Gz -
B1 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 88.4
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 12.3
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
Gβ,
Gγ,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Ionic | TM5 | R | 232 | 5x68 | G.H5 | D | 342 | G.H5.13 |
Polar | TM5 | R | 232 | 5x68 | G.H5 | D | 342 | G.H5.13 |
Hydrophobic | TM5 | R | 232 | 5x68 | G.H5 | D | 342 | G.H5.13 |
Van-der-waals | TM5 | R | 232 | 5x68 | G.H5 | D | 342 | G.H5.13 |
Polar | TM5 | R | 239 | 5x75 | G.S6 | H | 323 | G.S6.04 |
Hydrophobic | TM5 | R | 239 | 5x75 | G.S6 | H | 323 | G.S6.04 |
Van-der-waals | TM5 | R | 239 | 5x75 | G.S6 | H | 323 | G.S6.04 |
Hydrophobic | TM3 | L | 139 | 3x54 | G.H5 | I | 352 | G.H5.23 |
Hydrophobic | TM5 | L | 229 | 5x65 | G.H5 | I | 345 | G.H5.16 |
Hydrophobic | TM5 | L | 229 | 5x65 | G.H5 | L | 349 | G.H5.20 |
Polar | ICL2 | R | 147 | 34x55 | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | ICL2 | R | 147 | 34x55 | G.hns1 | R | 32 | G.hns1.03 |
Van-der-waals | ICL2 | R | 147 | 34x55 | G.hns1 | R | 32 | G.hns1.03 |
Polar | H8 | R | 317 | 8x48 | G.H5 | C | 355 | G.H5.26 |
Hydrophobic | H8 | R | 317 | 8x48 | G.H5 | C | 355 | G.H5.26 |
Van-der-waals | H8 | R | 317 | 8x48 | G.H5 | C | 355 | G.H5.26 |
Hydrophobic | TM3 | V | 138 | 3x53 | G.H5 | I | 352 | G.H5.23 |
Polar | ICL2 | R | 146 | 34x54 | G.hns1 | R | 31 | G.hns1.02 |
Van-der-waals | ICL2 | R | 146 | 34x54 | G.hns1 | R | 31 | G.hns1.02 |
Polar | TM3 | R | 135 | 3x50 | G.H5 | I | 352 | G.H5.23 |
Hydrophobic | TM3 | R | 135 | 3x50 | G.H5 | I | 352 | G.H5.23 |
Van-der-waals | TM3 | R | 135 | 3x50 | G.H5 | I | 352 | G.H5.23 |
Polar | TM5 | S | 236 | 5x72 | G.h4s6 | E | 319 | G.h4s6.12 |
Van-der-waals | TM5 | S | 236 | 5x72 | G.h4s6 | E | 319 | G.h4s6.12 |
Hydrophobic | C-term | F | 350 | - | G.H3 | N | 257 | G.H3.15 |
Van-der-waals | C-term | F | 350 | - | G.H3 | N | 257 | G.H3.15 |
Hydrophobic | TM3 | R | 135 | 3x50 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | ICL2 | M | 143 | 34x51 | G.S3 | L | 195 | G.S3.01 |
Van-der-waals | ICL2 | M | 143 | 34x51 | G.S3 | L | 195 | G.S3.01 |
Hydrophobic | ICL2 | R | 146 | 34x54 | G.H5 | I | 344 | G.H5.15 |
Van-der-waals | ICL2 | R | 146 | 34x54 | G.H5 | I | 344 | G.H5.15 |
Hydrophobic | TM6 | T | 248 | 6x33 | G.H5 | L | 349 | G.H5.20 |
Van-der-waals | TM6 | T | 248 | 6x33 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | ICL2 | P | 142 | 34x50 | G.H5 | I | 345 | G.H5.16 |
Hydrophobic | ICL2 | P | 142 | 34x50 | G.H5 | I | 344 | G.H5.15 |
Hydrophobic | ICL2 | M | 143 | 34x51 | G.S1 | I | 34 | G.S1.02 |
Polar | ICL3 | C | 240 | - | G.S6 | I | 320 | G.S6.01 |
Hydrophobic | ICL3 | C | 240 | - | G.S6 | I | 320 | G.S6.01 |
Van-der-waals | ICL3 | C | 240 | - | G.S6 | I | 320 | G.S6.01 |
Polar | ICL3 | D | 245 | - | G.H5 | Q | 346 | G.H5.17 |
Van-der-waals | ICL3 | D | 245 | - | G.H5 | Q | 346 | G.H5.17 |
Hydrophobic | TM3 | L | 139 | 3x54 | G.H5 | I | 345 | G.H5.16 |
Van-der-waals | TM3 | L | 139 | 3x54 | G.H5 | I | 345 | G.H5.16 |
Polar | TM3 | V | 138 | 3x53 | G.H5 | N | 348 | G.H5.19 |
Hydrophobic | TM3 | V | 138 | 3x53 | G.H5 | N | 348 | G.H5.19 |
Van-der-waals | TM3 | V | 138 | 3x53 | G.H5 | N | 348 | G.H5.19 |
Hydrophobic | TM5 | R | 232 | 5x68 | G.H5 | I | 345 | G.H5.16 |
Van-der-waals | TM5 | R | 232 | 5x68 | G.H5 | I | 345 | G.H5.16 |
Polar | ICL3 | C | 240 | - | G.H4 | E | 309 | G.H4.16 |
Ionic | ICL2 | R | 147 | 34x55 | G.s2s3 | E | 194 | G.s2s3.02 |
Polar | ICL2 | R | 147 | 34x55 | G.s2s3 | E | 194 | G.s2s3.02 |
Hydrophobic | ICL2 | R | 147 | 34x55 | G.s2s3 | E | 194 | G.s2s3.02 |
Van-der-waals | ICL2 | R | 147 | 34x55 | G.s2s3 | E | 194 | G.s2s3.02 |
Hydrophobic | ICL2 | M | 143 | 34x51 | G.H5 | F | 337 | G.H5.08 |
Polar | TM6 | K | 247 | 6x32 | G.H5 | C | 355 | G.H5.26 |
Hydrophobic | TM6 | K | 247 | 6x32 | G.H5 | C | 355 | G.H5.26 |
Van-der-waals | TM6 | K | 247 | 6x32 | G.H5 | C | 355 | G.H5.26 |
Hydrophobic | TM6 | L | 251 | 6x36 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | C-term | I | 346 | - | G.h3s5 | I | 261 | G.h3s5.01 |
Hydrophobic | C-term | W | 351 | - | G.H2 | K | 211 | G.H2.06 |
Van-der-waals | C-term | W | 351 | - | G.H2 | K | 211 | G.H2.06 |
Aromatic | C-term | F | 350 | - | G.H3 | W | 259 | G.H3.17 |
Hydrophobic | C-term | F | 350 | - | G.H3 | W | 259 | G.H3.17 |
Van-der-waals | C-term | F | 350 | - | G.H3 | W | 259 | G.H3.17 |
Hydrophobic | TM6 | I | 252 | 6x37 | G.H5 | L | 354 | G.H5.25 |
Ionic | ICL3 | R | 243 | - | G.h4s6 | E | 316 | G.h4s6.09 |
Polar | ICL3 | R | 243 | - | G.h4s6 | E | 316 | G.h4s6.09 |
Hydrophobic | ICL3 | R | 243 | - | G.h4s6 | E | 316 | G.h4s6.09 |
Van-der-waals | ICL3 | R | 243 | - | G.h4s6 | E | 316 | G.h4s6.09 |
Polar | TM4 | Q | 149 | 4x37 | G.HN | Q | 28 | G.HN.52 |
Hydrophobic | C-term | W | 351 | - | G.H2 | K | 210 | G.H2.05 |
Van-der-waals | C-term | W | 351 | - | G.H2 | K | 210 | G.H2.05 |
Polar | H8 | G | 316 | 8x47 | G.H5 | G | 353 | G.H5.24 |
Hydrophobic | H8 | G | 316 | 8x47 | G.H5 | G | 353 | G.H5.24 |
Van-der-waals | H8 | G | 316 | 8x47 | G.H5 | G | 353 | G.H5.24 |
Hydrophobic | ICL2 | M | 143 | 34x51 | G.H5 | T | 341 | G.H5.12 |
Van-der-waals | ICL2 | M | 143 | 34x51 | G.H5 | T | 341 | G.H5.12 |
Polar | ICL2 | R | 146 | 34x54 | G.h2s4 | T | 220 | G.h2s4.05 |
Hydrophobic | H8 | L | 318 | 8x49 | G.H5 | Y | 351 | G.H5.22 |
Polar | C-term | I | 346 | - | G.H3 | N | 258 | G.H3.16 |
Hydrophobic | C-term | I | 346 | - | G.H3 | N | 258 | G.H3.16 |
Van-der-waals | C-term | I | 346 | - | G.H3 | N | 258 | G.H3.16 |
Hydrophobic | ICL2 | P | 142 | 34x50 | G.H5 | T | 341 | G.H5.12 |
Van-der-waals | ICL2 | P | 142 | 34x50 | G.H5 | T | 341 | G.H5.12 |
Polar | TM5 | R | 232 | 5x68 | G.H5 | D | 338 | G.H5.09 |
Ionic | TM5 | R | 239 | 5x75 | G.H5 | D | 338 | G.H5.09 |
Polar | TM6 | T | 248 | 6x33 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM6 | T | 248 | 6x33 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM2 | A | 72 | 2x39 | G.H5 | I | 352 | G.H5.23 |
Hydrophobic | TM3 | L | 139 | 3x54 | G.H5 | N | 348 | G.H5.19 |
Polar | ICL2 | R | 146 | 34x54 | G.S1 | E | 33 | G.S1.01 |
Ionic | TM5 | R | 239 | 5x75 | G.H5 | D | 342 | G.H5.13 |
Hydrophobic | ICL2 | M | 143 | 34x51 | G.H5 | I | 344 | G.H5.15 |
Van-der-waals | ICL2 | M | 143 | 34x51 | G.H5 | I | 344 | G.H5.15 |
Hydrophobic | ICL2 | M | 143 | 34x51 | G.H5 | V | 340 | G.H5.11 |
Hydrophobic | TM3 | L | 139 | 3x54 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | C-term | F | 347 | - | G.H3 | W | 259 | G.H3.17 |
Hydrophobic | TM3 | L | 139 | 3x54 | G.H5 | L | 349 | G.H5.20 |
Van-der-waals | TM3 | L | 139 | 3x54 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | ICL2 | R | 146 | 34x54 | G.S1 | I | 34 | G.S1.02 |
Hydrophobic | C-term | F | 350 | - | G.H3 | N | 258 | G.H3.16 |
Van-der-waals | C-term | F | 350 | - | G.H3 | N | 258 | G.H3.16 |
Polar | TM5 | R | 232 | 5x68 | G.H5 | T | 341 | G.H5.12 |
Hydrophobic | TM5 | R | 232 | 5x68 | G.H5 | T | 341 | G.H5.12 |
Van-der-waals | TM5 | R | 232 | 5x68 | G.H5 | T | 341 | G.H5.12 |