Gi3 -
C5a1 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 84.5
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.1
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM3 | L | 137 | 3x53 | G.H5 | C | 351 | G.H5.23 |
Polar | TM6 | K | 239 | 6x32 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | TM6 | K | 239 | 6x32 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | TM6 | K | 239 | 6x32 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | C-term | E | 325 | - | G.H5 | E | 350 | G.H5.22 |
Hydrophobic | ICL2 | I | 142 | 34x51 | G.S3 | L | 194 | G.S3.01 |
Van-der-waals | ICL2 | I | 142 | 34x51 | G.S3 | L | 194 | G.S3.01 |
Polar | TM6 | K | 239 | 6x32 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | TM6 | K | 239 | 6x32 | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | TM6 | K | 239 | 6x32 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | ICL3 | T | 235 | - | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | ICL3 | T | 235 | - | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | ICL2 | I | 142 | 34x51 | G.s2s3 | D | 193 | G.s2s3.02 |
Hydrophobic | ICL3 | T | 235 | - | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | ICL3 | A | 234 | - | G.S6 | Y | 320 | G.S6.02 |
Van-der-waals | ICL3 | A | 234 | - | G.S6 | Y | 320 | G.S6.02 |
Polar | ICL3 | R | 233 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | ICL3 | R | 233 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Polar | ICL3 | A | 234 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | ICL3 | A | 234 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | ICL3 | A | 234 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | ICL3 | R | 236 | - | G.H5 | Y | 354 | G.H5.26 |
Polar | ICL3 | S | 237 | - | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | C-term | V | 350 | - | G.hfs2 | K | 180 | G.hfs2.04 |
Hydrophobic | ICL2 | Q | 145 | 34x54 | G.H5 | I | 343 | G.H5.15 |
Hydrophobic | ICL2 | P | 141 | 34x50 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | TM5 | R | 228 | 5x64 | G.H5 | I | 344 | G.H5.16 |
Polar | TM3 | R | 134 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM3 | R | 134 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | R | 134 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Polar | TM3 | L | 137 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM3 | L | 137 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | TM3 | L | 137 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | ICL3 | A | 234 | - | G.H5 | K | 345 | G.H5.17 |
Van-der-waals | ICL3 | A | 234 | - | G.H5 | K | 345 | G.H5.17 |
Polar | ICL2 | Q | 145 | 34x54 | G.hns1 | A | 31 | G.hns1.02 |
Van-der-waals | ICL2 | Q | 145 | 34x54 | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | ICL2 | Q | 145 | 34x54 | G.S3 | L | 194 | G.S3.01 |
Van-der-waals | ICL2 | Q | 145 | 34x54 | G.S3 | L | 194 | G.S3.01 |
Polar | ICL3 | A | 234 | - | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | ICL3 | A | 234 | - | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | ICL3 | A | 234 | - | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | C-term | F | 335 | - | G.h2s4 | E | 216 | G.h2s4.02 |
Van-der-waals | C-term | F | 335 | - | G.h2s4 | E | 216 | G.h2s4.02 |
Hydrophobic | TM3 | V | 138 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Ionic | C-term | R | 330 | - | G.HN | E | 28 | G.HN.52 |
Hydrophobic | C-term | R | 330 | - | G.HN | E | 28 | G.HN.52 |
Van-der-waals | C-term | R | 330 | - | G.HN | E | 28 | G.HN.52 |
Hydrophobic | C-term | E | 326 | - | G.H5 | E | 350 | G.H5.22 |
Hydrophobic | ICL2 | Q | 145 | 34x54 | G.hns1 | K | 32 | G.hns1.03 |
Van-der-waals | ICL2 | Q | 145 | 34x54 | G.hns1 | K | 32 | G.hns1.03 |
Hydrophobic | ICL3 | S | 237 | - | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | ICL3 | S | 237 | - | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | TM2 | N | 71 | 2x39 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | ICL3 | T | 235 | - | G.H5 | L | 348 | G.H5.20 |
Polar | TM6 | T | 240 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM6 | T | 240 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | T | 240 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Polar | ICL2 | N | 146 | 34x55 | G.s2s3 | D | 193 | G.s2s3.02 |
Van-der-waals | ICL2 | N | 146 | 34x55 | G.s2s3 | D | 193 | G.s2s3.02 |
Hydrophobic | C-term | T | 347 | - | G.hfs2 | V | 179 | G.hfs2.03 |
Hydrophobic | TM5 | T | 229 | 5x65 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM5 | T | 229 | 5x65 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | TM6 | K | 239 | 6x32 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | K | 239 | 6x32 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM3 | V | 138 | 3x54 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | TM3 | V | 138 | 3x54 | G.H5 | I | 344 | G.H5.16 |
Polar | C-term | R | 330 | - | G.HN | R | 24 | G.HN.48 |
Polar | C-term | V | 350 | - | H.HA | S | 75 | H.HA.13 |
Ionic | ICL2 | R | 148 | 34x57 | G.H5 | E | 350 | G.H5.22 |
Polar | ICL2 | R | 148 | 34x57 | G.H5 | E | 350 | G.H5.22 |
Van-der-waals | ICL2 | R | 148 | 34x57 | G.H5 | E | 350 | G.H5.22 |
Hydrophobic | TM6 | V | 244 | 6x37 | G.H5 | L | 353 | G.H5.25 |
Polar | TM2 | N | 71 | 2x39 | G.H5 | E | 350 | G.H5.22 |
Van-der-waals | TM2 | N | 71 | 2x39 | G.H5 | E | 350 | G.H5.22 |
Hydrophobic | TM3 | R | 134 | 3x50 | G.H5 | L | 353 | G.H5.25 |
Polar | TM5 | R | 232 | 5x68 | G.H5 | D | 337 | G.H5.09 |
Polar | C-term | S | 327 | - | G.H5 | E | 350 | G.H5.22 |
Hydrophobic | C-term | S | 327 | - | G.H5 | E | 350 | G.H5.22 |
Van-der-waals | C-term | S | 327 | - | G.H5 | E | 350 | G.H5.22 |
Polar | C-term | S | 327 | - | G.H5 | N | 346 | G.H5.18 |
Polar | C-term | V | 328 | - | G.H5 | E | 350 | G.H5.22 |
Hydrophobic | C-term | V | 328 | - | G.H5 | E | 350 | G.H5.22 |
Van-der-waals | C-term | V | 328 | - | G.H5 | E | 350 | G.H5.22 |
Hydrophobic | TM6 | V | 243 | 6x36 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | C-term | K | 333 | - | G.h2s4 | E | 216 | G.h2s4.02 |
Van-der-waals | C-term | K | 333 | - | G.h2s4 | E | 216 | G.h2s4.02 |
Hydrophobic | ICL2 | I | 142 | 34x51 | G.H5 | F | 336 | G.H5.08 |
Van-der-waals | ICL2 | I | 142 | 34x51 | G.H5 | F | 336 | G.H5.08 |
Polar | C-term | Q | 345 | - | G.H2 | K | 210 | G.H2.06 |
Polar | C-term | R | 330 | - | G.HN | G | 27 | G.HN.51 |
Hydrophobic | C-term | R | 330 | - | G.HN | G | 27 | G.HN.51 |
Van-der-waals | C-term | R | 330 | - | G.HN | G | 27 | G.HN.51 |
Ionic | TM5 | R | 228 | 5x64 | G.H5 | D | 341 | G.H5.13 |
Polar | TM5 | R | 228 | 5x64 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM5 | R | 228 | 5x64 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | ICL2 | P | 141 | 34x50 | G.H5 | I | 343 | G.H5.15 |
Van-der-waals | ICL2 | P | 141 | 34x50 | G.H5 | I | 343 | G.H5.15 |
Hydrophobic | ICL2 | P | 141 | 34x50 | G.H5 | T | 340 | G.H5.12 |
Van-der-waals | ICL2 | P | 141 | 34x50 | G.H5 | T | 340 | G.H5.12 |
Polar | ICL2 | N | 146 | 34x55 | G.hns1 | K | 32 | G.hns1.03 |
Hydrophobic | ICL2 | N | 146 | 34x55 | G.hns1 | K | 32 | G.hns1.03 |
Ionic | TM5 | R | 232 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Polar | TM5 | R | 232 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM5 | R | 232 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM5 | R | 232 | 5x68 | G.H5 | D | 341 | G.H5.13 |