Gi2 - apelin receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 85.8

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 12.9


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 V 135 34x51 G.s2s3 D 194 G.s2s3.02
Polar ICL2 R 141 34x57 G.H5 N 348 G.H5.19
Hydrophobic ICL2 R 141 34x57 G.H5 N 348 G.H5.19
Van-der-waals ICL2 R 141 34x57 G.H5 N 348 G.H5.19
Hydrophobic ICL3 E 235 - G.h4s6 E 319 G.h4s6.12
Hydrophobic TM4 L 142 4x38 G.hns1 R 32 G.hns1.03
Polar TM3 R 127 3x50 G.H5 C 352 G.H5.23
Hydrophobic TM3 R 127 3x50 G.H5 C 352 G.H5.23
Van-der-waals TM3 R 127 3x50 G.H5 C 352 G.H5.23
Hydrophobic ICL2 V 135 34x51 G.s2s3 K 193 G.s2s3.01
Van-der-waals ICL2 V 135 34x51 G.s2s3 K 193 G.s2s3.01
Ionic ICL3 E 235 - G.H5 K 346 G.H5.17
Polar ICL3 E 235 - G.H5 K 346 G.H5.17
Hydrophobic ICL3 E 235 - G.H5 K 346 G.H5.17
Van-der-waals ICL3 E 235 - G.H5 K 346 G.H5.17
Polar TM6 K 242 6x29 G.h4s6 D 316 G.h4s6.09
Van-der-waals TM6 K 242 6x29 G.h4s6 D 316 G.h4s6.09
Hydrophobic H8 D 313 8x47 G.H5 G 353 G.H5.24
Hydrophobic TM3 I 131 3x54 G.H5 L 354 G.H5.25
Hydrophobic TM5 H 231 5x68 G.H5 K 346 G.H5.17
Van-der-waals TM5 H 231 5x68 G.H5 K 346 G.H5.17
Hydrophobic TM3 A 130 3x53 G.H5 C 352 G.H5.23
Hydrophobic TM6 L 246 6x33 G.H5 F 355 G.H5.26
Hydrophobic TM6 L 253 6x40 G.H5 L 354 G.H5.25
Ionic TM5 H 231 5x68 G.H5 D 342 G.H5.13
Polar TM5 H 231 5x68 G.H5 D 342 G.H5.13
Hydrophobic TM5 H 231 5x68 G.H5 D 342 G.H5.13
Van-der-waals TM5 H 231 5x68 G.H5 D 342 G.H5.13
Hydrophobic TM4 L 142 4x38 G.HN E 28 G.HN.52
Van-der-waals TM4 L 142 4x38 G.HN E 28 G.HN.52
Hydrophobic TM5 F 232 5x69 G.H5 K 346 G.H5.17
Hydrophobic TM5 F 232 5x69 G.H5 L 349 G.H5.20
Polar TM6 E 238 6x25 G.h4s6 D 316 G.h4s6.09
Hydrophobic TM6 E 238 6x25 G.h4s6 D 316 G.h4s6.09
Van-der-waals TM6 E 238 6x25 G.h4s6 D 316 G.h4s6.09
Polar TM6 R 245 6x32 G.H5 F 355 G.H5.26
Hydrophobic TM6 R 245 6x32 G.H5 F 355 G.H5.26
Van-der-waals TM6 R 245 6x32 G.H5 F 355 G.H5.26
Van-der-waals TM7 F 312 7x56 G.H5 G 353 G.H5.24
Ionic TM6 R 236 6x23 G.H4 E 309 G.H4.16
Polar TM6 R 236 6x23 G.H4 E 309 G.H4.16
Van-der-waals TM6 R 236 6x23 G.H4 E 309 G.H4.16
Hydrophobic TM5 H 231 5x68 G.H5 I 345 G.H5.16
Hydrophobic TM6 L 246 6x33 G.H5 L 349 G.H5.20
Hydrophobic TM6 L 246 6x33 G.H5 L 354 G.H5.25
Van-der-waals TM6 L 246 6x33 G.H5 L 354 G.H5.25
Hydrophobic ICL2 A 138 34x54 G.hns1 R 32 G.hns1.03
Polar TM2 R 62 2x37 G.H5 D 351 G.H5.22
Hydrophobic TM2 R 62 2x37 G.H5 D 351 G.H5.22
Van-der-waals TM2 R 62 2x37 G.H5 D 351 G.H5.22
Hydrophobic TM5 I 228 5x65 G.H5 L 349 G.H5.20
Ionic H8 R 315 8x49 G.H5 D 351 G.H5.22
Polar H8 R 315 8x49 G.H5 D 351 G.H5.22
Hydrophobic H8 R 315 8x49 G.H5 D 351 G.H5.22
Van-der-waals H8 R 315 8x49 G.H5 D 351 G.H5.22
Hydrophobic ICL2 P 134 34x50 G.H5 I 345 G.H5.16
Polar TM3 A 130 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM3 A 130 3x53 G.H5 N 348 G.H5.19
Van-der-waals TM3 A 130 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM3 I 131 3x54 G.H5 L 349 G.H5.20
Van-der-waals TM3 I 131 3x54 G.H5 L 349 G.H5.20
Hydrophobic ICL2 V 135 34x51 G.S3 L 195 G.S3.01
Van-der-waals ICL2 V 135 34x51 G.S3 L 195 G.S3.01
Hydrophobic ICL2 P 134 34x50 G.H5 I 344 G.H5.15
Van-der-waals ICL2 P 134 34x50 G.H5 I 344 G.H5.15
Hydrophobic TM6 I 249 6x36 G.H5 L 354 G.H5.25
Van-der-waals TM6 I 249 6x36 G.H5 L 354 G.H5.25
Hydrophobic TM3 R 127 3x50 G.H5 L 354 G.H5.25