G12 - B2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 85.6

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 12.1


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 V 250 5x64 G.H5 L 371 G.H5.16
Hydrophobic TM6 A 268 6x33 G.H5 L 375 G.H5.20
Hydrophobic ICL2 M 163 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 M 163 34x51 G.S3 I 221 G.S3.01
Hydrophobic ICL2 M 163 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 M 163 34x51 G.H5 I 370 G.H5.15
Ionic TM5 E 255 5x69 G.H5 H 364 G.H5.09
Polar TM5 E 255 5x69 G.H5 H 364 G.H5.09
Hydrophobic TM5 E 255 5x69 G.H5 H 364 G.H5.09
Van-der-waals TM5 E 255 5x69 G.H5 H 364 G.H5.09
Hydrophobic TM2 A 92 2x39 G.H5 I 378 G.H5.23
Hydrophobic ICL3 F 259 - G.h4s6 P 345 G.h4s6.20
Van-der-waals ICL3 F 259 - G.h4s6 P 345 G.h4s6.20
Hydrophobic ICL2 R 167 34x55 G.S1 V 58 G.S1.02
Van-der-waals ICL2 R 167 34x55 G.S1 V 58 G.S1.02
Polar ICL2 R 167 34x55 G.h2s4 T 246 G.h2s4.05
Van-der-waals ICL2 R 167 34x55 G.h2s4 T 246 G.h2s4.05
Hydrophobic TM5 V 250 5x64 G.H5 K 367 G.H5.12
Ionic ICL3 K 260 - G.H5 D 368 G.H5.13
Polar ICL3 K 260 - G.H5 D 368 G.H5.13
Hydrophobic ICL3 K 260 - G.H5 D 368 G.H5.13
Van-der-waals ICL3 K 260 - G.H5 D 368 G.H5.13
Hydrophobic TM7 V 333 7x54 G.H5 L 380 G.H5.25
Hydrophobic H8 K 337 8x48 G.H5 Q 381 G.H5.26
Hydrophobic ICL2 M 163 34x51 G.S1 V 58 G.S1.02
Van-der-waals ICL2 M 163 34x51 G.S1 V 58 G.S1.02
Polar H8 R 338 8x49 G.H5 L 380 G.H5.25
Hydrophobic H8 R 338 8x49 G.H5 L 380 G.H5.25
Van-der-waals H8 R 338 8x49 G.H5 L 380 G.H5.25
Hydrophobic ICL2 T 162 34x50 G.H5 I 370 G.H5.15
Van-der-waals ICL2 T 162 34x50 G.H5 I 370 G.H5.15
Polar ICL2 R 167 34x55 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 R 167 34x55 G.hns1 R 55 G.hns1.02
Hydrophobic TM5 M 256 5x70 G.H5 H 364 G.H5.09
Van-der-waals TM5 M 256 5x70 G.H5 H 364 G.H5.09
Hydrophobic TM5 M 256 5x70 G.H5 A 365 G.H5.10
Hydrophobic TM2 E 93 2x40 G.H5 L 380 G.H5.25
Polar H8 K 337 8x48 G.H5 L 380 G.H5.25
Van-der-waals H8 K 337 8x48 G.H5 L 380 G.H5.25
Polar H8 R 338 8x49 G.H5 Q 381 G.H5.26
Hydrophobic H8 R 338 8x49 G.H5 Q 381 G.H5.26
Van-der-waals H8 R 338 8x49 G.H5 Q 381 G.H5.26
Polar TM2 T 90 2x37 G.H5 D 377 G.H5.22
Hydrophobic TM2 T 90 2x37 G.H5 D 377 G.H5.22
Van-der-waals TM2 T 90 2x37 G.H5 D 377 G.H5.22
Hydrophobic TM6 E 265 6x30 G.H5 L 375 G.H5.20
Polar ICL2 R 167 34x55 G.S1 L 57 G.S1.01
Hydrophobic ICL2 R 167 34x55 G.S1 L 57 G.S1.01
Van-der-waals ICL2 R 167 34x55 G.S1 L 57 G.S1.01
Polar TM6 E 265 6x30 G.H5 Q 372 G.H5.17
Van-der-waals TM6 E 265 6x30 G.H5 Q 372 G.H5.17
Hydrophobic TM5 M 256 5x70 G.H5 D 368 G.H5.13
Hydrophobic ICL2 M 163 34x51 G.H5 K 367 G.H5.12
Van-der-waals ICL2 M 163 34x51 G.H5 K 367 G.H5.12
Aromatic ICL3 F 259 - G.S6 H 348 G.S6.03
Hydrophobic ICL3 F 259 - G.S6 H 348 G.S6.03
Van-der-waals ICL3 F 259 - G.S6 H 348 G.S6.03
Hydrophobic H8 G 336 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 G 336 8x47 G.H5 L 380 G.H5.25
Polar ICL2 S 164 34x52 G.hns1 R 56 G.hns1.03
Hydrophobic TM3 L 159 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 L 159 3x54 G.H5 L 371 G.H5.16
Ionic TM5 E 255 5x69 G.H5 R 360 G.H5.05
Polar TM5 E 255 5x69 G.H5 R 360 G.H5.05
Van-der-waals TM5 E 255 5x69 G.H5 R 360 G.H5.05
Hydrophobic ICL3 F 259 - G.H5 F 361 G.H5.06
Van-der-waals ICL3 F 259 - G.H5 F 361 G.H5.06
Hydrophobic C-term T 369 - G.H3 L 285 G.H3.17
Hydrophobic ICL2 M 163 34x51 G.H5 V 366 G.H5.11
Hydrophobic ICL2 R 169 34x57 G.H5 I 378 G.H5.23
Van-der-waals ICL2 R 169 34x57 G.H5 I 378 G.H5.23
Hydrophobic TM3 A 158 3x53 G.H5 I 378 G.H5.23
Van-der-waals TM3 A 158 3x53 G.H5 I 378 G.H5.23
Polar ICL2 R 169 34x57 G.H5 N 374 G.H5.19
Polar C-term G 368 - G.H3 K 284 G.H3.16
Hydrophobic C-term G 368 - G.H3 K 284 G.H3.16
Van-der-waals C-term G 368 - G.H3 K 284 G.H3.16
Ionic H8 R 338 8x49 G.H5 D 377 G.H5.22
Polar H8 R 338 8x49 G.H5 D 377 G.H5.22
Hydrophobic H8 R 338 8x49 G.H5 D 377 G.H5.22
Van-der-waals H8 R 338 8x49 G.H5 D 377 G.H5.22
Polar C-term T 372 - G.H3 K 284 G.H3.16
Hydrophobic C-term T 372 - G.H3 K 284 G.H3.16
Van-der-waals C-term T 372 - G.H3 K 284 G.H3.16
Hydrophobic TM5 M 256 5x70 G.H5 F 361 G.H5.06
Hydrophobic TM3 R 155 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 155 3x50 G.H5 I 378 G.H5.23
Ionic ICL2 R 169 34x57 G.H5 D 377 G.H5.22
Polar ICL2 R 169 34x57 G.H5 D 377 G.H5.22
Hydrophobic TM3 L 159 3x54 G.H5 L 375 G.H5.20
Hydrophobic TM5 L 251 5x65 G.H5 L 371 G.H5.16
Van-der-waals C-term I 380 - G.H2 Q 236 G.H2.05
Polar TM6 T 264 6x29 G.H5 Q 372 G.H5.17
Van-der-waals TM6 T 264 6x29 G.H5 Q 372 G.H5.17
Hydrophobic TM6 T 264 6x29 G.H5 L 375 G.H5.20
Hydrophobic ICL2 R 167 34x55 G.H5 I 370 G.H5.15
Van-der-waals ICL2 R 167 34x55 G.H5 I 370 G.H5.15
Hydrophobic ICL3 K 260 - G.H5 Q 372 G.H5.17
Van-der-waals ICL3 K 260 - G.H5 Q 372 G.H5.17
Polar H8 R 338 8x49 G.H5 K 376 G.H5.21
Hydrophobic H8 R 338 8x49 G.H5 K 376 G.H5.21
Van-der-waals H8 R 338 8x49 G.H5 K 376 G.H5.21
Hydrophobic C-term V 376 - G.H2 Q 236 G.H2.05
Van-der-waals C-term V 376 - G.H2 Q 236 G.H2.05
Hydrophobic TM6 L 271 6x36 G.H5 M 379 G.H5.24
Van-der-waals TM6 L 271 6x36 G.H5 M 379 G.H5.24
Hydrophobic ICL2 M 163 34x51 G.S3 F 223 G.S3.03
Hydrophobic TM6 A 268 6x33 G.H5 M 379 G.H5.24
Hydrophobic ICL2 M 168 34x56 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 M 168 34x56 G.hns1 R 56 G.hns1.03
Hydrophobic ICL3 K 260 - G.h4s6 P 345 G.h4s6.20
Hydrophobic TM2 L 96 2x43 G.H5 L 380 G.H5.25
Van-der-waals TM2 L 96 2x43 G.H5 L 380 G.H5.25
Polar ICL2 R 169 34x57 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 R 169 34x57 G.hns1 R 55 G.hns1.02
Hydrophobic TM5 L 251 5x65 G.H5 L 375 G.H5.20
Polar TM3 A 158 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 A 158 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 A 158 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 R 155 3x50 G.H5 M 379 G.H5.24
Polar H8 F 339 8x50 G.H5 L 380 G.H5.25
Hydrophobic H8 F 339 8x50 G.H5 L 380 G.H5.25
Polar TM5 N 254 5x68 G.H5 D 368 G.H5.13
Hydrophobic TM5 N 254 5x68 G.H5 D 368 G.H5.13
Van-der-waals TM5 N 254 5x68 G.H5 D 368 G.H5.13
Hydrophobic TM3 L 159 3x54 G.H5 N 374 G.H5.19
Polar C-term R 371 - G.H3 K 284 G.H3.16
Hydrophobic C-term R 371 - G.H3 K 284 G.H3.16
Van-der-waals C-term R 371 - G.H3 K 284 G.H3.16
Polar C-term Q 379 - G.h4s6 R 340 G.h4s6.09
Van-der-waals C-term Q 379 - G.h4s6 R 340 G.h4s6.09
Hydrophobic TM5 M 256 5x70 G.S6 F 347 G.S6.02
Hydrophobic ICL2 T 162 34x50 G.H5 L 371 G.H5.16
Polar ICL2 R 167 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 R 167 34x55 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 R 167 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic TM6 V 272 6x37 G.H5 M 379 G.H5.24
Hydrophobic ICL3 F 259 - G.S6 F 347 G.S6.02
Hydrophobic ICL3 F 259 - G.S6 L 346 G.S6.01