GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 66.0
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.6
iPTM Score: 0.6
PAE mean: 14.0
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | C-term | R | 1143 | - | G.h2s4 | E | 216 | G.h2s4.02 |
Van-der-waals | C-term | R | 1143 | - | G.h2s4 | E | 216 | G.h2s4.02 |
Hydrophobic | C-term | M | 1155 | - | G.H3 | F | 258 | G.H3.17 |
Van-der-waals | C-term | M | 1155 | - | G.H3 | F | 258 | G.H3.17 |
Hydrophobic | C-term | Y | 1393 | - | G.S2 | I | 184 | G.S2.01 |
Van-der-waals | C-term | Y | 1393 | - | G.S2 | I | 184 | G.S2.01 |
Hydrophobic | C-term | Y | 1393 | - | G.S3 | F | 199 | G.S3.06 |
Aromatic | C-term | Y | 1392 | - | G.H2 | H | 213 | G.H2.09 |
Hydrophobic | C-term | Y | 1392 | - | G.H2 | H | 213 | G.H2.09 |
Hydrophobic | C-term | L | 1408 | - | H.HA | F | 69 | H.HA.07 |
Hydrophobic | ICL2 | E | 961 | - | G.s2s3 | D | 193 | G.s2s3.02 |
Hydrophobic | C-term | L | 1363 | - | H.HA | E | 65 | H.HA.03 |
Hydrophobic | C-term | I | 1152 | - | G.H3 | F | 258 | G.H3.17 |
Van-der-waals | C-term | I | 1152 | - | G.H3 | F | 258 | G.H3.17 |
Hydrophobic | TM3 | L | 956 | 3x58 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | C-term | I | 1423 | - | H.HA | A | 87 | H.HA.25 |
Van-der-waals | C-term | I | 1423 | - | H.HA | A | 87 | H.HA.25 |
Hydrophobic | TM5 | M | 1033 | 5x61 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | C-term | S | 1395 | - | G.S2 | I | 185 | G.S2.02 |
Ionic | ICL1 | R | 890 | 12x48 | G.HN | E | 20 | G.HN.44 |
Polar | ICL1 | R | 890 | 12x48 | G.HN | E | 20 | G.HN.44 |
Hydrophobic | ICL1 | R | 890 | 12x48 | G.HN | E | 20 | G.HN.44 |
Van-der-waals | ICL1 | R | 890 | 12x48 | G.HN | E | 20 | G.HN.44 |
Van-der-waals | ICL2 | F | 960 | - | G.s2s3 | K | 192 | G.s2s3.01 |
Hydrophobic | C-term | L | 1399 | - | H.HA | F | 69 | H.HA.07 |
Hydrophobic | TM3 | L | 952 | 3x54 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | L | 952 | 3x54 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | C-term | I | 1152 | - | G.h2s4 | F | 215 | G.h2s4.01 |
Hydrophobic | C-term | R | 1153 | - | G.H2 | I | 212 | G.H2.08 |
Hydrophobic | C-term | V | 1424 | - | G.s4h3 | V | 233 | G.s4h3.07 |
Hydrophobic | C-term | F | 1422 | - | G.s4h3 | D | 238 | G.s4h3.12 |
Van-der-waals | C-term | F | 1422 | - | G.s4h3 | D | 238 | G.s4h3.12 |
Polar | TM5 | L | 1040 | 5x68 | G.H5 | K | 345 | G.H5.17 |
Hydrophobic | TM5 | L | 1040 | 5x68 | G.H5 | K | 345 | G.H5.17 |
Van-der-waals | TM5 | L | 1040 | 5x68 | G.H5 | K | 345 | G.H5.17 |
Hydrophobic | ICL2 | F | 960 | - | G.H5 | V | 339 | G.H5.11 |
Hydrophobic | C-term | T | 1140 | - | G.HN | L | 23 | G.HN.47 |
Polar | TM2 | R | 896 | 2x46 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM2 | R | 896 | 2x46 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM2 | R | 896 | 2x46 | G.H5 | C | 351 | G.H5.23 |
Polar | C-term | Y | 1411 | - | G.hfs2 | T | 182 | G.hfs2.06 |
Polar | C-term | Q | 1149 | - | G.h2s4 | E | 216 | G.h2s4.02 |
Van-der-waals | C-term | Q | 1149 | - | G.h2s4 | E | 216 | G.h2s4.02 |
Hydrophobic | C-term | W | 1156 | - | G.H2 | W | 211 | G.H2.07 |
Van-der-waals | C-term | W | 1156 | - | G.H2 | W | 211 | G.H2.07 |
Hydrophobic | ICL2 | F | 960 | - | G.H5 | I | 343 | G.H5.15 |
Hydrophobic | C-term | L | 1408 | - | H.HA | I | 72 | H.HA.10 |
Van-der-waals | C-term | L | 1408 | - | H.HA | I | 72 | H.HA.10 |
Polar | C-term | T | 1170 | - | G.H3 | H | 248 | G.H3.07 |
Hydrophobic | C-term | T | 1170 | - | G.H3 | H | 248 | G.H3.07 |
Van-der-waals | C-term | T | 1170 | - | G.H3 | H | 248 | G.H3.07 |
Hydrophobic | C-term | I | 1423 | - | H.HA | R | 86 | H.HA.24 |
Van-der-waals | C-term | I | 1423 | - | H.HA | R | 86 | H.HA.24 |
Hydrophobic | C-term | M | 1396 | - | G.H1 | K | 54 | G.H1.09 |
Hydrophobic | ICL2 | F | 960 | - | G.H5 | T | 340 | G.H5.12 |
Van-der-waals | ICL2 | F | 960 | - | G.H5 | T | 340 | G.H5.12 |
Hydrophobic | ICL2 | E | 963 | - | G.s2s3 | D | 193 | G.s2s3.02 |
Hydrophobic | C-term | Y | 1392 | - | G.hfs2 | G | 183 | G.hfs2.07 |
Van-der-waals | C-term | Y | 1392 | - | G.hfs2 | G | 183 | G.hfs2.07 |
Hydrophobic | TM5 | H | 1036 | 5x64 | G.H5 | L | 348 | G.H5.20 |
Polar | C-term | Y | 1144 | - | G.h2s4 | E | 216 | G.h2s4.02 |
Hydrophobic | C-term | Y | 1144 | - | G.h2s4 | E | 216 | G.h2s4.02 |
Van-der-waals | C-term | Y | 1144 | - | G.h2s4 | E | 216 | G.h2s4.02 |
Hydrophobic | TM3 | L | 956 | 3x58 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM3 | L | 956 | 3x58 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | C-term | W | 1156 | - | G.H2 | I | 212 | G.H2.08 |
Van-der-waals | C-term | W | 1156 | - | G.H2 | I | 212 | G.H2.08 |
Hydrophobic | ICL2 | F | 960 | - | G.S3 | L | 194 | G.S3.01 |
Van-der-waals | ICL2 | F | 960 | - | G.S3 | L | 194 | G.S3.01 |
Hydrophobic | C-term | Y | 1392 | - | G.H2 | K | 210 | G.H2.06 |
Van-der-waals | C-term | Y | 1392 | - | G.H2 | K | 210 | G.H2.06 |
Polar | H8 | Q | 1105 | 8x47 | G.H5 | C | 351 | G.H5.23 |
Polar | C-term | R | 1153 | - | G.H2 | H | 213 | G.H2.09 |
Hydrophobic | C-term | R | 1153 | - | G.H2 | H | 213 | G.H2.09 |
Van-der-waals | C-term | R | 1153 | - | G.H2 | H | 213 | G.H2.09 |
Van-der-waals | C-term | W | 1156 | - | G.H3 | S | 252 | G.H3.11 |
Polar | C-term | K | 1394 | - | G.S2 | I | 185 | G.S2.02 |
Hydrophobic | C-term | K | 1394 | - | G.S2 | I | 185 | G.S2.02 |
Van-der-waals | C-term | K | 1394 | - | G.S2 | I | 185 | G.S2.02 |
Hydrophobic | C-term | M | 1396 | - | G.S2 | I | 185 | G.S2.02 |
Van-der-waals | C-term | M | 1396 | - | G.S2 | I | 185 | G.S2.02 |
Hydrophobic | TM5 | M | 1033 | 5x61 | G.H5 | L | 348 | G.H5.20 |
Ionic | ICL3 | E | 1043 | - | G.h4s6 | K | 314 | G.h4s6.08 |
Hydrophobic | ICL3 | E | 1043 | - | G.h4s6 | K | 314 | G.h4s6.08 |
Van-der-waals | ICL3 | E | 1043 | - | G.h4s6 | K | 314 | G.h4s6.08 |
Hydrophobic | C-term | M | 1396 | - | G.H1 | V | 50 | G.H1.05 |
Polar | TM3 | M | 955 | 3x57 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM3 | M | 955 | 3x57 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | TM3 | M | 955 | 3x57 | G.H5 | N | 347 | G.H5.19 |
Polar | H8 | Q | 1105 | 8x47 | G.H5 | D | 350 | G.H5.22 |
Van-der-waals | H8 | Q | 1105 | 8x47 | G.H5 | D | 350 | G.H5.22 |
Hydrophobic | C-term | L | 1408 | - | H.HA | E | 68 | H.HA.06 |
Van-der-waals | C-term | L | 1408 | - | H.HA | E | 68 | H.HA.06 |
Polar | C-term | L | 1399 | - | H.HA | E | 65 | H.HA.03 |
Hydrophobic | C-term | L | 1399 | - | H.HA | E | 65 | H.HA.03 |
Van-der-waals | C-term | L | 1399 | - | H.HA | E | 65 | H.HA.03 |
Polar | C-term | K | 1394 | - | G.hfs2 | T | 182 | G.hfs2.06 |
Van-der-waals | C-term | K | 1394 | - | G.hfs2 | T | 182 | G.hfs2.06 |
Polar | C-term | Q | 1163 | - | G.H3 | H | 248 | G.H3.07 |
Hydrophobic | C-term | Q | 1163 | - | G.H3 | L | 249 | G.H3.08 |
Van-der-waals | C-term | Q | 1163 | - | G.H3 | L | 249 | G.H3.08 |
Hydrophobic | C-term | I | 1423 | - | H.HA | T | 90 | H.HA.28 |
Van-der-waals | C-term | I | 1423 | - | H.HA | T | 90 | H.HA.28 |
Polar | C-term | Y | 1393 | - | G.H2 | C | 214 | G.H2.10 |
Hydrophobic | C-term | Y | 1393 | - | G.H2 | C | 214 | G.H2.10 |
Polar | C-term | M | 1396 | - | G.S2 | E | 186 | G.S2.03 |
Polar | C-term | G | 1400 | - | H.HA | E | 65 | H.HA.03 |
Aromatic | C-term | W | 1156 | - | G.H3 | H | 256 | G.H3.15 |
Hydrophobic | C-term | W | 1156 | - | G.H3 | H | 256 | G.H3.15 |
Hydrophobic | C-term | R | 1416 | - | H.hbhc | E | 116 | H.hbhc.04 |
Van-der-waals | C-term | R | 1416 | - | H.hbhc | E | 116 | H.hbhc.04 |
Hydrophobic | TM5 | L | 1040 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | ICL2 | V | 959 | - | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | ICL2 | V | 959 | - | G.H5 | I | 344 | G.H5.16 |
Polar | C-term | Q | 1163 | - | G.H3 | S | 252 | G.H3.11 |
Van-der-waals | C-term | Q | 1163 | - | G.H3 | S | 252 | G.H3.11 |
Polar | C-term | Y | 1392 | - | G.S2 | I | 184 | G.S2.01 |
Hydrophobic | C-term | Y | 1392 | - | G.S2 | I | 184 | G.S2.01 |
Van-der-waals | C-term | Y | 1392 | - | G.S2 | I | 184 | G.S2.01 |
Polar | C-term | S | 1419 | - | H.HA | R | 86 | H.HA.24 |
Hydrophobic | TM3 | L | 956 | 3x58 | G.H5 | I | 344 | G.H5.16 |
Aromatic | ICL3 | K | 1041 | - | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | ICL3 | K | 1041 | - | G.H5 | F | 354 | G.H5.26 |
Van-der-waals | ICL3 | K | 1041 | - | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | C-term | M | 1155 | - | G.H3 | K | 257 | G.H3.16 |
Polar | C-term | G | 1415 | - | H.HA | Q | 79 | H.HA.17 |
Hydrophobic | C-term | V | 1160 | - | G.H2 | R | 208 | G.H2.04 |
Hydrophobic | C-term | W | 1156 | - | G.H3 | I | 253 | G.H3.12 |
Van-der-waals | C-term | W | 1156 | - | G.H3 | I | 253 | G.H3.12 |
Hydrophobic | C-term | T | 1159 | - | G.H3 | S | 252 | G.H3.11 |
Van-der-waals | C-term | T | 1159 | - | G.H3 | S | 252 | G.H3.11 |
Polar | ICL2 | S | 962 | - | G.hns1 | K | 32 | G.hns1.03 |
Hydrophobic | ICL2 | S | 962 | - | G.hns1 | K | 32 | G.hns1.03 |
Van-der-waals | ICL2 | S | 962 | - | G.hns1 | K | 32 | G.hns1.03 |
Polar | TM6 | S | 1052 | 6x37 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM6 | G | 1056 | 6x41 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | G | 1056 | 6x41 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | C-term | I | 1423 | - | H.hdhe | Y | 146 | H.hdhe.01 |
Hydrophobic | C-term | P | 1425 | - | H.HA | T | 90 | H.HA.28 |
Hydrophobic | TM6 | L | 1060 | 6x45 | G.H5 | L | 353 | G.H5.25 |
Ionic | TM5 | H | 1036 | 5x64 | G.H5 | D | 341 | G.H5.13 |
Polar | TM5 | H | 1036 | 5x64 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM5 | H | 1036 | 5x64 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM5 | H | 1036 | 5x64 | G.H5 | D | 341 | G.H5.13 |
Polar | C-term | S | 1395 | - | G.S2 | E | 186 | G.S2.03 |
Hydrophobic | C-term | S | 1395 | - | G.S2 | E | 186 | G.S2.03 |
Van-der-waals | C-term | S | 1395 | - | G.S2 | E | 186 | G.S2.03 |
Hydrophobic | C-term | Y | 1412 | - | G.hfs2 | V | 179 | G.hfs2.03 |
Van-der-waals | C-term | Y | 1412 | - | G.hfs2 | V | 179 | G.hfs2.03 |
Polar | C-term | Y | 1393 | - | G.H2 | H | 213 | G.H2.09 |
Hydrophobic | C-term | Y | 1393 | - | G.H2 | H | 213 | G.H2.09 |
Van-der-waals | C-term | Y | 1393 | - | G.H2 | H | 213 | G.H2.09 |
Hydrophobic | TM3 | M | 955 | 3x57 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | M | 955 | 3x57 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | ICL2 | V | 959 | - | G.H5 | I | 343 | G.H5.15 |
Van-der-waals | ICL2 | V | 959 | - | G.H5 | I | 343 | G.H5.15 |
Hydrophobic | C-term | L | 1414 | - | H.HA | I | 72 | H.HA.10 |
Aromatic | C-term | W | 1156 | - | G.h2s4 | F | 215 | G.h2s4.01 |
Hydrophobic | C-term | W | 1156 | - | G.h2s4 | F | 215 | G.h2s4.01 |
Van-der-waals | C-term | W | 1156 | - | G.h2s4 | F | 215 | G.h2s4.01 |
Hydrophobic | C-term | G | 1417 | - | H.HA | Q | 79 | H.HA.17 |
Polar | H8 | K | 1106 | 8x48 | G.H5 | F | 354 | G.H5.26 |
Van-der-waals | H8 | K | 1106 | 8x48 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | TM5 | L | 1040 | 5x68 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | TM5 | H | 1036 | 5x64 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | TM5 | H | 1036 | 5x64 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | C-term | Y | 1412 | - | G.hfs2 | K | 180 | G.hfs2.04 |
Aromatic | ICL2 | F | 960 | - | G.H5 | F | 336 | G.H5.08 |
Hydrophobic | ICL2 | F | 960 | - | G.H5 | F | 336 | G.H5.08 |
Van-der-waals | ICL2 | F | 960 | - | G.H5 | F | 336 | G.H5.08 |
Hydrophobic | C-term | L | 1363 | - | H.HA | E | 68 | H.HA.06 |
Van-der-waals | C-term | L | 1363 | - | H.HA | E | 68 | H.HA.06 |
Hydrophobic | C-term | M | 1360 | - | G.S2 | T | 187 | G.S2.04 |
Hydrophobic | C-term | R | 1151 | - | G.H3 | F | 258 | G.H3.17 |
Hydrophobic | TM5 | T | 1037 | 5x65 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | C-term | M | 1155 | - | G.H3 | H | 256 | G.H3.15 |
Van-der-waals | C-term | M | 1155 | - | G.H3 | H | 256 | G.H3.15 |
Ionic | H8 | K | 1107 | 8x49 | G.H5 | D | 350 | G.H5.22 |
Polar | H8 | K | 1107 | 8x49 | G.H5 | D | 350 | G.H5.22 |
Hydrophobic | H8 | K | 1107 | 8x49 | G.H5 | D | 350 | G.H5.22 |
Van-der-waals | H8 | K | 1107 | 8x49 | G.H5 | D | 350 | G.H5.22 |
Polar | TM6 | S | 1052 | 6x37 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | H8 | Q | 1105 | 8x47 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | H8 | Q | 1105 | 8x47 | G.H5 | G | 352 | G.H5.24 |
Polar | C-term | W | 1156 | - | G.H2 | R | 208 | G.H2.04 |
Van-der-waals | C-term | W | 1156 | - | G.H2 | R | 208 | G.H2.04 |
Hydrophobic | C-term | I | 1152 | - | G.H3 | H | 256 | G.H3.15 |
Polar | ICL2 | E | 963 | - | G.hns1 | K | 32 | G.hns1.03 |
Hydrophobic | ICL2 | E | 963 | - | G.hns1 | K | 32 | G.hns1.03 |
Van-der-waals | ICL2 | E | 963 | - | G.hns1 | K | 32 | G.hns1.03 |
Hydrophobic | C-term | S | 1167 | - | G.H2 | R | 205 | G.H2.01 |
Hydrophobic | C-term | I | 1423 | - | H.HA | L | 91 | H.HA.29 |
Van-der-waals | C-term | I | 1423 | - | H.HA | L | 91 | H.HA.29 |
Hydrophobic | C-term | I | 1152 | - | G.H2 | I | 212 | G.H2.08 |
Van-der-waals | C-term | I | 1152 | - | G.H2 | I | 212 | G.H2.08 |
Polar | TM2 | R | 896 | 2x46 | G.H5 | D | 350 | G.H5.22 |
Van-der-waals | TM2 | R | 896 | 2x46 | G.H5 | D | 350 | G.H5.22 |
Hydrophobic | C-term | S | 1167 | - | G.s4h3 | V | 240 | G.s4h3.14 |
Hydrophobic | ICL2 | V | 959 | - | G.H5 | T | 340 | G.H5.12 |
Polar | C-term | G | 1417 | - | H.HA | R | 86 | H.HA.24 |
Van-der-waals | C-term | G | 1417 | - | H.HA | R | 86 | H.HA.24 |
Hydrophobic | TM5 | L | 1040 | 5x68 | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | TM5 | L | 1040 | 5x68 | G.h4s6 | E | 318 | G.h4s6.12 |
Polar | C-term | K | 1394 | - | G.S2 | I | 184 | G.S2.01 |
Hydrophobic | C-term | K | 1394 | - | G.S2 | I | 184 | G.S2.01 |
Van-der-waals | C-term | K | 1394 | - | G.S2 | I | 184 | G.S2.01 |
Polar | C-term | S | 1395 | - | G.S2 | I | 184 | G.S2.01 |
Ionic | C-term | R | 1143 | - | G.hns1 | E | 30 | G.hns1.01 |
Polar | C-term | R | 1143 | - | G.hns1 | E | 30 | G.hns1.01 |
Hydrophobic | C-term | R | 1143 | - | G.hns1 | E | 30 | G.hns1.01 |
Van-der-waals | C-term | R | 1143 | - | G.hns1 | E | 30 | G.hns1.01 |
Hydrophobic | C-term | S | 1175 | - | G.hgh4 | P | 288 | G.hgh4.03 |
Hydrophobic | C-term | V | 1424 | - | G.s4h3 | D | 238 | G.s4h3.12 |
Polar | C-term | Q | 1163 | - | G.H2 | R | 208 | G.H2.04 |
Van-der-waals | C-term | Q | 1163 | - | G.H2 | R | 208 | G.H2.04 |
Hydrophobic | C-term | V | 1160 | - | G.H2 | K | 209 | G.H2.05 |
Hydrophobic | C-term | Y | 1412 | - | G.S2 | I | 185 | G.S2.02 |