G13 -
C5a2 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 76.2
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.5
iPTM Score: 0.3
PAE mean: 25.9
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | N-term | Y | 8 | - | G.H4 | Q | 323 | G.H4.08 |
Hydrophobic | N-term | Y | 8 | - | G.H4 | Q | 323 | G.H4.08 |
Van-der-waals | N-term | Y | 8 | - | G.H4 | Q | 323 | G.H4.08 |
Aromatic | N-term | Y | 10 | - | G.S6 | H | 345 | G.S6.04 |
Hydrophobic | N-term | Y | 10 | - | G.S6 | H | 345 | G.S6.04 |
Van-der-waals | N-term | Y | 10 | - | G.S6 | H | 345 | G.S6.04 |
Ionic | N-term | D | 22 | - | G.s2s3 | K | 214 | G.s2s3.01 |
Polar | N-term | D | 22 | - | G.s2s3 | K | 214 | G.s2s3.01 |
Hydrophobic | N-term | D | 22 | - | G.s2s3 | K | 214 | G.s2s3.01 |
Van-der-waals | N-term | D | 22 | - | G.s2s3 | K | 214 | G.s2s3.01 |
Polar | ECL2 | D | 189 | - | G.HN | T | 43 | G.HN.52 |
Hydrophobic | ECL2 | D | 189 | - | G.HN | T | 43 | G.HN.52 |
Van-der-waals | ECL2 | D | 189 | - | G.HN | T | 43 | G.HN.52 |
Hydrophobic | N-term | D | 12 | - | G.S6 | Y | 343 | G.S6.02 |
Van-der-waals | N-term | D | 12 | - | G.S6 | Y | 343 | G.S6.02 |
Polar | N-term | Y | 13 | - | G.S6 | H | 345 | G.S6.04 |
Aromatic | N-term | Y | 13 | - | G.S6 | H | 345 | G.S6.04 |
Hydrophobic | N-term | Y | 13 | - | G.S6 | H | 345 | G.S6.04 |
Van-der-waals | N-term | Y | 13 | - | G.S6 | H | 345 | G.S6.04 |
Hydrophobic | TM7 | L | 270 | 7x31 | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | TM7 | L | 270 | 7x31 | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | ECL2 | H | 179 | - | G.s2s3 | K | 214 | G.s2s3.01 |
Hydrophobic | N-term | V | 21 | - | G.H5 | H | 368 | G.H5.17 |
Van-der-waals | N-term | V | 21 | - | G.H5 | H | 368 | G.H5.17 |
Hydrophobic | ECL2 | E | 178 | - | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | ECL2 | E | 178 | - | G.H5 | L | 374 | G.H5.23 |
Polar | ECL2 | Y | 190 | - | G.HN | R | 40 | G.HN.49 |
Hydrophobic | ECL2 | Y | 190 | - | G.HN | R | 40 | G.HN.49 |
Van-der-waals | ECL2 | Y | 190 | - | G.HN | R | 40 | G.HN.49 |
Hydrophobic | ECL2 | F | 180 | - | G.S3 | V | 216 | G.S3.01 |
Van-der-waals | ECL2 | F | 180 | - | G.S3 | V | 216 | G.S3.01 |
Polar | TM5 | S | 193 | 5x32 | G.HN | K | 36 | G.HN.45 |
Hydrophobic | TM5 | S | 193 | 5x32 | G.HN | K | 36 | G.HN.45 |
Van-der-waals | TM5 | S | 193 | 5x32 | G.HN | K | 36 | G.HN.45 |
Polar | ECL2 | H | 179 | - | G.S3 | P | 217 | G.S3.02 |
Hydrophobic | ECL2 | H | 179 | - | G.S3 | P | 217 | G.S3.02 |
Van-der-waals | ECL2 | H | 179 | - | G.S3 | P | 217 | G.S3.02 |
Polar | N-term | Y | 10 | - | G.S6 | F | 346 | G.S6.05 |
Hydrophobic | N-term | Y | 10 | - | G.S6 | F | 346 | G.S6.05 |
Van-der-waals | N-term | Y | 10 | - | G.S6 | F | 346 | G.S6.05 |
Polar | ECL2 | H | 176 | - | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | ECL2 | H | 176 | - | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | ECL2 | H | 176 | - | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | N-term | Y | 8 | - | G.HG | T | 293 | G.HG.01 |
Van-der-waals | N-term | Y | 8 | - | G.HG | T | 293 | G.HG.01 |
Hydrophobic | N-term | V | 21 | - | G.H5 | L | 367 | G.H5.16 |
Van-der-waals | N-term | V | 21 | - | G.H5 | L | 367 | G.H5.16 |
Hydrophobic | ECL2 | G | 191 | - | G.HN | E | 41 | G.HN.50 |
Polar | ECL2 | H | 176 | - | G.HN | Y | 44 | G.HN.53 |
Hydrophobic | ECL2 | H | 176 | - | G.HN | Y | 44 | G.HN.53 |
Van-der-waals | ECL2 | H | 176 | - | G.HN | Y | 44 | G.HN.53 |
Polar | ECL2 | G | 192 | - | G.HN | L | 38 | G.HN.47 |
Van-der-waals | ECL2 | G | 192 | - | G.HN | L | 38 | G.HN.47 |
Polar | TM7 | S | 263 | 7x24 | G.h3s5 | N | 283 | G.h3s5.02 |
Hydrophobic | TM7 | S | 263 | 7x24 | G.h3s5 | N | 283 | G.h3s5.02 |
Van-der-waals | TM7 | S | 263 | 7x24 | G.h3s5 | N | 283 | G.h3s5.02 |
Polar | ECL2 | H | 179 | - | G.S3 | V | 216 | G.S3.01 |
Hydrophobic | ECL2 | H | 179 | - | G.S3 | V | 216 | G.S3.01 |
Van-der-waals | ECL2 | H | 179 | - | G.S3 | V | 216 | G.S3.01 |
Hydrophobic | ECL3 | P | 261 | - | G.H5 | Q | 377 | G.H5.26 |
Polar | ECL2 | H | 176 | - | G.hns1 | V | 45 | G.hns1.01 |
Hydrophobic | ECL2 | H | 176 | - | G.hns1 | V | 45 | G.hns1.01 |
Van-der-waals | ECL2 | H | 176 | - | G.hns1 | V | 45 | G.hns1.01 |
Polar | TM5 | T | 196 | 5x35 | G.HN | R | 40 | G.HN.49 |
Hydrophobic | TM5 | T | 196 | 5x35 | G.HN | R | 40 | G.HN.49 |
Van-der-waals | TM5 | T | 196 | 5x35 | G.HN | R | 40 | G.HN.49 |
Hydrophobic | N-term | L | 16 | - | G.S6 | Y | 343 | G.S6.02 |
Van-der-waals | N-term | L | 16 | - | G.S6 | Y | 343 | G.S6.02 |
Hydrophobic | ECL2 | A | 182 | - | G.s2s3 | N | 215 | G.s2s3.02 |
Van-der-waals | ECL2 | A | 182 | - | G.s2s3 | N | 215 | G.s2s3.02 |
Hydrophobic | TM1 | R | 35 | 1x32 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | ECL2 | Y | 190 | - | G.HN | K | 42 | G.HN.51 |
Van-der-waals | ECL2 | Y | 190 | - | G.HN | K | 42 | G.HN.51 |
Polar | ECL2 | V | 188 | 45x52 | G.HN | K | 42 | G.HN.51 |
Hydrophobic | ECL2 | V | 188 | 45x52 | G.HN | K | 42 | G.HN.51 |
Van-der-waals | ECL2 | V | 188 | 45x52 | G.HN | K | 42 | G.HN.51 |
Hydrophobic | ECL2 | V | 187 | 45x51 | G.HN | T | 43 | G.HN.52 |
Van-der-waals | ECL2 | V | 187 | 45x51 | G.HN | T | 43 | G.HN.52 |
Van-der-waals | ECL2 | G | 192 | - | G.HN | D | 35 | G.HN.44 |
Polar | N-term | D | 22 | - | G.H5 | D | 364 | G.H5.13 |
Van-der-waals | N-term | D | 22 | - | G.H5 | D | 364 | G.H5.13 |
Polar | TM6 | L | 256 | 6x58 | G.HN | K | 42 | G.HN.51 |
Van-der-waals | TM6 | L | 256 | 6x58 | G.HN | K | 42 | G.HN.51 |
Hydrophobic | ECL2 | R | 174 | - | G.hns1 | V | 45 | G.hns1.01 |
Polar | ECL3 | N | 262 | - | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | ECL3 | N | 262 | - | G.H5 | Q | 377 | G.H5.26 |
Polar | ECL2 | H | 179 | - | G.s2s3 | N | 215 | G.s2s3.02 |
Hydrophobic | ECL2 | H | 179 | - | G.s2s3 | N | 215 | G.s2s3.02 |
Van-der-waals | ECL2 | H | 179 | - | G.s2s3 | N | 215 | G.s2s3.02 |
Polar | N-term | D | 15 | - | G.H5 | K | 372 | G.H5.21 |
Polar | ECL2 | V | 188 | 45x52 | G.HN | T | 43 | G.HN.52 |
Hydrophobic | ECL2 | V | 188 | 45x52 | G.HN | T | 43 | G.HN.52 |
Van-der-waals | ECL2 | V | 188 | 45x52 | G.HN | T | 43 | G.HN.52 |
Polar | TM5 | S | 193 | 5x32 | G.HN | D | 35 | G.HN.44 |
Hydrophobic | TM5 | S | 193 | 5x32 | G.HN | D | 35 | G.HN.44 |
Van-der-waals | TM5 | S | 193 | 5x32 | G.HN | D | 35 | G.HN.44 |
Polar | N-term | S | 17 | - | G.H5 | H | 368 | G.H5.17 |
Hydrophobic | N-term | L | 24 | - | G.s2s3 | K | 214 | G.s2s3.01 |
Polar | ECL2 | H | 179 | - | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | ECL2 | H | 179 | - | G.hns1 | K | 46 | G.hns1.02 |
Van-der-waals | ECL2 | H | 179 | - | G.hns1 | K | 46 | G.hns1.02 |
Polar | ECL2 | H | 176 | - | G.S1 | L | 48 | G.S1.01 |
Hydrophobic | N-term | Y | 13 | - | G.H5 | T | 365 | G.H5.14 |
Van-der-waals | N-term | Y | 13 | - | G.H5 | T | 365 | G.H5.14 |
Hydrophobic | N-term | V | 21 | - | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | N-term | V | 21 | - | G.H5 | L | 371 | G.H5.20 |
Polar | ECL2 | G | 191 | - | G.HN | R | 40 | G.HN.49 |
Hydrophobic | ECL2 | G | 191 | - | G.HN | R | 40 | G.HN.49 |
Van-der-waals | ECL2 | G | 191 | - | G.HN | R | 40 | G.HN.49 |
Polar | ECL2 | Q | 177 | - | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | ECL2 | Q | 177 | - | G.hns1 | K | 46 | G.hns1.02 |
Van-der-waals | ECL2 | Q | 177 | - | G.hns1 | K | 46 | G.hns1.02 |
Ionic | TM5 | E | 197 | 5x36 | G.HN | K | 42 | G.HN.51 |
Polar | TM5 | E | 197 | 5x36 | G.HN | K | 42 | G.HN.51 |
Hydrophobic | TM5 | E | 197 | 5x36 | G.HN | K | 42 | G.HN.51 |
Van-der-waals | TM5 | E | 197 | 5x36 | G.HN | K | 42 | G.HN.51 |
Polar | ECL2 | H | 176 | - | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | ECL2 | H | 176 | - | G.hns1 | K | 46 | G.hns1.02 |
Van-der-waals | ECL2 | H | 176 | - | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | TM7 | R | 271 | 7x32 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | ECL2 | F | 180 | - | G.H5 | L | 367 | G.H5.16 |
Van-der-waals | ECL2 | F | 180 | - | G.H5 | L | 367 | G.H5.16 |
Hydrophobic | TM7 | A | 264 | 7x25 | G.h4s6 | Q | 339 | G.h4s6.13 |
Van-der-waals | TM7 | A | 264 | 7x25 | G.h4s6 | Q | 339 | G.h4s6.13 |
Hydrophobic | ECL2 | R | 174 | - | G.HN | T | 43 | G.HN.52 |
Polar | N-term | Y | 13 | - | G.S6 | H | 344 | G.S6.03 |
Hydrophobic | N-term | Y | 13 | - | G.S6 | H | 344 | G.S6.03 |
Van-der-waals | N-term | Y | 13 | - | G.S6 | H | 344 | G.S6.03 |
Polar | ECL3 | N | 262 | - | G.H5 | Q | 373 | G.H5.22 |
Hydrophobic | ECL3 | N | 262 | - | G.H5 | Q | 373 | G.H5.22 |
Van-der-waals | ECL3 | N | 262 | - | G.H5 | Q | 373 | G.H5.22 |
Hydrophobic | N-term | P | 20 | - | G.H5 | D | 364 | G.H5.13 |
Van-der-waals | N-term | P | 20 | - | G.H5 | D | 364 | G.H5.13 |
Polar | TM5 | S | 193 | 5x32 | G.HN | R | 40 | G.HN.49 |
Hydrophobic | TM5 | S | 193 | 5x32 | G.HN | R | 40 | G.HN.49 |
Van-der-waals | TM5 | S | 193 | 5x32 | G.HN | R | 40 | G.HN.49 |
Hydrophobic | TM7 | L | 266 | 7x27 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | TM7 | L | 266 | 7x27 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | N-term | L | 16 | - | G.H5 | T | 365 | G.H5.14 |
Van-der-waals | N-term | L | 16 | - | G.H5 | T | 365 | G.H5.14 |
Ionic | N-term | D | 12 | - | G.H4 | R | 331 | G.H4.16 |
Polar | N-term | D | 12 | - | G.H4 | R | 331 | G.H4.16 |
Van-der-waals | N-term | D | 12 | - | G.H4 | R | 331 | G.H4.16 |
Polar | TM5 | S | 194 | 5x33 | G.HN | S | 39 | G.HN.48 |
Hydrophobic | TM5 | S | 194 | 5x33 | G.HN | S | 39 | G.HN.48 |
Van-der-waals | TM5 | S | 194 | 5x33 | G.HN | S | 39 | G.HN.48 |
Hydrophobic | ECL2 | F | 180 | - | G.S2 | I | 213 | G.S2.08 |
Van-der-waals | ECL2 | F | 180 | - | G.S2 | I | 213 | G.S2.08 |
Ionic | N-term | D | 22 | - | G.H5 | K | 363 | G.H5.12 |
Polar | N-term | D | 22 | - | G.H5 | K | 363 | G.H5.12 |
Hydrophobic | N-term | D | 22 | - | G.H5 | K | 363 | G.H5.12 |
Van-der-waals | N-term | D | 22 | - | G.H5 | K | 363 | G.H5.12 |
Hydrophobic | N-term | D | 12 | - | G.h4s6 | P | 341 | G.h4s6.20 |
Polar | ECL3 | P | 261 | - | G.h3s5 | N | 283 | G.h3s5.02 |
Hydrophobic | ECL3 | P | 261 | - | G.h3s5 | N | 283 | G.h3s5.02 |
Van-der-waals | ECL3 | P | 261 | - | G.h3s5 | N | 283 | G.h3s5.02 |
Hydrophobic | ECL3 | N | 262 | - | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | ECL3 | N | 262 | - | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | TM7 | S | 263 | 7x24 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | TM7 | S | 263 | 7x24 | G.H5 | L | 376 | G.H5.25 |
Aromatic | N-term | Y | 8 | - | G.S6 | F | 346 | G.S6.05 |
Hydrophobic | N-term | Y | 8 | - | G.S6 | F | 346 | G.S6.05 |
Van-der-waals | N-term | Y | 8 | - | G.S6 | F | 346 | G.S6.05 |
Polar | TM5 | S | 193 | 5x32 | G.HN | S | 39 | G.HN.48 |
Hydrophobic | TM5 | S | 193 | 5x32 | G.HN | S | 39 | G.HN.48 |
Van-der-waals | TM5 | S | 193 | 5x32 | G.HN | S | 39 | G.HN.48 |
Hydrophobic | ECL2 | V | 187 | 45x51 | G.HN | Y | 44 | G.HN.53 |
Van-der-waals | ECL2 | V | 187 | 45x51 | G.HN | Y | 44 | G.HN.53 |
Polar | ECL2 | G | 192 | - | G.HN | R | 40 | G.HN.49 |
Hydrophobic | ECL2 | G | 192 | - | G.HN | R | 40 | G.HN.49 |
Van-der-waals | ECL2 | G | 192 | - | G.HN | R | 40 | G.HN.49 |
Hydrophobic | ECL2 | F | 180 | - | G.s2s3 | K | 214 | G.s2s3.01 |
Van-der-waals | ECL2 | F | 180 | - | G.s2s3 | K | 214 | G.s2s3.01 |
Ionic | N-term | D | 12 | - | G.S6 | H | 344 | G.S6.03 |
Polar | N-term | D | 12 | - | G.S6 | H | 344 | G.S6.03 |
Hydrophobic | N-term | D | 12 | - | G.S6 | H | 344 | G.S6.03 |
Van-der-waals | N-term | D | 12 | - | G.S6 | H | 344 | G.S6.03 |
Hydrophobic | N-term | D | 22 | - | G.H5 | L | 367 | G.H5.16 |
Polar | ECL3 | N | 262 | - | G.h3s5 | N | 283 | G.h3s5.02 |
Hydrophobic | ECL3 | N | 262 | - | G.h3s5 | N | 283 | G.h3s5.02 |
Van-der-waals | ECL3 | N | 262 | - | G.h3s5 | N | 283 | G.h3s5.02 |
Hydrophobic | TM7 | L | 270 | 7x31 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | TM7 | L | 270 | 7x31 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | TM7 | L | 270 | 7x31 | G.H5 | L | 376 | G.H5.25 |
Polar | ECL2 | G | 192 | - | G.HN | S | 39 | G.HN.48 |
Hydrophobic | ECL2 | G | 192 | - | G.HN | S | 39 | G.HN.48 |
Van-der-waals | ECL2 | G | 192 | - | G.HN | S | 39 | G.HN.48 |
Hydrophobic | N-term | L | 16 | - | G.H5 | H | 368 | G.H5.17 |
Hydrophobic | ECL2 | G | 192 | - | G.HN | K | 36 | G.HN.45 |
Van-der-waals | ECL2 | G | 192 | - | G.HN | K | 36 | G.HN.45 |
Ionic | ECL2 | H | 179 | - | G.S2 | E | 212 | G.S2.07 |
Hydrophobic | ECL2 | H | 179 | - | G.S2 | E | 212 | G.S2.07 |
Hydrophobic | TM7 | L | 270 | 7x31 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM7 | L | 270 | 7x31 | G.H5 | M | 375 | G.H5.24 |
Polar | TM4 | Y | 172 | 4x64 | G.HN | R | 40 | G.HN.49 |
Hydrophobic | ECL2 | Q | 185 | - | G.HN | Y | 44 | G.HN.53 |
Van-der-waals | ECL2 | Q | 185 | - | G.HN | Y | 44 | G.HN.53 |
Hydrophobic | N-term | D | 12 | - | G.S6 | L | 342 | G.S6.01 |
Van-der-waals | TM7 | A | 267 | 7x28 | G.H5 | M | 375 | G.H5.24 |
Aromatic | ECL2 | F | 180 | - | G.S3 | F | 218 | G.S3.03 |
Hydrophobic | ECL2 | F | 180 | - | G.S3 | F | 218 | G.S3.03 |
Van-der-waals | ECL2 | F | 180 | - | G.S3 | F | 218 | G.S3.03 |
Polar | N-term | V | 21 | - | G.H5 | D | 364 | G.H5.13 |
Hydrophobic | N-term | V | 21 | - | G.H5 | D | 364 | G.H5.13 |
Van-der-waals | N-term | V | 21 | - | G.H5 | D | 364 | G.H5.13 |
Hydrophobic | N-term | Y | 10 | - | G.S6 | H | 344 | G.S6.03 |
Van-der-waals | N-term | Y | 10 | - | G.S6 | H | 344 | G.S6.03 |
Van-der-waals | ECL2 | R | 183 | - | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | TM7 | A | 267 | 7x28 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | TM7 | A | 267 | 7x28 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | TM7 | L | 266 | 7x27 | G.H5 | Q | 377 | G.H5.26 |
Polar | TM7 | R | 268 | 7x29 | G.h4s6 | Q | 339 | G.h4s6.13 |
Hydrophobic | ECL2 | C | 186 | 45x50 | G.HN | Y | 44 | G.HN.53 |
Van-der-waals | ECL2 | C | 186 | 45x50 | G.HN | Y | 44 | G.HN.53 |
Aromatic | N-term | Y | 13 | - | G.S6 | Y | 343 | G.S6.02 |
Hydrophobic | N-term | Y | 13 | - | G.S6 | Y | 343 | G.S6.02 |
Van-der-waals | N-term | Y | 13 | - | G.S6 | Y | 343 | G.S6.02 |
Polar | ECL2 | G | 192 | - | G.HN | C | 37 | G.HN.46 |
Hydrophobic | ECL2 | G | 192 | - | G.HN | C | 37 | G.HN.46 |
Van-der-waals | ECL2 | G | 192 | - | G.HN | C | 37 | G.HN.46 |