GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 63.2
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.6
iPTM Score: 0.6
PAE mean: 15.2
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM6 | L | 1043 | 6x45 | G.H5 | L | 353 | G.H5.25 |
Polar | C-term | N | 1188 | - | G.S2 | I | 184 | G.S2.01 |
Hydrophobic | C-term | N | 1188 | - | G.S2 | I | 184 | G.S2.01 |
Van-der-waals | C-term | N | 1188 | - | G.S2 | I | 184 | G.S2.01 |
Polar | C-term | W | 1140 | - | G.H2 | R | 208 | G.H2.04 |
Van-der-waals | C-term | W | 1140 | - | G.H2 | R | 208 | G.H2.04 |
Polar | TM3 | M | 938 | 3x57 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM3 | M | 938 | 3x57 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | TM3 | M | 938 | 3x57 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | C-term | L | 1178 | - | H.HA | V | 72 | H.HA.10 |
Aromatic | C-term | W | 1140 | - | G.h2s4 | F | 215 | G.h2s4.01 |
Hydrophobic | C-term | W | 1140 | - | G.h2s4 | F | 215 | G.h2s4.01 |
Van-der-waals | C-term | W | 1140 | - | G.h2s4 | F | 215 | G.h2s4.01 |
Polar | ICL2 | Y | 947 | - | G.HN | E | 28 | G.HN.52 |
Van-der-waals | ICL2 | Y | 947 | - | G.HN | E | 28 | G.HN.52 |
Ionic | TM5 | H | 1019 | 5x64 | G.H5 | D | 341 | G.H5.13 |
Polar | TM5 | H | 1019 | 5x64 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM5 | H | 1019 | 5x64 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM5 | H | 1019 | 5x64 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | ICL2 | F | 943 | - | G.S3 | L | 194 | G.S3.01 |
Van-der-waals | ICL2 | F | 943 | - | G.S3 | L | 194 | G.S3.01 |
Hydrophobic | C-term | T | 1143 | - | G.H3 | S | 252 | G.H3.11 |
Van-der-waals | C-term | T | 1143 | - | G.H3 | S | 252 | G.H3.11 |
Hydrophobic | C-term | L | 1191 | - | G.H2 | H | 213 | G.H2.09 |
Polar | C-term | Q | 1147 | - | G.H2 | R | 208 | G.H2.04 |
Van-der-waals | C-term | Q | 1147 | - | G.H2 | R | 208 | G.H2.04 |
Polar | TM5 | L | 1023 | 5x68 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | TM5 | L | 1023 | 5x68 | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | TM5 | L | 1023 | 5x68 | G.h4s6 | E | 318 | G.h4s6.12 |
Aromatic | ICL2 | F | 943 | - | G.H5 | F | 336 | G.H5.08 |
Hydrophobic | ICL2 | F | 943 | - | G.H5 | F | 336 | G.H5.08 |
Van-der-waals | ICL2 | F | 943 | - | G.H5 | F | 336 | G.H5.08 |
Hydrophobic | C-term | W | 1140 | - | G.H2 | I | 212 | G.H2.08 |
Van-der-waals | C-term | W | 1140 | - | G.H2 | I | 212 | G.H2.08 |
Polar | C-term | Q | 1147 | - | G.H3 | S | 252 | G.H3.11 |
Van-der-waals | C-term | Q | 1147 | - | G.H3 | S | 252 | G.H3.11 |
Polar | C-term | G | 1166 | - | H.HA | K | 86 | H.HA.24 |
Van-der-waals | C-term | G | 1166 | - | H.HA | K | 86 | H.HA.24 |
Polar | C-term | R | 1137 | - | G.H2 | H | 213 | G.H2.09 |
Hydrophobic | C-term | R | 1137 | - | G.H2 | H | 213 | G.H2.09 |
Van-der-waals | C-term | R | 1137 | - | G.H2 | H | 213 | G.H2.09 |
Polar | TM2 | R | 879 | 2x46 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM2 | R | 879 | 2x46 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM2 | R | 879 | 2x46 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM6 | G | 1039 | 6x41 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | G | 1039 | 6x41 | G.H5 | L | 353 | G.H5.25 |
Polar | C-term | S | 1151 | - | G.H2 | R | 205 | G.H2.01 |
Hydrophobic | C-term | S | 1151 | - | G.H2 | R | 205 | G.H2.01 |
Van-der-waals | C-term | S | 1151 | - | G.H2 | R | 205 | G.H2.01 |
Hydrophobic | C-term | L | 1173 | - | H.HA | S | 75 | H.HA.13 |
Hydrophobic | ICL2 | F | 943 | - | G.H5 | V | 339 | G.H5.11 |
Hydrophobic | C-term | Y | 1187 | - | G.S2 | I | 184 | G.S2.01 |
Van-der-waals | C-term | Y | 1187 | - | G.S2 | I | 184 | G.S2.01 |
Hydrophobic | C-term | I | 1136 | - | G.H2 | I | 212 | G.H2.08 |
Van-der-waals | C-term | I | 1136 | - | G.H2 | I | 212 | G.H2.08 |
Polar | TM2 | R | 879 | 2x46 | G.H5 | D | 350 | G.H5.22 |
Van-der-waals | TM2 | R | 879 | 2x46 | G.H5 | D | 350 | G.H5.22 |
Polar | C-term | Q | 1133 | - | G.h2s4 | E | 216 | G.h2s4.02 |
Van-der-waals | C-term | Q | 1133 | - | G.h2s4 | E | 216 | G.h2s4.02 |
Hydrophobic | C-term | Q | 1147 | - | G.H3 | L | 249 | G.H3.08 |
Van-der-waals | C-term | Q | 1147 | - | G.H3 | L | 249 | G.H3.08 |
Polar | ICL2 | E | 944 | - | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | ICL2 | E | 944 | - | G.hns1 | R | 32 | G.hns1.03 |
Van-der-waals | ICL2 | E | 944 | - | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | C-term | T | 1124 | - | G.HN | L | 23 | G.HN.47 |
Hydrophobic | ICL2 | V | 942 | - | G.H5 | T | 340 | G.H5.12 |
Hydrophobic | TM3 | M | 938 | 3x57 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | M | 938 | 3x57 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | ICL2 | S | 945 | - | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | H8 | Q | 1088 | 8x47 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | H8 | Q | 1088 | 8x47 | G.H5 | G | 352 | G.H5.24 |
Polar | C-term | N | 1185 | - | G.S2 | I | 184 | G.S2.01 |
Van-der-waals | C-term | N | 1185 | - | G.S2 | I | 184 | G.S2.01 |
Polar | TM5 | L | 1023 | 5x68 | G.H5 | K | 345 | G.H5.17 |
Hydrophobic | TM5 | L | 1023 | 5x68 | G.H5 | K | 345 | G.H5.17 |
Van-der-waals | TM5 | L | 1023 | 5x68 | G.H5 | K | 345 | G.H5.17 |
Polar | H8 | Q | 1088 | 8x47 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | H8 | Q | 1088 | 8x47 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | C-term | R | 1135 | - | G.H3 | Y | 258 | G.H3.17 |
Van-der-waals | C-term | R | 1135 | - | G.H3 | Y | 258 | G.H3.17 |
Hydrophobic | C-term | M | 1139 | - | G.H3 | K | 257 | G.H3.16 |
Aromatic | ICL3 | K | 1024 | - | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | ICL3 | K | 1024 | - | G.H5 | F | 354 | G.H5.26 |
Van-der-waals | ICL3 | K | 1024 | - | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | TM3 | L | 939 | 3x58 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | TM5 | M | 1016 | 5x61 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM5 | M | 1016 | 5x61 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | TM5 | T | 1012 | 5x57 | G.H5 | L | 353 | G.H5.25 |
Polar | ICL2 | S | 948 | - | G.HN | E | 28 | G.HN.52 |
Hydrophobic | ICL2 | S | 948 | - | G.HN | E | 28 | G.HN.52 |
Van-der-waals | ICL2 | S | 948 | - | G.HN | E | 28 | G.HN.52 |
Ionic | ICL2 | E | 946 | - | G.hns1 | R | 32 | G.hns1.03 |
Polar | ICL2 | E | 946 | - | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | ICL2 | E | 946 | - | G.hns1 | R | 32 | G.hns1.03 |
Van-der-waals | ICL2 | E | 946 | - | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | ICL2 | V | 942 | - | G.H5 | I | 343 | G.H5.15 |
Van-der-waals | ICL2 | V | 942 | - | G.H5 | I | 343 | G.H5.15 |
Polar | TM6 | S | 1035 | 6x37 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | C-term | Y | 1187 | - | G.S3 | F | 199 | G.S3.06 |
Van-der-waals | C-term | Y | 1187 | - | G.S3 | F | 199 | G.S3.06 |
Hydrophobic | C-term | R | 1137 | - | G.H2 | I | 212 | G.H2.08 |
Van-der-waals | C-term | R | 1137 | - | G.H2 | I | 212 | G.H2.08 |
Hydrophobic | TM3 | L | 939 | 3x58 | G.H5 | L | 348 | G.H5.20 |
Ionic | H8 | K | 1090 | 8x49 | G.H5 | D | 350 | G.H5.22 |
Polar | H8 | K | 1090 | 8x49 | G.H5 | D | 350 | G.H5.22 |
Hydrophobic | H8 | K | 1090 | 8x49 | G.H5 | D | 350 | G.H5.22 |
Van-der-waals | H8 | K | 1090 | 8x49 | G.H5 | D | 350 | G.H5.22 |
Hydrophobic | C-term | S | 1151 | - | G.s4h3 | V | 240 | G.s4h3.14 |
Hydrophobic | C-term | L | 1178 | - | G.hfs2 | V | 179 | G.hfs2.03 |
Polar | C-term | T | 1132 | - | G.H3 | Y | 258 | G.H3.17 |
Hydrophobic | C-term | T | 1132 | - | G.H3 | Y | 258 | G.H3.17 |
Hydrophobic | TM5 | L | 1023 | 5x68 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | C-term | L | 1178 | - | H.HA | F | 69 | H.HA.07 |
Van-der-waals | C-term | L | 1178 | - | H.HA | F | 69 | H.HA.07 |
Hydrophobic | ICL2 | V | 942 | - | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | C-term | V | 1144 | - | G.H2 | K | 209 | G.H2.05 |
Hydrophobic | TM5 | T | 1022 | 5x67 | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | TM5 | T | 1022 | 5x67 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | C-term | M | 1139 | - | G.H3 | H | 256 | G.H3.15 |
Van-der-waals | C-term | M | 1139 | - | G.H3 | H | 256 | G.H3.15 |
Hydrophobic | C-term | M | 1167 | - | G.s4h3 | E | 238 | G.s4h3.12 |
Van-der-waals | C-term | M | 1167 | - | G.s4h3 | E | 238 | G.s4h3.12 |
Hydrophobic | TM3 | L | 935 | 3x54 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | C-term | L | 1173 | - | H.hbhc | D | 116 | H.hbhc.04 |
Van-der-waals | C-term | L | 1173 | - | H.hbhc | D | 116 | H.hbhc.04 |
Hydrophobic | C-term | M | 1139 | - | G.H3 | Y | 258 | G.H3.17 |
Van-der-waals | C-term | M | 1139 | - | G.H3 | Y | 258 | G.H3.17 |
Hydrophobic | C-term | V | 1144 | - | G.H2 | R | 208 | G.H2.04 |
Van-der-waals | C-term | V | 1144 | - | G.H2 | R | 208 | G.H2.04 |
Hydrophobic | C-term | Y | 1187 | - | G.H2 | H | 213 | G.H2.09 |
Van-der-waals | C-term | Y | 1187 | - | G.H2 | H | 213 | G.H2.09 |
Hydrophobic | C-term | W | 1140 | - | G.H3 | I | 253 | G.H3.12 |
Hydrophobic | C-term | I | 1136 | - | G.H3 | H | 256 | G.H3.15 |
Hydrophobic | C-term | S | 1129 | - | G.h2s4 | E | 216 | G.h2s4.02 |
Van-der-waals | C-term | S | 1129 | - | G.h2s4 | E | 216 | G.h2s4.02 |
Polar | C-term | I | 1136 | - | G.H3 | Y | 258 | G.H3.17 |
Hydrophobic | C-term | I | 1136 | - | G.H3 | Y | 258 | G.H3.17 |
Van-der-waals | C-term | I | 1136 | - | G.H3 | Y | 258 | G.H3.17 |
Hydrophobic | TM5 | M | 1016 | 5x61 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM5 | M | 1016 | 5x61 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM5 | H | 1019 | 5x64 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | C-term | T | 1174 | - | G.hfs2 | K | 180 | G.hfs2.04 |
Hydrophobic | TM5 | L | 1023 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM5 | L | 1023 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Polar | TM5 | T | 1022 | 5x67 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM5 | T | 1022 | 5x67 | G.H5 | D | 341 | G.H5.13 |
Polar | H8 | Q | 1088 | 8x47 | G.H5 | D | 350 | G.H5.22 |
Polar | C-term | Y | 1187 | - | G.S3 | R | 197 | G.S3.04 |
Hydrophobic | C-term | L | 1191 | - | G.H2 | K | 210 | G.H2.06 |
Van-der-waals | C-term | L | 1191 | - | G.H2 | K | 210 | G.H2.06 |
Polar | C-term | Q | 1165 | - | H.HA | T | 90 | H.HA.28 |
Hydrophobic | C-term | Q | 1165 | - | H.HA | T | 90 | H.HA.28 |
Van-der-waals | C-term | Q | 1165 | - | H.HA | T | 90 | H.HA.28 |
Aromatic | C-term | W | 1140 | - | G.H3 | H | 256 | G.H3.15 |
Hydrophobic | C-term | W | 1140 | - | G.H3 | H | 256 | G.H3.15 |
Hydrophobic | C-term | L | 1190 | - | G.H2 | H | 213 | G.H2.09 |
Hydrophobic | C-term | N | 1188 | - | G.hfs2 | G | 183 | G.hfs2.07 |
Van-der-waals | C-term | N | 1188 | - | G.hfs2 | G | 183 | G.hfs2.07 |
Polar | C-term | T | 1168 | - | H.HA | K | 86 | H.HA.24 |
Van-der-waals | C-term | T | 1168 | - | H.HA | K | 86 | H.HA.24 |
Hydrophobic | C-term | W | 1140 | - | G.H2 | W | 211 | G.H2.07 |
Van-der-waals | C-term | W | 1140 | - | G.H2 | W | 211 | G.H2.07 |
Polar | C-term | Y | 1171 | - | H.HA | Q | 79 | H.HA.17 |
Van-der-waals | C-term | Y | 1171 | - | H.HA | Q | 79 | H.HA.17 |
Hydrophobic | ICL3 | D | 1026 | - | G.h4s6 | K | 314 | G.h4s6.08 |
Van-der-waals | ICL3 | D | 1026 | - | G.h4s6 | K | 314 | G.h4s6.08 |
Hydrophobic | ICL2 | F | 943 | - | G.H5 | T | 340 | G.H5.12 |
Van-der-waals | ICL2 | F | 943 | - | G.H5 | T | 340 | G.H5.12 |
Hydrophobic | ICL2 | F | 943 | - | G.H5 | I | 343 | G.H5.15 |
Hydrophobic | TM3 | L | 935 | 3x54 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | L | 935 | 3x54 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | C-term | I | 1136 | - | G.h2s4 | F | 215 | G.h2s4.01 |
Van-der-waals | C-term | I | 1136 | - | G.h2s4 | F | 215 | G.h2s4.01 |
Hydrophobic | TM5 | L | 1023 | 5x68 | G.H5 | F | 354 | G.H5.26 |