GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 62.8
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.6
iPTM Score: 0.7
PAE mean: 13.0
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | C-term | W | 1153 | - | G.H3 | I | 263 | G.H3.12 |
Ionic | C-term | D | 1240 | - | G.S2 | R | 198 | G.S2.05 |
Polar | C-term | D | 1240 | - | G.S2 | R | 198 | G.S2.05 |
Hydrophobic | C-term | D | 1240 | - | G.S2 | R | 198 | G.S2.05 |
Van-der-waals | C-term | D | 1240 | - | G.S2 | R | 198 | G.S2.05 |
Hydrophobic | C-term | T | 1241 | - | G.S2 | F | 195 | G.S2.02 |
Hydrophobic | C-term | Q | 1146 | - | G.h2s4 | N | 226 | G.h2s4.02 |
Van-der-waals | C-term | Q | 1146 | - | G.h2s4 | N | 226 | G.h2s4.02 |
Hydrophobic | TM6 | G | 1052 | 6x41 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM6 | G | 1052 | 6x41 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | C-term | I | 1149 | - | G.h2s4 | F | 225 | G.h2s4.01 |
Hydrophobic | C-term | C | 1237 | - | G.S2 | R | 198 | G.S2.05 |
Polar | ICL2 | E | 959 | - | G.S3 | N | 205 | G.S3.02 |
Van-der-waals | ICL2 | E | 959 | - | G.S3 | N | 205 | G.S3.02 |
Hydrophobic | ICL3 | K | 1037 | - | G.h4s6 | Y | 345 | G.h4s6.20 |
Van-der-waals | ICL3 | K | 1037 | - | G.h4s6 | Y | 345 | G.h4s6.20 |
Hydrophobic | TM5 | L | 1036 | 5x68 | G.S6 | Y | 347 | G.S6.02 |
Van-der-waals | TM5 | L | 1036 | 5x68 | G.S6 | Y | 347 | G.S6.02 |
Hydrophobic | C-term | Q | 1160 | - | G.H3 | L | 259 | G.H3.08 |
Hydrophobic | C-term | W | 1153 | - | G.H2 | I | 222 | G.H2.08 |
Van-der-waals | C-term | W | 1153 | - | G.H2 | I | 222 | G.H2.08 |
Polar | TM6 | S | 1048 | 6x37 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM6 | S | 1048 | 6x37 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | C-term | W | 1153 | - | G.H2 | W | 221 | G.H2.07 |
Van-der-waals | C-term | W | 1153 | - | G.H2 | W | 221 | G.H2.07 |
Hydrophobic | C-term | M | 1152 | - | G.H3 | R | 267 | G.H3.16 |
Van-der-waals | C-term | M | 1152 | - | G.H3 | R | 267 | G.H3.16 |
Polar | C-term | Q | 1160 | - | G.H2 | R | 218 | G.H2.04 |
Van-der-waals | C-term | Q | 1160 | - | G.H2 | R | 218 | G.H2.04 |
Hydrophobic | TM3 | L | 951 | 3x57 | G.H5 | H | 374 | G.H5.19 |
Van-der-waals | TM3 | L | 951 | 3x57 | G.H5 | H | 374 | G.H5.19 |
Hydrophobic | TM5 | L | 1036 | 5x68 | G.h4s6 | Y | 345 | G.h4s6.20 |
Polar | TM5 | S | 1032 | 5x64 | G.H5 | R | 372 | G.H5.17 |
Hydrophobic | TM5 | S | 1032 | 5x64 | G.H5 | R | 372 | G.H5.17 |
Van-der-waals | TM5 | S | 1032 | 5x64 | G.H5 | R | 372 | G.H5.17 |
Hydrophobic | C-term | R | 1150 | - | G.H2 | I | 222 | G.H2.08 |
Van-der-waals | C-term | R | 1150 | - | G.H2 | I | 222 | G.H2.08 |
Hydrophobic | C-term | T | 1156 | - | G.H3 | S | 262 | G.H3.11 |
Polar | C-term | T | 1156 | - | G.H3 | N | 266 | G.H3.15 |
Hydrophobic | TM5 | L | 1036 | 5x68 | G.H5 | R | 372 | G.H5.17 |
Van-der-waals | TM5 | L | 1036 | 5x68 | G.H5 | R | 372 | G.H5.17 |
Hydrophobic | TM5 | L | 1036 | 5x68 | G.S6 | C | 346 | G.S6.01 |
Van-der-waals | TM5 | L | 1036 | 5x68 | G.S6 | C | 346 | G.S6.01 |
Hydrophobic | C-term | L | 1244 | - | G.H2 | Q | 223 | G.H2.09 |
Van-der-waals | C-term | L | 1244 | - | G.H2 | Q | 223 | G.H2.09 |
Hydrophobic | ICL2 | V | 955 | - | G.H5 | R | 367 | G.H5.12 |
Van-der-waals | ICL2 | V | 955 | - | G.H5 | R | 367 | G.H5.12 |
Aromatic | ICL2 | F | 956 | - | G.H5 | F | 363 | G.H5.08 |
Hydrophobic | ICL2 | F | 956 | - | G.H5 | F | 363 | G.H5.08 |
Van-der-waals | ICL2 | F | 956 | - | G.H5 | F | 363 | G.H5.08 |
Polar | C-term | Q | 1160 | - | G.H3 | D | 258 | G.H3.07 |
Hydrophobic | TM6 | L | 1056 | 6x45 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | C-term | M | 1152 | - | G.H3 | N | 266 | G.H3.15 |
Hydrophobic | ICL2 | V | 955 | - | G.H5 | I | 370 | G.H5.15 |
Van-der-waals | ICL2 | V | 955 | - | G.H5 | I | 370 | G.H5.15 |
Hydrophobic | C-term | M | 1468 | - | H.HA | E | 74 | H.HA.03 |
Van-der-waals | C-term | M | 1468 | - | H.HA | E | 74 | H.HA.03 |
Hydrophobic | C-term | T | 1161 | - | G.H2 | R | 215 | G.H2.01 |
Hydrophobic | C-term | T | 1145 | - | G.H3 | W | 268 | G.H3.17 |
Polar | C-term | Q | 1160 | - | G.H3 | S | 262 | G.H3.11 |
Van-der-waals | C-term | Q | 1160 | - | G.H3 | S | 262 | G.H3.11 |
Hydrophobic | C-term | M | 1239 | - | G.H1 | R | 63 | G.H1.09 |
Polar | ICL2 | V | 955 | - | G.H5 | H | 374 | G.H5.19 |
Hydrophobic | C-term | W | 1153 | - | G.H2 | R | 219 | G.H2.05 |
Polar | C-term | G | 1238 | - | G.S2 | R | 198 | G.S2.05 |
Van-der-waals | C-term | G | 1238 | - | G.S2 | R | 198 | G.S2.05 |
Hydrophobic | C-term | L | 1242 | - | G.S2 | E | 196 | G.S2.03 |
Van-der-waals | C-term | L | 1242 | - | G.S2 | E | 196 | G.S2.03 |
Hydrophobic | TM3 | L | 951 | 3x57 | G.H5 | Y | 378 | G.H5.23 |
Van-der-waals | TM3 | L | 951 | 3x57 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | H8 | Q | 1101 | 8x47 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | C-term | I | 1149 | - | G.H2 | I | 222 | G.H2.08 |
Van-der-waals | C-term | I | 1149 | - | G.H2 | I | 222 | G.H2.08 |
Ionic | ICL2 | E | 957 | - | G.hns1 | K | 40 | G.hns1.02 |
Polar | ICL2 | E | 957 | - | G.hns1 | K | 40 | G.hns1.02 |
Hydrophobic | ICL2 | E | 957 | - | G.hns1 | K | 40 | G.hns1.02 |
Van-der-waals | ICL2 | E | 957 | - | G.hns1 | K | 40 | G.hns1.02 |
Polar | TM6 | W | 1049 | 6x38 | G.H5 | L | 380 | G.H5.25 |
Polar | C-term | R | 1148 | - | G.H3 | R | 267 | G.H3.16 |
Van-der-waals | C-term | R | 1148 | - | G.H3 | R | 267 | G.H3.16 |
Hydrophobic | TM5 | T | 1025 | 5x57 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM5 | M | 1029 | 5x61 | G.H5 | L | 381 | G.H5.26 |
Hydrophobic | C-term | M | 1239 | - | G.S2 | T | 197 | G.S2.04 |
Hydrophobic | ICL2 | F | 956 | - | G.H5 | C | 366 | G.H5.11 |
Hydrophobic | ICL2 | F | 956 | - | G.S3 | V | 204 | G.S3.01 |
Van-der-waals | ICL2 | F | 956 | - | G.S3 | V | 204 | G.S3.01 |
Hydrophobic | ICL2 | E | 959 | - | G.hns1 | A | 41 | G.hns1.03 |
Van-der-waals | ICL2 | E | 959 | - | G.hns1 | A | 41 | G.hns1.03 |
Polar | C-term | R | 1148 | - | G.H3 | W | 268 | G.H3.17 |
Hydrophobic | C-term | R | 1148 | - | G.H3 | W | 268 | G.H3.17 |
Van-der-waals | C-term | R | 1148 | - | G.H3 | W | 268 | G.H3.17 |
Polar | TM2 | R | 892 | 2x46 | G.H5 | Q | 377 | G.H5.22 |
Van-der-waals | TM2 | R | 892 | 2x46 | G.H5 | Q | 377 | G.H5.22 |
Hydrophobic | ICL2 | F | 956 | - | G.H5 | I | 370 | G.H5.15 |
Van-der-waals | ICL2 | F | 956 | - | G.H5 | I | 370 | G.H5.15 |
Polar | ICL3 | K | 1037 | - | G.h4s6 | G | 340 | G.h4s6.09 |
Hydrophobic | C-term | V | 1157 | - | G.H2 | R | 218 | G.H2.04 |
Hydrophobic | C-term | I | 1149 | - | G.H3 | W | 268 | G.H3.17 |
Van-der-waals | C-term | I | 1149 | - | G.H3 | W | 268 | G.H3.17 |
Hydrophobic | TM3 | L | 952 | 3x58 | G.H5 | L | 375 | G.H5.20 |
Van-der-waals | TM3 | L | 952 | 3x58 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | ICL2 | F | 956 | - | G.S3 | F | 206 | G.S3.03 |
Hydrophobic | C-term | V | 1157 | - | G.H2 | R | 219 | G.H2.05 |
Polar | TM2 | R | 892 | 2x46 | G.H5 | Y | 378 | G.H5.23 |
Aromatic | TM2 | R | 892 | 2x46 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | TM2 | R | 892 | 2x46 | G.H5 | Y | 378 | G.H5.23 |
Van-der-waals | TM2 | R | 892 | 2x46 | G.H5 | Y | 378 | G.H5.23 |
Van-der-waals | C-term | R | 1150 | - | G.H2 | Q | 223 | G.H2.09 |
Hydrophobic | C-term | V | 1471 | - | G.S2 | I | 194 | G.S2.01 |
Van-der-waals | C-term | V | 1471 | - | G.S2 | I | 194 | G.S2.01 |
Hydrophobic | C-term | W | 1153 | - | G.H3 | N | 266 | G.H3.15 |
Van-der-waals | C-term | W | 1153 | - | G.H3 | N | 266 | G.H3.15 |
Hydrophobic | C-term | M | 1152 | - | G.H3 | W | 268 | G.H3.17 |
Ionic | H8 | K | 1102 | 8x48 | G.H5 | E | 379 | G.H5.24 |
Polar | H8 | K | 1102 | 8x48 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | H8 | K | 1102 | 8x48 | G.H5 | E | 379 | G.H5.24 |
Van-der-waals | H8 | K | 1102 | 8x48 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | TM5 | M | 1029 | 5x61 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM5 | M | 1029 | 5x61 | G.H5 | L | 380 | G.H5.25 |
Polar | TM3 | L | 952 | 3x58 | G.H5 | Q | 371 | G.H5.16 |
Van-der-waals | TM3 | L | 952 | 3x58 | G.H5 | Q | 371 | G.H5.16 |
Polar | TM3 | H | 947 | 3x53 | G.H5 | Y | 378 | G.H5.23 |
Van-der-waals | TM3 | H | 947 | 3x53 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | TM3 | L | 948 | 3x54 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | ICL2 | F | 956 | - | G.H5 | R | 367 | G.H5.12 |
Aromatic | ICL2 | F | 956 | - | G.S1 | H | 43 | G.S1.02 |
Hydrophobic | ICL2 | F | 956 | - | G.S1 | H | 43 | G.S1.02 |
Hydrophobic | ICL2 | V | 955 | - | G.H5 | Q | 371 | G.H5.16 |
Van-der-waals | ICL2 | V | 955 | - | G.H5 | Q | 371 | G.H5.16 |
Hydrophobic | C-term | L | 1242 | - | G.S3 | F | 209 | G.S3.06 |
Hydrophobic | ICL2 | E | 957 | - | G.hns1 | A | 41 | G.hns1.03 |
Van-der-waals | ICL2 | E | 957 | - | G.hns1 | A | 41 | G.hns1.03 |
Polar | C-term | W | 1153 | - | G.H2 | R | 218 | G.H2.04 |
Hydrophobic | C-term | W | 1153 | - | G.H2 | R | 218 | G.H2.04 |
Van-der-waals | C-term | W | 1153 | - | G.H2 | R | 218 | G.H2.04 |
Hydrophobic | TM5 | M | 1029 | 5x61 | G.H5 | L | 375 | G.H5.20 |
Aromatic | C-term | W | 1153 | - | G.h2s4 | F | 225 | G.h2s4.01 |
Hydrophobic | C-term | W | 1153 | - | G.h2s4 | F | 225 | G.h2s4.01 |
Van-der-waals | C-term | W | 1153 | - | G.h2s4 | F | 225 | G.h2s4.01 |