Gi2 -
BB3 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 80.1
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 13.2
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM6 | R | 266 | 6x30 | G.H5 | L | 349 | G.H5.20 |
Van-der-waals | TM6 | R | 266 | 6x30 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | ICL3 | E | 255 | - | G.H5 | F | 335 | G.H5.06 |
Van-der-waals | ICL3 | E | 255 | - | G.H5 | F | 335 | G.H5.06 |
Hydrophobic | TM6 | V | 273 | 6x37 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM2 | N | 83 | 2x40 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM2 | N | 83 | 2x40 | G.H5 | L | 354 | G.H5.25 |
Polar | ICL2 | L | 153 | 34x51 | G.H5 | N | 348 | G.H5.19 |
Van-der-waals | ICL2 | L | 153 | 34x51 | G.H5 | N | 348 | G.H5.19 |
Hydrophobic | ICL2 | P | 157 | 34x55 | G.hns1 | A | 31 | G.hns1.02 |
Van-der-waals | ICL2 | P | 157 | 34x55 | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | C-term | L | 362 | - | G.H3 | W | 259 | G.H3.17 |
Hydrophobic | ICL2 | L | 153 | 34x51 | G.H5 | I | 345 | G.H5.16 |
Van-der-waals | ICL2 | L | 153 | 34x51 | G.H5 | I | 345 | G.H5.16 |
Polar | ICL2 | R | 155 | 34x53 | G.h2s4 | T | 220 | G.h2s4.05 |
Hydrophobic | ICL2 | R | 155 | 34x53 | G.h2s4 | T | 220 | G.h2s4.05 |
Van-der-waals | ICL2 | R | 155 | 34x53 | G.h2s4 | T | 220 | G.h2s4.05 |
Hydrophobic | C-term | L | 365 | - | G.H3 | S | 253 | G.H3.11 |
Van-der-waals | C-term | L | 365 | - | G.H3 | S | 253 | G.H3.11 |
Hydrophobic | TM4 | K | 163 | 4x41 | G.HN | R | 24 | G.HN.48 |
Polar | H8 | S | 334 | 8x47 | G.H5 | F | 355 | G.H5.26 |
Hydrophobic | C-term | A | 366 | - | G.H2 | K | 210 | G.H2.05 |
Van-der-waals | C-term | A | 366 | - | G.H2 | K | 210 | G.H2.05 |
Hydrophobic | C-term | V | 357 | - | G.H3 | N | 257 | G.H3.15 |
Hydrophobic | ICL3 | E | 255 | - | G.H5 | D | 338 | G.H5.09 |
Van-der-waals | ICL3 | E | 255 | - | G.H5 | D | 338 | G.H5.09 |
Polar | ICL2 | P | 152 | 34x50 | G.H5 | N | 348 | G.H5.19 |
Hydrophobic | ICL2 | P | 152 | 34x50 | G.H5 | N | 348 | G.H5.19 |
Van-der-waals | ICL2 | P | 152 | 34x50 | G.H5 | N | 348 | G.H5.19 |
Hydrophobic | TM6 | T | 272 | 6x36 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM6 | T | 272 | 6x36 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM6 | R | 268 | 6x32 | G.H5 | F | 355 | G.H5.26 |
Van-der-waals | TM6 | R | 268 | 6x32 | G.H5 | F | 355 | G.H5.26 |
Hydrophobic | TM2 | P | 82 | 2x39 | G.H5 | C | 352 | G.H5.23 |
Van-der-waals | TM2 | P | 82 | 2x39 | G.H5 | C | 352 | G.H5.23 |
Hydrophobic | ICL2 | L | 153 | 34x51 | G.H5 | I | 344 | G.H5.15 |
Hydrophobic | ICL2 | Q | 156 | 34x54 | G.hns1 | A | 31 | G.hns1.02 |
Van-der-waals | ICL2 | Q | 156 | 34x54 | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | ICL2 | P | 152 | 34x50 | G.H5 | I | 345 | G.H5.16 |
Van-der-waals | ICL2 | P | 152 | 34x50 | G.H5 | I | 345 | G.H5.16 |
Hydrophobic | C-term | F | 387 | - | H.HA | Q | 68 | H.HA.06 |
Van-der-waals | C-term | F | 387 | - | H.HA | Q | 68 | H.HA.06 |
Ionic | C-term | D | 359 | - | G.H3 | K | 258 | G.H3.16 |
Polar | C-term | D | 359 | - | G.H3 | K | 258 | G.H3.16 |
Hydrophobic | C-term | D | 359 | - | G.H3 | K | 258 | G.H3.16 |
Van-der-waals | C-term | D | 359 | - | G.H3 | K | 258 | G.H3.16 |
Hydrophobic | ICL2 | L | 153 | 34x51 | G.H5 | T | 341 | G.H5.12 |
Van-der-waals | ICL2 | L | 153 | 34x51 | G.H5 | T | 341 | G.H5.12 |
Hydrophobic | C-term | M | 368 | - | G.H2 | R | 206 | G.H2.01 |
Hydrophobic | C-term | V | 357 | - | G.H3 | K | 258 | G.H3.16 |
Van-der-waals | C-term | V | 357 | - | G.H3 | K | 258 | G.H3.16 |
Hydrophobic | ICL2 | R | 155 | 34x53 | G.hns1 | A | 31 | G.hns1.02 |
Van-der-waals | ICL2 | R | 155 | 34x53 | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | C-term | L | 365 | - | G.H3 | L | 250 | G.H3.08 |
Van-der-waals | C-term | L | 365 | - | G.H3 | L | 250 | G.H3.08 |
Hydrophobic | TM3 | A | 148 | 3x53 | G.H5 | C | 352 | G.H5.23 |
Van-der-waals | TM3 | A | 148 | 3x53 | G.H5 | C | 352 | G.H5.23 |
Van-der-waals | TM2 | T | 80 | 2x37 | G.H5 | D | 351 | G.H5.22 |
Hydrophobic | ICL2 | R | 155 | 34x53 | G.S1 | V | 34 | G.S1.02 |
Hydrophobic | ICL2 | L | 153 | 34x51 | G.s2s3 | K | 193 | G.s2s3.01 |
Hydrophobic | TM3 | A | 148 | 3x53 | G.H5 | L | 349 | G.H5.20 |
Van-der-waals | TM3 | A | 148 | 3x53 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | C-term | V | 384 | - | G.hfs2 | V | 180 | G.hfs2.03 |
Ionic | TM6 | K | 261 | 6x25 | G.h4s6 | E | 319 | G.h4s6.12 |
Polar | TM6 | K | 261 | 6x25 | G.h4s6 | E | 319 | G.h4s6.12 |
Van-der-waals | TM6 | K | 261 | 6x25 | G.h4s6 | E | 319 | G.h4s6.12 |
Polar | TM3 | R | 145 | 3x50 | G.H5 | C | 352 | G.H5.23 |
Hydrophobic | TM3 | R | 145 | 3x50 | G.H5 | C | 352 | G.H5.23 |
Van-der-waals | TM3 | R | 145 | 3x50 | G.H5 | C | 352 | G.H5.23 |
Hydrophobic | TM6 | H | 258 | 6x22 | G.H5 | D | 342 | G.H5.13 |
Van-der-waals | TM6 | H | 258 | 6x22 | G.H5 | D | 342 | G.H5.13 |
Polar | C-term | T | 360 | - | G.H3 | N | 257 | G.H3.15 |
Hydrophobic | TM6 | I | 269 | 6x33 | G.H5 | L | 349 | G.H5.20 |
Van-der-waals | TM6 | I | 269 | 6x33 | G.H5 | L | 349 | G.H5.20 |
Polar | ICL2 | Q | 156 | 34x54 | G.H5 | C | 352 | G.H5.23 |
Hydrophobic | ICL2 | Q | 156 | 34x54 | G.H5 | C | 352 | G.H5.23 |
Van-der-waals | ICL2 | Q | 156 | 34x54 | G.H5 | C | 352 | G.H5.23 |
Polar | TM2 | T | 80 | 2x37 | G.H5 | G | 353 | G.H5.24 |
Hydrophobic | C-term | L | 365 | - | G.H3 | I | 254 | G.H3.12 |
Hydrophobic | ICL2 | P | 157 | 34x55 | G.HN | E | 28 | G.HN.52 |
Polar | TM6 | Q | 262 | 6x26 | G.H5 | D | 342 | G.H5.13 |
Hydrophobic | TM6 | Q | 262 | 6x26 | G.H5 | D | 342 | G.H5.13 |
Van-der-waals | TM6 | Q | 262 | 6x26 | G.H5 | D | 342 | G.H5.13 |
Hydrophobic | ICL2 | L | 153 | 34x51 | G.S3 | L | 195 | G.S3.01 |
Van-der-waals | ICL2 | L | 153 | 34x51 | G.S3 | L | 195 | G.S3.01 |
Hydrophobic | TM7 | L | 330 | 7x53 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | C-term | L | 362 | - | G.H3 | I | 254 | G.H3.12 |
Hydrophobic | TM6 | S | 265 | 6x29 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | TM6 | H | 258 | 6x22 | G.S6 | H | 323 | G.S6.04 |
Polar | ICL2 | S | 158 | 34x56 | G.HN | G | 27 | G.HN.51 |
Hydrophobic | TM2 | P | 82 | 2x39 | G.H5 | G | 353 | G.H5.24 |
Hydrophobic | C-term | I | 382 | - | H.HA | S | 75 | H.HA.13 |
Hydrophobic | TM2 | P | 82 | 2x39 | G.H5 | L | 354 | G.H5.25 |
Polar | ICL2 | R | 155 | 34x53 | G.S1 | E | 33 | G.S1.01 |
Van-der-waals | ICL2 | R | 155 | 34x53 | G.S1 | E | 33 | G.S1.01 |
Hydrophobic | TM6 | I | 269 | 6x33 | G.H5 | F | 355 | G.H5.26 |
Van-der-waals | TM6 | I | 269 | 6x33 | G.H5 | F | 355 | G.H5.26 |
Polar | H8 | S | 334 | 8x47 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | H8 | S | 334 | 8x47 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | H8 | S | 334 | 8x47 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | C-term | L | 362 | - | G.h2s4 | F | 216 | G.h2s4.01 |
Van-der-waals | C-term | L | 362 | - | G.h2s4 | F | 216 | G.h2s4.01 |
Aromatic | TM6 | H | 258 | 6x22 | G.S6 | Y | 321 | G.S6.02 |
Hydrophobic | TM6 | H | 258 | 6x22 | G.S6 | Y | 321 | G.S6.02 |
Van-der-waals | TM6 | H | 258 | 6x22 | G.S6 | Y | 321 | G.S6.02 |
Ionic | TM4 | K | 163 | 4x41 | G.HN | E | 28 | G.HN.52 |
Polar | TM4 | K | 163 | 4x41 | G.HN | E | 28 | G.HN.52 |
Hydrophobic | ICL3 | E | 254 | - | G.H5 | F | 335 | G.H5.06 |
Van-der-waals | ICL3 | E | 254 | - | G.H5 | F | 335 | G.H5.06 |
Polar | TM6 | A | 259 | 6x23 | G.H5 | D | 342 | G.H5.13 |
Hydrophobic | C-term | L | 362 | - | G.H3 | N | 257 | G.H3.15 |
Polar | ICL2 | R | 155 | 34x53 | G.H5 | N | 348 | G.H5.19 |
Hydrophobic | ICL2 | R | 155 | 34x53 | G.H5 | N | 348 | G.H5.19 |
Van-der-waals | ICL2 | R | 155 | 34x53 | G.H5 | N | 348 | G.H5.19 |
Hydrophobic | C-term | M | 368 | - | G.H3 | K | 249 | G.H3.07 |
Van-der-waals | C-term | M | 368 | - | G.H3 | K | 249 | G.H3.07 |
Hydrophobic | TM6 | Q | 262 | 6x26 | G.H5 | I | 345 | G.H5.16 |
Van-der-waals | TM6 | Q | 262 | 6x26 | G.H5 | I | 345 | G.H5.16 |
Polar | C-term | L | 365 | - | G.H2 | R | 209 | G.H2.04 |
Hydrophobic | C-term | L | 365 | - | G.H2 | R | 209 | G.H2.04 |
Hydrophobic | TM2 | I | 86 | 2x43 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM2 | I | 86 | 2x43 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | C-term | M | 368 | - | G.s4h3 | M | 241 | G.s4h3.14 |
Polar | H8 | S | 336 | 8x49 | G.H5 | F | 355 | G.H5.26 |
Hydrophobic | H8 | S | 336 | 8x49 | G.H5 | F | 355 | G.H5.26 |
Van-der-waals | H8 | S | 336 | 8x49 | G.H5 | F | 355 | G.H5.26 |
Hydrophobic | C-term | V | 357 | - | G.h4s6 | R | 314 | G.h4s6.04 |
Van-der-waals | C-term | V | 357 | - | G.h4s6 | R | 314 | G.h4s6.04 |