GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 66.6
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.6
iPTM Score: 0.7
PAE mean: 12.1
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | ICL2 | F | 960 | - | G.S3 | I | 221 | G.S3.01 |
Van-der-waals | ICL2 | F | 960 | - | G.S3 | I | 221 | G.S3.01 |
Hydrophobic | C-term | I | 1152 | - | G.H3 | L | 285 | G.H3.17 |
Van-der-waals | C-term | I | 1152 | - | G.H3 | L | 285 | G.H3.17 |
Hydrophobic | ICL3 | K | 1041 | - | G.H5 | Q | 381 | G.H5.26 |
Van-der-waals | ICL3 | K | 1041 | - | G.H5 | Q | 381 | G.H5.26 |
Hydrophobic | TM5 | L | 1040 | 5x68 | G.H5 | K | 376 | G.H5.21 |
Van-der-waals | TM5 | L | 1040 | 5x68 | G.H5 | K | 376 | G.H5.21 |
Hydrophobic | C-term | W | 1156 | - | G.H2 | F | 239 | G.H2.08 |
Hydrophobic | C-term | Y | 1392 | - | G.s4h3 | M | 262 | G.s4h3.09 |
Van-der-waals | C-term | Y | 1392 | - | G.s4h3 | M | 262 | G.s4h3.09 |
Van-der-waals | ICL2 | S | 962 | - | G.HN | R | 52 | G.HN.52 |
Aromatic | ICL2 | F | 960 | - | G.H5 | F | 363 | G.H5.08 |
Hydrophobic | ICL2 | F | 960 | - | G.H5 | F | 363 | G.H5.08 |
Van-der-waals | ICL2 | F | 960 | - | G.H5 | F | 363 | G.H5.08 |
Hydrophobic | C-term | T | 1159 | - | G.H3 | T | 279 | G.H3.11 |
Van-der-waals | C-term | T | 1159 | - | G.H3 | T | 279 | G.H3.11 |
Hydrophobic | C-term | N | 1398 | - | H.HA | K | 114 | H.HA.28 |
Van-der-waals | C-term | N | 1398 | - | H.HA | K | 114 | H.HA.28 |
Hydrophobic | TM2 | R | 896 | 2x46 | G.H5 | I | 378 | G.H5.23 |
Hydrophobic | TM7 | L | 1104 | 7x60 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM3 | M | 955 | 3x57 | G.H5 | I | 378 | G.H5.23 |
Polar | C-term | W | 1156 | - | G.H2 | R | 235 | G.H2.04 |
Van-der-waals | C-term | W | 1156 | - | G.H2 | R | 235 | G.H2.04 |
Ionic | C-term | K | 1394 | - | G.s1h1 | E | 67 | G.s1h1.04 |
Polar | C-term | K | 1394 | - | G.s1h1 | E | 67 | G.s1h1.04 |
Hydrophobic | ICL2 | V | 959 | - | G.H5 | I | 370 | G.H5.15 |
Van-der-waals | ICL2 | V | 959 | - | G.H5 | I | 370 | G.H5.15 |
Polar | C-term | Q | 1163 | - | G.H3 | T | 279 | G.H3.11 |
Hydrophobic | C-term | Q | 1163 | - | G.H3 | T | 279 | G.H3.11 |
Van-der-waals | C-term | Q | 1163 | - | G.H3 | T | 279 | G.H3.11 |
Polar | ICL1 | Q | 893 | 12x51 | G.HN | R | 51 | G.HN.51 |
Ionic | TM5 | H | 1036 | 5x64 | G.H5 | D | 368 | G.H5.13 |
Hydrophobic | TM5 | H | 1036 | 5x64 | G.H5 | D | 368 | G.H5.13 |
Van-der-waals | TM5 | H | 1036 | 5x64 | G.H5 | D | 368 | G.H5.13 |
Hydrophobic | C-term | Q | 1163 | - | G.H3 | I | 276 | G.H3.08 |
Van-der-waals | C-term | Q | 1163 | - | G.H3 | I | 276 | G.H3.08 |
Hydrophobic | C-term | S | 1395 | - | H.HA | D | 110 | H.HA.24 |
Ionic | TM2 | D | 895 | 2x45 | G.HN | R | 52 | G.HN.52 |
Polar | TM2 | D | 895 | 2x45 | G.HN | R | 52 | G.HN.52 |
Van-der-waals | TM2 | D | 895 | 2x45 | G.HN | R | 52 | G.HN.52 |
Polar | ICL1 | Q | 893 | 12x51 | G.hns1 | R | 55 | G.hns1.02 |
Polar | ICL2 | S | 965 | - | G.HN | R | 52 | G.HN.52 |
Hydrophobic | ICL2 | S | 965 | - | G.HN | R | 52 | G.HN.52 |
Van-der-waals | ICL2 | S | 965 | - | G.HN | R | 52 | G.HN.52 |
Hydrophobic | ICL2 | V | 959 | - | G.H5 | L | 371 | G.H5.16 |
Van-der-waals | ICL2 | V | 959 | - | G.H5 | L | 371 | G.H5.16 |
Hydrophobic | TM5 | M | 1033 | 5x61 | G.H5 | M | 379 | G.H5.24 |
Van-der-waals | TM5 | M | 1033 | 5x61 | G.H5 | M | 379 | G.H5.24 |
Hydrophobic | C-term | R | 1153 | - | G.H2 | F | 239 | G.H2.08 |
Van-der-waals | C-term | R | 1153 | - | G.H2 | F | 239 | G.H2.08 |
Hydrophobic | TM5 | M | 1033 | 5x61 | G.H5 | I | 378 | G.H5.23 |
Van-der-waals | TM5 | L | 1040 | 5x68 | G.h4s6 | S | 343 | G.h4s6.12 |
Polar | TM6 | S | 1052 | 6x37 | G.H5 | Q | 381 | G.H5.26 |
Van-der-waals | TM6 | S | 1052 | 6x37 | G.H5 | Q | 381 | G.H5.26 |
Hydrophobic | ICL2 | F | 960 | - | G.H5 | V | 366 | G.H5.11 |
Polar | H8 | Q | 1105 | 8x47 | G.H5 | D | 377 | G.H5.22 |
Van-der-waals | H8 | Q | 1105 | 8x47 | G.H5 | D | 377 | G.H5.22 |
Polar | C-term | S | 1395 | - | G.s4h3 | R | 265 | G.s4h3.12 |
Van-der-waals | C-term | S | 1395 | - | G.s4h3 | R | 265 | G.s4h3.12 |
Polar | TM3 | E | 958 | 3x60 | G.H5 | K | 367 | G.H5.12 |
Hydrophobic | TM3 | E | 958 | 3x60 | G.H5 | K | 367 | G.H5.12 |
Hydrophobic | C-term | W | 1156 | - | G.H3 | T | 279 | G.H3.11 |
Van-der-waals | C-term | W | 1156 | - | G.H3 | T | 279 | G.H3.11 |
Polar | C-term | K | 1394 | - | H.hdhe | Q | 174 | H.hdhe.02 |
Hydrophobic | C-term | K | 1394 | - | H.hdhe | Q | 174 | H.hdhe.02 |
Van-der-waals | C-term | K | 1394 | - | H.hdhe | Q | 174 | H.hdhe.02 |
Polar | TM6 | S | 1052 | 6x37 | G.H5 | M | 379 | G.H5.24 |
Hydrophobic | C-term | W | 1156 | - | G.H2 | W | 238 | G.H2.07 |
Van-der-waals | C-term | W | 1156 | - | G.H2 | W | 238 | G.H2.07 |
Hydrophobic | C-term | L | 1399 | - | H.HA | K | 114 | H.HA.28 |
Van-der-waals | C-term | L | 1399 | - | H.HA | K | 114 | H.HA.28 |
Hydrophobic | H8 | K | 1106 | 8x48 | G.H5 | Q | 381 | G.H5.26 |
Van-der-waals | H8 | K | 1106 | 8x48 | G.H5 | Q | 381 | G.H5.26 |
Hydrophobic | TM3 | L | 956 | 3x58 | G.H5 | I | 378 | G.H5.23 |
Polar | C-term | Y | 1393 | - | H.HA | R | 106 | H.HA.20 |
Hydrophobic | C-term | Y | 1393 | - | H.HA | R | 106 | H.HA.20 |
Van-der-waals | C-term | Y | 1393 | - | H.HA | R | 106 | H.HA.20 |
Polar | C-term | M | 1396 | - | H.HA | D | 110 | H.HA.24 |
Van-der-waals | C-term | M | 1396 | - | H.HA | D | 110 | H.HA.24 |
Polar | C-term | M | 1396 | - | H.HA | K | 114 | H.HA.28 |
Hydrophobic | C-term | M | 1396 | - | H.HA | K | 114 | H.HA.28 |
Van-der-waals | C-term | M | 1396 | - | H.HA | K | 114 | H.HA.28 |
Hydrophobic | C-term | P | 1397 | - | H.HA | K | 114 | H.HA.28 |
Van-der-waals | C-term | P | 1397 | - | H.HA | K | 114 | H.HA.28 |
Hydrophobic | TM5 | T | 1037 | 5x65 | G.H5 | M | 379 | G.H5.24 |
Van-der-waals | TM5 | T | 1037 | 5x65 | G.H5 | M | 379 | G.H5.24 |
Hydrophobic | TM5 | L | 1040 | 5x68 | G.H5 | Q | 372 | G.H5.17 |
Van-der-waals | TM5 | L | 1040 | 5x68 | G.H5 | Q | 372 | G.H5.17 |
Hydrophobic | C-term | W | 1156 | - | G.H3 | I | 280 | G.H3.12 |
Van-der-waals | C-term | W | 1156 | - | G.H3 | I | 280 | G.H3.12 |
Hydrophobic | C-term | M | 1155 | - | G.H3 | N | 283 | G.H3.15 |
Van-der-waals | C-term | M | 1155 | - | G.H3 | N | 283 | G.H3.15 |
Hydrophobic | TM6 | W | 1053 | 6x38 | G.H5 | M | 379 | G.H5.24 |
Polar | TM3 | M | 955 | 3x57 | G.H5 | N | 374 | G.H5.19 |
Hydrophobic | TM3 | M | 955 | 3x57 | G.H5 | N | 374 | G.H5.19 |
Van-der-waals | TM3 | M | 955 | 3x57 | G.H5 | N | 374 | G.H5.19 |
Hydrophobic | ICL2 | S | 962 | - | G.hns1 | R | 56 | G.hns1.03 |
Hydrophobic | TM6 | A | 1059 | 6x44 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | C-term | M | 1155 | - | G.H3 | L | 285 | G.H3.17 |
Polar | ICL3 | E | 1043 | - | G.h4s6 | S | 343 | G.h4s6.12 |
Hydrophobic | ICL3 | E | 1043 | - | G.h4s6 | S | 343 | G.h4s6.12 |
Van-der-waals | ICL3 | E | 1043 | - | G.h4s6 | S | 343 | G.h4s6.12 |
Hydrophobic | TM5 | L | 1040 | 5x68 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | TM5 | K | 1032 | 5x60 | G.H5 | L | 371 | G.H5.16 |
Hydrophobic | H8 | Q | 1105 | 8x47 | G.H5 | L | 380 | G.H5.25 |
Polar | ICL2 | H | 964 | - | G.HN | R | 52 | G.HN.52 |
Hydrophobic | ICL2 | H | 964 | - | G.HN | R | 52 | G.HN.52 |
Hydrophobic | TM5 | H | 1036 | 5x64 | G.H5 | L | 371 | G.H5.16 |
Van-der-waals | TM5 | H | 1036 | 5x64 | G.H5 | L | 371 | G.H5.16 |
Hydrophobic | TM6 | L | 1060 | 6x45 | G.H5 | I | 378 | G.H5.23 |
Hydrophobic | C-term | V | 1160 | - | G.H2 | Q | 236 | G.H2.05 |
Hydrophobic | C-term | M | 1396 | - | H.HA | A | 111 | H.HA.25 |
Van-der-waals | C-term | M | 1396 | - | H.HA | A | 111 | H.HA.25 |
Hydrophobic | C-term | I | 1152 | - | G.h2s4 | F | 242 | G.h2s4.01 |
Van-der-waals | C-term | I | 1152 | - | G.h2s4 | F | 242 | G.h2s4.01 |
Polar | ICL2 | V | 959 | - | G.H5 | N | 374 | G.H5.19 |
Hydrophobic | TM3 | L | 956 | 3x58 | G.H5 | L | 371 | G.H5.16 |
Van-der-waals | TM3 | L | 956 | 3x58 | G.H5 | L | 371 | G.H5.16 |
Hydrophobic | ICL3 | P | 1042 | - | G.h4s6 | S | 343 | G.h4s6.12 |
Van-der-waals | ICL3 | P | 1042 | - | G.h4s6 | S | 343 | G.h4s6.12 |
Hydrophobic | C-term | M | 1396 | - | H.HA | L | 115 | H.HA.29 |
Hydrophobic | TM6 | G | 1056 | 6x41 | G.H5 | M | 379 | G.H5.24 |
Hydrophobic | TM3 | L | 952 | 3x54 | G.H5 | I | 378 | G.H5.23 |
Van-der-waals | TM3 | L | 952 | 3x54 | G.H5 | I | 378 | G.H5.23 |
Hydrophobic | TM5 | M | 1033 | 5x61 | G.H5 | L | 375 | G.H5.20 |
Van-der-waals | TM5 | M | 1033 | 5x61 | G.H5 | L | 375 | G.H5.20 |
Polar | C-term | Q | 1163 | - | G.H3 | N | 275 | G.H3.07 |
Hydrophobic | C-term | Q | 1163 | - | G.H3 | N | 275 | G.H3.07 |
Van-der-waals | C-term | Q | 1163 | - | G.H3 | N | 275 | G.H3.07 |
Hydrophobic | TM5 | I | 1039 | 5x67 | G.h4s6 | P | 345 | G.h4s6.20 |
Van-der-waals | TM5 | I | 1039 | 5x67 | G.h4s6 | P | 345 | G.h4s6.20 |
Polar | H8 | K | 1106 | 8x48 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | C-term | M | 1396 | - | H.hdhe | F | 173 | H.hdhe.01 |
Van-der-waals | C-term | M | 1396 | - | H.hdhe | F | 173 | H.hdhe.01 |
Hydrophobic | TM5 | H | 1036 | 5x64 | G.H5 | L | 375 | G.H5.20 |
Van-der-waals | TM5 | H | 1036 | 5x64 | G.H5 | L | 375 | G.H5.20 |
Polar | C-term | Q | 1149 | - | G.H2 | Q | 240 | G.H2.09 |
Van-der-waals | C-term | Q | 1149 | - | G.H2 | Q | 240 | G.H2.09 |
Hydrophobic | ICL2 | E | 963 | - | G.HN | R | 52 | G.HN.52 |
Hydrophobic | TM5 | L | 1040 | 5x68 | G.H5 | M | 379 | G.H5.24 |
Hydrophobic | ICL2 | F | 960 | - | G.H5 | I | 370 | G.H5.15 |
Van-der-waals | ICL2 | F | 960 | - | G.H5 | I | 370 | G.H5.15 |
Hydrophobic | TM5 | K | 1032 | 5x60 | G.H5 | L | 375 | G.H5.20 |
Polar | TM3 | V | 957 | 3x59 | G.H5 | K | 367 | G.H5.12 |
Hydrophobic | TM3 | V | 957 | 3x59 | G.H5 | K | 367 | G.H5.12 |
Van-der-waals | TM3 | V | 957 | 3x59 | G.H5 | K | 367 | G.H5.12 |
Polar | ICL3 | E | 1043 | - | G.h4s6 | R | 342 | G.h4s6.11 |
Hydrophobic | ICL3 | E | 1043 | - | G.h4s6 | R | 342 | G.h4s6.11 |
Van-der-waals | ICL3 | E | 1043 | - | G.h4s6 | R | 342 | G.h4s6.11 |
Ionic | TM2 | R | 896 | 2x46 | G.H5 | D | 377 | G.H5.22 |
Polar | TM2 | R | 896 | 2x46 | G.H5 | D | 377 | G.H5.22 |
Hydrophobic | TM7 | F | 1100 | 7x56 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM7 | F | 1100 | 7x56 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | C-term | I | 1152 | - | G.H2 | F | 239 | G.H2.08 |
Aromatic | C-term | W | 1156 | - | G.h2s4 | F | 242 | G.h2s4.01 |
Hydrophobic | C-term | W | 1156 | - | G.h2s4 | F | 242 | G.h2s4.01 |
Van-der-waals | C-term | W | 1156 | - | G.h2s4 | F | 242 | G.h2s4.01 |
Ionic | ICL2 | E | 963 | - | G.hns1 | R | 56 | G.hns1.03 |
Polar | ICL2 | E | 963 | - | G.hns1 | R | 56 | G.hns1.03 |
Hydrophobic | ICL2 | E | 963 | - | G.hns1 | R | 56 | G.hns1.03 |
Van-der-waals | ICL2 | E | 963 | - | G.hns1 | R | 56 | G.hns1.03 |
Hydrophobic | TM6 | I | 1055 | 6x40 | G.H5 | L | 380 | G.H5.25 |
Ionic | H8 | K | 1107 | 8x49 | G.H5 | D | 377 | G.H5.22 |
Polar | H8 | K | 1107 | 8x49 | G.H5 | D | 377 | G.H5.22 |
Hydrophobic | H8 | K | 1107 | 8x49 | G.H5 | D | 377 | G.H5.22 |
Van-der-waals | H8 | K | 1107 | 8x49 | G.H5 | D | 377 | G.H5.22 |
Polar | C-term | Q | 1163 | - | G.H2 | R | 235 | G.H2.04 |
Van-der-waals | C-term | Q | 1163 | - | G.H2 | R | 235 | G.H2.04 |
Hydrophobic | C-term | K | 1394 | - | G.s4h3 | M | 262 | G.s4h3.09 |
Van-der-waals | C-term | K | 1394 | - | G.s4h3 | M | 262 | G.s4h3.09 |
Ionic | ICL2 | E | 961 | - | G.HN | R | 52 | G.HN.52 |
Polar | ICL2 | E | 961 | - | G.HN | R | 52 | G.HN.52 |
Hydrophobic | ICL2 | E | 961 | - | G.HN | R | 52 | G.HN.52 |
Van-der-waals | ICL2 | E | 961 | - | G.HN | R | 52 | G.HN.52 |
Hydrophobic | TM7 | H | 1101 | 7x57 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | ICL2 | V | 959 | - | G.H5 | K | 367 | G.H5.12 |
Van-der-waals | ICL2 | V | 959 | - | G.H5 | K | 367 | G.H5.12 |
Ionic | C-term | E | 1389 | - | G.hfs2 | K | 209 | G.hfs2.06 |
Ionic | ICL2 | E | 961 | - | G.hns1 | R | 55 | G.hns1.02 |
Hydrophobic | ICL2 | E | 961 | - | G.hns1 | R | 55 | G.hns1.02 |
Van-der-waals | ICL2 | E | 961 | - | G.hns1 | R | 55 | G.hns1.02 |
Hydrophobic | TM3 | L | 956 | 3x58 | G.H5 | L | 375 | G.H5.20 |
Van-der-waals | TM3 | L | 956 | 3x58 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | ICL2 | F | 960 | - | G.H5 | K | 367 | G.H5.12 |
Polar | ICL2 | E | 961 | - | G.hns1 | R | 56 | G.hns1.03 |
Hydrophobic | ICL2 | E | 961 | - | G.hns1 | R | 56 | G.hns1.03 |
Van-der-waals | ICL2 | E | 961 | - | G.hns1 | R | 56 | G.hns1.03 |
Hydrophobic | ICL2 | F | 960 | - | G.S1 | V | 58 | G.S1.02 |