GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 85.2
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 21.5
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM3 | I | 518 | 3x57 | G.H5 | I | 352 | G.H5.23 |
Van-der-waals | TM3 | I | 518 | 3x57 | G.H5 | I | 352 | G.H5.23 |
Hydrophobic | ICL2 | G | 527 | - | G.hns1 | R | 31 | G.hns1.02 |
Van-der-waals | ICL2 | G | 527 | - | G.hns1 | R | 31 | G.hns1.02 |
Hydrophobic | TM6 | L | 623 | 6x45 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM6 | L | 623 | 6x45 | G.H5 | L | 354 | G.H5.25 |
Polar | TM2 | R | 459 | 2x46 | G.H5 | Y | 351 | G.H5.22 |
Hydrophobic | TM2 | R | 459 | 2x46 | G.H5 | Y | 351 | G.H5.22 |
Hydrophobic | TM3 | I | 518 | 3x57 | G.H5 | N | 348 | G.H5.19 |
Van-der-waals | TM3 | I | 518 | 3x57 | G.H5 | N | 348 | G.H5.19 |
Hydrophobic | ICL2 | I | 523 | - | G.hns1 | R | 31 | G.hns1.02 |
Van-der-waals | ICL2 | I | 523 | - | G.hns1 | R | 31 | G.hns1.02 |
Hydrophobic | TM6 | G | 619 | 6x41 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM3 | V | 520 | 3x59 | G.H5 | I | 345 | G.H5.16 |
Hydrophobic | ICL2 | V | 522 | - | G.S3 | L | 195 | G.S3.01 |
Van-der-waals | ICL2 | V | 522 | - | G.S3 | L | 195 | G.S3.01 |
Aromatic | TM4 | H | 530 | 4x43 | G.hns1 | R | 31 | G.hns1.02 |
Polar | ICL2 | N | 525 | - | G.HN | S | 27 | G.HN.51 |
Hydrophobic | ICL2 | N | 525 | - | G.HN | S | 27 | G.HN.51 |
Van-der-waals | ICL2 | N | 525 | - | G.HN | S | 27 | G.HN.51 |
Ionic | TM5 | H | 599 | 5x64 | G.H5 | D | 342 | G.H5.13 |
Polar | TM5 | H | 599 | 5x64 | G.H5 | D | 342 | G.H5.13 |
Hydrophobic | TM5 | H | 599 | 5x64 | G.H5 | D | 342 | G.H5.13 |
Van-der-waals | TM5 | H | 599 | 5x64 | G.H5 | D | 342 | G.H5.13 |
Hydrophobic | ICL2 | I | 523 | - | G.S3 | L | 195 | G.S3.01 |
Van-der-waals | ICL2 | I | 523 | - | G.S3 | L | 195 | G.S3.01 |
Hydrophobic | TM2 | R | 459 | 2x46 | G.H5 | G | 353 | G.H5.24 |
Van-der-waals | TM2 | R | 459 | 2x46 | G.H5 | G | 353 | G.H5.24 |
Hydrophobic | TM3 | L | 515 | 3x54 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM3 | L | 515 | 3x54 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM3 | V | 519 | 3x58 | G.H5 | L | 349 | G.H5.20 |
Van-der-waals | TM3 | V | 519 | 3x58 | G.H5 | L | 349 | G.H5.20 |
Van-der-waals | TM3 | V | 520 | 3x59 | G.s2s3 | K | 193 | G.s2s3.01 |
Hydrophobic | TM3 | V | 519 | 3x58 | G.H5 | I | 345 | G.H5.16 |
Van-der-waals | TM3 | V | 519 | 3x58 | G.H5 | I | 345 | G.H5.16 |
Hydrophobic | ICL2 | V | 522 | - | G.s2s3 | E | 194 | G.s2s3.02 |
Hydrophobic | ICL2 | I | 523 | - | G.S1 | E | 33 | G.S1.01 |
Van-der-waals | ICL2 | I | 523 | - | G.S1 | E | 33 | G.S1.01 |
Hydrophobic | ICL2 | F | 528 | - | G.HN | Q | 28 | G.HN.52 |
Van-der-waals | ICL2 | F | 528 | - | G.HN | Q | 28 | G.HN.52 |
Hydrophobic | ICL2 | I | 523 | - | G.S1 | I | 34 | G.S1.02 |
Van-der-waals | ICL2 | I | 523 | - | G.S1 | I | 34 | G.S1.02 |
Hydrophobic | TM5 | V | 596 | 5x61 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | TM5 | I | 592 | 5x57 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM5 | I | 592 | 5x57 | G.H5 | L | 354 | G.H5.25 |
Polar | ICL2 | N | 525 | - | G.hns1 | R | 31 | G.hns1.02 |
Hydrophobic | ICL2 | N | 525 | - | G.hns1 | R | 31 | G.hns1.02 |
Van-der-waals | ICL2 | N | 525 | - | G.hns1 | R | 31 | G.hns1.02 |
Hydrophobic | TM3 | G | 521 | 3x60 | G.H5 | I | 345 | G.H5.16 |
Van-der-waals | TM3 | G | 521 | 3x60 | G.H5 | I | 345 | G.H5.16 |
Hydrophobic | TM3 | L | 515 | 3x54 | G.H5 | I | 352 | G.H5.23 |
Van-der-waals | TM3 | L | 515 | 3x54 | G.H5 | I | 352 | G.H5.23 |
Hydrophobic | TM3 | G | 521 | 3x60 | G.s2s3 | E | 194 | G.s2s3.02 |
Van-der-waals | TM3 | G | 521 | 3x60 | G.s2s3 | E | 194 | G.s2s3.02 |
Polar | ICL2 | N | 525 | - | G.HN | Q | 28 | G.HN.52 |
Hydrophobic | ICL2 | N | 525 | - | G.HN | Q | 28 | G.HN.52 |
Van-der-waals | ICL2 | N | 525 | - | G.HN | Q | 28 | G.HN.52 |
Polar | TM2 | R | 459 | 2x46 | G.H5 | I | 352 | G.H5.23 |
Hydrophobic | TM2 | R | 459 | 2x46 | G.H5 | I | 352 | G.H5.23 |
Van-der-waals | TM2 | R | 459 | 2x46 | G.H5 | I | 352 | G.H5.23 |
Hydrophobic | ICL2 | I | 523 | - | G.hns1 | R | 32 | G.hns1.03 |
Van-der-waals | ICL2 | I | 523 | - | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | ICL2 | N | 525 | - | G.hns1 | R | 32 | G.hns1.03 |
Van-der-waals | ICL2 | N | 525 | - | G.hns1 | R | 32 | G.hns1.03 |
Polar | ICL2 | G | 527 | - | G.HN | Q | 28 | G.HN.52 |
Hydrophobic | ICL2 | G | 527 | - | G.HN | Q | 28 | G.HN.52 |
Polar | ICL2 | K | 526 | - | G.hns1 | R | 31 | G.hns1.02 |
Hydrophobic | ICL2 | K | 526 | - | G.hns1 | R | 31 | G.hns1.02 |
Van-der-waals | ICL2 | K | 526 | - | G.hns1 | R | 31 | G.hns1.02 |
Hydrophobic | ICL2 | Y | 524 | - | G.hns1 | R | 32 | G.hns1.03 |
Van-der-waals | ICL2 | Y | 524 | - | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | TM5 | V | 596 | 5x61 | G.H5 | C | 355 | G.H5.26 |
Van-der-waals | TM3 | G | 521 | 3x60 | G.s2s3 | K | 193 | G.s2s3.01 |
Polar | ICL2 | N | 525 | - | G.HN | R | 29 | G.HN.53 |
Hydrophobic | ICL2 | N | 525 | - | G.HN | R | 29 | G.HN.53 |
Van-der-waals | ICL2 | N | 525 | - | G.HN | R | 29 | G.HN.53 |
Polar | ICL2 | Y | 524 | - | G.hns1 | R | 31 | G.hns1.02 |
Hydrophobic | ICL2 | Y | 524 | - | G.hns1 | R | 31 | G.hns1.02 |
Van-der-waals | ICL2 | Y | 524 | - | G.hns1 | R | 31 | G.hns1.02 |
Hydrophobic | TM3 | I | 518 | 3x57 | G.H5 | I | 345 | G.H5.16 |
Van-der-waals | TM3 | I | 518 | 3x57 | G.H5 | I | 345 | G.H5.16 |
Hydrophobic | ICL2 | I | 523 | - | G.h2s4 | T | 220 | G.h2s4.05 |
Van-der-waals | ICL2 | N | 525 | - | G.hns1 | Q | 30 | G.hns1.01 |
Hydrophobic | TM3 | L | 515 | 3x54 | G.H5 | L | 349 | G.H5.20 |
Ionic | ICL3 | K | 604 | - | G.h4s6 | E | 319 | G.h4s6.12 |
Polar | ICL3 | K | 604 | - | G.h4s6 | E | 319 | G.h4s6.12 |
Hydrophobic | TM3 | V | 520 | 3x59 | G.s2s3 | E | 194 | G.s2s3.02 |
Van-der-waals | TM3 | V | 520 | 3x59 | G.s2s3 | E | 194 | G.s2s3.02 |
Polar | H8 | K | 670 | 8x49 | G.H5 | Y | 351 | G.H5.22 |
Hydrophobic | H8 | K | 670 | 8x49 | G.H5 | Y | 351 | G.H5.22 |
Van-der-waals | H8 | K | 670 | 8x49 | G.H5 | Y | 351 | G.H5.22 |
Polar | TM3 | G | 521 | 3x60 | G.S3 | L | 195 | G.S3.01 |
Hydrophobic | TM3 | G | 521 | 3x60 | G.S3 | L | 195 | G.S3.01 |
Van-der-waals | TM3 | G | 521 | 3x60 | G.S3 | L | 195 | G.S3.01 |
Hydrophobic | TM3 | I | 518 | 3x57 | G.H5 | L | 349 | G.H5.20 |
Van-der-waals | TM3 | I | 518 | 3x57 | G.H5 | L | 349 | G.H5.20 |