 T 659 - G.S6 H 348 G.S6.03
Hydrophobic ICL2 P 561 - G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 P 561 - G.hns1 R 56 G.hns1.03
Polar ICL3 T 661 - G.S6 L 346 G.S6.01
Hydrophobic ICL3 T 661 - G.S6 L 346 G.S6.01
Van-der-waals ICL3 T 661 - G.S6 L 346 G.S6.01
Hydrophobic ICL2 M 559 - G.S3 I 221 G.S3.01
Van-der-waals ICL2 M 559 - G.S3 I 221 G.S3.01
Hydrophobic TM7 Y 720 7x57 G.H5 I 378 G.H5.23
Van-der-waals TM7 Y 720 7x57 G.H5 I 378 G.H5.23
Hydrophobic ICL2 M 559 - G.S1 V 58 G.S1.02
Hydrophobic TM7 Y 720 7x57 G.H5 M 379 G.H5.24
Van-der-waals TM7 Y 720 7x57 G.H5 M 379 G.H5.24
Hydrophobic TM2 V 467 2x46 G.H5 D 377 G.H5.22
Hydrophobic ICL2 M 559 - G.H5 K 367 G.H5.12
Van-der-waals ICL2 M 559 - G.H5 K 367 G.H5.12
Hydrophobic ICL3 T 661 - G.H4 V 332 G.H4.12
Polar ICL3 T 661 - G.H4 D 336 G.H4.16
Hydrophobic ICL3 T 661 - G.H4 D 336 G.H4.16
Hydrophobic ICL1 R 463 12x51 G.H5 M 379 G.H5.24
Polar TM3 L 554 3x57 G.H5 N 374 G.H5.19
Hydrophobic TM3 L 554 3x57 G.H5 N 374 G.H5.19
Van-der-waals TM3 L 554 3x57 G.H5 N 374 G.H5.19
Hydrophobic ICL3 K 662 - G.h4s6 P 345 G.h4s6.20
Hydrophobic TM3 L 555 3x58 G.H5 L 371 G.H5.16
Van-der-waals TM3 L 555 3x58 G.H5 L 371 G.H5.16
Hydrophobic ICL2 R 564 - G.HN R 52 G.HN.52
Van-der-waals ICL2 R 564 - G.HN R 52 G.HN.52
Polar ICL3 K 662 - G.h4s6 S 343 G.h4s6.12
Van-der-waals ICL3 K 662 - G.h4s6 S 343 G.h4s6.12
Hydrophobic ICL3 S 660 - G.S6 H 348 G.S6.03