GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 81.8
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.0
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM3 | L | 551 | 3x54 | G.H5 | L | 354 | G.H5.25 |
Polar | ICL2 | T | 558 | - | G.hns1 | R | 34 | G.hns1.03 |
Van-der-waals | ICL2 | T | 558 | - | G.hns1 | R | 34 | G.hns1.03 |
Hydrophobic | ICL1 | R | 463 | 12x51 | G.H5 | E | 351 | G.H5.22 |
Van-der-waals | ICL1 | R | 463 | 12x51 | G.H5 | E | 351 | G.H5.22 |
Hydrophobic | TM6 | V | 676 | 6x45 | G.H5 | L | 354 | G.H5.25 |
Polar | TM7 | R | 723 | 7x60 | G.H5 | V | 355 | G.H5.26 |
Van-der-waals | TM7 | R | 723 | 7x60 | G.H5 | V | 355 | G.H5.26 |
Polar | TM6 | S | 672 | 6x41 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM6 | S | 672 | 6x41 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM6 | S | 672 | 6x41 | G.H5 | L | 354 | G.H5.25 |
Polar | ICL1 | K | 464 | - | G.H5 | N | 348 | G.H5.19 |
Van-der-waals | ICL1 | K | 464 | - | G.H5 | N | 348 | G.H5.19 |
Hydrophobic | TM7 | Y | 720 | 7x57 | G.H5 | F | 352 | G.H5.23 |
Van-der-waals | TM7 | Y | 720 | 7x57 | G.H5 | F | 352 | G.H5.23 |
Polar | TM7 | R | 723 | 7x60 | G.H5 | N | 353 | G.H5.24 |
Hydrophobic | ICL2 | M | 559 | - | G.H5 | V | 340 | G.H5.11 |
Ionic | ICL2 | R | 564 | - | G.HN | D | 28 | G.HN.50 |
Polar | ICL2 | R | 564 | - | G.HN | D | 28 | G.HN.50 |
Hydrophobic | ICL2 | R | 564 | - | G.HN | D | 28 | G.HN.50 |
Van-der-waals | ICL2 | R | 564 | - | G.HN | D | 28 | G.HN.50 |
Hydrophobic | C-term | F | 762 | - | G.h2s4 | F | 216 | G.h2s4.01 |
Hydrophobic | ICL3 | L | 658 | - | G.H5 | A | 338 | G.H5.09 |
Van-der-waals | ICL3 | L | 658 | - | G.H5 | A | 338 | G.H5.09 |
Hydrophobic | TM3 | L | 554 | 3x57 | G.H5 | F | 352 | G.H5.23 |
Van-der-waals | TM3 | L | 554 | 3x57 | G.H5 | F | 352 | G.H5.23 |
Hydrophobic | TM5 | V | 650 | 5x61 | G.H5 | L | 345 | G.H5.16 |
Hydrophobic | ICL3 | L | 658 | - | G.H5 | D | 342 | G.H5.13 |
Hydrophobic | ICL2 | T | 558 | - | G.H5 | L | 345 | G.H5.16 |
Van-der-waals | ICL2 | T | 558 | - | G.H5 | L | 345 | G.H5.16 |
Hydrophobic | TM5 | V | 650 | 5x61 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | TM6 | S | 675 | 6x44 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM2 | V | 467 | 2x46 | G.H5 | F | 352 | G.H5.23 |
Van-der-waals | TM2 | V | 467 | 2x46 | G.H5 | F | 352 | G.H5.23 |
Hydrophobic | TM3 | L | 555 | 3x58 | G.H5 | L | 345 | G.H5.16 |
Van-der-waals | TM3 | L | 555 | 3x58 | G.H5 | L | 345 | G.H5.16 |
Hydrophobic | C-term | F | 762 | - | G.H2 | I | 213 | G.H2.08 |
Van-der-waals | C-term | F | 762 | - | G.H2 | I | 213 | G.H2.08 |
Polar | ICL3 | T | 661 | - | G.h4s6 | K | 318 | G.h4s6.13 |
Ionic | ICL2 | R | 564 | - | G.HN | D | 31 | G.HN.53 |
Polar | ICL2 | R | 564 | - | G.HN | D | 31 | G.HN.53 |
Hydrophobic | ICL2 | R | 564 | - | G.HN | D | 31 | G.HN.53 |
Van-der-waals | ICL2 | R | 564 | - | G.HN | D | 31 | G.HN.53 |
Hydrophobic | ICL2 | P | 561 | - | G.hns1 | R | 34 | G.hns1.03 |
Hydrophobic | ICL3 | K | 662 | - | G.h4s6 | V | 319 | G.h4s6.20 |
Van-der-waals | ICL3 | K | 662 | - | G.h4s6 | V | 319 | G.h4s6.20 |
Hydrophobic | ICL2 | M | 559 | - | G.S1 | L | 36 | G.S1.02 |
Hydrophobic | ICL2 | M | 559 | - | G.S3 | I | 195 | G.S3.01 |
Van-der-waals | ICL2 | M | 559 | - | G.S3 | I | 195 | G.S3.01 |
Hydrophobic | ICL3 | L | 658 | - | G.H5 | F | 335 | G.H5.06 |
Hydrophobic | C-term | F | 773 | - | G.S2 | I | 185 | G.S2.01 |
Polar | C-term | Y | 760 | - | G.H2 | R | 209 | G.H2.04 |
Aromatic | C-term | Y | 760 | - | G.H2 | R | 209 | G.H2.04 |
Polar | ICL3 | K | 662 | - | G.H5 | Q | 346 | G.H5.17 |
Van-der-waals | ICL3 | K | 662 | - | G.H5 | Q | 346 | G.H5.17 |
Polar | ICL3 | T | 661 | - | G.S6 | I | 320 | G.S6.01 |
Hydrophobic | ICL3 | T | 661 | - | G.S6 | I | 320 | G.S6.01 |
Van-der-waals | ICL3 | T | 661 | - | G.S6 | I | 320 | G.S6.01 |
Hydrophobic | TM3 | L | 551 | 3x54 | G.H5 | F | 352 | G.H5.23 |
Van-der-waals | TM3 | L | 551 | 3x54 | G.H5 | F | 352 | G.H5.23 |
Hydrophobic | ICL2 | M | 559 | - | G.S3 | F | 197 | G.S3.03 |
Hydrophobic | ICL2 | M | 559 | - | G.H5 | I | 344 | G.H5.15 |
Van-der-waals | ICL2 | M | 559 | - | G.H5 | I | 344 | G.H5.15 |
Hydrophobic | C-term | V | 757 | - | G.H3 | K | 252 | G.H3.10 |
Van-der-waals | C-term | V | 757 | - | G.H3 | K | 252 | G.H3.10 |
Hydrophobic | C-term | F | 762 | - | G.H2 | R | 209 | G.H2.04 |
Van-der-waals | C-term | F | 762 | - | G.H2 | R | 209 | G.H2.04 |
Hydrophobic | ICL3 | K | 662 | - | G.H5 | V | 355 | G.H5.26 |
Van-der-waals | ICL3 | K | 662 | - | G.H5 | V | 355 | G.H5.26 |
Hydrophobic | TM3 | L | 555 | 3x58 | G.H5 | L | 349 | G.H5.20 |
Van-der-waals | TM3 | L | 555 | 3x58 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | ICL2 | P | 561 | - | G.hns1 | A | 32 | G.hns1.01 |
Van-der-waals | ICL2 | P | 561 | - | G.hns1 | A | 32 | G.hns1.01 |
Polar | C-term | Y | 760 | - | G.H3 | Y | 257 | G.H3.15 |
Van-der-waals | C-term | Y | 760 | - | G.H3 | Y | 257 | G.H3.15 |
Polar | C-term | F | 762 | - | G.H3 | Y | 257 | G.H3.15 |
Aromatic | C-term | F | 762 | - | G.H3 | Y | 257 | G.H3.15 |
Hydrophobic | C-term | F | 762 | - | G.H3 | Y | 257 | G.H3.15 |
Van-der-waals | C-term | F | 762 | - | G.H3 | Y | 257 | G.H3.15 |
Hydrophobic | C-term | M | 759 | - | G.H3 | T | 256 | G.H3.14 |
Van-der-waals | C-term | M | 759 | - | G.H3 | T | 256 | G.H3.14 |
Polar | C-term | L | 763 | - | G.H3 | Y | 257 | G.H3.15 |
Hydrophobic | ICL3 | T | 661 | - | G.H4 | Q | 310 | G.H4.16 |
Van-der-waals | ICL3 | T | 661 | - | G.H4 | Q | 310 | G.H4.16 |
Polar | C-term | Y | 760 | - | G.H3 | T | 253 | G.H3.11 |
Hydrophobic | C-term | Y | 760 | - | G.H3 | T | 253 | G.H3.11 |
Van-der-waals | C-term | Y | 760 | - | G.H3 | T | 253 | G.H3.11 |
Polar | TM3 | L | 554 | 3x57 | G.H5 | N | 348 | G.H5.19 |
Hydrophobic | TM3 | L | 554 | 3x57 | G.H5 | N | 348 | G.H5.19 |
Van-der-waals | TM3 | L | 554 | 3x57 | G.H5 | N | 348 | G.H5.19 |
Hydrophobic | C-term | M | 759 | - | G.H3 | T | 253 | G.H3.11 |
Ionic | ICL1 | K | 464 | - | G.H5 | E | 351 | G.H5.22 |
Polar | ICL1 | K | 464 | - | G.H5 | E | 351 | G.H5.22 |
Hydrophobic | ICL1 | K | 464 | - | G.H5 | E | 351 | G.H5.22 |
Van-der-waals | ICL1 | K | 464 | - | G.H5 | E | 351 | G.H5.22 |
Hydrophobic | ICL3 | T | 659 | - | G.S6 | Y | 321 | G.S6.02 |
Van-der-waals | ICL3 | T | 659 | - | G.S6 | Y | 321 | G.S6.02 |
Polar | C-term | Y | 760 | - | G.H3 | E | 246 | G.H3.04 |
Hydrophobic | C-term | Y | 760 | - | G.H3 | E | 246 | G.H3.04 |
Van-der-waals | C-term | Y | 760 | - | G.H3 | E | 246 | G.H3.04 |
Hydrophobic | TM5 | L | 651 | 5x62 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | ICL3 | S | 660 | - | G.S6 | I | 320 | G.S6.01 |
Van-der-waals | ICL3 | S | 660 | - | G.S6 | I | 320 | G.S6.01 |
Hydrophobic | C-term | F | 762 | - | G.H3 | T | 253 | G.H3.11 |
Hydrophobic | C-term | F | 762 | - | G.H2 | W | 212 | G.H2.07 |
Van-der-waals | C-term | F | 762 | - | G.H2 | W | 212 | G.H2.07 |
Hydrophobic | TM3 | L | 555 | 3x58 | G.H5 | N | 348 | G.H5.19 |
Hydrophobic | C-term | F | 762 | - | G.H3 | I | 254 | G.H3.12 |
Hydrophobic | TM6 | K | 668 | 6x37 | G.H5 | V | 355 | G.H5.26 |
Van-der-waals | TM6 | K | 668 | 6x37 | G.H5 | V | 355 | G.H5.26 |
Hydrophobic | ICL3 | S | 660 | - | G.S6 | Y | 321 | G.S6.02 |
Hydrophobic | ICL3 | S | 660 | - | G.h4s6 | V | 319 | G.h4s6.20 |
Van-der-waals | ICL3 | S | 660 | - | G.h4s6 | V | 319 | G.h4s6.20 |
Polar | TM7 | L | 719 | 7x56 | G.H5 | N | 353 | G.H5.24 |
Van-der-waals | TM7 | L | 719 | 7x56 | G.H5 | N | 353 | G.H5.24 |
Polar | C-term | K | 758 | - | G.H3 | T | 253 | G.H3.11 |
Van-der-waals | C-term | K | 758 | - | G.H3 | T | 253 | G.H3.11 |
Hydrophobic | C-term | F | 762 | - | G.H3 | L | 250 | G.H3.08 |
Hydrophobic | TM7 | T | 724 | 7x61 | G.H5 | N | 353 | G.H5.24 |
Van-der-waals | TM7 | T | 724 | 7x61 | G.H5 | N | 353 | G.H5.24 |
Hydrophobic | ICL2 | M | 559 | - | G.H5 | K | 341 | G.H5.12 |
Polar | ICL3 | T | 659 | - | G.S6 | S | 322 | G.S6.03 |
Van-der-waals | ICL3 | T | 659 | - | G.S6 | S | 322 | G.S6.03 |
Ionic | C-term | K | 758 | - | G.s4h3 | E | 241 | G.s4h3.14 |
Polar | C-term | K | 758 | - | G.s4h3 | E | 241 | G.s4h3.14 |
Van-der-waals | C-term | K | 758 | - | G.s4h3 | E | 241 | G.s4h3.14 |
Hydrophobic | ICL3 | L | 658 | - | G.H5 | A | 339 | G.H5.10 |
Van-der-waals | ICL3 | L | 658 | - | G.H5 | A | 339 | G.H5.10 |
Polar | C-term | Y | 760 | - | G.H2 | R | 206 | G.H2.01 |
Van-der-waals | C-term | Y | 760 | - | G.H2 | R | 206 | G.H2.01 |
Hydrophobic | ICL3 | L | 658 | - | G.S6 | Y | 321 | G.S6.02 |
Van-der-waals | ICL3 | L | 658 | - | G.S6 | Y | 321 | G.S6.02 |
Hydrophobic | ICL2 | T | 558 | - | G.H5 | I | 344 | G.H5.15 |
Van-der-waals | ICL2 | T | 558 | - | G.H5 | I | 344 | G.H5.15 |
Hydrophobic | ICL2 | M | 559 | - | G.H5 | F | 337 | G.H5.08 |
Van-der-waals | ICL2 | M | 559 | - | G.H5 | F | 337 | G.H5.08 |
Polar | ICL2 | R | 564 | - | G.HN | R | 27 | G.HN.49 |
Hydrophobic | TM3 | Q | 550 | 3x53 | G.H5 | F | 352 | G.H5.23 |
Hydrophobic | TM2 | V | 467 | 2x46 | G.H5 | E | 351 | G.H5.22 |
Ionic | H8 | K | 725 | 8x48 | G.h4s6 | E | 317 | G.h4s6.12 |
Polar | H8 | K | 725 | 8x48 | G.h4s6 | E | 317 | G.h4s6.12 |
Hydrophobic | H8 | K | 725 | 8x48 | G.h4s6 | E | 317 | G.h4s6.12 |
Van-der-waals | H8 | K | 725 | 8x48 | G.h4s6 | E | 317 | G.h4s6.12 |