Ggust -
apelin receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 81.5
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 13.7
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Aromatic | TM6 | R | 245 | 6x32 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | TM5 | H | 231 | 5x68 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | TM5 | H | 231 | 5x68 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | ICL2 | P | 134 | 34x50 | G.H5 | T | 340 | G.H5.12 |
Polar | TM3 | D | 126 | 3x49 | G.H5 | C | 351 | G.H5.23 |
Polar | C-term | L | 377 | - | G.S2 | Q | 188 | G.S2.05 |
Hydrophobic | C-term | L | 377 | - | G.S2 | Q | 188 | G.S2.05 |
Van-der-waals | C-term | L | 377 | - | G.S2 | Q | 188 | G.S2.05 |
Polar | C-term | E | 375 | - | G.h1ha | K | 58 | G.h1ha.01 |
Van-der-waals | C-term | E | 375 | - | G.h1ha | K | 58 | G.h1ha.01 |
Hydrophobic | TM5 | F | 232 | 5x69 | G.H5 | K | 345 | G.H5.17 |
Van-der-waals | TM5 | F | 232 | 5x69 | G.H5 | K | 345 | G.H5.17 |
Hydrophobic | TM2 | R | 62 | 2x37 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | TM2 | R | 62 | 2x37 | G.H5 | G | 352 | G.H5.24 |
Ionic | TM4 | R | 143 | 4x39 | G.HN | E | 28 | G.HN.52 |
Polar | TM4 | R | 143 | 4x39 | G.HN | E | 28 | G.HN.52 |
Hydrophobic | TM4 | L | 142 | 4x38 | G.hns1 | A | 31 | G.hns1.02 |
Ionic | ICL3 | E | 235 | - | G.H5 | K | 345 | G.H5.17 |
Polar | ICL3 | E | 235 | - | G.H5 | K | 345 | G.H5.17 |
Van-der-waals | ICL3 | E | 235 | - | G.H5 | K | 345 | G.H5.17 |
Polar | TM3 | R | 127 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM3 | R | 127 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | R | 127 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM3 | I | 131 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM3 | I | 131 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | TM3 | R | 127 | 3x50 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM3 | R | 127 | 3x50 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM6 | L | 246 | 6x33 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | H8 | P | 314 | 8x48 | G.H5 | F | 354 | G.H5.26 |
Van-der-waals | H8 | P | 314 | 8x48 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | TM5 | I | 228 | 5x65 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | ICL2 | P | 134 | 34x50 | G.H5 | I | 344 | G.H5.16 |
Ionic | TM5 | H | 231 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Polar | TM5 | H | 231 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM5 | H | 231 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM5 | H | 231 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Polar | TM3 | A | 130 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM3 | A | 130 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | TM3 | A | 130 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | H8 | D | 313 | 8x47 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | TM2 | A | 64 | 2x39 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | C-term | Y | 372 | - | G.S2 | I | 185 | G.S2.02 |
Van-der-waals | C-term | Y | 372 | - | G.S2 | I | 185 | G.S2.02 |
Hydrophobic | TM4 | L | 142 | 4x38 | G.HN | E | 28 | G.HN.52 |
Van-der-waals | TM4 | L | 142 | 4x38 | G.HN | E | 28 | G.HN.52 |
Van-der-waals | ICL2 | P | 134 | 34x50 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | C-term | L | 377 | - | G.S2 | F | 189 | G.S2.06 |
Van-der-waals | C-term | L | 377 | - | G.S2 | F | 189 | G.S2.06 |
Hydrophobic | TM5 | H | 231 | 5x68 | G.H5 | K | 345 | G.H5.17 |
Hydrophobic | TM4 | L | 142 | 4x38 | G.HN | A | 27 | G.HN.51 |
Van-der-waals | TM4 | L | 142 | 4x38 | G.HN | A | 27 | G.HN.51 |
Polar | TM6 | R | 236 | 6x23 | G.H4 | N | 305 | G.H4.13 |
Polar | ICL2 | R | 141 | 34x57 | G.H5 | N | 347 | G.H5.19 |
Ionic | ICL3 | K | 234 | - | G.H5 | D | 337 | G.H5.09 |
Polar | ICL3 | K | 234 | - | G.H5 | D | 337 | G.H5.09 |
Hydrophobic | TM5 | F | 232 | 5x69 | G.H5 | L | 348 | G.H5.20 |
Ionic | C-term | E | 367 | - | G.hfs2 | K | 180 | G.hfs2.04 |
Polar | C-term | E | 367 | - | G.hfs2 | K | 180 | G.hfs2.04 |
Hydrophobic | C-term | E | 367 | - | G.hfs2 | K | 180 | G.hfs2.04 |
Van-der-waals | C-term | E | 367 | - | G.hfs2 | K | 180 | G.hfs2.04 |
Hydrophobic | ICL2 | V | 135 | 34x51 | G.H5 | I | 343 | G.H5.15 |
Hydrophobic | ICL2 | V | 135 | 34x51 | G.s2s3 | K | 192 | G.s2s3.01 |
Van-der-waals | ICL2 | V | 135 | 34x51 | G.s2s3 | K | 192 | G.s2s3.01 |
Polar | ICL2 | R | 141 | 34x57 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | ICL2 | V | 135 | 34x51 | G.S3 | L | 194 | G.S3.01 |
Van-der-waals | ICL2 | V | 135 | 34x51 | G.S3 | L | 194 | G.S3.01 |
Hydrophobic | TM6 | L | 246 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | L | 246 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | C-term | Y | 372 | - | G.H1 | K | 51 | G.H1.06 |
Hydrophobic | ICL2 | P | 134 | 34x50 | G.H5 | I | 343 | G.H5.15 |
Van-der-waals | ICL2 | P | 134 | 34x50 | G.H5 | I | 343 | G.H5.15 |
Hydrophobic | C-term | T | 376 | - | G.S2 | Q | 188 | G.S2.05 |
Van-der-waals | C-term | T | 376 | - | G.S2 | Q | 188 | G.S2.05 |
Hydrophobic | ICL3 | E | 235 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | ICL3 | E | 235 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | C-term | I | 370 | - | H.HA | F | 69 | H.HA.07 |
Polar | TM6 | K | 242 | 6x29 | G.h4s6 | E | 315 | G.h4s6.09 |
Van-der-waals | TM6 | K | 242 | 6x29 | G.h4s6 | E | 315 | G.h4s6.09 |
Hydrophobic | C-term | M | 365 | - | H.HA | Q | 79 | H.HA.17 |
Van-der-waals | C-term | M | 365 | - | H.HA | Q | 79 | H.HA.17 |
Hydrophobic | TM3 | I | 131 | 3x54 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | C-term | L | 377 | - | G.h1ha | K | 58 | G.h1ha.01 |
Van-der-waals | C-term | L | 377 | - | G.h1ha | K | 58 | G.h1ha.01 |
Hydrophobic | ICL2 | V | 135 | 34x51 | G.s2s3 | D | 193 | G.s2s3.02 |
Van-der-waals | ICL2 | V | 135 | 34x51 | G.s2s3 | D | 193 | G.s2s3.02 |
Hydrophobic | TM6 | R | 236 | 6x23 | G.H4 | L | 308 | G.H4.16 |
Ionic | ICL2 | R | 139 | 34x55 | G.HN | E | 28 | G.HN.52 |
Polar | ICL2 | R | 139 | 34x55 | G.HN | E | 28 | G.HN.52 |
Hydrophobic | ICL2 | R | 139 | 34x55 | G.HN | E | 28 | G.HN.52 |
Van-der-waals | ICL2 | R | 139 | 34x55 | G.HN | E | 28 | G.HN.52 |
Ionic | ICL2 | R | 141 | 34x57 | G.H5 | D | 350 | G.H5.22 |
Polar | ICL2 | R | 141 | 34x57 | G.H5 | D | 350 | G.H5.22 |
Hydrophobic | ICL2 | R | 141 | 34x57 | G.H5 | D | 350 | G.H5.22 |
Van-der-waals | ICL2 | R | 141 | 34x57 | G.H5 | D | 350 | G.H5.22 |
Hydrophobic | TM2 | R | 62 | 2x37 | G.H5 | D | 350 | G.H5.22 |
Van-der-waals | TM2 | R | 62 | 2x37 | G.H5 | D | 350 | G.H5.22 |
Hydrophobic | TM3 | I | 131 | 3x54 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | C-term | I | 370 | - | H.HA | V | 72 | H.HA.10 |
Van-der-waals | C-term | I | 370 | - | H.HA | V | 72 | H.HA.10 |
Hydrophobic | C-term | I | 370 | - | G.hfs2 | V | 179 | G.hfs2.03 |
Van-der-waals | C-term | I | 370 | - | G.hfs2 | V | 179 | G.hfs2.03 |
Hydrophobic | ICL2 | R | 139 | 34x55 | G.hns1 | R | 32 | G.hns1.03 |
Van-der-waals | ICL2 | R | 139 | 34x55 | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | TM6 | L | 246 | 6x33 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | TM6 | K | 242 | 6x29 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | TM5 | T | 227 | 5x64 | G.H5 | I | 344 | G.H5.16 |
Ionic | C-term | K | 368 | - | H.hbhc | D | 116 | H.hbhc.04 |
Polar | C-term | K | 368 | - | H.hbhc | D | 116 | H.hbhc.04 |
Hydrophobic | C-term | K | 368 | - | H.hbhc | D | 116 | H.hbhc.04 |
Van-der-waals | C-term | K | 368 | - | H.hbhc | D | 116 | H.hbhc.04 |
Ionic | C-term | E | 375 | - | G.H1 | K | 54 | G.H1.09 |
Polar | C-term | E | 375 | - | G.H1 | K | 54 | G.H1.09 |
Van-der-waals | C-term | E | 375 | - | G.H1 | K | 54 | G.H1.09 |
Hydrophobic | TM6 | I | 249 | 6x36 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | I | 249 | 6x36 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM3 | A | 130 | 3x53 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | A | 130 | 3x53 | G.H5 | C | 351 | G.H5.23 |
Polar | TM4 | L | 142 | 4x38 | G.HN | Q | 24 | G.HN.48 |
Hydrophobic | TM4 | L | 142 | 4x38 | G.HN | Q | 24 | G.HN.48 |
Van-der-waals | TM4 | L | 142 | 4x38 | G.HN | Q | 24 | G.HN.48 |
Polar | TM2 | R | 62 | 2x37 | G.H5 | K | 349 | G.H5.21 |