G12 - B1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 87.1

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 13.2


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM3 V 138 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 V 138 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 V 138 3x53 G.H5 N 374 G.H5.19
Polar C-term E 345 - G.H3 K 284 G.H3.16
Van-der-waals C-term E 345 - G.H3 K 284 G.H3.16
Hydrophobic TM5 R 239 5x75 G.S6 L 346 G.S6.01
Van-der-waals TM5 R 239 5x75 G.S6 L 346 G.S6.01
Hydrophobic TM3 L 139 3x54 G.H5 L 375 G.H5.20
Van-der-waals TM3 L 139 3x54 G.H5 L 375 G.H5.20
Polar ICL3 D 245 - G.H5 Q 372 G.H5.17
Van-der-waals ICL3 D 245 - G.H5 Q 372 G.H5.17
Hydrophobic ICL2 P 142 34x50 G.H5 K 367 G.H5.12
Polar TM3 R 135 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM3 R 135 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 135 3x50 G.H5 I 378 G.H5.23
Hydrophobic ICL2 M 143 34x51 G.H5 F 363 G.H5.08
Polar ICL3 C 240 - G.S6 H 348 G.S6.03
Hydrophobic ICL3 C 240 - G.S6 H 348 G.S6.03
Van-der-waals ICL3 C 240 - G.S6 H 348 G.S6.03
Hydrophobic TM6 T 248 6x33 G.H5 L 375 G.H5.20
Van-der-waals TM6 T 248 6x33 G.H5 L 375 G.H5.20
Polar ICL2 R 147 34x55 G.s2s3 K 220 G.s2s3.02
Hydrophobic ICL2 R 147 34x55 G.s2s3 K 220 G.s2s3.02
Van-der-waals ICL2 R 147 34x55 G.s2s3 K 220 G.s2s3.02
Hydrophobic TM6 L 251 6x36 G.H5 L 380 G.H5.25
Hydrophobic TM3 L 139 3x54 G.H5 I 378 G.H5.23
Van-der-waals TM3 L 139 3x54 G.H5 I 378 G.H5.23
Polar C-term I 346 - G.H3 K 284 G.H3.16
Hydrophobic C-term I 346 - G.H3 K 284 G.H3.16
Van-der-waals C-term I 346 - G.H3 K 284 G.H3.16
Polar ICL3 G 242 - G.h4s6 R 342 G.h4s6.11
Hydrophobic TM5 L 229 5x65 G.H5 L 371 G.H5.16
Hydrophobic ICL2 P 142 34x50 G.H5 L 371 G.H5.16
Hydrophobic TM5 R 239 5x75 G.h4s6 P 345 G.h4s6.20
Van-der-waals TM5 R 239 5x75 G.h4s6 P 345 G.h4s6.20
Hydrophobic TM3 R 135 3x50 G.H5 L 380 G.H5.25
Hydrophobic C-term F 350 - G.H3 N 283 G.H3.15
Van-der-waals C-term F 350 - G.H3 N 283 G.H3.15
Hydrophobic TM3 L 139 3x54 G.H5 N 374 G.H5.19
Hydrophobic ICL3 G 241 - G.h4s6 P 345 G.h4s6.20
Hydrophobic TM5 R 232 5x68 G.H5 H 364 G.H5.09
Hydrophobic TM2 E 73 2x40 G.H5 M 379 G.H5.24
Hydrophobic TM6 I 252 6x37 G.H5 L 380 G.H5.25
Polar ICL2 R 147 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 R 147 34x55 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 R 147 34x55 G.hns1 R 56 G.hns1.03
Van-der-waals TM5 R 232 5x68 G.H5 Q 372 G.H5.17
Polar ICL3 C 240 - G.S6 L 346 G.S6.01
Hydrophobic ICL3 C 240 - G.S6 L 346 G.S6.01
Van-der-waals ICL3 C 240 - G.S6 L 346 G.S6.01
Polar TM6 K 247 6x32 G.H5 Q 381 G.H5.26
Hydrophobic TM6 K 247 6x32 G.H5 Q 381 G.H5.26
Van-der-waals TM6 K 247 6x32 G.H5 Q 381 G.H5.26
Hydrophobic C-term F 350 - G.H3 K 284 G.H3.16
Van-der-waals C-term F 350 - G.H3 K 284 G.H3.16
Van-der-waals H8 G 316 8x47 G.H5 Q 381 G.H5.26
Polar C-term L 349 - G.H3 K 284 G.H3.16
Hydrophobic C-term L 349 - G.H3 K 284 G.H3.16
Van-der-waals C-term L 349 - G.H3 K 284 G.H3.16
Polar ICL3 R 243 - G.h4s6 S 343 G.h4s6.12
Hydrophobic H8 G 316 8x47 G.H5 M 379 G.H5.24
Ionic TM5 R 232 5x68 G.H5 D 368 G.H5.13
Polar TM5 R 232 5x68 G.H5 D 368 G.H5.13
Hydrophobic TM5 R 232 5x68 G.H5 D 368 G.H5.13
Van-der-waals TM5 R 232 5x68 G.H5 D 368 G.H5.13
Van-der-waals TM4 Q 149 4x37 G.HN R 52 G.HN.52
Hydrophobic H8 F 319 8x50 G.H5 M 379 G.H5.24
Hydrophobic TM5 R 239 5x75 G.S6 F 347 G.S6.02
Hydrophobic ICL2 M 143 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 M 143 34x51 G.S3 I 221 G.S3.01
Hydrophobic TM2 A 72 2x39 G.H5 I 378 G.H5.23
Hydrophobic TM3 V 138 3x53 G.H5 I 378 G.H5.23
Polar TM5 T 238 5x74 G.S6 H 348 G.S6.03
Hydrophobic TM5 T 238 5x74 G.S6 H 348 G.S6.03
Van-der-waals TM5 T 238 5x74 G.S6 H 348 G.S6.03
Hydrophobic H8 L 318 8x49 G.H5 K 376 G.H5.21
Polar ICL2 R 146 34x54 G.h2s4 T 246 G.h2s4.05
Polar TM6 T 248 6x33 G.H5 L 380 G.H5.25
Hydrophobic TM6 T 248 6x33 G.H5 L 380 G.H5.25
Hydrophobic TM2 A 72 2x39 G.H5 D 377 G.H5.22
Van-der-waals TM2 A 72 2x39 G.H5 D 377 G.H5.22
Hydrophobic TM7 V 313 7x54 G.H5 M 379 G.H5.24
Hydrophobic ICL2 M 143 34x51 G.H5 K 367 G.H5.12
Van-der-waals ICL2 M 143 34x51 G.H5 K 367 G.H5.12
Hydrophobic TM3 L 139 3x54 G.H5 L 380 G.H5.25
Polar ICL3 G 242 - G.h4s6 K 344 G.h4s6.19
Hydrophobic ICL3 G 242 - G.h4s6 K 344 G.h4s6.19
Polar H8 R 317 8x48 G.H5 Q 381 G.H5.26
Hydrophobic H8 R 317 8x48 G.H5 Q 381 G.H5.26
Van-der-waals H8 R 317 8x48 G.H5 Q 381 G.H5.26
Polar ICL2 R 147 34x55 G.s2s3 K 219 G.s2s3.01
Hydrophobic TM5 V 235 5x71 G.H5 H 364 G.H5.09
Van-der-waals TM5 V 235 5x71 G.H5 H 364 G.H5.09
Hydrophobic TM5 R 232 5x68 G.H5 L 371 G.H5.16
Van-der-waals TM5 R 232 5x68 G.H5 L 371 G.H5.16
Hydrophobic ICL3 C 240 - G.H4 V 332 G.H4.12
Van-der-waals ICL3 C 240 - G.H4 V 332 G.H4.12
Hydrophobic ICL3 C 240 - G.H4 D 336 G.H4.16
Polar TM5 R 232 5x68 G.H5 K 367 G.H5.12
Van-der-waals TM5 R 232 5x68 G.H5 K 367 G.H5.12
Ionic TM5 R 239 5x75 G.H5 D 368 G.H5.13
Polar TM5 R 239 5x75 G.H5 D 368 G.H5.13
Hydrophobic TM5 T 238 5x74 G.H5 F 361 G.H5.06
Hydrophobic H8 L 318 8x49 G.H5 D 377 G.H5.22
Hydrophobic ICL3 G 242 - G.h4s6 S 343 G.h4s6.12
Van-der-waals ICL3 G 242 - G.h4s6 S 343 G.h4s6.12
Hydrophobic ICL2 R 146 34x54 G.H5 I 370 G.H5.15
Hydrophobic ICL2 M 143 34x51 G.H5 V 366 G.H5.11
Hydrophobic TM3 L 139 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 L 139 3x54 G.H5 L 371 G.H5.16
Hydrophobic ICL2 P 142 34x50 G.H5 I 370 G.H5.15
Ionic ICL2 R 146 34x54 G.H5 E 373 G.H5.18
Polar ICL2 R 146 34x54 G.H5 E 373 G.H5.18
Van-der-waals ICL2 R 146 34x54 G.H5 E 373 G.H5.18
Hydrophobic ICL2 R 147 34x55 G.S3 I 221 G.S3.01
Van-der-waals ICL2 R 147 34x55 G.S3 I 221 G.S3.01
Hydrophobic ICL2 M 143 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 M 143 34x51 G.H5 I 370 G.H5.15
Hydrophobic TM1 F 62 1x57 G.H5 M 379 G.H5.24
Van-der-waals TM1 F 62 1x57 G.H5 M 379 G.H5.24
Hydrophobic TM2 L 76 2x43 G.H5 M 379 G.H5.24
Van-der-waals TM2 L 76 2x43 G.H5 M 379 G.H5.24
Polar ICL3 C 240 - G.h4s6 R 339 G.h4s6.08