GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 64.7
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.6
iPTM Score: 0.7
PAE mean: 12.0
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM2 | R | 879 | 2x46 | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | TM2 | R | 879 | 2x46 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | C-term | I | 1136 | - | G.h2s4 | F | 237 | G.h2s4.01 |
Van-der-waals | C-term | I | 1136 | - | G.h2s4 | F | 237 | G.h2s4.01 |
Ionic | ICL2 | E | 944 | - | G.hns1 | K | 46 | G.hns1.02 |
Polar | ICL2 | E | 944 | - | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | ICL2 | E | 944 | - | G.hns1 | K | 46 | G.hns1.02 |
Van-der-waals | ICL2 | E | 944 | - | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | TM6 | G | 1039 | 6x41 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | ICL2 | F | 943 | - | G.H5 | K | 363 | G.H5.12 |
Hydrophobic | C-term | L | 1190 | - | H.hdhe | F | 168 | H.hdhe.01 |
Van-der-waals | C-term | L | 1190 | - | H.hdhe | F | 168 | H.hdhe.01 |
Hydrophobic | TM5 | L | 1023 | 5x68 | G.H5 | H | 368 | G.H5.17 |
Van-der-waals | TM5 | L | 1023 | 5x68 | G.H5 | H | 368 | G.H5.17 |
Hydrophobic | C-term | W | 1140 | - | G.H2 | F | 234 | G.H2.08 |
Hydrophobic | ICL3 | K | 1024 | - | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | ICL3 | K | 1024 | - | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | ICL2 | V | 942 | - | G.H5 | I | 366 | G.H5.15 |
Van-der-waals | ICL2 | V | 942 | - | G.H5 | I | 366 | G.H5.15 |
Hydrophobic | C-term | M | 1139 | - | G.H3 | N | 278 | G.H3.15 |
Van-der-waals | C-term | M | 1139 | - | G.H3 | N | 278 | G.H3.15 |
Hydrophobic | TM5 | L | 1023 | 5x68 | G.H5 | K | 372 | G.H5.21 |
Van-der-waals | TM5 | L | 1023 | 5x68 | G.H5 | K | 372 | G.H5.21 |
Polar | C-term | Y | 1187 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Van-der-waals | C-term | Y | 1187 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Hydrophobic | TM5 | L | 1023 | 5x68 | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | TM5 | L | 1023 | 5x68 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | TM5 | H | 1019 | 5x64 | G.H5 | L | 367 | G.H5.16 |
Van-der-waals | TM5 | H | 1019 | 5x64 | G.H5 | L | 367 | G.H5.16 |
Hydrophobic | C-term | R | 1137 | - | G.H2 | F | 234 | G.H2.08 |
Van-der-waals | C-term | R | 1137 | - | G.H2 | F | 234 | G.H2.08 |
Polar | C-term | K | 1261 | - | G.HN | S | 31 | G.HN.40 |
Hydrophobic | C-term | K | 1261 | - | G.HN | S | 31 | G.HN.40 |
Van-der-waals | C-term | K | 1261 | - | G.HN | S | 31 | G.HN.40 |
Polar | TM5 | H | 1019 | 5x64 | G.H5 | H | 368 | G.H5.17 |
Hydrophobic | TM5 | H | 1019 | 5x64 | G.H5 | H | 368 | G.H5.17 |
Polar | C-term | N | 1175 | - | G.HG | D | 307 | G.HG.17 |
Hydrophobic | C-term | N | 1175 | - | G.HG | D | 307 | G.HG.17 |
Van-der-waals | C-term | N | 1175 | - | G.HG | D | 307 | G.HG.17 |
Polar | TM3 | V | 940 | 3x59 | G.H5 | K | 363 | G.H5.12 |
Van-der-waals | TM3 | V | 940 | 3x59 | G.H5 | K | 363 | G.H5.12 |
Hydrophobic | C-term | L | 1190 | - | H.HA | D | 101 | H.HA.24 |
Van-der-waals | C-term | L | 1190 | - | H.HA | D | 101 | H.HA.24 |
Hydrophobic | TM3 | L | 939 | 3x58 | G.H5 | L | 374 | G.H5.23 |
Polar | H8 | Q | 1088 | 8x47 | G.H5 | Q | 373 | G.H5.22 |
Van-der-waals | H8 | Q | 1088 | 8x47 | G.H5 | Q | 373 | G.H5.22 |
Hydrophobic | TM6 | L | 1038 | 6x40 | G.H5 | L | 376 | G.H5.25 |
Polar | TM5 | T | 1022 | 5x67 | G.H5 | H | 368 | G.H5.17 |
Hydrophobic | TM5 | T | 1022 | 5x67 | G.H5 | H | 368 | G.H5.17 |
Van-der-waals | TM5 | T | 1022 | 5x67 | G.H5 | H | 368 | G.H5.17 |
Hydrophobic | ICL2 | F | 943 | - | G.H5 | V | 362 | G.H5.11 |
Polar | C-term | L | 1190 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Hydrophobic | C-term | L | 1190 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Van-der-waals | C-term | L | 1190 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Hydrophobic | H8 | Q | 1088 | 8x47 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | H8 | Q | 1088 | 8x47 | G.H5 | L | 376 | G.H5.25 |
Polar | C-term | N | 1188 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Hydrophobic | C-term | N | 1188 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Van-der-waals | C-term | N | 1188 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Polar | TM6 | S | 1035 | 6x37 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | TM6 | S | 1035 | 6x37 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM6 | S | 1035 | 6x37 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | ICL2 | F | 943 | - | G.S1 | V | 49 | G.S1.02 |
Hydrophobic | C-term | I | 1136 | - | G.H2 | F | 234 | G.H2.08 |
Hydrophobic | C-term | W | 1140 | - | G.H2 | W | 233 | G.H2.07 |
Van-der-waals | C-term | W | 1140 | - | G.H2 | W | 233 | G.H2.07 |
Hydrophobic | C-term | A | 1192 | - | H.hdhe | Q | 169 | H.hdhe.02 |
Ionic | ICL2 | E | 946 | - | G.hns1 | R | 47 | G.hns1.03 |
Polar | ICL2 | E | 946 | - | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | ICL2 | E | 946 | - | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | ICL2 | E | 946 | - | G.hns1 | R | 47 | G.hns1.03 |
Polar | TM6 | S | 1035 | 6x37 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | TM6 | S | 1035 | 6x37 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | H8 | K | 1089 | 8x48 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | H8 | K | 1089 | 8x48 | G.H5 | Q | 377 | G.H5.26 |
Polar | C-term | Y | 1187 | - | H.HD | R | 164 | H.HD.09 |
Van-der-waals | C-term | Y | 1187 | - | H.HD | R | 164 | H.HD.09 |
Hydrophobic | C-term | L | 1254 | - | G.HN | Q | 27 | G.HN.36 |
Van-der-waals | C-term | L | 1254 | - | G.HN | Q | 27 | G.HN.36 |
Hydrophobic | C-term | V | 1195 | - | G.s4h3 | M | 257 | G.s4h3.09 |
Hydrophobic | TM3 | L | 939 | 3x58 | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | TM3 | L | 939 | 3x58 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | C-term | M | 1221 | - | G.H2 | R | 232 | G.H2.06 |
Van-der-waals | C-term | M | 1221 | - | G.H2 | R | 232 | G.H2.06 |
Polar | TM3 | M | 938 | 3x57 | G.H5 | N | 370 | G.H5.19 |
Hydrophobic | TM3 | M | 938 | 3x57 | G.H5 | N | 370 | G.H5.19 |
Van-der-waals | TM3 | M | 938 | 3x57 | G.H5 | N | 370 | G.H5.19 |
Hydrophobic | TM3 | L | 939 | 3x58 | G.H5 | L | 367 | G.H5.16 |
Van-der-waals | TM3 | L | 939 | 3x58 | G.H5 | L | 367 | G.H5.16 |
Hydrophobic | C-term | K | 1261 | - | G.HN | I | 34 | G.HN.43 |
Hydrophobic | C-term | W | 1140 | - | G.H3 | I | 275 | G.H3.12 |
Van-der-waals | C-term | W | 1140 | - | G.H3 | I | 275 | G.H3.12 |
Aromatic | ICL2 | F | 943 | - | G.H5 | F | 359 | G.H5.08 |
Hydrophobic | ICL2 | F | 943 | - | G.H5 | F | 359 | G.H5.08 |
Van-der-waals | ICL2 | F | 943 | - | G.H5 | F | 359 | G.H5.08 |
Hydrophobic | ICL2 | E | 946 | - | G.HN | T | 43 | G.HN.52 |
Hydrophobic | C-term | M | 1139 | - | G.H3 | V | 280 | G.H3.17 |
Polar | H8 | K | 1090 | 8x49 | G.H5 | Q | 373 | G.H5.22 |
Hydrophobic | H8 | K | 1090 | 8x49 | G.H5 | Q | 373 | G.H5.22 |
Van-der-waals | H8 | K | 1090 | 8x49 | G.H5 | Q | 373 | G.H5.22 |
Hydrophobic | C-term | I | 1264 | - | G.HN | L | 38 | G.HN.47 |
Hydrophobic | ICL2 | F | 943 | - | G.S3 | V | 216 | G.S3.01 |
Hydrophobic | H8 | H | 1101 | 8x60 | G.HN | F | 4 | G.HN.04 |
Hydrophobic | C-term | W | 1140 | - | G.H3 | T | 274 | G.H3.11 |
Van-der-waals | C-term | W | 1140 | - | G.H3 | T | 274 | G.H3.11 |
Hydrophobic | TM7 | L | 1087 | 7x60 | G.H5 | L | 376 | G.H5.25 |
Polar | C-term | W | 1140 | - | G.H2 | R | 230 | G.H2.04 |
Van-der-waals | C-term | W | 1140 | - | G.H2 | R | 230 | G.H2.04 |
Hydrophobic | C-term | I | 1136 | - | G.H3 | V | 280 | G.H3.17 |
Hydrophobic | C-term | L | 1173 | - | G.hgh4 | L | 310 | G.hgh4.03 |
Hydrophobic | TM6 | L | 1043 | 6x45 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | C-term | L | 1178 | - | G.s4h3 | V | 255 | G.s4h3.07 |
Hydrophobic | TM5 | M | 1016 | 5x61 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM5 | M | 1016 | 5x61 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | TM5 | T | 1012 | 5x57 | G.H5 | L | 374 | G.H5.23 |
Polar | C-term | Y | 1187 | - | H.HD | E | 167 | H.HD.12 |
Hydrophobic | C-term | Y | 1187 | - | H.HD | E | 167 | H.HD.12 |
Van-der-waals | C-term | Y | 1187 | - | H.HD | E | 167 | H.HD.12 |
Hydrophobic | TM3 | L | 935 | 3x54 | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | TM3 | L | 935 | 3x54 | G.H5 | L | 374 | G.H5.23 |
Polar | C-term | Q | 1147 | - | G.H3 | T | 274 | G.H3.11 |
Van-der-waals | C-term | Q | 1147 | - | G.H3 | T | 274 | G.H3.11 |
Hydrophobic | C-term | A | 1192 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Van-der-waals | C-term | A | 1192 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Polar | C-term | Q | 1147 | - | G.H3 | N | 270 | G.H3.07 |
Hydrophobic | C-term | Q | 1147 | - | G.H3 | N | 270 | G.H3.07 |
Van-der-waals | C-term | Q | 1147 | - | G.H3 | N | 270 | G.H3.07 |
Hydrophobic | ICL2 | V | 942 | - | G.H5 | K | 363 | G.H5.12 |
Van-der-waals | ICL2 | V | 942 | - | G.H5 | K | 363 | G.H5.12 |
Hydrophobic | TM3 | L | 939 | 3x58 | G.H5 | N | 370 | G.H5.19 |
Hydrophobic | ICL2 | Y | 947 | - | G.HN | T | 43 | G.HN.52 |
Hydrophobic | TM7 | F | 1083 | 7x56 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | TM7 | F | 1083 | 7x56 | G.H5 | L | 376 | G.H5.25 |
Polar | C-term | N | 1255 | - | G.HN | Q | 27 | G.HN.36 |
Polar | C-term | N | 1175 | - | G.hgh4 | Y | 308 | G.hgh4.01 |
Hydrophobic | C-term | N | 1175 | - | G.hgh4 | Y | 308 | G.hgh4.01 |
Van-der-waals | C-term | N | 1175 | - | G.hgh4 | Y | 308 | G.hgh4.01 |
Polar | ICL2 | E | 944 | - | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | ICL2 | E | 944 | - | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | ICL2 | E | 944 | - | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | C-term | P | 1180 | - | G.s4h3 | L | 261 | G.s4h3.13 |
Hydrophobic | C-term | P | 1186 | - | H.HA | K | 105 | H.HA.28 |
Van-der-waals | C-term | P | 1186 | - | H.HA | K | 105 | H.HA.28 |
Polar | C-term | L | 1191 | - | H.HA | D | 101 | H.HA.24 |
Hydrophobic | C-term | L | 1191 | - | H.HA | D | 101 | H.HA.24 |
Van-der-waals | C-term | L | 1191 | - | H.HA | D | 101 | H.HA.24 |
Hydrophobic | H8 | C | 1098 | 8x57 | G.HN | F | 4 | G.HN.04 |
Ionic | C-term | K | 1261 | - | G.HN | D | 35 | G.HN.44 |
Polar | C-term | K | 1261 | - | G.HN | D | 35 | G.HN.44 |
Hydrophobic | C-term | K | 1261 | - | G.HN | D | 35 | G.HN.44 |
Van-der-waals | C-term | K | 1261 | - | G.HN | D | 35 | G.HN.44 |
Hydrophobic | TM5 | M | 1016 | 5x61 | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | TM5 | M | 1016 | 5x61 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | TM6 | W | 1036 | 6x38 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | C-term | L | 1191 | - | H.HA | V | 98 | H.HA.21 |
Van-der-waals | C-term | L | 1191 | - | H.HA | V | 98 | H.HA.21 |
Hydrophobic | TM5 | K | 1015 | 5x60 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | TM1 | F | 871 | 1x63 | G.HN | L | 5 | G.HN.05 |
Van-der-waals | TM1 | F | 871 | 1x63 | G.HN | L | 5 | G.HN.05 |
Hydrophobic | C-term | L | 1190 | - | H.HA | K | 105 | H.HA.28 |
Van-der-waals | C-term | L | 1190 | - | H.HA | K | 105 | H.HA.28 |
Hydrophobic | ICL2 | V | 942 | - | G.H5 | L | 367 | G.H5.16 |
Van-der-waals | ICL2 | V | 942 | - | G.H5 | L | 367 | G.H5.16 |
Hydrophobic | TM5 | H | 1019 | 5x64 | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | TM5 | H | 1019 | 5x64 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | C-term | T | 1143 | - | G.H3 | T | 274 | G.H3.11 |
Van-der-waals | C-term | T | 1143 | - | G.H3 | T | 274 | G.H3.11 |
Polar | C-term | Q | 1147 | - | G.H2 | R | 230 | G.H2.04 |
Hydrophobic | C-term | L | 1190 | - | H.HA | A | 102 | H.HA.25 |
Van-der-waals | C-term | L | 1190 | - | H.HA | A | 102 | H.HA.25 |
Hydrophobic | ICL1 | R | 873 | 12x48 | G.HN | P | 6 | G.HN.06 |
Van-der-waals | ICL1 | R | 873 | 12x48 | G.HN | P | 6 | G.HN.06 |
Hydrophobic | ICL2 | F | 943 | - | G.H5 | I | 366 | G.H5.15 |
Hydrophobic | C-term | Y | 1187 | - | H.HA | L | 106 | H.HA.29 |
Van-der-waals | C-term | Y | 1187 | - | H.HA | L | 106 | H.HA.29 |
Hydrophobic | ICL2 | S | 945 | - | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | C-term | L | 1178 | - | G.hgh4 | Y | 308 | G.hgh4.01 |
Van-der-waals | C-term | L | 1178 | - | G.hgh4 | Y | 308 | G.hgh4.01 |
Polar | C-term | Q | 1133 | - | G.h2s4 | D | 238 | G.h2s4.02 |
Hydrophobic | C-term | Q | 1133 | - | G.h2s4 | D | 238 | G.h2s4.02 |
Van-der-waals | C-term | Q | 1133 | - | G.h2s4 | D | 238 | G.h2s4.02 |
Aromatic | C-term | W | 1140 | - | G.h2s4 | F | 237 | G.h2s4.01 |
Hydrophobic | C-term | W | 1140 | - | G.h2s4 | F | 237 | G.h2s4.01 |
Hydrophobic | TM5 | L | 1023 | 5x68 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM5 | L | 1023 | 5x68 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | C-term | L | 1191 | - | H.HB | M | 123 | H.HB.10 |
Hydrophobic | C-term | A | 1192 | - | G.s4h3 | M | 257 | G.s4h3.09 |
Hydrophobic | C-term | M | 1139 | - | G.H3 | R | 279 | G.H3.16 |
Polar | ICL3 | D | 1026 | - | G.h4s6 | Q | 338 | G.h4s6.12 |
Hydrophobic | ICL3 | D | 1026 | - | G.h4s6 | Q | 338 | G.h4s6.12 |
Van-der-waals | ICL3 | D | 1026 | - | G.h4s6 | Q | 338 | G.h4s6.12 |
Hydrophobic | C-term | V | 1144 | - | G.H2 | K | 231 | G.H2.05 |
Polar | C-term | T | 1189 | - | H.HA | K | 105 | H.HA.28 |
Hydrophobic | C-term | T | 1189 | - | H.HA | K | 105 | H.HA.28 |
Van-der-waals | C-term | T | 1189 | - | H.HA | K | 105 | H.HA.28 |
Hydrophobic | C-term | L | 1177 | - | G.HG | D | 307 | G.HG.17 |
Van-der-waals | C-term | Q | 1147 | - | G.H3 | I | 271 | G.H3.08 |
Hydrophobic | TM5 | M | 1016 | 5x61 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | C-term | E | 1193 | - | G.s4h3 | M | 257 | G.s4h3.09 |
Van-der-waals | C-term | E | 1193 | - | G.s4h3 | M | 257 | G.s4h3.09 |
Ionic | C-term | E | 1193 | - | H.HA | K | 94 | H.HA.17 |
Polar | C-term | E | 1193 | - | H.HA | K | 94 | H.HA.17 |
Hydrophobic | C-term | E | 1193 | - | H.HA | K | 94 | H.HA.17 |
Van-der-waals | C-term | E | 1193 | - | H.HA | K | 94 | H.HA.17 |