GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 64.8
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.6
iPTM Score: 0.7
PAE mean: 14.2
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM5 | H | 1036 | 5x64 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | C-term | I | 1152 | - | G.H3 | W | 259 | G.H3.17 |
Van-der-waals | C-term | I | 1152 | - | G.H3 | W | 259 | G.H3.17 |
Hydrophobic | TM3 | L | 956 | 3x58 | G.H5 | L | 349 | G.H5.20 |
Van-der-waals | TM3 | L | 956 | 3x58 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | TM3 | L | 952 | 3x54 | G.H5 | I | 352 | G.H5.23 |
Van-der-waals | TM3 | L | 952 | 3x54 | G.H5 | I | 352 | G.H5.23 |
Hydrophobic | TM6 | L | 1060 | 6x45 | G.H5 | I | 352 | G.H5.23 |
Hydrophobic | C-term | M | 1155 | - | G.H3 | W | 259 | G.H3.17 |
Hydrophobic | TM5 | L | 1040 | 5x68 | G.S6 | Y | 321 | G.S6.02 |
Hydrophobic | C-term | W | 1156 | - | G.H3 | I | 254 | G.H3.12 |
Van-der-waals | C-term | W | 1156 | - | G.H3 | I | 254 | G.H3.12 |
Hydrophobic | TM3 | L | 956 | 3x58 | G.H5 | I | 345 | G.H5.16 |
Hydrophobic | TM5 | M | 1033 | 5x61 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | ICL2 | V | 959 | - | G.H5 | I | 345 | G.H5.16 |
Van-der-waals | ICL2 | V | 959 | - | G.H5 | I | 345 | G.H5.16 |
Hydrophobic | TM5 | H | 1036 | 5x64 | G.H5 | I | 345 | G.H5.16 |
Van-der-waals | TM5 | H | 1036 | 5x64 | G.H5 | I | 345 | G.H5.16 |
Polar | TM2 | R | 896 | 2x46 | G.H5 | Y | 351 | G.H5.22 |
Aromatic | TM2 | R | 896 | 2x46 | G.H5 | Y | 351 | G.H5.22 |
Hydrophobic | C-term | W | 1156 | - | G.H3 | L | 250 | G.H3.08 |
Polar | C-term | Q | 1163 | - | G.H2 | R | 206 | G.H2.01 |
Hydrophobic | C-term | K | 1394 | - | G.S2 | V | 186 | G.S2.02 |
Hydrophobic | C-term | Q | 1149 | - | G.H2 | I | 213 | G.H2.08 |
Van-der-waals | C-term | Q | 1149 | - | G.H2 | I | 213 | G.H2.08 |
Hydrophobic | C-term | V | 1160 | - | G.H2 | K | 210 | G.H2.05 |
Aromatic | ICL2 | F | 960 | - | G.H5 | F | 337 | G.H5.08 |
Hydrophobic | ICL2 | F | 960 | - | G.H5 | F | 337 | G.H5.08 |
Van-der-waals | ICL2 | F | 960 | - | G.H5 | F | 337 | G.H5.08 |
Hydrophobic | C-term | Y | 1393 | - | G.S2 | I | 185 | G.S2.01 |
Van-der-waals | C-term | Y | 1393 | - | G.S2 | I | 185 | G.S2.01 |
Polar | C-term | T | 1170 | - | G.H3 | R | 249 | G.H3.07 |
Van-der-waals | C-term | T | 1170 | - | G.H3 | R | 249 | G.H3.07 |
Hydrophobic | C-term | M | 1396 | - | G.H1 | K | 54 | G.H1.09 |
Hydrophobic | ICL2 | F | 960 | - | G.H5 | V | 340 | G.H5.11 |
Polar | ICL2 | S | 965 | - | G.HN | Q | 28 | G.HN.52 |
Hydrophobic | ICL2 | S | 965 | - | G.HN | Q | 28 | G.HN.52 |
Van-der-waals | ICL2 | S | 965 | - | G.HN | Q | 28 | G.HN.52 |
Polar | TM5 | T | 1037 | 5x65 | G.H5 | C | 355 | G.H5.26 |
Hydrophobic | TM5 | M | 1033 | 5x61 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM5 | M | 1033 | 5x61 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM3 | L | 956 | 3x58 | G.H5 | N | 348 | G.H5.19 |
Aromatic | C-term | W | 1156 | - | G.H2 | W | 212 | G.H2.07 |
Hydrophobic | C-term | W | 1156 | - | G.H2 | W | 212 | G.H2.07 |
Van-der-waals | C-term | W | 1156 | - | G.H2 | W | 212 | G.H2.07 |
Polar | H8 | Q | 1105 | 8x47 | G.H5 | Y | 351 | G.H5.22 |
Van-der-waals | H8 | Q | 1105 | 8x47 | G.H5 | Y | 351 | G.H5.22 |
Hydrophobic | C-term | R | 1153 | - | G.H2 | I | 213 | G.H2.08 |
Van-der-waals | C-term | R | 1153 | - | G.H2 | I | 213 | G.H2.08 |
Polar | C-term | K | 1394 | - | G.S2 | I | 185 | G.S2.01 |
Hydrophobic | C-term | M | 1396 | - | G.S2 | N | 188 | G.S2.04 |
Hydrophobic | C-term | L | 1399 | - | H.HA | A | 65 | H.HA.03 |
Van-der-waals | C-term | L | 1399 | - | H.HA | A | 65 | H.HA.03 |
Polar | C-term | T | 1159 | - | G.H3 | S | 253 | G.H3.11 |
Hydrophobic | C-term | T | 1159 | - | G.H3 | S | 253 | G.H3.11 |
Van-der-waals | C-term | T | 1159 | - | G.H3 | S | 253 | G.H3.11 |
Hydrophobic | C-term | M | 1396 | - | H.HA | Y | 69 | H.HA.07 |
Van-der-waals | C-term | M | 1396 | - | H.HA | Y | 69 | H.HA.07 |
Hydrophobic | C-term | M | 1396 | - | G.S2 | V | 186 | G.S2.02 |
Polar | TM2 | R | 896 | 2x46 | G.H5 | I | 352 | G.H5.23 |
Hydrophobic | TM2 | R | 896 | 2x46 | G.H5 | I | 352 | G.H5.23 |
Van-der-waals | TM2 | R | 896 | 2x46 | G.H5 | I | 352 | G.H5.23 |
Hydrophobic | TM3 | M | 955 | 3x57 | G.H5 | I | 352 | G.H5.23 |
Van-der-waals | TM3 | M | 955 | 3x57 | G.H5 | I | 352 | G.H5.23 |
Hydrophobic | ICL2 | V | 959 | - | G.H5 | I | 344 | G.H5.15 |
Van-der-waals | ICL2 | V | 959 | - | G.H5 | I | 344 | G.H5.15 |
Polar | TM6 | S | 1052 | 6x37 | G.H5 | C | 355 | G.H5.26 |
Hydrophobic | ICL2 | F | 960 | - | G.S3 | L | 195 | G.S3.01 |
Van-der-waals | ICL2 | F | 960 | - | G.S3 | L | 195 | G.S3.01 |
Hydrophobic | C-term | M | 1155 | - | G.H3 | N | 257 | G.H3.15 |
Van-der-waals | C-term | M | 1155 | - | G.H3 | N | 257 | G.H3.15 |
Hydrophobic | C-term | I | 1152 | - | G.h2s4 | F | 216 | G.h2s4.01 |
Van-der-waals | C-term | I | 1152 | - | G.h2s4 | F | 216 | G.h2s4.01 |
Polar | C-term | Q | 1163 | - | G.H2 | R | 209 | G.H2.04 |
Hydrophobic | C-term | Q | 1163 | - | G.H2 | R | 209 | G.H2.04 |
Van-der-waals | C-term | Q | 1163 | - | G.H2 | R | 209 | G.H2.04 |
Polar | TM2 | S | 894 | 2x44 | G.H5 | Y | 351 | G.H5.22 |
Van-der-waals | TM2 | S | 894 | 2x44 | G.H5 | Y | 351 | G.H5.22 |
Polar | C-term | R | 1153 | - | G.H2 | H | 214 | G.H2.09 |
Hydrophobic | C-term | R | 1153 | - | G.H2 | H | 214 | G.H2.09 |
Van-der-waals | C-term | R | 1153 | - | G.H2 | H | 214 | G.H2.09 |
Hydrophobic | ICL2 | S | 962 | - | G.hns1 | R | 32 | G.hns1.03 |
Ionic | ICL2 | E | 961 | - | G.hns1 | R | 31 | G.hns1.02 |
Polar | ICL2 | E | 961 | - | G.hns1 | R | 31 | G.hns1.02 |
Hydrophobic | ICL2 | E | 961 | - | G.hns1 | R | 31 | G.hns1.02 |
Van-der-waals | ICL2 | E | 961 | - | G.hns1 | R | 31 | G.hns1.02 |
Polar | ICL3 | K | 1041 | - | G.h4s6 | E | 316 | G.h4s6.09 |
Hydrophobic | ICL3 | K | 1041 | - | G.h4s6 | E | 316 | G.h4s6.09 |
Van-der-waals | ICL3 | K | 1041 | - | G.h4s6 | E | 316 | G.h4s6.09 |
Hydrophobic | ICL2 | F | 960 | - | G.S1 | I | 34 | G.S1.02 |
Van-der-waals | ICL2 | F | 960 | - | G.S1 | I | 34 | G.S1.02 |
Hydrophobic | C-term | M | 1194 | - | H.HA | R | 86 | H.HA.24 |
Polar | C-term | R | 1151 | - | G.H3 | W | 259 | G.H3.17 |
Hydrophobic | C-term | R | 1151 | - | G.H3 | W | 259 | G.H3.17 |
Polar | C-term | W | 1156 | - | G.H2 | R | 209 | G.H2.04 |
Hydrophobic | C-term | W | 1156 | - | G.H2 | R | 209 | G.H2.04 |
Van-der-waals | C-term | W | 1156 | - | G.H2 | R | 209 | G.H2.04 |
Hydrophobic | C-term | L | 1197 | - | H.HB | G | 112 | H.HB.14 |
Hydrophobic | TM3 | M | 955 | 3x57 | G.H5 | Y | 351 | G.H5.22 |
Hydrophobic | C-term | I | 1152 | - | G.H2 | I | 213 | G.H2.08 |
Van-der-waals | C-term | I | 1152 | - | G.H2 | I | 213 | G.H2.08 |
Ionic | ICL2 | E | 963 | - | G.HN | R | 29 | G.HN.53 |
Polar | ICL2 | E | 963 | - | G.HN | R | 29 | G.HN.53 |
Hydrophobic | ICL2 | E | 963 | - | G.HN | R | 29 | G.HN.53 |
Van-der-waals | ICL2 | E | 963 | - | G.HN | R | 29 | G.HN.53 |
Hydrophobic | H8 | K | 1107 | 8x49 | G.H5 | Y | 351 | G.H5.22 |
Van-der-waals | H8 | K | 1107 | 8x49 | G.H5 | Y | 351 | G.H5.22 |
Hydrophobic | TM3 | L | 956 | 3x58 | G.H5 | I | 352 | G.H5.23 |
Hydrophobic | C-term | S | 1148 | - | G.H3 | W | 259 | G.H3.17 |
Van-der-waals | C-term | S | 1148 | - | G.H3 | W | 259 | G.H3.17 |
Polar | C-term | S | 1166 | - | G.H3 | R | 249 | G.H3.07 |
Hydrophobic | C-term | S | 1166 | - | G.H3 | R | 249 | G.H3.07 |
Van-der-waals | C-term | S | 1166 | - | G.H3 | R | 249 | G.H3.07 |
Polar | H8 | K | 1106 | 8x48 | G.H5 | C | 355 | G.H5.26 |
Hydrophobic | ICL2 | H | 964 | - | G.HN | Q | 28 | G.HN.52 |
Hydrophobic | TM6 | L | 1060 | 6x45 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM5 | K | 1032 | 5x60 | G.H5 | I | 345 | G.H5.16 |
Hydrophobic | C-term | L | 1399 | - | G.h1ha | F | 61 | G.h1ha.04 |
Hydrophobic | TM6 | G | 1056 | 6x41 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM6 | G | 1056 | 6x41 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | ICL2 | F | 960 | - | G.H5 | T | 341 | G.H5.12 |
Van-der-waals | ICL2 | F | 960 | - | G.H5 | T | 341 | G.H5.12 |
Polar | TM6 | S | 1052 | 6x37 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM6 | S | 1052 | 6x37 | G.H5 | L | 354 | G.H5.25 |
Polar | H8 | Q | 1105 | 8x47 | G.H5 | I | 352 | G.H5.23 |
Van-der-waals | H8 | Q | 1105 | 8x47 | G.H5 | I | 352 | G.H5.23 |
Ionic | TM5 | H | 1036 | 5x64 | G.H5 | D | 342 | G.H5.13 |
Polar | TM5 | H | 1036 | 5x64 | G.H5 | D | 342 | G.H5.13 |
Hydrophobic | TM5 | H | 1036 | 5x64 | G.H5 | D | 342 | G.H5.13 |
Van-der-waals | TM5 | H | 1036 | 5x64 | G.H5 | D | 342 | G.H5.13 |
Ionic | ICL2 | E | 963 | - | G.hns1 | R | 32 | G.hns1.03 |
Polar | ICL2 | E | 963 | - | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | ICL2 | E | 963 | - | G.hns1 | R | 32 | G.hns1.03 |
Van-der-waals | ICL2 | E | 963 | - | G.hns1 | R | 32 | G.hns1.03 |
Aromatic | C-term | W | 1156 | - | G.h2s4 | F | 216 | G.h2s4.01 |
Hydrophobic | C-term | W | 1156 | - | G.h2s4 | F | 216 | G.h2s4.01 |
Van-der-waals | C-term | W | 1156 | - | G.h2s4 | F | 216 | G.h2s4.01 |
Hydrophobic | ICL2 | V | 959 | - | G.H5 | T | 341 | G.H5.12 |
Hydrophobic | C-term | L | 1399 | - | G.h1ha | N | 62 | G.h1ha.05 |
Hydrophobic | ICL2 | F | 960 | - | G.H5 | I | 344 | G.H5.15 |
Van-der-waals | ICL2 | F | 960 | - | G.H5 | I | 344 | G.H5.15 |
Hydrophobic | C-term | Q | 1163 | - | G.H3 | L | 250 | G.H3.08 |
Van-der-waals | C-term | Q | 1163 | - | G.H3 | L | 250 | G.H3.08 |
Hydrophobic | ICL2 | E | 963 | - | G.HN | Q | 28 | G.HN.52 |
Polar | C-term | P | 1397 | - | G.H1 | K | 54 | G.H1.09 |
Van-der-waals | C-term | P | 1397 | - | G.H1 | K | 54 | G.H1.09 |
Hydrophobic | C-term | L | 1399 | - | G.H1 | K | 54 | G.H1.09 |
Polar | C-term | Q | 1149 | - | G.h2s4 | E | 217 | G.h2s4.02 |
Hydrophobic | C-term | Q | 1149 | - | G.h2s4 | E | 217 | G.h2s4.02 |
Van-der-waals | C-term | Q | 1149 | - | G.h2s4 | E | 217 | G.h2s4.02 |
Polar | ICL2 | E | 961 | - | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | ICL2 | E | 961 | - | G.hns1 | R | 32 | G.hns1.03 |
Van-der-waals | ICL2 | E | 961 | - | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | TM5 | L | 1040 | 5x68 | G.H5 | Q | 346 | G.H5.17 |
Van-der-waals | TM5 | L | 1040 | 5x68 | G.H5 | Q | 346 | G.H5.17 |
Hydrophobic | C-term | L | 1199 | - | H.hbhc | S | 116 | H.hbhc.04 |
Polar | C-term | S | 1167 | - | G.H2 | R | 206 | G.H2.01 |
Hydrophobic | C-term | S | 1167 | - | G.H2 | R | 206 | G.H2.01 |
Polar | TM3 | M | 955 | 3x57 | G.H5 | N | 348 | G.H5.19 |
Hydrophobic | TM3 | M | 955 | 3x57 | G.H5 | N | 348 | G.H5.19 |
Van-der-waals | TM3 | M | 955 | 3x57 | G.H5 | N | 348 | G.H5.19 |
Hydrophobic | TM5 | L | 1040 | 5x68 | G.h4s6 | E | 319 | G.h4s6.12 |
Van-der-waals | TM5 | L | 1040 | 5x68 | G.h4s6 | E | 319 | G.h4s6.12 |
Hydrophobic | C-term | V | 1160 | - | G.H2 | R | 209 | G.H2.04 |
Van-der-waals | C-term | V | 1160 | - | G.H2 | R | 209 | G.H2.04 |