G12 - AT1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 84.2

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 14.5


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 M 134 34x51 G.H5 V 366 G.H5.11
Hydrophobic ICL1 M 57 12x48 G.H5 L 380 G.H5.25
Van-der-waals ICL1 M 57 12x48 G.H5 L 380 G.H5.25
Polar ICL2 R 140 34x57 G.H5 N 374 G.H5.19
Van-der-waals ICL2 R 140 34x57 G.H5 N 374 G.H5.19
Polar H8 K 308 8x49 G.H5 L 380 G.H5.25
Hydrophobic H8 K 308 8x49 G.H5 L 380 G.H5.25
Van-der-waals H8 K 308 8x49 G.H5 L 380 G.H5.25
Hydrophobic ICL2 L 138 34x55 G.HN R 52 G.HN.52
Van-der-waals ICL2 L 138 34x55 G.HN R 52 G.HN.52
Hydrophobic ICL2 P 133 34x50 G.H5 K 367 G.H5.12
Hydrophobic ICL2 M 134 34x51 G.S3 F 223 G.S3.03
Polar C-term N 329 - G.H3 K 284 G.H3.16
Van-der-waals C-term N 329 - G.H3 K 284 G.H3.16
Hydrophobic ICL2 P 133 34x50 G.H5 L 371 G.H5.16
Hydrophobic ICL2 P 133 34x50 G.H5 I 370 G.H5.15
Hydrophobic ICL2 M 134 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 M 134 34x51 G.S3 I 221 G.S3.01
Polar C-term S 331 - G.H3 K 284 G.H3.16
Van-der-waals C-term S 331 - G.H3 K 284 G.H3.16
Hydrophobic TM2 A 63 2x39 G.H5 I 378 G.H5.23
Hydrophobic C-term M 334 - G.H2 F 239 G.H2.08
Hydrophobic TM3 R 126 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 126 3x50 G.H5 I 378 G.H5.23
Hydrophobic ICL2 L 138 34x55 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 L 138 34x55 G.hns1 R 56 G.hns1.03
Polar ICL2 S 136 34x53 G.H5 N 374 G.H5.19
Hydrophobic C-term L 330 - G.H3 K 284 G.H3.16
Van-der-waals C-term L 330 - G.H3 K 284 G.H3.16
Hydrophobic ICL2 M 134 34x51 G.S1 V 58 G.S1.02
Van-der-waals ICL2 M 134 34x51 G.S1 V 58 G.S1.02
Hydrophobic TM6 I 242 6x37 G.H5 I 378 G.H5.23
Van-der-waals TM6 I 242 6x37 G.H5 I 378 G.H5.23
Hydrophobic TM6 N 235 6x30 G.H5 L 375 G.H5.20
Hydrophobic ICL2 R 137 34x54 G.H5 I 370 G.H5.15
Polar H8 K 308 8x49 G.H5 Q 381 G.H5.26
Hydrophobic H8 K 308 8x49 G.H5 Q 381 G.H5.26
Van-der-waals H8 K 308 8x49 G.H5 Q 381 G.H5.26
Hydrophobic TM7 Y 302 7x53 G.H5 L 380 G.H5.25
Hydrophobic TM3 I 130 3x54 G.H5 I 378 G.H5.23
Hydrophobic TM3 I 130 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 I 130 3x54 G.H5 L 371 G.H5.16
Hydrophobic TM3 I 130 3x54 G.H5 L 375 G.H5.20
Polar TM6 N 235 6x30 G.H5 Q 372 G.H5.17
Hydrophobic TM6 N 235 6x30 G.H5 Q 372 G.H5.17
Van-der-waals TM6 N 235 6x30 G.H5 Q 372 G.H5.17
Hydrophobic TM6 I 238 6x33 G.H5 L 375 G.H5.20
Polar ICL3 Q 229 - G.H5 D 368 G.H5.13
Van-der-waals ICL3 Q 229 - G.H5 D 368 G.H5.13
Polar ICL2 R 137 34x54 G.S1 L 57 G.S1.01
Van-der-waals ICL2 R 137 34x54 G.S1 L 57 G.S1.01
Hydrophobic TM6 I 241 6x36 G.H5 M 379 G.H5.24
Van-der-waals TM6 I 241 6x36 G.H5 M 379 G.H5.24
Polar TM2 T 61 2x37 G.H5 D 377 G.H5.22
Hydrophobic TM2 T 61 2x37 G.H5 D 377 G.H5.22
Van-der-waals TM2 T 61 2x37 G.H5 D 377 G.H5.22
Hydrophobic H8 G 306 8x47 G.H5 L 380 G.H5.25
Hydrophobic ICL2 M 134 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 M 134 34x51 G.H5 I 370 G.H5.15
Ionic ICL2 R 140 34x57 G.H5 D 377 G.H5.22
Polar ICL2 R 140 34x57 G.H5 D 377 G.H5.22
Van-der-waals ICL2 R 140 34x57 G.H5 D 377 G.H5.22
Hydrophobic TM6 I 238 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 I 238 6x33 G.H5 M 379 G.H5.24
Hydrophobic TM3 A 129 3x53 G.H5 I 378 G.H5.23
Van-der-waals TM3 A 129 3x53 G.H5 I 378 G.H5.23
Hydrophobic ICL2 M 134 34x51 G.H5 K 367 G.H5.12
Polar ICL2 R 137 34x54 G.hns1 R 55 G.hns1.02
Polar TM3 A 129 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 A 129 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 A 129 3x53 G.H5 N 374 G.H5.19
Polar TM4 T 141 4x38 G.hns1 R 55 G.hns1.02
Hydrophobic TM4 T 141 4x38 G.hns1 R 55 G.hns1.02
Van-der-waals TM4 T 141 4x38 G.hns1 R 55 G.hns1.02
Hydrophobic TM2 L 67 2x43 G.H5 L 380 G.H5.25
Van-der-waals TM2 L 67 2x43 G.H5 L 380 G.H5.25
Hydrophobic TM6 I 242 6x37 G.H5 M 379 G.H5.24