GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 65.9
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.6
iPTM Score: 0.8
PAE mean: 12.6
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | ICL2 | H | 964 | - | G.HN | Q | 35 | G.HN.52 |
Hydrophobic | TM5 | L | 1040 | 5x68 | G.H5 | R | 385 | G.H5.17 |
Van-der-waals | TM5 | L | 1040 | 5x68 | G.H5 | R | 385 | G.H5.17 |
Hydrophobic | ICL2 | F | 960 | - | G.H5 | I | 383 | G.H5.15 |
Van-der-waals | ICL2 | F | 960 | - | G.H5 | I | 383 | G.H5.15 |
Hydrophobic | ICL2 | F | 960 | - | G.S3 | V | 217 | G.S3.01 |
Van-der-waals | ICL2 | F | 960 | - | G.S3 | V | 217 | G.S3.01 |
Van-der-waals | C-term | F | 1168 | - | G.H3 | S | 275 | G.H3.11 |
Hydrophobic | C-term | I | 1169 | - | G.H2 | R | 231 | G.H2.04 |
Van-der-waals | ICL3 | K | 1041 | - | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | ICL2 | V | 959 | - | G.H5 | H | 387 | G.H5.19 |
Van-der-waals | ICL2 | V | 959 | - | G.H5 | H | 387 | G.H5.19 |
Polar | H8 | K | 1106 | 8x48 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | H8 | K | 1106 | 8x48 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | H8 | K | 1106 | 8x48 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | ICL2 | F | 960 | - | G.H5 | R | 380 | G.H5.12 |
Polar | H8 | K | 1107 | 8x49 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | H8 | K | 1107 | 8x49 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | H8 | Q | 1105 | 8x47 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | H8 | Q | 1105 | 8x47 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | C-term | I | 1209 | - | G.HN | E | 15 | G.HN.32 |
Van-der-waals | C-term | I | 1209 | - | G.HN | E | 15 | G.HN.32 |
Ionic | C-term | R | 1151 | - | G.h2s4 | D | 240 | G.h2s4.03 |
Polar | C-term | R | 1151 | - | G.h2s4 | D | 240 | G.h2s4.03 |
Hydrophobic | C-term | R | 1151 | - | G.h2s4 | D | 240 | G.h2s4.03 |
Van-der-waals | C-term | R | 1151 | - | G.h2s4 | D | 240 | G.h2s4.03 |
Polar | C-term | K | 1162 | - | G.h2s4 | F | 238 | G.h2s4.01 |
Van-der-waals | C-term | K | 1162 | - | G.h2s4 | F | 238 | G.h2s4.01 |
Polar | TM5 | L | 1040 | 5x68 | G.h4s6 | Y | 358 | G.h4s6.20 |
Hydrophobic | TM5 | L | 1040 | 5x68 | G.h4s6 | Y | 358 | G.h4s6.20 |
Van-der-waals | TM5 | L | 1040 | 5x68 | G.h4s6 | Y | 358 | G.h4s6.20 |
Hydrophobic | ICL2 | E | 963 | - | G.hns1 | A | 39 | G.hns1.03 |
Hydrophobic | TM5 | M | 1033 | 5x61 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM5 | M | 1033 | 5x61 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | C-term | T | 1159 | - | G.H2 | Q | 236 | G.H2.09 |
Hydrophobic | TM5 | H | 1036 | 5x64 | G.H5 | L | 394 | G.H5.26 |
Aromatic | ICL2 | F | 960 | - | G.H5 | F | 376 | G.H5.08 |
Hydrophobic | ICL2 | F | 960 | - | G.H5 | F | 376 | G.H5.08 |
Van-der-waals | ICL2 | F | 960 | - | G.H5 | F | 376 | G.H5.08 |
Hydrophobic | C-term | I | 1169 | - | G.H2 | W | 234 | G.H2.07 |
Polar | C-term | Y | 1207 | - | G.HN | Q | 19 | G.HN.36 |
Hydrophobic | C-term | Y | 1207 | - | G.HN | Q | 19 | G.HN.36 |
Van-der-waals | C-term | Y | 1207 | - | G.HN | Q | 19 | G.HN.36 |
Hydrophobic | ICL2 | V | 959 | - | G.H5 | R | 380 | G.H5.12 |
Van-der-waals | ICL2 | V | 959 | - | G.H5 | R | 380 | G.H5.12 |
Hydrophobic | ICL2 | V | 959 | - | G.H5 | I | 383 | G.H5.15 |
Van-der-waals | ICL2 | V | 959 | - | G.H5 | I | 383 | G.H5.15 |
Polar | ICL2 | S | 962 | - | G.HN | Q | 35 | G.HN.52 |
Van-der-waals | ICL2 | S | 962 | - | G.HN | Q | 35 | G.HN.52 |
Hydrophobic | C-term | K | 1162 | - | G.H2 | I | 235 | G.H2.08 |
Van-der-waals | C-term | K | 1162 | - | G.H2 | I | 235 | G.H2.08 |
Hydrophobic | TM5 | L | 1040 | 5x68 | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | TM5 | L | 1040 | 5x68 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | ICL2 | S | 962 | - | G.hns1 | A | 39 | G.hns1.03 |
Polar | TM5 | H | 1036 | 5x64 | G.H5 | R | 385 | G.H5.17 |
Hydrophobic | TM5 | H | 1036 | 5x64 | G.H5 | R | 385 | G.H5.17 |
Van-der-waals | TM5 | H | 1036 | 5x64 | G.H5 | R | 385 | G.H5.17 |
Polar | ICL2 | E | 963 | - | G.S3 | N | 218 | G.S3.02 |
Van-der-waals | ICL2 | E | 963 | - | G.S3 | N | 218 | G.S3.02 |
Polar | TM5 | K | 1032 | 5x60 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | TM5 | K | 1032 | 5x60 | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | TM5 | K | 1032 | 5x60 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | ICL2 | F | 960 | - | G.H5 | C | 379 | G.H5.11 |
Hydrophobic | C-term | K | 1162 | - | G.H3 | W | 281 | G.H3.17 |
Van-der-waals | C-term | K | 1162 | - | G.H3 | W | 281 | G.H3.17 |
Hydrophobic | C-term | I | 1169 | - | G.H3 | L | 272 | G.H3.08 |
Hydrophobic | ICL2 | E | 963 | - | G.HN | Q | 35 | G.HN.52 |
Van-der-waals | ICL2 | E | 963 | - | G.HN | Q | 35 | G.HN.52 |
Hydrophobic | TM5 | H | 1036 | 5x64 | G.H5 | L | 388 | G.H5.20 |
Van-der-waals | TM5 | H | 1036 | 5x64 | G.H5 | L | 388 | G.H5.20 |
Hydrophobic | TM5 | I | 1039 | 5x67 | G.H5 | R | 385 | G.H5.17 |
Hydrophobic | C-term | F | 1168 | - | G.H3 | N | 279 | G.H3.15 |
Polar | TM3 | M | 955 | 3x57 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | TM3 | M | 955 | 3x57 | G.H5 | H | 387 | G.H5.19 |
Van-der-waals | TM3 | M | 955 | 3x57 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | TM3 | M | 955 | 3x57 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM3 | M | 955 | 3x57 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | C-term | M | 1155 | - | G.h2s4 | N | 239 | G.h2s4.02 |
Van-der-waals | C-term | M | 1155 | - | G.h2s4 | N | 239 | G.h2s4.02 |
Hydrophobic | C-term | Q | 1163 | - | G.H2 | I | 235 | G.H2.08 |
Aromatic | ICL2 | F | 960 | - | G.S1 | H | 41 | G.S1.02 |
Hydrophobic | ICL2 | F | 960 | - | G.S1 | H | 41 | G.S1.02 |
Van-der-waals | ICL2 | F | 960 | - | G.S1 | H | 41 | G.S1.02 |
Hydrophobic | TM3 | L | 956 | 3x58 | G.H5 | L | 388 | G.H5.20 |
Van-der-waals | TM3 | L | 956 | 3x58 | G.H5 | L | 388 | G.H5.20 |
Hydrophobic | TM5 | M | 1033 | 5x61 | G.H5 | L | 394 | G.H5.26 |
Polar | TM3 | L | 956 | 3x58 | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | TM3 | L | 956 | 3x58 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | ICL2 | E | 961 | - | G.hns1 | A | 39 | G.hns1.03 |
Van-der-waals | ICL2 | E | 961 | - | G.hns1 | A | 39 | G.hns1.03 |
Ionic | C-term | E | 1165 | - | G.H3 | R | 280 | G.H3.16 |
Polar | C-term | E | 1165 | - | G.H3 | R | 280 | G.H3.16 |
Hydrophobic | C-term | E | 1165 | - | G.H3 | R | 280 | G.H3.16 |
Van-der-waals | C-term | E | 1165 | - | G.H3 | R | 280 | G.H3.16 |
Ionic | TM5 | H | 1036 | 5x64 | G.H5 | D | 381 | G.H5.13 |
Polar | TM5 | H | 1036 | 5x64 | G.H5 | D | 381 | G.H5.13 |
Hydrophobic | TM5 | H | 1036 | 5x64 | G.H5 | D | 381 | G.H5.13 |
Van-der-waals | TM5 | H | 1036 | 5x64 | G.H5 | D | 381 | G.H5.13 |
Polar | ICL2 | E | 961 | - | G.HN | Q | 35 | G.HN.52 |
Van-der-waals | ICL2 | E | 961 | - | G.HN | Q | 35 | G.HN.52 |
Hydrophobic | ICL2 | F | 960 | - | G.S3 | F | 219 | G.S3.03 |
Hydrophobic | TM5 | T | 1037 | 5x65 | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | TM5 | T | 1037 | 5x65 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | TM5 | M | 1033 | 5x61 | G.H5 | L | 388 | G.H5.20 |
Van-der-waals | TM5 | M | 1033 | 5x61 | G.H5 | L | 388 | G.H5.20 |
Polar | H8 | K | 1107 | 8x49 | G.H5 | Q | 390 | G.H5.22 |
Hydrophobic | H8 | K | 1107 | 8x49 | G.H5 | Q | 390 | G.H5.22 |
Van-der-waals | H8 | K | 1107 | 8x49 | G.H5 | Q | 390 | G.H5.22 |
Hydrophobic | TM6 | L | 1060 | 6x45 | G.H5 | L | 393 | G.H5.25 |
Polar | TM5 | H | 1036 | 5x64 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | TM5 | H | 1036 | 5x64 | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | TM5 | H | 1036 | 5x64 | G.H5 | Q | 384 | G.H5.16 |
Polar | TM2 | R | 896 | 2x46 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM2 | R | 896 | 2x46 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM2 | R | 896 | 2x46 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | C-term | E | 1165 | - | G.H3 | W | 281 | G.H3.17 |
Hydrophobic | ICL2 | V | 959 | - | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | ICL2 | V | 959 | - | G.H5 | Q | 384 | G.H5.16 |
Ionic | ICL2 | E | 961 | - | G.hns1 | R | 38 | G.hns1.02 |
Polar | ICL2 | E | 961 | - | G.hns1 | R | 38 | G.hns1.02 |
Hydrophobic | ICL2 | E | 961 | - | G.hns1 | R | 38 | G.hns1.02 |
Van-der-waals | ICL2 | E | 961 | - | G.hns1 | R | 38 | G.hns1.02 |
Hydrophobic | C-term | S | 1166 | - | G.H2 | I | 235 | G.H2.08 |