G13 -
C5a1 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 85.4
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 15.2
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
Gβ,
Gγ,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM3 | V | 138 | 3x54 | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | TM3 | V | 138 | 3x54 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | ICL2 | Q | 145 | 34x54 | G.H5 | I | 366 | G.H5.15 |
Van-der-waals | ICL2 | Q | 145 | 34x54 | G.H5 | I | 366 | G.H5.15 |
Polar | C-term | R | 330 | - | G.h2s4 | T | 241 | G.h2s4.05 |
Van-der-waals | C-term | R | 330 | - | G.h2s4 | T | 241 | G.h2s4.05 |
Hydrophobic | ICL2 | P | 141 | 34x50 | G.H5 | L | 367 | G.H5.16 |
Hydrophobic | C-term | V | 350 | - | G.H2 | R | 230 | G.H2.04 |
Van-der-waals | C-term | V | 350 | - | G.H2 | R | 230 | G.H2.04 |
Polar | C-term | Q | 348 | - | G.H2 | R | 230 | G.H2.04 |
Van-der-waals | C-term | Q | 348 | - | G.H2 | R | 230 | G.H2.04 |
Polar | C-term | Q | 348 | - | G.s4h3 | D | 259 | G.s4h3.11 |
Van-der-waals | C-term | Q | 348 | - | G.s4h3 | D | 259 | G.s4h3.11 |
Hydrophobic | C-term | A | 349 | - | G.H2 | R | 230 | G.H2.04 |
Van-der-waals | C-term | A | 349 | - | G.H2 | R | 230 | G.H2.04 |
Hydrophobic | C-term | V | 328 | - | G.H5 | Q | 373 | G.H5.22 |
Van-der-waals | C-term | V | 328 | - | G.H5 | Q | 373 | G.H5.22 |
Polar | C-term | V | 322 | - | G.H5 | Q | 377 | G.H5.26 |
Polar | C-term | R | 330 | - | G.hns1 | K | 46 | G.hns1.02 |
Polar | C-term | R | 330 | - | G.S1 | L | 48 | G.S1.01 |
Van-der-waals | C-term | R | 330 | - | G.S1 | L | 48 | G.S1.01 |
Hydrophobic | C-term | V | 350 | - | G.s1h1 | A | 56 | G.s1h1.02 |
Hydrophobic | ICL3 | T | 235 | - | G.H5 | H | 368 | G.H5.17 |
Hydrophobic | H8 | F | 307 | 8x50 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | H8 | F | 307 | 8x50 | G.H5 | L | 376 | G.H5.25 |
Polar | TM3 | R | 134 | 3x50 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | TM3 | R | 134 | 3x50 | G.H5 | Q | 377 | G.H5.26 |
Polar | ICL2 | N | 146 | 34x55 | G.s2s3 | N | 215 | G.s2s3.02 |
Van-der-waals | ICL2 | N | 146 | 34x55 | G.s2s3 | N | 215 | G.s2s3.02 |
Polar | C-term | E | 325 | - | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | C-term | E | 325 | - | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | C-term | E | 325 | - | G.H5 | Q | 377 | G.H5.26 |
Polar | TM6 | K | 239 | 6x32 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM6 | K | 239 | 6x32 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | ICL2 | Q | 145 | 34x54 | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | ICL2 | Q | 145 | 34x54 | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | C-term | A | 349 | - | G.H2 | R | 227 | G.H2.01 |
Hydrophobic | ICL3 | R | 236 | - | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | ICL2 | P | 141 | 34x50 | G.H5 | I | 366 | G.H5.15 |
Hydrophobic | TM3 | V | 138 | 3x54 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | ICL3 | T | 235 | - | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | ICL3 | T | 235 | - | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | C-term | A | 349 | - | G.H3 | E | 267 | G.H3.04 |
Polar | C-term | T | 339 | - | G.H2 | K | 231 | G.H2.05 |
Hydrophobic | C-term | T | 339 | - | G.H2 | K | 231 | G.H2.05 |
Van-der-waals | C-term | T | 339 | - | G.H2 | K | 231 | G.H2.05 |
Hydrophobic | ICL2 | I | 142 | 34x51 | G.H5 | K | 363 | G.H5.12 |
Hydrophobic | TM5 | T | 229 | 5x65 | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | TM5 | T | 229 | 5x65 | G.H5 | L | 371 | G.H5.20 |
Ionic | TM5 | R | 232 | 5x68 | G.H5 | D | 364 | G.H5.13 |
Polar | TM5 | R | 232 | 5x68 | G.H5 | D | 364 | G.H5.13 |
Hydrophobic | TM5 | R | 232 | 5x68 | G.H5 | D | 364 | G.H5.13 |
Van-der-waals | TM5 | R | 232 | 5x68 | G.H5 | D | 364 | G.H5.13 |
Hydrophobic | ICL3 | A | 234 | - | G.H5 | H | 368 | G.H5.17 |
Van-der-waals | ICL3 | A | 234 | - | G.H5 | H | 368 | G.H5.17 |
Hydrophobic | TM3 | R | 134 | 3x50 | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | TM3 | R | 134 | 3x50 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | C-term | E | 325 | - | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | C-term | E | 325 | - | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | C-term | V | 329 | - | G.H5 | Q | 373 | G.H5.22 |
Van-der-waals | C-term | V | 329 | - | G.H5 | Q | 373 | G.H5.22 |
Hydrophobic | TM6 | K | 239 | 6x32 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | TM6 | K | 239 | 6x32 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | C-term | V | 350 | - | G.H3 | I | 271 | G.H3.08 |
Van-der-waals | C-term | V | 350 | - | G.H3 | I | 271 | G.H3.08 |
Hydrophobic | ICL3 | T | 235 | - | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | ICL3 | T | 235 | - | G.H5 | M | 375 | G.H5.24 |
Polar | TM3 | L | 137 | 3x53 | G.H5 | N | 370 | G.H5.19 |
Hydrophobic | TM3 | L | 137 | 3x53 | G.H5 | N | 370 | G.H5.19 |
Van-der-waals | TM3 | L | 137 | 3x53 | G.H5 | N | 370 | G.H5.19 |
Hydrophobic | C-term | V | 328 | - | G.hns1 | K | 46 | G.hns1.02 |
Polar | C-term | L | 323 | - | G.H5 | Q | 377 | G.H5.26 |
Polar | TM6 | T | 240 | 6x33 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | TM6 | T | 240 | 6x33 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM6 | T | 240 | 6x33 | G.H5 | M | 375 | G.H5.24 |
Polar | C-term | S | 327 | - | G.H5 | Q | 373 | G.H5.22 |
Hydrophobic | C-term | S | 327 | - | G.H5 | Q | 373 | G.H5.22 |
Van-der-waals | C-term | S | 327 | - | G.H5 | Q | 373 | G.H5.22 |
Hydrophobic | TM3 | L | 137 | 3x53 | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | TM3 | L | 137 | 3x53 | G.H5 | L | 374 | G.H5.23 |
Polar | TM2 | N | 71 | 2x39 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | TM2 | N | 71 | 2x39 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | TM2 | N | 71 | 2x39 | G.H5 | Q | 377 | G.H5.26 |
Polar | TM6 | T | 240 | 6x33 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | TM6 | T | 240 | 6x33 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | TM6 | T | 240 | 6x33 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | ICL2 | I | 142 | 34x51 | G.H5 | F | 359 | G.H5.08 |
Van-der-waals | ICL2 | I | 142 | 34x51 | G.H5 | F | 359 | G.H5.08 |
Hydrophobic | H8 | F | 307 | 8x50 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | H8 | F | 307 | 8x50 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | ICL2 | N | 146 | 34x55 | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | ICL2 | N | 146 | 34x55 | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | ICL2 | P | 141 | 34x50 | G.H5 | K | 363 | G.H5.12 |
Hydrophobic | ICL2 | I | 142 | 34x51 | G.S3 | V | 216 | G.S3.01 |
Van-der-waals | ICL2 | I | 142 | 34x51 | G.S3 | V | 216 | G.S3.01 |
Polar | TM6 | T | 240 | 6x33 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | TM6 | T | 240 | 6x33 | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | TM6 | T | 240 | 6x33 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | TM3 | L | 137 | 3x53 | G.H5 | L | 367 | G.H5.16 |
Hydrophobic | C-term | V | 350 | - | G.s1h1 | G | 55 | G.s1h1.01 |
Van-der-waals | C-term | V | 350 | - | G.s1h1 | G | 55 | G.s1h1.01 |
Hydrophobic | TM5 | R | 232 | 5x68 | G.H5 | L | 367 | G.H5.16 |
Van-der-waals | TM5 | R | 232 | 5x68 | G.H5 | L | 367 | G.H5.16 |
Polar | C-term | R | 330 | - | G.hns1 | V | 45 | G.hns1.01 |
Hydrophobic | TM5 | R | 232 | 5x68 | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | ICL2 | P | 141 | 34x50 | G.H5 | N | 370 | G.H5.19 |
Polar | ICL3 | S | 237 | - | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | ICL3 | S | 237 | - | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | ICL3 | S | 237 | - | G.H5 | M | 375 | G.H5.24 |
Polar | ICL2 | R | 148 | 34x57 | G.hns1 | K | 46 | G.hns1.02 |
Van-der-waals | ICL2 | R | 148 | 34x57 | G.hns1 | K | 46 | G.hns1.02 |
Polar | TM6 | L | 241 | 6x34 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | TM3 | V | 138 | 3x54 | G.H5 | L | 367 | G.H5.16 |
Van-der-waals | TM3 | V | 138 | 3x54 | G.H5 | L | 367 | G.H5.16 |