GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 63.5
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.6
iPTM Score: 0.7
PAE mean: 12.5
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM5 | T | 1012 | 5x57 | G.H5 | L | 354 | G.H5.25 |
Aromatic | ICL2 | Y | 947 | - | G.HN | K | 30 | G.HN.52 |
Hydrophobic | ICL2 | Y | 947 | - | G.HN | K | 30 | G.HN.52 |
Hydrophobic | C-term | L | 1172 | - | G.hfs2 | P | 181 | G.hfs2.04 |
Van-der-waals | C-term | L | 1172 | - | G.hfs2 | P | 181 | G.hfs2.04 |
Hydrophobic | ICL2 | V | 942 | - | G.H5 | L | 345 | G.H5.16 |
Van-der-waals | ICL2 | V | 942 | - | G.H5 | L | 345 | G.H5.16 |
Hydrophobic | TM3 | L | 939 | 3x58 | G.H5 | L | 345 | G.H5.16 |
Van-der-waals | TM3 | L | 939 | 3x58 | G.H5 | L | 345 | G.H5.16 |
Hydrophobic | C-term | W | 1140 | - | G.H3 | L | 250 | G.H3.08 |
Polar | C-term | Q | 1147 | - | G.H2 | R | 206 | G.H2.01 |
Hydrophobic | C-term | Q | 1147 | - | G.H2 | R | 206 | G.H2.01 |
Van-der-waals | C-term | Q | 1147 | - | G.H2 | R | 206 | G.H2.01 |
Hydrophobic | TM3 | E | 931 | 3x50 | G.H5 | F | 352 | G.H5.23 |
Van-der-waals | TM3 | E | 931 | 3x50 | G.H5 | F | 352 | G.H5.23 |
Hydrophobic | TM5 | M | 1016 | 5x61 | G.H5 | L | 349 | G.H5.20 |
Van-der-waals | TM5 | M | 1016 | 5x61 | G.H5 | L | 349 | G.H5.20 |
Ionic | H8 | K | 1090 | 8x49 | G.H5 | E | 351 | G.H5.22 |
Polar | H8 | K | 1090 | 8x49 | G.H5 | E | 351 | G.H5.22 |
Hydrophobic | H8 | K | 1090 | 8x49 | G.H5 | E | 351 | G.H5.22 |
Van-der-waals | H8 | K | 1090 | 8x49 | G.H5 | E | 351 | G.H5.22 |
Hydrophobic | C-term | K | 1261 | - | G.HN | I | 17 | G.HN.39 |
Hydrophobic | C-term | L | 1173 | - | H.HA | Q | 77 | H.HA.13 |
Hydrophobic | C-term | P | 1180 | - | G.S2 | I | 186 | G.S2.02 |
Van-der-waals | C-term | P | 1180 | - | G.S2 | I | 186 | G.S2.02 |
Hydrophobic | ICL2 | F | 943 | - | G.H5 | K | 341 | G.H5.12 |
Van-der-waals | ICL2 | F | 943 | - | G.H5 | K | 341 | G.H5.12 |
Hydrophobic | C-term | I | 1264 | - | G.HN | L | 25 | G.HN.47 |
Hydrophobic | TM5 | L | 1023 | 5x68 | G.H5 | Q | 346 | G.H5.17 |
Van-der-waals | TM5 | L | 1023 | 5x68 | G.H5 | Q | 346 | G.H5.17 |
Polar | C-term | Q | 1133 | - | G.h2s4 | E | 217 | G.h2s4.02 |
Van-der-waals | C-term | Q | 1133 | - | G.h2s4 | E | 217 | G.h2s4.02 |
Hydrophobic | C-term | W | 1140 | - | G.H2 | W | 212 | G.H2.07 |
Van-der-waals | C-term | W | 1140 | - | G.H2 | W | 212 | G.H2.07 |
Polar | TM7 | F | 1083 | 7x56 | G.H5 | N | 353 | G.H5.24 |
Hydrophobic | C-term | R | 1137 | - | G.H2 | I | 213 | G.H2.08 |
Van-der-waals | C-term | R | 1137 | - | G.H2 | I | 213 | G.H2.08 |
Hydrophobic | C-term | L | 1190 | - | G.H2 | H | 214 | G.H2.09 |
Hydrophobic | TM5 | H | 1019 | 5x64 | G.H5 | L | 345 | G.H5.16 |
Van-der-waals | TM5 | H | 1019 | 5x64 | G.H5 | L | 345 | G.H5.16 |
Polar | C-term | S | 1151 | - | G.H2 | R | 206 | G.H2.01 |
Hydrophobic | C-term | S | 1151 | - | G.H2 | R | 206 | G.H2.01 |
Van-der-waals | C-term | S | 1151 | - | G.H2 | R | 206 | G.H2.01 |
Polar | C-term | Q | 1147 | - | G.H2 | R | 209 | G.H2.04 |
Van-der-waals | C-term | Q | 1147 | - | G.H2 | R | 209 | G.H2.04 |
Polar | TM2 | R | 879 | 2x46 | G.H5 | E | 351 | G.H5.22 |
Van-der-waals | TM2 | R | 879 | 2x46 | G.H5 | E | 351 | G.H5.22 |
Hydrophobic | TM6 | G | 1039 | 6x41 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM6 | G | 1039 | 6x41 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | C-term | Y | 1187 | - | G.H2 | H | 214 | G.H2.09 |
Van-der-waals | C-term | Y | 1187 | - | G.H2 | H | 214 | G.H2.09 |
Hydrophobic | C-term | L | 1191 | - | G.H2 | H | 214 | G.H2.09 |
Hydrophobic | TM3 | L | 935 | 3x54 | G.H5 | F | 352 | G.H5.23 |
Polar | C-term | Q | 1147 | - | G.H3 | A | 249 | G.H3.07 |
Hydrophobic | C-term | W | 1140 | - | G.H2 | I | 213 | G.H2.08 |
Van-der-waals | C-term | W | 1140 | - | G.H2 | I | 213 | G.H2.08 |
Hydrophobic | ICL2 | F | 943 | - | G.S3 | F | 197 | G.S3.03 |
Hydrophobic | ICL2 | F | 943 | - | G.H5 | I | 344 | G.H5.15 |
Hydrophobic | C-term | L | 1173 | - | G.hfs2 | V | 180 | G.hfs2.03 |
Van-der-waals | C-term | L | 1173 | - | G.hfs2 | V | 180 | G.hfs2.03 |
Polar | ICL2 | V | 942 | - | G.H5 | N | 348 | G.H5.19 |
Hydrophobic | C-term | Q | 1133 | - | G.H3 | W | 259 | G.H3.17 |
Polar | C-term | W | 1140 | - | G.H2 | R | 209 | G.H2.04 |
Hydrophobic | C-term | W | 1140 | - | G.H2 | R | 209 | G.H2.04 |
Van-der-waals | C-term | W | 1140 | - | G.H2 | R | 209 | G.H2.04 |
Polar | H8 | Q | 1088 | 8x47 | G.H5 | E | 351 | G.H5.22 |
Van-der-waals | H8 | Q | 1088 | 8x47 | G.H5 | E | 351 | G.H5.22 |
Hydrophobic | C-term | T | 1257 | - | G.HN | E | 22 | G.HN.44 |
Van-der-waals | C-term | T | 1257 | - | G.HN | E | 22 | G.HN.44 |
Polar | C-term | S | 1151 | - | G.s4h3 | E | 241 | G.s4h3.14 |
Hydrophobic | C-term | S | 1151 | - | G.s4h3 | E | 241 | G.s4h3.14 |
Van-der-waals | C-term | S | 1151 | - | G.s4h3 | E | 241 | G.s4h3.14 |
Hydrophobic | C-term | E | 1260 | - | G.HN | I | 21 | G.HN.43 |
Hydrophobic | C-term | K | 1261 | - | G.HN | I | 21 | G.HN.43 |
Polar | C-term | S | 1150 | - | G.s4h3 | E | 241 | G.s4h3.14 |
Hydrophobic | TM5 | L | 1023 | 5x68 | G.S6 | Y | 321 | G.S6.02 |
Van-der-waals | TM5 | L | 1023 | 5x68 | G.S6 | Y | 321 | G.S6.02 |
Hydrophobic | C-term | I | 1136 | - | G.H3 | W | 259 | G.H3.17 |
Van-der-waals | C-term | I | 1136 | - | G.H3 | W | 259 | G.H3.17 |
Hydrophobic | C-term | M | 1139 | - | G.H3 | Y | 257 | G.H3.15 |
Van-der-waals | C-term | M | 1139 | - | G.H3 | Y | 257 | G.H3.15 |
Polar | TM6 | S | 1035 | 6x37 | G.H5 | V | 355 | G.H5.26 |
Hydrophobic | TM6 | S | 1035 | 6x37 | G.H5 | V | 355 | G.H5.26 |
Van-der-waals | TM6 | S | 1035 | 6x37 | G.H5 | V | 355 | G.H5.26 |
Polar | C-term | L | 1178 | - | G.S2 | Y | 188 | G.S2.04 |
Hydrophobic | C-term | L | 1178 | - | G.S2 | Y | 188 | G.S2.04 |
Van-der-waals | C-term | L | 1178 | - | G.S2 | Y | 188 | G.S2.04 |
Polar | C-term | Y | 1187 | - | G.S2 | E | 187 | G.S2.03 |
Hydrophobic | C-term | Y | 1187 | - | G.S2 | E | 187 | G.S2.03 |
Van-der-waals | C-term | Y | 1187 | - | G.S2 | E | 187 | G.S2.03 |
Polar | TM3 | M | 938 | 3x57 | G.H5 | N | 348 | G.H5.19 |
Hydrophobic | TM3 | M | 938 | 3x57 | G.H5 | N | 348 | G.H5.19 |
Van-der-waals | TM3 | M | 938 | 3x57 | G.H5 | N | 348 | G.H5.19 |
Polar | H8 | Q | 1088 | 8x47 | G.H5 | N | 353 | G.H5.24 |
Hydrophobic | H8 | Q | 1088 | 8x47 | G.H5 | N | 353 | G.H5.24 |
Van-der-waals | H8 | Q | 1088 | 8x47 | G.H5 | N | 353 | G.H5.24 |
Ionic | ICL2 | E | 946 | - | G.hns1 | R | 34 | G.hns1.03 |
Polar | ICL2 | E | 946 | - | G.hns1 | R | 34 | G.hns1.03 |
Hydrophobic | ICL2 | E | 946 | - | G.hns1 | R | 34 | G.hns1.03 |
Van-der-waals | ICL2 | E | 946 | - | G.hns1 | R | 34 | G.hns1.03 |
Hydrophobic | C-term | T | 1143 | - | G.H3 | T | 253 | G.H3.11 |
Van-der-waals | C-term | T | 1143 | - | G.H3 | T | 253 | G.H3.11 |
Hydrophobic | TM6 | L | 1043 | 6x45 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM6 | L | 1043 | 6x45 | G.H5 | L | 354 | G.H5.25 |
Polar | C-term | S | 1148 | - | G.H2 | R | 210 | G.H2.05 |
Polar | C-term | Q | 1147 | - | G.H3 | T | 253 | G.H3.11 |
Van-der-waals | C-term | Q | 1147 | - | G.H3 | T | 253 | G.H3.11 |
Hydrophobic | C-term | L | 1177 | - | H.HA | F | 71 | H.HA.07 |
Van-der-waals | C-term | L | 1177 | - | H.HA | F | 71 | H.HA.07 |
Ionic | ICL3 | K | 1024 | - | G.h4s6 | E | 317 | G.h4s6.12 |
Polar | ICL3 | K | 1024 | - | G.h4s6 | E | 317 | G.h4s6.12 |
Hydrophobic | ICL3 | K | 1024 | - | G.h4s6 | E | 317 | G.h4s6.12 |
Van-der-waals | ICL3 | K | 1024 | - | G.h4s6 | E | 317 | G.h4s6.12 |
Hydrophobic | C-term | Y | 1187 | - | G.H2 | C | 215 | G.H2.10 |
Hydrophobic | C-term | S | 1151 | - | G.s4h3 | C | 238 | G.s4h3.11 |
Van-der-waals | C-term | S | 1151 | - | G.s4h3 | C | 238 | G.s4h3.11 |
Aromatic | TM2 | R | 879 | 2x46 | G.H5 | F | 352 | G.H5.23 |
Hydrophobic | TM2 | R | 879 | 2x46 | G.H5 | F | 352 | G.H5.23 |
Van-der-waals | TM2 | R | 879 | 2x46 | G.H5 | F | 352 | G.H5.23 |
Hydrophobic | ICL3 | K | 1024 | - | G.h4s6 | V | 319 | G.h4s6.20 |
Hydrophobic | C-term | L | 1177 | - | H.HA | L | 74 | H.HA.10 |
Van-der-waals | C-term | L | 1177 | - | H.HA | L | 74 | H.HA.10 |
Aromatic | C-term | W | 1140 | - | G.h2s4 | F | 216 | G.h2s4.01 |
Hydrophobic | C-term | W | 1140 | - | G.h2s4 | F | 216 | G.h2s4.01 |
Hydrophobic | C-term | I | 1136 | - | G.H2 | I | 213 | G.H2.08 |
Hydrophobic | C-term | V | 1144 | - | G.H2 | R | 210 | G.H2.05 |
Ionic | TM5 | H | 1019 | 5x64 | G.H5 | D | 342 | G.H5.13 |
Polar | TM5 | H | 1019 | 5x64 | G.H5 | D | 342 | G.H5.13 |
Hydrophobic | TM5 | H | 1019 | 5x64 | G.H5 | D | 342 | G.H5.13 |
Van-der-waals | TM5 | H | 1019 | 5x64 | G.H5 | D | 342 | G.H5.13 |
Hydrophobic | ICL2 | F | 943 | - | G.S1 | L | 36 | G.S1.02 |
Van-der-waals | ICL2 | F | 943 | - | G.S1 | L | 36 | G.S1.02 |
Hydrophobic | ICL2 | F | 943 | - | G.S3 | I | 195 | G.S3.01 |
Van-der-waals | ICL2 | F | 943 | - | G.S3 | I | 195 | G.S3.01 |
Hydrophobic | ICL2 | V | 942 | - | G.H5 | I | 344 | G.H5.15 |
Van-der-waals | ICL2 | V | 942 | - | G.H5 | I | 344 | G.H5.15 |
Hydrophobic | C-term | V | 1144 | - | G.H2 | R | 209 | G.H2.04 |
Hydrophobic | C-term | I | 1264 | - | G.HN | I | 21 | G.HN.43 |
Hydrophobic | C-term | M | 1139 | - | G.H3 | P | 258 | G.H3.16 |
Van-der-waals | C-term | M | 1139 | - | G.H3 | P | 258 | G.H3.16 |
Aromatic | ICL2 | F | 943 | - | G.H5 | F | 337 | G.H5.08 |
Hydrophobic | ICL2 | F | 943 | - | G.H5 | F | 337 | G.H5.08 |
Van-der-waals | ICL2 | F | 943 | - | G.H5 | F | 337 | G.H5.08 |
Hydrophobic | TM5 | M | 1016 | 5x61 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM5 | M | 1016 | 5x61 | G.H5 | L | 354 | G.H5.25 |
Ionic | ICL2 | E | 946 | - | G.HN | K | 30 | G.HN.52 |
Polar | ICL2 | E | 946 | - | G.HN | K | 30 | G.HN.52 |
Hydrophobic | ICL2 | E | 946 | - | G.HN | K | 30 | G.HN.52 |
Van-der-waals | ICL2 | E | 946 | - | G.HN | K | 30 | G.HN.52 |
Polar | C-term | L | 1177 | - | G.H1 | R | 56 | G.H1.09 |
Hydrophobic | C-term | W | 1140 | - | G.H3 | T | 253 | G.H3.11 |
Hydrophobic | C-term | I | 1136 | - | G.H3 | P | 258 | G.H3.16 |
Hydrophobic | TM5 | L | 1023 | 5x68 | G.H5 | D | 342 | G.H5.13 |
Van-der-waals | TM5 | L | 1023 | 5x68 | G.H5 | D | 342 | G.H5.13 |
Hydrophobic | TM3 | L | 935 | 3x54 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | C-term | Q | 1147 | - | G.H3 | L | 250 | G.H3.08 |
Hydrophobic | C-term | Y | 1171 | - | H.hbhc | D | 115 | H.hbhc.01 |
Van-der-waals | C-term | Y | 1171 | - | H.hbhc | D | 115 | H.hbhc.01 |
Polar | C-term | K | 1261 | - | G.HN | S | 18 | G.HN.40 |
Hydrophobic | C-term | K | 1261 | - | G.HN | S | 18 | G.HN.40 |
Van-der-waals | C-term | K | 1261 | - | G.HN | S | 18 | G.HN.40 |
Ionic | TM2 | D | 878 | 2x45 | G.hns1 | R | 33 | G.hns1.02 |
Polar | TM2 | D | 878 | 2x45 | G.hns1 | R | 33 | G.hns1.02 |
Hydrophobic | TM2 | D | 878 | 2x45 | G.hns1 | R | 33 | G.hns1.02 |
Van-der-waals | TM2 | D | 878 | 2x45 | G.hns1 | R | 33 | G.hns1.02 |
Hydrophobic | TM3 | L | 939 | 3x58 | G.H5 | L | 349 | G.H5.20 |
Van-der-waals | TM3 | L | 939 | 3x58 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | C-term | W | 1140 | - | G.H3 | I | 254 | G.H3.12 |
Van-der-waals | C-term | W | 1140 | - | G.H3 | I | 254 | G.H3.12 |
Polar | C-term | K | 1261 | - | G.HN | S | 14 | G.HN.36 |
Van-der-waals | C-term | K | 1261 | - | G.HN | S | 14 | G.HN.36 |
Polar | C-term | I | 1136 | - | G.H3 | Y | 257 | G.H3.15 |
Hydrophobic | C-term | I | 1136 | - | G.H3 | Y | 257 | G.H3.15 |
Van-der-waals | C-term | I | 1136 | - | G.H3 | Y | 257 | G.H3.15 |
Hydrophobic | C-term | Y | 1187 | - | G.S2 | I | 185 | G.S2.01 |
Van-der-waals | C-term | Y | 1187 | - | G.S2 | I | 185 | G.S2.01 |
Hydrophobic | TM5 | L | 1023 | 5x68 | G.h4s6 | V | 319 | G.h4s6.20 |
Van-der-waals | TM5 | L | 1023 | 5x68 | G.h4s6 | V | 319 | G.h4s6.20 |
Hydrophobic | ICL2 | V | 942 | - | G.H5 | K | 341 | G.H5.12 |
Van-der-waals | ICL2 | V | 942 | - | G.H5 | K | 341 | G.H5.12 |
Ionic | ICL2 | E | 944 | - | G.hns1 | R | 33 | G.hns1.02 |
Polar | ICL2 | E | 944 | - | G.hns1 | R | 33 | G.hns1.02 |
Hydrophobic | ICL2 | E | 944 | - | G.hns1 | R | 33 | G.hns1.02 |
Van-der-waals | ICL2 | E | 944 | - | G.hns1 | R | 33 | G.hns1.02 |
Hydrophobic | C-term | E | 1260 | - | G.HN | L | 25 | G.HN.47 |
Van-der-waals | C-term | E | 1260 | - | G.HN | L | 25 | G.HN.47 |
Hydrophobic | C-term | S | 1148 | - | G.H2 | R | 206 | G.H2.01 |
Hydrophobic | ICL2 | F | 943 | - | G.H5 | V | 340 | G.H5.11 |
Hydrophobic | TM6 | L | 1043 | 6x45 | G.H5 | F | 352 | G.H5.23 |
Hydrophobic | C-term | W | 1140 | - | G.H2 | R | 210 | G.H2.05 |
Polar | C-term | R | 1137 | - | G.H2 | H | 214 | G.H2.09 |
Aromatic | C-term | R | 1137 | - | G.H2 | H | 214 | G.H2.09 |
Hydrophobic | C-term | R | 1137 | - | G.H2 | H | 214 | G.H2.09 |
Van-der-waals | C-term | R | 1137 | - | G.H2 | H | 214 | G.H2.09 |
Hydrophobic | C-term | L | 1172 | - | G.hfs2 | T | 183 | G.hfs2.06 |
Van-der-waals | C-term | L | 1172 | - | G.hfs2 | T | 183 | G.hfs2.06 |
Hydrophobic | C-term | L | 1173 | - | H.HA | L | 74 | H.HA.10 |
Hydrophobic | C-term | N | 1175 | - | G.hfs2 | V | 180 | G.hfs2.03 |
Polar | TM6 | S | 1035 | 6x37 | G.H5 | L | 354 | G.H5.25 |
Polar | C-term | Y | 1187 | - | G.S1 | K | 37 | G.S1.03 |
Hydrophobic | TM3 | M | 938 | 3x57 | G.H5 | F | 352 | G.H5.23 |
Van-der-waals | TM3 | M | 938 | 3x57 | G.H5 | F | 352 | G.H5.23 |
Polar | C-term | W | 1140 | - | G.H3 | Y | 257 | G.H3.15 |
Aromatic | C-term | W | 1140 | - | G.H3 | Y | 257 | G.H3.15 |
Hydrophobic | C-term | W | 1140 | - | G.H3 | Y | 257 | G.H3.15 |
Van-der-waals | C-term | W | 1140 | - | G.H3 | Y | 257 | G.H3.15 |
Polar | C-term | N | 1185 | - | G.S2 | I | 185 | G.S2.01 |
Van-der-waals | C-term | N | 1185 | - | G.S2 | I | 185 | G.S2.01 |
Hydrophobic | C-term | L | 1191 | - | G.H2 | K | 211 | G.H2.06 |
Van-der-waals | C-term | L | 1191 | - | G.H2 | K | 211 | G.H2.06 |
Hydrophobic | C-term | L | 1177 | - | H.HA | G | 70 | H.HA.06 |
Van-der-waals | C-term | L | 1177 | - | H.HA | G | 70 | H.HA.06 |